journal
https://read.qxmd.com/read/36941592/impact-of-dysautonomic-symptom-burden-on-the-quality-of-life-in-neuromyelitis-optica-spectrum-disorder-patients
#1
JOURNAL ARTICLE
Lili Yang, Wenjing Li, Yan Xie, Shuai Ma, Xiaobo Zhou, Xinyue Huang, Song Tan
BACKGROUND: This study aimed to investigate the clinical risk factors of dysautonomic symptom burden in neuromyelitis optica spectrum disorder (NMOSD) and its impact on patients' quality of life. METHODS: A total of 63 NMOSD patients and healthy controls were enrolled. All participants completed the Composite Autonomic Symptom Score 31 (COMPASS-31) to screen for symptoms of autonomic dysfunction. A comprehensive clinical evaluation was performed on NMOSD patients, such as disease characteristics and composite evaluations of life status, including quality of life, anxiety/depression, sleep, and fatigue...
March 20, 2023: BMC Neurology
https://read.qxmd.com/read/36941577/low-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-predict-favorable-outcomes-after-endovascular-treatment-in-acute-basilar-artery-occlusion-subgroup-analysis-of-the-basilar-registry
#2
JOURNAL ARTICLE
Jia Sheng Liao, Changwei Guo, Bo Zhang, Jie Yang, Wenjie Zi, Jing Lun Li
BACKGROUND: Recently, the BAOCHE trial and ATTENTION trial registry have demonstrated the efficacy of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO), however, the proportion of patients with favorable post-EVT outcomes remains low. The present study aimed to investigate the individual and joint prognostic values of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with acute BAO who have undergone EVT. METHODS: We enrolled patients who underwent EVT from the BASILAR registry...
March 20, 2023: BMC Neurology
https://read.qxmd.com/read/36932413/mature-b-cell-lymphoma-with-acute-myelitis-as-the-first-presentation-a-case-report-and-literature-review
#3
JOURNAL ARTICLE
Yang Fan, Gen-Hui Zeng, Wei Xiao, Ju-Ming Yu, Xiao-Dong Zhang
BACKGROUND: Lymphomas are malignant tumors of the immune system that arise in lymphoid organs and can impact the central nervous system. However, lymphomas with acute myelitis as the first manifestation are exceedingly rare, and most of them are symptoms of spinal cord damage due to the lack of specificity in their clinical manifestations. The rate of early misdiagnosis is exceedingly high, and the prognosis is dire. Here, we report a case of mature B-cell lymphoma with acute myelitis as the first presentation and review the related literature...
March 17, 2023: BMC Neurology
https://read.qxmd.com/read/36932361/the-impact-of-inotersen-on-neuropathy-impairment-score-in-patients-with-hereditary-transthyretin-amyloidosis-with-polyneuropathy
#4
JOURNAL ARTICLE
Aaron Yarlas, Andrew Lovley, Duncan Brown, Montserrat Vera-Llonch, Sami Khella, Chafic Karam
BACKGROUND: Patients with hereditary transthyretin amyloidosis (ATTRv) frequently experience symptoms of polyneuropathy (PN) that worsen over time and impair daily functioning. Previous analyses supported efficacy of inotersen, an antisense oligonucleotide, to slow neuropathic progression in patients with ATTRv-PN, as indicated by larger mean changes, relative to placebo, in total score and several subscales of the Neuropathy Impairment Score (NIS), and for the subset of NIS items specific to lower limbs (NIS-LL) for the overall study sample...
March 17, 2023: BMC Neurology
https://read.qxmd.com/read/36932355/cerebrovascular-reactivity-after-functional-activation-of-the-brain-using-photic-stimulation-in-migraine-and-tension-type-headache-a-transcranial-doppler-ultrasonography-study
#5
JOURNAL ARTICLE
Eman M Khedr, Mohammed A Abbas, Ayman Gamea, Mohamed A Sadek, Ahmed F Zaki
BACKGROUND: Previous studies in headache patients measured the cerebrovascular reactivity (CVR) in response to photic stimulation but they have yielded contradictory results. The purpose of study was to measure CVR of both migraine and chronic tension headache (TTH) patients in response to photic stimulation. METHODS: The study included 37 migraineurs and 24 chronic TTH patients compared with 50 age- and sex-matched healthy volunteers. Peak systolic, end diastolic, mean flow velocities and CVR (PSV, EDV, MFV, and CVR) were measured using TCD ultrasonography of the middle, anterior, posterior cerebral and vertebral arteries (MCA, ACA, PCA, and VA) before and after 100 s of 14 Hz photic stimulation...
