Isabelle Dewandel, Margaret van Niekerk, Elisabetta Ghimenton-Walters, Megan Palmer, Michaile G Anthony, Carla McKenzie, Rolanda Croucamp, Galit Alter, Anne-Marie Demers, Gert van Zyl, Mathilda Claassen, Pierre Goussard, Ruan Swanepoel, Graeme Hoddinott, Corne Bosch, Rory Dunbar, Brian Allwood, Eric D McCollum, H Simon Schaaf, Anneke C Hesseling, Marieke M van der Zalm
BACKGROUND: Despite a high paediatric tuberculosis (TB) burden globally, sensitive and specific diagnostic tools are lacking. In addition, no data exist on the impact of pulmonary TB on long-term child lung health in low- and middle-income countries. The prospective observational UMOYA study aims (1) to build a state-of-the-art clinical, radiological, and biological repository of well-characterised children with presumptive pulmonary TB as a platform for future studies to explore new emerging diagnostic tools and biomarkers for early diagnosis and treatment response; and (2) to investigate the short and long-term impact of pulmonary TB on lung health and quality of life in children...
March 22, 2023: BMC Pulmonary Medicine