Swiss Society Of General Internal Medicine
No abstract text is available yet for this article.
May 21, 2024: Swiss Medical Weekly
Eric P Heymann, Valerie Romann, Rod Lim, Kristine Van Aarsen, Nour Khatib, Thomas Sauter, Barbara Schild, Stefan Mueller
Emergency physicians are the most at-risk medical specialist group for burnout. Given its consequences for patient care and physician health and its resulting increased attrition rates, ensuring the wellbeing of emergency physicians is vital for preserving the integrity of the safety net for the healthcare system that is emergency medicine. In an effort to understand the current state of practicing physicians, this study reviews the results of the first national e-survey on physician wellbeing and burnout in emergency medicine in Switzerland...
May 16, 2024: Swiss Medical Weekly
Christoph Becker, Katharina Beck, Céline Moser, Clara Lessing, Armon Arpagaus, Sebastian Gross, Tabita Urben, Rainer Schaefert, Simon Amacher, Stefano Bassetti, Philipp Schuetz, Sabina Hunziker
STUDY AIMS: During the COVID-19 pandemic, there was increasing pressure to be vaccinated to prevent further spread of the virus and improve outcomes. At the same time, part of the population expressed reluctance to vaccination, for various reasons. Only a few studies have compared the perceptions of vaccinated and non-vaccinated patients being treated in hospitals for COVID-19. Our aim was to investigate the association between vaccination status and perceived healthcare-associated discrimination in patients with COVID-19 receiving hospital treatment...
May 10, 2024: Swiss Medical Weekly
Sabina Rodriguez Velásquez, Loza Estifanos Biru, Sandrine Marie Hakiza, Muaamar Al-Gobari, Isotta Triulzi, Jyoti Dalal, Camille Beatrice Gaza Varela, Sara Botero Mesa, Olivia Keiser
INTRODUCTION: With the emergence of newer SARS-CoV-2 variants and their substantial effects on the levels and duration of protection against infection, an understanding of these characteristics of the protection conferred by humoral and cellular immunity can aid in the proper development and implementation of vaccine and safety guidelines. METHODS: We conducted a rapid literature review and searched five electronic databases weekly from 1 November 2021 to 30 September 2022...
May 6, 2024: Swiss Medical Weekly
Dominik Heim, Helen Baldomero, Michael Medinger, Stavroula Masouridi-Levrat, Urs Schanz, Gayathri Nair, Tayfun Güngör, Jörg Halter, Jakob R Passweg, Yves Chalandon
AIM: Until the year 2000, allogeneic haematopoietic cell transplantation (HCT) was the standard treatment for young and fit chronic myeloid leukaemia (CML) patients. CML was the main indication for allogeneic HCT. The introduction of tyrosine kinase inhibitors changed the treatment of CML patients dramatically. Allogeneic HCT was rapidly replaced by tyrosine kinase inhibitors as first-line treatment for CML, and the indication shifted to the treatment of non-responders, patients intolerant to tyrosine kinase inhibitors and patients whose CML is transforming to the accelerated phase and blast crisis...
May 3, 2024: Swiss Medical Weekly
Cornelia Speich, Roger Stephan, Nicola Dhima, Florian Hollenstein, Jule Horlbog, Giulia Delvento, Ekkehardt Altpeter, Meike Zuske, Michelle Raess, Helena Greter
AIMS OF THE STUDY: Listeriosis is a notifiable disease in Switzerland. In summer 2022, the Swiss Federal Office of Public Health noticed an increase in reports of listeriosis cases, indicating a possible ongoing outbreak. Here we present the approaches applied for rapidly confirming the outbreak, detecting the underlying source of infection and the measures put in place to eliminate it and contain the outbreak. METHODS: For close surveillance and early detection of outbreak situations with their possible sources, listeriosis patients in Switzerland are systematically interviewed about risk behaviours and foods consumed prior to the infection...
May 3, 2024: Swiss Medical Weekly
Roxane Dumont, Elsa Lorthe, Viviane Richard, Andrea Loizeau, Guillaume Fernandez, David De Ridder, Francesco Pennacchio, Julien Lamour, María-Eugenia Zaballa, Helene Baysson, Klara M Posfay-Barbe, Remy P Barbe, Silvia Stringhini, Idris Guessous
BACKGROUND AND OBJECTIVES: Pandemic-related life changes may have had a deleterious impact on suicidal behaviours. Early detection of suicidal ideation and identification of subgroups at increased risk could help prevent suicide, one of the leading causes of death among adolescents worldwide. Here, we aimed to investigate the prevalence of and risk factors for suicidal ideation in adolescents using a population-based sample from Switzerland, two years into the pandemic. METHODS: Between December 2021 and June 2022, adolescents aged 14 to 17 years already enrolled in a population-based cohort study (State of Geneva, Switzerland) were asked about suicidal ideation over the previous year...
