Saurabh Kataria, Jeremiah Hilkiah Wijaya, Utsav Patel, Kevin Yabut, Tawfiq Turjman, Muhammad Abubakar Ayub, Nihar Upadhyay, Moinulhaq Makrani, Hisham Turjman, Ahmed Mostafa Abdalla Mohamed, Alan D Kaye
No abstract text is available yet for this article.
July 10, 2024: Current Pain and Headache Reports
Xin Chen, Shaoze Jing, Chenhui Xue, Xiaoming Guan
PURPOSE OF REVIEW: Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously affects the work and life of patients and causes a large economic burden to society. The traditional treatment of IVDD mainly involves early pain relief and late surgical intervention, but it cannot reverse the pathological course of IVDD. Current studies suggest that IVDD is related to the imbalance between the anabolic and catabolic functions of the extracellular matrix (ECM)...
July 10, 2024: Current Pain and Headache Reports
Keiko Ihara, Gina Dumkrieger, Pengfei Zhang, Tsubasa Takizawa, Todd J Schwedt, Chia-Chun Chiang
PURPOSE OF REVIEW: Headache disorders are highly prevalent worldwide. Rapidly advancing capabilities in artificial intelligence (AI) have expanded headache-related research with the potential to solve unmet needs in the headache field. We provide an overview of AI in headache research in this article. RECENT FINDINGS: We briefly introduce machine learning models and commonly used evaluation metrics. We then review studies that have utilized AI in the field to advance diagnostic accuracy and classification, predict treatment responses, gather insights from various data sources, and forecast migraine attacks...
July 8, 2024: Current Pain and Headache Reports
Alan D Kaye, Anne M Lindberg, Shivam S Shah, Rebecca J Maitski, Emily B Pendarvis, Jada F Cooley, Sam Amarasinghe, Sagar Patel, Zachary Palowsky, Charles J Fox, Shahab Ahmadzadeh, Sahar Shekoohi, Christopher L Robinson
PURPOSE OF REVIEW: Pain management is a critical aspect of care during and following a cesarean delivery. Without proper control of pain, individuals can experience poor mobility, increased thromboembolic events, and difficulty caring for the neonate in the postpartum period. There have been multiple methods for pain management for cesarean delivery and intrathecal morphine (ITM) has emerged as a prominent option for post-operative analgesia due to its efficacy, safety, and potential benefits over other treatments...
July 8, 2024: Current Pain and Headache Reports
Alan D Kaye, Jaeyeon Kweon, Ahmed Hashim, Mohamed Maher Elwaraky, Islam Mohammad Shehata, Patrick M Luther, Sahar Shekoohi
PURPOSE OF REVIEW: The elderly population typically suffer from a variety of diseases that mostly reflect the degenerative changes linked with the aging process. These diseases may be exacerbated by acute pain or by an abrupt aggravation of previously stable chronic pain. RECENT FINDINGS: Physical and psychological changes associated with aging may influence one's experience of pain and, as a result, the severity of pain. Pain treatment in the elderly can be complex and is often a budgetary burden on the nation's health care system...
July 5, 2024: Current Pain and Headache Reports
Emily X Zhang, Cyrus Yazdi, Rahib K Islam, Ahmed I Anwar, Alana Alvares-Amado, Horace Townsend, Kaitlyn E Allen, Elena Plakotaris, Jon D Hirsch, Ross G Rieger, Varsha Allampalli, Jamal Hasoon, Kazi N Islam, Sahar Shekoohi, Alan D Kaye, Christopher L Robinson
PURPOSE OF REVIEW: Diabetic neuropathy is a common complication of diabetes mellitus (DM) and can affect up to 50% of DM patients during their lifetime. Patients typically present with numbness, tingling, pain, and loss of sensation in the extremities. Since there is no treatment targeting the underlying mechanism of neuropathy, strategies focus on preventative care and pain management. RECENT FINDINGS: Up to 69% of patients with diabetic neuropathy receive pharmacological treatment for neuropathic pain...