March 17, 2023: BMC Neurology
https://read.qxmd.com/read/36932354/effects-of-a-cognitive-stimulation-program-on-physical-and-cognitive-dimensions-in-community-dwelling-faller-older-adults-with-cognitive-impairment-study-protocol
#6
JOURNAL ARTICLE
José Emanuel Alves, Lucas N de Carvalho Pelegrini, Luana Rafaela Porcatti, Juliana Hotta Ansai, Maria Juana Beatriz Lima Candanedo, Karina Gramani-Say
BACKGROUND: Cognitive functioning is an important dimension among the elderly. Cognitive maintenance is vital for aging due to its association with autonomy and independence. Considering the importance of preventive programs in older adults' health, this study aims to share an intervention protocol of a falls prevention program for community-dwelling faller older adults with cognitive impairment. METHODS: This is the protocol of an experimental and longitudinal study, consisting of cognitive stimulation associated with physical exercise in a 16-week fall prevention program...
March 17, 2023: BMC Neurology
https://read.qxmd.com/read/36932352/serum-alpha-cgrp-levels-are-increased-in-covid-19-patients-with-headache-indicating-an-activation-of-the-trigeminal-system
#7
JOURNAL ARTICLE
Gabriel Gárate, María Toriello, Vicente González-Quintanilla, Sara Pérez-Pereda, Jorge Madera, Marta Pascual, José Manuel Olmos, Julio Pascual
BACKGROUND: Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account for its underlying pathophysiology. METHODS: Our aim was to compare the serum levels of CGRP, as a theoretical marker of trigemino-vascular activation, in 25 COVID-19 inpatients with lung involvement experiencing headache, against 15 COVID-19 inpatients without headache and with those of 25 matched healthy controls with no headache history...
March 17, 2023: BMC Neurology
https://read.qxmd.com/read/36918827/hypertrophic-olivary-degeneration-associated-with-bilateral-vocal-cord-adductor-dystonia
#8
JOURNAL ARTICLE
Mitchell Lycett, Cathy Kexin Cui, Dijana Dragicevich, Roger Harris, Karl Ng
BACKGROUND: Hypertrophic olivary degeneration (HOD) is a rare condition caused by lesions within the dentato-rubro-olivary pathway, resulting in ocular nystagmus and palatal myoclonus (oculopalatal tremor) but not usually dystonia. Dystonia is an uncommon association, and we present the first reported association of hypertrophic olivary degeneration with bilateral vocal cord dystonia. CASE PRESENTATION: A 33 year old male presented initially with acute hydrocephalus on the background of previous ventriculoperitoneal (VP) shunting for previously treated medulloblastoma...
March 14, 2023: BMC Neurology
https://read.qxmd.com/read/36918775/the-association-between-malnutrition-status-and-hemorrhagic-transformation-in-patients-with-acute-ischemic-stroke-receiving-intravenous-thrombolysis
#9
MULTICENTER STUDY
Yerim Kim, Minwoo Lee, Hee Jung Mo, Chulho Kim, Jong-Hee Sohn, Kyung-Ho Yu, Sang-Hwa Lee
OBJECTIVES: We evaluated the impact of malnutrition as estimated by the controlling nutritional status (CONUT) score and prognostic nutritional index (PNI) on hemorrhagic transformation (HT) and stroke outcomes after intravenous thrombolysis (IVT). MATERIALS AND METHODS: Using a multicenter registry database, we enrolled 808 patients with acute ischemic stroke who received IVT between August 2013 and May 2021. We defined malnutrition as a CONUT score ≥ 2 and low PNI...
March 14, 2023: BMC Neurology
https://read.qxmd.com/read/36906546/susceptibility-weighted-imaging-can-be-a-sensitive-sequence-to-detect-brain-damage-in-neonates-with-kernicterus-a-case-report
#10
JOURNAL ARTICLE
Maarten Lequin, Floris Groenendaal, Jeroen Dudink, Paul Govaert
BACKGROUND: Kernicterus in the acute phase is difficult to diagnose. It depends on a high signal on T1 at the globus pallidum and subthalamic nucleus level. Unfortunately, these areas also show a relatively high signal on T1 in neonates as an expression of early myelination. Therefore, a less myelin-dependent sequence, like SWI, may be more sensitive to detecting damage in the globus pallidum area. CASE PRESENTATION: A term baby developed jaundice on day three following an uncomplicated pregnancy and delivery...
