journal
https://read.qxmd.com/read/39026320/attitudes-toward-and-preparedness-for-lung-transplantation-among-individuals-with-cystic-fibrosis-in-the-era-of-highly-effective-modulators
#1
JOURNAL ARTICLE
Nora Burdis, Siddhartha G Kapnadak, Lauren E Bartlett, Oliver McElvaney, Tijana Milinic, Travis Hee Wai, Allison V Lange, Nick Reid, Jordan M Dunitz, Joanne L Billings, Joseph M Pilewski, Milene Saavedra, Christopher H Goss, Andrea L Hartzler, Kathleen J Ramos
BACKGROUND: Outcomes for individuals with cystic fibrosis (CF) have improved due to highly effective modulator therapy (HEMT). However, lung transplant (LTx) remains an important treatment for people with advanced lung disease. This study assessed attitudes and knowledge about LTx in the HEMT era. METHODS: All patients from the University of Washington CF clinic were surveyed March 25-May 30, 2020. Questions addressed self-rated LTx preparedness and knowledge, as well as barriers and facilitators to discussing LTx...
July 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39026224/thoracic-and-vertebral-deformities-in-lung-transplantation-perioperative-complications-and-long-term-prognoses
#2
JOURNAL ARTICLE
Etsuhiro Nikkuni, Takashi Hirama, Masahiro Ui, Toshikazu Watanabe, Shunta Mukai, Tatsuaki Watanabe, Yui Watanabe, Hisashi Oishi, Satoru Ebihara, Yoshinori Okada
BACKGROUND: Lung transplantation (LTx) is a crucial therapeutic strategy for patients suffering from end-stage respiratory diseases, necessitating precise donor-recipient size matching to ensure optimal graft function. While standard allocation protocols rely on predicted lung capacity based on factors such as sex, age, and height, a subset of patients with respiratory diseases presents an additional challenge - thoracic or vertebral deformities. These deformities can complicate accurate volume predictions and may impact the success of lung transplantation...
July 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39026200/understanding-the-determinants-of-self-reported-asthma-in-turkey-insights-from-national-data-on-individual-lifestyle-socioeconomic-and-healthcare-access-factors
#3
JOURNAL ARTICLE
Aslı Davas, Meltem Çiçeklioğlu
Asthma, influenced by genetic, environmental, and social factors is leading to poor outcomes and preventable mortality due to inadequate care and limited access to effective treatments. This study aimed to analyze self-reported asthma prevalence in Turkey, focusing on its determinants, such as individual factors, lifestyle, socioeconomic status, and healthcare access.This study conducts a secondary analysis of the 2019 Turkiye Health Survey (THS), employing a nationally representative cross-sectional design by the Turkish Statistical Institute...
July 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39014431/sarcoidosis-associated-pulmonary-hypertension-due-to-pulmonary-arteries-stenosis-a-case-report
#4
JOURNAL ARTICLE
Malgorzata Sobiecka, Izabela Siemion-Szczesniak, Barbara Burakowska, Marcin Kurzyna, Malgorzata Dybowska, Witold Tomkowski, Monika Szturmowicz
BACKGROUND: Sarcoidosis-associated pulmonary hypertension (SAPH) is listed in Group 5 of the clinical classification of pulmonary hypertension, due to its complex and multifactorial pathophysiology. The most common cause of SAPH development is advanced lung fibrosis with the associated destruction of the vascular bed, and/or alveolar hypoxia. However, a substantial proportion of SAPH patients (up to 30%) do not have significant fibrosis on chest imaging. In such cases, the development of pulmonary hypertension may be due to the lesions directly affecting the pulmonary vasculature, such as granulomatous angiitis, pulmonary veno-occlusive disease, chronic thromboembolism or external compression of vessels by enlarged lymph nodes...
July 16, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39014338/retraction-note-lncrna-linc00520-aggravates-cell-proliferation-and-migration-in-lung-adenocarcinoma-via-a-positive-feedback-loop
#5
Wen Huang, Xinxing Wang, Fubing Wu, Fanggui Xu
No abstract text is available yet for this article.