April 28, 2024: Swiss Medical Weekly
Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J Metzner, Laurent Decosterd, Huldrych F Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, Alexandra Calmy
BACKGROUND: Clinical and laboratory monitoring of patients on antiretroviral therapy is an integral part of HIV care and determines whether treatment needs enhanced adherence or modification of the drug regimen. However, different monitoring and treatment strategies carry different costs and health consequences. MATERIALS AND METHODS: The SIMPL'HIV study was a randomised trial that assessed the non-inferiority of dual maintenance therapy. The co-primary outcome was a comparison of costs over 48 weeks of dual therapy with standard antiretroviral therapy and the costs associated with a simplified HIV care approach (patient-centred monitoring [PCM]) versus standard, tri-monthly routine monitoring...
April 15, 2024: Swiss Medical Weekly
Saskia Schlootz, Flurina A M Saner, Manuela Rabaglio, Sara Imboden, Julian Wampfler
BACKGROUND AND AIMS OF THE STUDY: Due to its importance for treatment and potential prevention in family members, germline testing for BRCA1/2 in patients with newly diagnosed ovarian cancer is decisive and considered a standard of care. Maintenance therapy with poly(ADP-ribose) polymerase (PARP) inhibitors substantially improves progression-free survival in patients with BRCA mutations and homologous recombination-deficient tumours by inducing synthetic lethality...
April 15, 2024: Swiss Medical Weekly
Selina Albrecht, Fabian Grässli, Alexia Cusini, Angela Brucher, Stephan Goppel, Elsbeth Betschon, J Carsten Möller, Manuela Ortner, Markus Ruetti, Reto Stocker, Danielle Vuichard-Gysin, Ulrike Besold, Lorenz Risch, Matthias Von Kietzell, Matthias Schlegel, Pietro Vernazza, Stefan P Kuster, Christian R Kahlert, Philipp Kohler
AIMS OF THE STUDY: We aimed to assess the extent of SARS-CoV-2 humoral immunity elicited by previous infections and/or vaccination among healthcare workers, and to identify reasons why healthcare workers decided against vaccination. METHODS: This nested cross-sectional study included volunteer healthcare workers from 14 healthcare institutions in German-speaking Switzerland. In January 2021, SARS-CoV-2 vaccines were available for healthcare workers. In May and June 2022, participants answered electronic questionnaires regarding baseline characteristics including SARS-CoV-2 vaccination status (with one or more vaccine doses defined as vaccinated) and previous SARS-CoV-2 infections...
April 13, 2024: Swiss Medical Weekly
Marc Schapira, Mark J Koury, Irene Roberts
No abstract text is available yet for this article.
April 10, 2024: Swiss Medical Weekly
Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M Posfay-Barbe, John Van den Anker, Marc Pfister
BACKGROUND AND AIMS: Pharmacometric in silico approaches are frequently applied to guide decisions concerning dosage regimes during the development of new medicines. We aimed to demonstrate how such pharmacometric modelling and simulation can provide a scientific rationale for optimising drug doses in the context of the Swiss national dose standardisation project in paediatrics using amikacin as a case study. METHODS: Amikacin neonatal dosage is stratified by post-menstrual age (PMA) and post-natal age (PNA) in Switzerland and many other countries...
April 8, 2024: Swiss Medical Weekly
Verena Kufner, Andrea C Frey, Sara H Burkhard, Stefan Schmutz, Gabriela Ziltener, Maryam Zaheri, Caroline V Wiedmer, Andreas Plate, Alexandra Trkola, Michael Huber, Nicolas J Mueller
AIMS OF THE STUDY: Upper respiratory tract infections are among the most common reasons for primary care consultations. They are diagnosed predominantly based on clinical assessment. Here, we investigated the benefit of viral metagenomic next-generation sequencing (mNGS) in an outpatient setting. METHODS: This prospective cross-sectional study included immunocompetent patients with acute upper respiratory tract infections. General practitioners collected pharyngeal swabs and demographic and clinical data...
April 5, 2024: Swiss Medical Weekly
Bruno Fuchs, Beata Bode, Philip Heesen, Barbara Kopf, Christian Michelitsch, Manfred Odermatt, Pietro Giovanoli, Stefan Breitenstein, Paul Schneider, Guido Schüpfer, Stefan Boes, Gabriela Studer
No abstract text is available yet for this article.