March 11, 2023: BMC Neurology
https://read.qxmd.com/read/36906541/higher-serum-homocysteine-levels-are-associated-with-an-increased-risk-of-hemorrhagic-transformation-in-patients-with-acute-ischemic-stroke
#11
JOURNAL ARTICLE
Qian Wu, Junfeng Liu, Yanan Wang, Yajun Cheng, Ming Liu
BACKGROUND: Hemorrhagic transformation (HT) is a common complication of acute ischemic stroke (AIS), and may develop into parenchyma hemorrhage (PH). We aimed to investigate the association between serum homocysteine levels and HT as well as PH in all AIS patients, and in those with and without thrombolysis by subgroup analysis. METHODS: AIS patients who were admitted within 24 h after onset were enrolled and categorized into the higher homocysteine level group (≥ 15...
March 11, 2023: BMC Neurology
https://read.qxmd.com/read/36899302/ampa-and-nmda-receptor-antibody-autoimmune-encephalitis-preceded-by-ocular-myasthenia-gravis-a-case-report
#12
JOURNAL ARTICLE
Jakob Schäfer, Peter Brøgger Christensen, Kimmo Jensen
BACKGROUND: α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the brain and may be targeted by autoantibodies, leading to autoimmune synaptic encephalitis (AE). AE can be associated with other autoimmune diseases. However, the cooccurrence of anti-AMPA and NMDA receptor AE together with myasthenia gravis (MG) is unusual. CASE PRESENTATION: A 24-year-old previously healthy male presented with seronegative ocular MG, the diagnosis of which was supported by single-fiber electrophysiology findings...
March 10, 2023: BMC Neurology
https://read.qxmd.com/read/36890473/epidemiological-and-clinical-characteristics-predictive-of-icu-mortality-of-patients-with-traumatic-brain-injury-treated-at-a-trauma-referral-hospital-a-cohort-study
#13
JOURNAL ARTICLE
Álvaro Réa-Neto, Elizeu Daniel da Silva Júnior, Gabriela Hassler, Valkiria Backes Dos Santos, Rafaella Stradiotto Bernardelli, Amanda Christina Kozesinski-Nakatani, Marcelo José Martins-Junior, Fernanda Baeumle Reese, Mariana Bruinje Cosentino, Mirella Cristine Oliveira, Hélio Afonso Ghizoni Teive
BACKGROUND: Traumatic brain injury (TBI) has substantial physical, psychological, social and economic impacts, with high rates of morbidity and mortality. Considering its high incidence, the aim of this study was to identify epidemiological and clinical characteristics that predict mortality in patients hospitalized for TBI in intensive care units (ICUs). METHODS: A retrospective cohort study was carried out with patients over 18 years old with TBI admitted to an ICU of a Brazilian trauma referral hospital between January 2012 and August 2019...
March 8, 2023: BMC Neurology
https://read.qxmd.com/read/36890455/intramedullary-spinal-cord-metastasis-from-esophageal-squamous-cell-carcinoma-case-report-and-literature-review
#14
JOURNAL ARTICLE
Beiduo Shen, Zhaoyu Ba, Yufeng Huang, Desheng Wu
BACKGROUND: Intramedullary spinal cord metastasis (ISCM) of malignant tumors rarely happens. To the best of our knowledge, only five cases of ISCM from esophageal cancer have been reported in literature. We here report the sixth descripted case of ISCM from esophageal cancer. CASE PRESENTATION: A 68-year-old male presented with weakness of right limbs and localized neck pain two years after diagnosed esophageal squamous cell carcinoma. The gadolinium enhanced Magnetic resonance imaging (MRI) of cervical spine showed a mixed-intense intramedullary tumor with typical more intense thin rim of peripheral enhancement in C4-C5...
March 8, 2023: BMC Neurology
https://read.qxmd.com/read/36882749/limitations-on-knowledge-of-autoimmune-encephalitis-and-barriers-to-its-treatment-among-neurologists-a-survey-from-western-china
#15
JOURNAL ARTICLE
Aiqing Li, Kundian Guo, Xu Liu, Xue Gong, Xingjie Li, Dong Zhou, Zhen Hong
BACKGROUND: Autoimmune encephalitis (AE) is a group of severe antibody-mediated brain diseases. The understanding of clinical management of AE has developed rapidly. However, the knowledge level of AE and barriers to effective treatment among neurologists remains unstudied. METHODS: We conducted a questionnaire survey among neurologist in western China on knowledge of AE, treatment practices, and perspectives on barriers to treatment. RESULTS: A total of 1113 neurologists were invited and 690 neurologists from 103 hospitals completed the questionnaire with a response rate of 61...
