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Swiss Medical Weekly

Marie-Caroline Loustalot, Sarah Berdot, Pierre Sabatier, Pierre Durieux, Germain Perrin, Alexandre Karras, Brigitte Sabatier
AIMS OF THE STUDY: This study assesses clinical interventions by pharmacists prospectively collected from medical and surgical wards, notably the acceptance of interventions, computerised physician order entry (CPOE)related problems, the potential impact of interventions on patient safety evaluated by a multidisciplinary committee, and their evolution over the 10 years since a first assessment. METHODS: A prospective observational study covering 13 months was conducted in a French teaching hospital with a patient information system that integrates an electronic health record (EHR) with a CPOE...
February 11, 2019: Swiss Medical Weekly
Christoph A Meier
No abstract text is available yet for this article.
February 11, 2019: Swiss Medical Weekly
Laure Cochand, Eric Masserey, Patrick Bodenmann, Nicolas Troillet
OBJECTIVE: To evaluate the feasibility of HIV screening, offered to newly arrived asylum seekers in the Swiss cantons of Valais (VS) and Vaud (VD) in order to meet the national and international standards for early detection and effective treatment of HIV infections. METHODS: HIV screening was offered free of charge to every asylum seeker who arrived from June 2015 to November 2016 in VS, and from June to October 2016 in VD. Pregnant women and children <16 were excluded...
February 11, 2019: Swiss Medical Weekly
Michael J Zellweger
Patient tailored diagnosis and risk stratification in patients with suspected or known coronary artery disease (CAD) are pivotal. At present, cardiac imaging modalities provide the possibility to evaluate the whole ischaemic cascade noninvasively. In asymptomatic patients, the evaluation of the calcium score may be beneficial and also guide the individual preventive strategy. Furthermore, the calcium score provides complimentary information to the information as assessed by functional testing. Coronary computed tomographic angiography (CCTA) is an excellent tool to exclude CAD, having a negative predictive value of 97–99%...
February 11, 2019: Swiss Medical Weekly
Elisante Mchomvu, Geoffrey Mbunda, Noemi Simon, Faradji Kitila, Yvan Temba, Isaiac Msumba, Jabir Namamba, Said Kilindimo, Hellen Mgubike, Winfrid Gingo, Christoph Hatz, Daniel H Paris, Maja Weisser, Martin Rohacek
BACKGROUND: Information on diagnoses made in emergency departments situated in rural sub-Saharan Africa is scarce. The aim was: to evaluate the frequency of different diagnoses made in a new emergency department to define relevant healthcare requirements; and to find out if in-hospital mortality rates would decrease after the implementation of the emergency department. METHODS: In this observational study, we prospectively collated diagnoses of all patients presenting to the emergency department of the St Francis Referral Hospital in Ifakara, Tanzania during 1 year...
January 28, 2019: Swiss Medical Weekly
Martin Siegemund, Alexa Hollinger, Eva C Gebhard, Jonas D Scheuzger, Daniel Bolliger
After decades of ordinary scientific interest, fluid resuscitation of patients with septic and haemorrhagic shock took centre stage in intensive care research at the turn of the millennium. By that time, resuscitation fluids were the mainstay of haemodynamic stabilisation, avoidance of vasopressors and treatment of hypovolaemia in patients in shock, but were accompanied by adverse events such as excessive tissue oedema. With the spread of early goal-directed therapy research intensified and it was realised that type, volume and timing of resuscitation fluids might affect the course and outcome of critically ill patients...
January 28, 2019: Swiss Medical Weekly
Louise Ostertag, Philippe Golay, Yves Dorogi, Sebastien Brovelli, Marta Bertran, Ioan Cromec, Bénédicte Van Der Vaeren, Riaz Khan, Alessandra Costanza, Karine Wyss, Anne Edan, Francesca Assandri, Rémy Barbe, Solenn Lorillard, Stéphane Saillant, Laurent Michaud
AIMS OF THE STUDY: Self-harm is a major risk factor for suicide but remains poorly documented. No data on self-harm in French-speaking Switzerland exist. To address this deficiency, the Swiss Federal Office of Public Health commissioned a specific self-harm monitoring programme. We present and discuss its implementation and first findings. METHODS: Every patient aged 18–65 years presenting for self-harm to the emergency departments of the Lausanne and Neuchâtel general hospitals were included in the monitoring programme over a 10-month period (December 2016 to September 2017)...