April 4, 2024: Swiss Medical Weekly
Gael Grandmaison, Thomas Grobéty, Philippe Dumont, Julien Vaucher, Daniel Hayoz, Philipp Suter
AIMS OF THE STUDY: Misuse of inhalers during chronic obstructive pulmonary disease (COPD) treatment is common and may result from errors in inhalation technique or insufficient peak inspiratory flow (PIF). We aimed to evaluate the impact of an in-hospital intervention to reduce inhaler misuse at hospital discharge among patients with COPD. METHODS: We conducted a monocentric, non-randomised intervention study to compare the proportion of misused inhalers at hospital discharge by patients with COPD between a group with standard care and a group receiving an in-hospital intervention...
April 4, 2024: Swiss Medical Weekly
Natalie Meyer, Roger Stephan, Nicole Cernela, Jule Anna Horlbog, Michael Biggel
STUDY AIMS: Although non-toxigenic Vibrio cholerae lack the ctxAB genes encoding cholera toxin, they can cause diarrhoeal disease and outbreaks in humans. In Switzerland, V. cholerae is a notifiable pathogen and all clinical isolates are analysed at the National Reference Laboratory for Enteropathogenic Bacteria and Listeria. Up to 20 infections are reported annually. In this study, we investigated the population structure and genetic characteristics of non-toxigenic V...
April 2, 2024: Swiss Medical Weekly
Salome Rudin, Lilian Kriemler, Tolga D Dittrich, Annaelle Zietz, Juliane Schweizer, Markus Arnold, Nils Peters, Filip Barinka, Simon Jung, Marcel Arnold, Urs Fischer, Katharina Rentsch, Mirjam Christ-Crain, Mira Katan, Gian Marco De Marchis
BACKGROUND: Lipoprotein (a) [Lp(a)] serum levels are highly genetically determined and promote atherogenesis. High Lp(a) levels are associated with increased cardiovascular morbidity. Serum Lp(a) levels have recently been associated with large artery atherosclerosis (LAA) stroke. We aimed to externally validate this association in an independent cohort. METHODS: This study stems from the prospective multicentre CoRisk study (CoPeptin for Risk Stratification in Acute Stroke patients [NCT00878813]), conducted at the University Hospital Bern, Switzerland, between 2009 and 2011, in which Lp(a) plasma levels were measured within the first 24 hours after stroke onset...
April 2, 2024: Swiss Medical Weekly
Christophe A Fehlmann, Monica Taljaard, Daniel I McIssac, Laurent Suppan, Elisabeth Andereggen, Arnaud Dupuis, Frederic Rouyer, Debra Eagles, Jeffrey J Perry
AIMS: Patients undergoing emergency general surgery are at high risk of complications and death. Our objectives were to estimate the incidence of emergency general surgery in a Swiss University Hospital, to describe the characteristics and outcomes of patients undergoing such procedures, and to study the impact of age on clinical outcomes. METHODS: This was a retrospective cohort study of adult patients who visited the emergency department (ED) of Geneva University Hospitals between January 2015 and December 2019...
April 1, 2024: Swiss Medical Weekly
Vanessa Kraege, Amaelle Gavin, Julieta Norambuena, Friedrich Stiefel, Marie Méan, Céline Bourquin
INTRODUCTION: The first COVID-19 wave (2020), W1, will remain extraordinary due to its novelty and the uncertainty on how to handle the pandemic. To understand what physicians went through, we collected narratives of frontline physicians working in a Swiss university hospital during W1. METHODS: Physicians in the Division of Internal Medicine of Lausanne University Hospital (CHUV) were invited to send anonymous narratives to an online platform, between 28 April and 30 June 2020...
March 29, 2024: Swiss Medical Weekly
Gianluca Mauro Menghini, Robert Thurnheer, Christian R Kahlert, Philipp Kohler, Fabian Grässli, Reto Stocker, Manuel Battegay, Danielle Vuichard-Gysin
BACKGROUND: Knowing whether shift work negatively affects the immune system's response to COVID-19 vaccinations could be valuable for planning future vaccination campaigns for healthcare workers. We aimed to determine the impact of working late or night shifts on serum anti-SARS-CoV-2 spike protein immunoglobulin G (anti-S) antibody levels after primary SARS-CoV-2-mRNA vaccination. METHODS: To obtain detailed information on shift work, we sent a separate online questionnaire to 1475 eligible healthcare workers who participated in a prospective longitudinal study conducted in 15 healthcare institutions in Switzerland...
March 27, 2024: Swiss Medical Weekly
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