July 5, 2024: Current Pain and Headache Reports
Alan D Kaye, Erin S Everett, Arianna M Lehuquet, Joseph W Mason, Rebecca Maitski, Michael J Plessala, Sonnah Barrie, Carlo Jean Baptiste, George Mychaskiw, Shahab Ahmadzadeh, Sahar Shekoohi, Giustino Varrassi
PURPOSE OF REVIEW: Despite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of associated adverse effects, including dependence and overdose, as demonstrated throughout the current opioid crisis. This is likely related to a failure in proving the efficacy of alternative analgesics in clinical trials, despite strong evidence supporting the potential for effective analgesia through in vitro studies. While NaV1.7 and NaV1.8 channels have shown to be key components of pain perception, studies regarding pharmacological agents utilizing these channels as targets have largely failed to demonstrate the efficacy of these proposed analgesics when compared to current multimodal pain treatment regimens...
July 4, 2024: Current Pain and Headache Reports
Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski
PURPOSE OF REVIEW: Cryoneurolysis refers to the process of reversibly ablating peripheral nerves with extremely cold temperatures to provide analgesia for weeks to months. With ultrasound-guidance or landmark-based techniques, it is an effective modality for managing both acute and chronic pain. In this review, we summarize the reported literature behind its potential applications and efficacy. RECENT FINDINGS: Here, we summarize several studies (from case reports to clinical trials) describing the use of ultrasound-guided and landmark-based cryoneurolysis for acute and chronic pain...
July 4, 2024: Current Pain and Headache Reports
Daniel Deuel, Andrew Sandgren, Evan O Nelson, Michael Cropes, Albojay Deacon, Tiffany Houdek, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Conservative management is consistently recommended as a first line intervention for occipital neuralgia (ON); however, there is limited clinical research regarding conservative intervention for ON. This lack of research may lead to underutilization or unwarranted variability in conservative treatment. This article provides mechanism-based guidance for conservative management of ON as a component of a multimodal treatment approach, and discusses the role of the physical therapist in the care team...
July 3, 2024: Current Pain and Headache Reports
Wei Zhang, Yun Zhang, Han Wang, Xuechun Sun, Lixue Chen, Jiying Zhou
PURPOSE OF REVIEW: Chronic migraine is a disabling progressive disorder without effective management approaches. Animal models have been developed and used in chronic migraine research. However, there are several problems with existing models. Therefore, we aimed to summarize and analyze existing animal models to facilitate translation from basic to clinical. RECENT FINDINGS: The most commonly used models are the inflammatory soup induction model and the nitric oxide donor induction model...
July 2, 2024: Current Pain and Headache Reports
Jing Cheng, Mengjiao Wan, Xiaoyan Yu, Rongrong Yan, Zirui Lin, Henry Liu, Lin Chen
PURPOSE OF THE REVIEW: With the increasing prevalence of cesarean section globally, the importance of perioperative analgesia for cesarean section is becoming increasingly evident. This article provides an overview and update on the current status of cesarean section worldwide and associated analgesic regimens. RECENT FINDINGS: Some recent studies unveiled potential association of neuraxial analgesia might be associated with children's autism, pharmacologic analgesia in obstetric will potentially gain some more attention...
July 1, 2024: Current Pain and Headache Reports
Deng Biao, KuyikAbasi Umoh, Cao Qiguang, Wang Xiaole, Fang Ting, Yang Yuqian, Zhu Jinchao, Liu Fushui
PURPOSE OF REVIEW: Mindfulness therapy is a widely used treatment for many diseases and has been shown to improve pain-related functions. There is growing support for the use of psychotherapy in the treatment of chronic pain. While studies have shown a positive effect of mindfulness therapy, it is important to consider psychosocial factors as there are still a small number of studies that question its effectiveness. RECENT FINDINGS: Based on current studies, mindfulness therapy involves cognitive factors related to chronic pain, both in terms of cognitive production and its impact on cognitive control...
June 29, 2024: Current Pain and Headache Reports
Karina Stech, Behnum Habibi
PURPOSE OF REVIEW: The purpose of this narrative review is to summarize pain symptomatology and mechanisms in neurofibromatosis type 1 (NF1), discuss the pain related quality of life impacts of NF1, and discuss the literature exploring interventions to improve quality of life. RECENT FINDINGS: Chronic pain in NF1 is described as headache and non-headache pain. The literature describes mechanisms contributing to neuronal hyperexcitability in the setting of reduced neurofibromin as key contributors to pain in NF1...