January 28, 2019: Swiss Medical Weekly
Mandip Kc, Clifford John Steer
The treatment of human diseases using gene-editing technology has been envisioned for several decades with the realisation that so many were associated with mutations in DNA. The Human Genome Project opened new doors for identifying the genetic bases for human suffering. Research on gene editing has been active since the 1970s, but the technology has seen substantial growth and application just within the past decade. Simply stated, CRISPR technology has become a phenomenon in both biomedical and therapeutics research...
January 14, 2019: Swiss Medical Weekly
François Taban, Nadia Elia, Elisabetta Rapiti, Christoph Rageth, Gérald Fioretta, Simone Benhamou, Giang Than Lam, Emmanuel David-Montefiore, Chirstine Bouchardy
AIMS OF THE STUDY: Previous studies have suggested that the surgeon’s experience in breast cancer surgery may affect patient survival. In this registry-based retrospective cohort study, we examined whether quality of care could partly explain this association. METHODS: All invasive breast cancers operated on in the private sector between 2000 and 2009 were identified in the Geneva Cancer Registry and followed up for 5 years. Surgeons were classified according to their experience into three categories: ≤5, 6–10, >10 breast cancer operations performed per year...
January 14, 2019: Swiss Medical Weekly
Andrea Uccelli, Thomas Wolff, Paolo Valente, Nunzia Di Maggio, Matteo Pellegrino, Lorenz Gürke, Andrea Banfi, Roberto Gianni-Barrera
Despite major advances in medical, catheter-based or surgical treatment, cardiovascular diseases such as peripheral artery disease and coronary artery disease still cause significant morbidity and mortality. Furthermore, many patients do not qualify for catheter-based treatment or bypass surgery because of advanced disease or surgical risk. There is therefore an urgent need for novel treatment strategies. Therapeutic angiogenesis aims to restore blood flow to ischaemic tissue by stimulating the growth of new blood vessels through the local delivery of angiogenic factors, and may thus be an attractive treatment alternative for these patients...
January 14, 2019: Swiss Medical Weekly
Henryk Zulewski, Luca Giovanella, Stefan Bilz, Emanuel Christ, Andreas Haldemann, Hans Steinert, Sabine Weidner, Daniel Oertli, Frédéric Triponez, Thomas Clerici, Anna Minder, Matthias Dettmer, Paul Komminoth
No abstract text is available yet for this article.
January 14, 2019: Swiss Medical Weekly
Evelyne Neurauter, Sebastian Leschka, Simon Wildermuth, Niklas F Ehl, Lucas Joerg, Hans Rickli, Micha T Maeder
AIMS OF THE STUDY: Coronary computed tomography angiography (CCTA) is recommended as a first-line option for the exclusion of coronary artery disease in patients with low to intermediate (15–50%) pretest probability. We aimed to study the use of CCTA in clinical practice in a single centre in Switzerland in light of this recommendation. METHODS: In 523 consecutive patients (age 56 ± 13 years, 48% females) undergoing CCTA during a period of 2 years, the pretest probability of coronary artery disease was assessed using the revised Diamond-Forrester model (CAD consortium score)...
January 14, 2019: Swiss Medical Weekly
Urs Rusch, Sarah Robbins, Homie Razavi, Pietro Vernazza, Sarah Blach, Philip Bruggmann, Beat Müllhaupt, Francesco Negro, David Semela
BACKGROUND AND AIMS: Direct-acting antiviral agents have revolutionised hepatitis C treatment. In 2014, the Swiss Hepatitis Strategy was developed to eliminate hepatitis C virus (HCV) infection and the associated liver-related morbidity and mortality by 2030. Though numerous national studies and assessments have identified a relatively low prevalence rate of 0.7% in the country, little has been done to identify the epidemiology of HCV on the regional, or micro, level. This study aimed to identify scenarios to achieve the objectives of Swiss Hepatitis Strategy by 2030 in eastern, western and northern regions in Switzerland...