July 16, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39014333/a-novel-splicing-mutation-dnah5-c-13-338%C3%A2-%C3%A2-5g%C3%A2-%C3%A2-c-is-involved-in-the-pathogenesis-of-primary-ciliary-dyskinesia-in-a-family-with-primary-familial-brain-calcification
#6
JOURNAL ARTICLE
Xiu-Juan Yao, Qian Chen, Hong-Ping Yu, Dan-Dan Ruan, Shi-Jie Li, Min Wu, Li-Sheng Liao, Xin-Fu Lin, Zhu-Ting Fang, Jie-Wei Luo, Bao-Song Xie
BACKGROUND: Primary ciliary dyskinesia (PCD) is an autosomal recessive hereditary disease characterized by recurrent respiratory infections. In clinical manifestations, DNAH5 (NM_001361.3) is one of the recessive pathogenic genes. Primary familial brain calcification (PFBC) is a neurodegenerative disease characterized by bilateral calcification in the basal ganglia and other brain regions. PFBC can be inherited in an autosomal dominant or recessive manner. A family with PCD caused by a DNAH5 compound heterozygous variant and PFBC caused by a MYORG homozygous variant was analyzed...
July 16, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39014325/hypercapnia-and-lung-function-parameters-in-chronic-obstructive-pulmonary-disease
#7
JOURNAL ARTICLE
Lukas Gernhold, Claus Neurohr, Konstantinos Tsitouras, Nina Lutz, Selina Briese, Alessandro Ghiani
BACKGROUND: In advanced chronic obstructive pulmonary disease (COPD), hypercapnia may occur due to severe bronchial obstruction with lung hyperinflation. Non-invasive ventilation (NIV) provides the standard of care intended to achieve physiological PCO2 levels, thereby reducing overall mortality. The present study aimed to evaluate pulmonary function parameters derived from spirometry (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV1]), body plethysmography (residual volume [RV], total lung capacity [TLC]), and lung diffusion capacity for carbon monoxide (single-breath method [DCO-SB], alveolar-volume corrected values [DCO-VA]) as predictors of chronic hypercapnia in patients with advanced COPD...
July 16, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39010041/copd-prism-and-lung-function-reduction-affect-the-brain-cortical-structure-a-mendelian-randomization-study
#8
JOURNAL ARTICLE
Chuangsen Fang, Ao Li, Yanming Li
Chronic obstructive pulmonary disease (COPD) has been associated with alterations in the brain cortical structure. Nonetheless, the causality between COPD and brain cortical structure has not been determined. In the present study, we used Mendelian randomization (MR) analysis to explore the causal effects of genetic predicated COPD on brain cortical structure, namely cortical surface area (SA) and cortical thickness (TH). Genetic association summary data for COPD were obtained from the FinnGen consortium (N = 358,369; Ncase = 20,066)...
July 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39010032/dirofilariasis-presenting-as-pleural-effusion-a-rare-case-report-with-unusual-manifestations-and-treatment-modalities
#9
JOURNAL ARTICLE
Rolanda Valčiukaitė-Žilinskienė, Birutė Zablockienė, Rolandas Zablockis
BACKGROUND: We present an extremely rare manifestation of dirofilariasis in the pleural cavity. This is the first human pulmonary dirofilariasis reported in Lithuania; according to our knowledge, only two other patients were documented with this pathology in the world. CASE PRESENTATION: A 72-year-old woman was admitted to the hospital complaining of dyspnea, left-side chest pain, and a dry cough. She was a retiree living alone in the countryside without domestic pets (sometimes stray dogs appear) or a travel history...
July 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/39010027/investigation-into-the-role-of-h2-ab1-in-vascular-remodeling-in-pulmonary-arterial-hypertension-via-bioinformatics
#10
JOURNAL ARTICLE
Guowen Wang, Zhuoyan Wang
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disease of vascular remodeling characterized by persistent pulmonary arterial pressure elevation, which can lead to right heart failure and premature death. Given the complex pathogenesis and poor prognosis of PAH, the identification and investigation of biomarkers become increasingly critical for advancing further understanding of the disease. METHODS: PAH-related datasets, GSE49114, GSE180169 and GSE154959, were downloaded from the publicly available GEO database...