June 27, 2024: Current Pain and Headache Reports
Stefano Coaccioli, Piercarlo Sarzi-Puttini, Diego M M Fornasari, Vittorio Schweiger, Panagiotis Zis, Omar Viswanath, Giustino Varrassi
PURPOSE OF REVIEW: This review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the development of acute and chronic pain (CP). Specifically, the review focuses on the role of immune cells involved in the innate and acquired immune response, emphasizing their bidirectional interactions with the nervous systems and discussing the implications of this crosstalk on acute and CP management. RECENT FINDINGS: In the last two decades, multiple studies have uncovered the important role of the immune system in initiating, maintaining, and resolving pain stimuli...
June 27, 2024: Current Pain and Headache Reports
Ronnie Stotts, Rishabh Jain, Amit Aggarwal DO, Rana Al-Jumah
PURPOSE OF REVIEW: The purpose of this review is to evaluate, discuss and explain the current literature regarding management of post dural puncture headaches (PDPH) during spinal cord stimulation (SCS) trials. RECENT FINDINGS: Although an epidural blood patch (EBP) remains the gold standard in treatment of PDPH, current literature describes other modalities including various peripheral nerve blocks and pharmacological treatments to reduce PDPH symptoms. PDPH management in SCS centers around conservative treatment and EBP...
June 25, 2024: Current Pain and Headache Reports
Leon Grinman, Brett Elmore, Alberto E Ardon, Adnan Hussain, Mohammed Faysal Malik, Nadia Hernandez, Mackenzie Janice Jacoby
PURPOSE OF REVIEW: The purpose of this review is to summarize the recent literature regarding regional anesthesia (RA) techniques and outcomes for total hip arthroplasty (THA) in the face of changing surgical techniques and perioperative considerations. RECENT FINDINGS: Based on large meta-analyses, peripheral nerve blocks are indicated for THA. Each block has its own risks and benefits and data for outcomes for particular techniques are limited. New surgical techniques, improved use of multimodal analgesia, and improved ultrasound guided regional anesthetics lead to better pain control for patients undergoing THA with less associated risks...
June 22, 2024: Current Pain and Headache Reports
Linda Kollenburg, Erkan Kurt, Wim Mulleners, Alaa Abd-Elsayed, Cyrus Yazdi, Michael E Schatman, R Jason Yong, Ivo H Cerda, Adlai Pappy, Sait Ashina, Christopher Louis Robinson, Moises Dominguez
PURPOSE OF REVIEW: Chronic headaches are a significant source of disability worldwide. Despite the development of conventional strategies, a subset of patients remain refractory and/or experience side effects following these treatments. Hence, occipital nerve stimulation (ONS) should be considered as an alternative strategy for intractable chronic headaches. This review aims to provide a comprehensive overview of the effectiveness, safety, mechanisms and practical application of ONS for the treatment of headache disorders...
June 22, 2024: Current Pain and Headache Reports
Ralph Foglia, Jasper Yan, Anis Dizdarevic
PURPOSE OF REVIEW: The purpose of this review is to highlight the most recent literature and guidelines regarding perioperative methadone and buprenorphine use. RECENT FINDINGS: Surgical patients taking methadone and buprenorphine are being encountered more frequently in the perioperative period, and providers are becoming more familiar with their pharmacologic properties, benefits as well as precautions. Recommendations pertaining to buprenorphine therapy in the perioperative settings have changed in recent years, owing to more clinical and basic science research...
June 22, 2024: Current Pain and Headache Reports
Ping Xu, Han Rui Fan, En Ming Zhang, Hao Nan Zhang, Yong Fei
PURPOSE OF REVIEW: To explore the mechanism and therapeutic effect of sympathetic nerve regulation on neuropathic pain. RECENT FINDINGS: A comprehensive search was conducted in the PubMed and CNKI libraries, using the following keywords: stele ganglion block, neuropathic pain, sympathetic nerve block, sympathetic chemical destruction, and sympathetic radiofrequency thermocoagulation. We selected and critically reviewed research articles published in English that were related to sympathetic modulation in the treatment of neuropathic pain...
June 22, 2024: Current Pain and Headache Reports
Alexander Bautista, Jordan Lee, Spender Delfino, Dani LaPreze, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Pain is a complex phenomenon that affects millions of individuals worldwide and poses a significant burden on public health. While pain management typically focuses on pharmacological and physical interventions, emerging research suggests that nutrition plays a crucial role in pain modulation. This narrative review aims to explore the relationship between nutrition and pain, providing a comprehensive overview of recent literature. The review covers various dietary factors, including macronutrients, micronutrients, dietary patterns, and specific dietary interventions...
June 14, 2024: Current Pain and Headache Reports
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