January 14, 2019: Swiss Medical Weekly
Valeria Spina, Davide Rossi
In the era of personalised medicine, genetic information is critical to directing therapeutic options, aiding risk stratification and disease monitoring of lymphomas. Liquid biopsy is a novel noninvasive, real-time and tumour-specific technique, reliably reflecting the comprehensive tumour genetic profile, and thus holds great promise for the genetic assessment, response monitoring and relapse detection of lymphomas. Standard methods for disease response assessment in patients with lymphoma, including positron emission tomography, are imperfect...
January 14, 2019: Swiss Medical Weekly
Kathrin Zürcher, Marcel Zwahlen, Claudia Berlin, Matthias Egger, Lukas Fenner
AIMS: We studied time trends in seasonal influenza vaccination and assessed associations with socioeconomic and health-related determinants in Switzerland (overall and people aged ≥65 years). METHODS: We used data from the Swiss Health Surveys of 2007 and 2012. We calculated the proportion of the population (overall and those ≥65 years old) reporting influenza vaccination in the last 12 months, and performed multivariate logistic regression analyses, presented as adjusted odds ratios (aORs)...
January 14, 2019: Swiss Medical Weekly
Onur Boyman, Natalia Arenas-Ramirez
Tumour immunotherapy, and particularly immue checkpoint inhibitors, have resulted in considerable response rates in patients with metastatic cancer. However, most of these approaches are limited to immunogenic tumours. Based on its ability to stimulate cytotoxic T cells, interleukin-2 (IL-2) has been used to treat patients with metastatic melanoma and metastatic kidney cancer. Clinical efficacy achieved through high doses is countered by severe adverse effects on vascular endothelial cells and various organs, a short in vivo half-life, and the stimulation of regulatory T cells that counteract antitumour immune responses...
January 14, 2019: Swiss Medical Weekly
Myrofora Goutaki, Marc O. Eich, Florian S. Halbeisen, Juerg Barben, Carmen Casaulta, Christian Clarenbach, Gaudenz Hafen, Philipp Latzin, Nicolas Regamey, Romain Lazor, Stefan Tschanz, Maura Zanolari, Elisabeth Maurer, Claudia E. Kuehni
Primary ciliary dyskinesia (PCD) is a rare, hereditary, multiorgan disease caused by defects in the structure and function of motile cilia. It results in a wide range of clinical manifestations, most commonly in the upper and lower airways. Central data collection in national and international registries is essential to studying the epidemiology of rare diseases and filling in gaps in knowledge of diseases such as PCD. For this reason, the Swiss Primary Ciliary Dyskinesia Registry (CH-PCD) was founded in 2013 as a collaborative project between epidemiologists and adult and paediatric pulmonologists...
January 1, 2019: Swiss Medical Weekly
George Haddad, Malte Kölling, Johan M Lorenzen
Acute kidney injury (AKI) is a disease entity of major importance, affecting approximately 6% of all patients on the intensive care unit. The mortality rate exceeds 60%. AKI is related to several underlying conditions, including sepsis, nephrotoxicity or major surgery. Ischaemia reperfusion injury or hypoxic conditions may lead to severe injury of the kidney and is associated with a steep decline in survival rates of patients. At present, AKI is diagnosed on the basis of creatinine levels and urine output. Novel markers and knowledge of their pathophysiological role is of major importance for targeted therapeutic interventions...
January 1, 2019: Swiss Medical Weekly
Jonas Marschall
No abstract text is available yet for this article.
January 1, 2019: Swiss Medical Weekly
Tony Foley
No abstract text is available yet for this article.
December 17, 2018: Swiss Medical Weekly
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