July 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38997738/retraction-note-association-of-the-location-and-initial-degree-of-malignant-central-airway-stenosis-with-the-risk-of-severe-restenosis-after-interventional-bronchoscopy
#11
Saibin Wang, Renzhi Zhou, Siyao Zhu, Dan Yan
No abstract text is available yet for this article.
July 12, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38997717/metagenomic-next-generation-sequencing-promotes-diagnosis-and-treatment-of-pneumocystis-jirovecii-pneumonia-in-non-hiv-infected-children-a-retrospective-study
#12
JOURNAL ARTICLE
Zhenyu Zhang, Tingyan Liu, Meixiu Ming, Meili Shen, Yi Zhang, Hanlin Chen, Weiming Chen, Jinhao Tao, Yixue Wang, Jing Liu, Jihua Zhou, Guoping Lu, Gangfeng Yan
BACKGROUND: Metagenomic next-generation sequencing (mNGS) excels in diagnosis of infection pathogens. We aimed to evaluate the performance of mNGS for the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in non-HIV infected children. METHODS: Totally 36 PJP children and 61 non-PJP children admitted to the pediatric intensive care unit from March 2018 to December 2021 were retrospectively enrolled. Clinical features of PJP children were summarized. 1,3-β-D glucan (BDG) test and bronchoalveolar lavage fluid (BALF) mNGS were used for evaluation of PJP diagnostic performance...
July 12, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38997707/an-elderly-case-of-paraneoplastic-anti-nmda-receptor-encephalitis-associated-with-large-cell-neuroendocrine-carcinoma-of-the-lung
#13
JOURNAL ARTICLE
Masamitsu Naka, Atsushi Inaba, Hana Miyasaka, Keisuke Suzue, Junichi Ishigaki, Hideki Shibuya, Kei Hara, Nobuya Ohishi, Yusuke Sugiyama, Yasushi Shiio, Ryosuke Tajiri, Yukiko Kishida, Tasuku Ishihara, Akihiro Yugeta
BACKGROUND: Recent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However, there have been no reports demonstrating the expression of NR1 subunit of the NMDA receptor in large cell neuroendocrine carcinoma (LCNEC). CASE PRESENTATION: Here, we report the first elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with LCNEC of the lung with NR1 expression. Of note, NR1 subunit expression in the tumor cells of the present case was confirmed by immunohistochemistry (IHC)...
July 12, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38997676/longitudinal-lung-function-trajectories-in-response-to-azithromycin-therapy-for-chronic-lung-disease-in-children-with-hiv-infection-a-secondary-analysis-of-the-breathe-trial
#14
RANDOMIZED CONTROLLED TRIAL
Tafadzwa Madanhire, Grace McHugh, Victoria Simms, Lucky Ngwira, Carmen Gonzalez-Martinez, Robina Semphere, Brewster Moyo, Claire Calderwood, Mark Nicol, Tsitsi Bandason, Jon O Odland, Andrea M Rehman, Rashida A Ferrand
BACKGROUND: Chronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has both antimicrobial and anti-inflammatory effects and has been effective in improving lung function in a variety of lung diseases. We investigated lung function trajectories among CWH with CLD on ART enrolled in a randomized controlled trial of adjuvant azithromycin. We also investigated factors that modified the effect of azithromycin on lung function...
July 12, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38992626/burden-of-illness-in-patients-with-pulmonary-hypertension-due-to-interstitial-lung-disease-a-real-world-analysis
#15
JOURNAL ARTICLE
Gustavo Heresi, Bonnie Dean, Benjamin Wu, Henry Lee, Margaret R Sketch, Dana Stafkey-Mailey, Kellie Morland, Peter Classi, Leslie Spikes
BACKGROUND: Pulmonary hypertension due to interstitial lung disease (PH-ILD) is associated with high rates of respiratory failure and death. Healthcare resource utilization (HCRU) and cost data are needed to characterize PH-ILD disease burden. METHODS: A retrospective cohort analysis of the Truven Health MarketScan® Commercial Claims and Encounters Database and Medicare Supplemental Database between June 2015 to June 2019 was conducted. Patients with ILD were identified and indexed based on their first claim with a PH diagnosis...