March 7, 2023: BMC Neurology
https://read.qxmd.com/read/36879228/explaining-the-burden-of-psychosocial-factors-on-the-worsening-symptoms-of-ms-a-qualitative-study-of-patients-experiences
#16
JOURNAL ARTICLE
Fahimeh Pourhaji, Nooshin Peyman, Mousa Mahdizadeh Taraghdar, Jamshid Jamali, Hadi Tehrani
BACKGROUND: This study was conducted with the aim of identifying the burden of psychosocial factors on the worsening symptoms of multiple sclerosis. METHODS: This as conducted with a qualitative approach and conventional content analysis among patients with Multiple sclerosis in Mashhad. Data were collected through semi-structured interviews with patients with Multiple sclerosis. Twenty-one patients with Multiple sclerosis were selected through purposive sampling and snowball sampling...
March 6, 2023: BMC Neurology
https://read.qxmd.com/read/36870985/stuttering-as-a-signal-of-encephalopathy-associated-with-toripalimab-in-a-pancreatic-ductal-adenocarcinoma-patient-a-case-report
#17
JOURNAL ARTICLE
Jianping He, Xi Chen, Ke Cheng, Wanrui Lv, Dan Cao, Zhiping Li
BACKGROUND: Immune checkpoint inhibitor (ICI) combined with chemotherapy has exhibited promising results in small sample studies of pancreatic cancer patients. The efficacy of toripalimab, a programmed cell death protein 1 (PD-1) monoclonal antibody has been explored in the previous studies and it was established that immune-related adverse events (irAEs) associated with administration of this drug deserve proper attention and adequate management. CASE PRESENTATION: A 43-year-old female patient with advanced pancreatic ductal adenocarcinoma (PDAC) was treated with toripalimab in combination with gemcitabine and nab-paclitaxel (T-GA) as the first-line treatment...
March 4, 2023: BMC Neurology
https://read.qxmd.com/read/36870949/establishment-of-a-single-center-based-early-prognostic-scoring-system-for-guillain-barr%C3%A3-syndrome
#18
JOURNAL ARTICLE
Xiaomeng Di, Jiawei Wang, Lei Li, Lei Liu
BACKGROUND: Previous studies have developed clinical prognostic models for Guillain-Barré syndrome including EGOS and mEGOS, they have good reliability and accuracy, but individual entries are poor. This study aims to establish a scoring system to predict the early prognosis, in order to provide additional treatment for patients with poor prognosis and shorten the length of hospital stay. METHODS: We retrospectively analyzed risk factors affecting the short-term prognosis of Guillain-Barré syndrome, and developed a scoring system for early determination of disease prognosis...
March 4, 2023: BMC Neurology
https://read.qxmd.com/read/36864378/development-and-validation-of-a-clinical-nomogram-for-differentiating-hemorrhagic-and-ischemic-stroke-prehospital
#19
JOURNAL ARTICLE
Sheng Ye, Huiqing Pan, Weijia Li, Jinqiang Wang, Hailong Zhang
OBJECTIVES: The early detection and identification of stroke are essential to the prognosis of patients with suspected stroke symptoms out-of-hospital. We aimed to develop a risk prediction model based on the FAST score to identify the different types of strokes early for emergency medical services (EMS). METHODS: This retrospective observational study enrolled 394 stroke patients at a single center from January 2020 to December 2021. Demographic data, clinical characteristics, and stroke risk factors with patients were collected from the EMS record database...
March 3, 2023: BMC Neurology
https://read.qxmd.com/read/36864392/association-between-hyperckemia-and-axonal-degeneration-in-guillain-barr%C3%A3-syndrome
#20
JOURNAL ARTICLE
Eun Kyoung Lee, Sooyoung Kim, Nathan Jo, Eunhee Sohn
BACKGROUND: Elevated serum creatine kinase (CK) levels have been reported in patients with Guillain-Barré syndrome (GBS), more frequently in patients with acute motor axonal neuropathy (AMAN) than in those with acute inflammatory demyelinating polyneuropathy (AIDP). However, some patients with AMAN show reversible conduction failure (RCF), characterized by rapid recovery without axonal degeneration. The present study tested the hypothesis that hyperCKemia is associated with axonal degeneration in GBS, regardless of the subtype...
March 2, 2023: BMC Neurology
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