July 11, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38987763/a-retrospective-analysis-of-treatment-patterns-overall-survival-and-real-world-disease-free-survival-in-early-stage-non-small-cell-lung-cancer-following-complete-resection
#16
JOURNAL ARTICLE
Xiaohan Hu, Diana Chirovsky, Mark S Walker, Yuexi Wang, Alpana Kaushiva, Jon Tepsick, Ayman Samkari
BACKGROUND: Real-world data regarding patient characteristics, adjuvant treatment patterns, and long-term survival outcomes are needed to better understand unmet needs among patients with completely resected early-stage non-small cell lung cancer (NSCLC). METHODS: Electronic medical records from the U.S.-based ConcertAI Patient360™ database were analyzed in patients with stage IB-IIIA NSCLC who underwent complete resection prior to March 1, 2016. Patients were followed until death or July 1, 2021...
July 10, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38987754/performance-of-risk-scores-in-predicting-mortality-at-3-6-and-12-months-in-patients-diagnosed-with-community-acquired-pneumonia
#17
MULTICENTER STUDY
Eduardo Tuta-Quintero, Alirio R Bastidas, Gabriela Guerrón-Gómez, Isabella Perna-Reyes, Daniela Torres, Laura Garcia, Javier Villanueva, Camilo Acuña, Eathan Mikler, Juan Arcila, Nicolas Chavez, Allison Riviera, Valentina Maldonado, María Galindo, María Fernández, Carolina Schloss, Luis Felipe Reyes
BACKGROUND: Risk scores (RS) evaluate the likelihood of short-term mortality in patients diagnosed with community-acquired pneumonia (CAP). However, there is a scarcity of evidence to determine the risk of long-term mortality. This article aims to compare the effectiveness of 16 scores in predicting mortality at three, six, and twelve months in adult patients with CAP. METHODS: A retrospective cohort study on individuals diagnosed with CAP was conducted across two hospitals in Colombia...
July 10, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38987733/analysis-of-risk-factors-of-postoperative-complication-for-non-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Nozomu Motono, Takaki Mizoguchi, Masahito Ishikawa, Shun Iwai, Yoshihito Iijima, Hidetaka Uramoto
BACKGROUND: The relationship between risk factors of common postoperative complications after pulmonary resection, such as air leakage, atelectasis, and arrhythmia, and patient characteristics, including nutritional status or perioperative factors, has not been sufficiently elucidated. METHODS: One thousand one hundred thirty-nine non-small cell lung cancer patients who underwent pulmonary resection were retrospectively analyzed for risk factors of common postoperative complications...
July 10, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38982423/biomarkers-of-tissue-remodelling-are-elevated-in-serum-of-covid-19-patients-who-develop-interstitial-lung-disease-an-exploratory-biomarker-study
#19
JOURNAL ARTICLE
Helene Wallem Breisnes, Diana Julie Leeming, Morten Asser Karsdal, Hannah Burke, Anna Freeman, Tom Wilkinson, Aishath Fazleen, Jannie Marie Bülow Sand
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a viral pneumonia that can result in serious respiratory illness. It is associated with extensive systemic inflammation, changes to the lung extracellular matrix, and long-term lung impairment such as interstitial lung disease (ILD). In this study, the aim was to investigate whether tissue remodelling, wound healing, and neutrophil activity is altered in patients with COVID-19 and how these relate to the development of post-COVID ILD...
July 10, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38982416/safety-and-efficacy-of-tract-embolization-using-gelatin-sponge-particles-in-reducing-pneumothorax-after-ct-guided-percutaneous-lung-biopsy-in-patients-with-emphysema
#20
JOURNAL ARTICLE
Xiong Yang, Hong-Tao Cheng, Yue Huang, Yuan Guo, Hang Yuan, Yue-Qi Chen, Hai-Liang Li
BACKGROUND: The incidence of pneumothorax is higher in patients with emphysema who undergo percutaneous lung biopsy. Needle embolization has been shown to reduce the incidence of pneumothorax in patients with emphysema. Existing studies have reported small sample sizes of patients with emphysema, or the degree of emphysema has not been graded. Therefore, the efficacy of biopsy embolization in the prevention of pneumothorax induced by percutaneous pulmonary biopsy in patients with emphysema remains to be determined...
July 9, 2024: BMC Pulmonary Medicine
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