journal
https://read.qxmd.com/read/37784069/diagnostic-challenge-of-creutzfeldt-jakob-disease-in-a-patient-with-multimorbidity-a-case-report
#1
JOURNAL ARTICLE
Amber Yaqub, Mohammad Kamran Ikram, Jeroen Blankevoort, Mohammad Arfan Ikram
BACKGROUND: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and ultimately fatal neurodegenerative condition caused by prions. The clinical symptoms of CJD vary with its subtype, and may include dementia, visual hallucinations, myoclonus, ataxia, (extra)pyramidal signs and akinetic mutism. In the early course of disease however, several clinical symptoms of CJD may mimic those of co-existing morbidities. CASE PRESENTATION: We report a male in his 60s with a history of situs inversus totalis and Churg Strauss syndrome, who presented with speech fluency disturbances, neuropsychiatric symptoms and allodynia, a few months after becoming a widower...
October 2, 2023: BMC Neurology
https://read.qxmd.com/read/37784047/an-exploratory-study-of-delayed-flash-visual-evoked-potential-p2-wave-latency-in-subcortical-arteriosclerotic-encephalopathy
#2
JOURNAL ARTICLE
Lei Duan, Yu Ding, Gao-Hui Sun, Yun-Tao Li
BACKGROUND: Patients with cognitive dysfunction may present with significantly prolonged the P2 wave latency of flash visual evoked potential. However, no studies have been reported on whether the P2 wave latency of flash visual evoked potential is prolonged in patients with subcortical arteriosclerotic encephalopathy (SAE). OBJECTIVE: To examine the relationship between flash visual evoked potential P2 wave latency (FVEP-P2 wave latency) and cognitive impairment in patients with SAE...
October 2, 2023: BMC Neurology
https://read.qxmd.com/read/37784012/correction-correlation-of-serum-complement-factor-5a-level-with-inflammatory-response-and-cognitive-function-in-patients-with-alzheimer-s-disease-of-different-severity
#3
Zhilian Li, Huifang Wu, Yi Luo, Xianpei Tan
No abstract text is available yet for this article.
October 2, 2023: BMC Neurology
https://read.qxmd.com/read/37775739/meningitis-caused-by-oral-anaerobes-detected-using-mngs-tool-a-case-report-and-review-of-literature
#4
JOURNAL ARTICLE
Xiaoqing Zhong, Miaomiao Wang, Qingxia Meng, Xuebin Jiang, Zhendong Guo, Yunzhou Zhang, Daiquan Gao
BACKGROUND: Bacterial meningitis is a central nervous system (CNS) infection disease of the meninges and brain parenchyma caused by the bacteria. Few cases of meningitis related to oral anaerobes have been reported in the literature. Here, we report a case of meningitis in a middle-aged woman, caused by oral anaerobes. CASE PRESENTATION: A 58-year-old woman was admitted to hospital with fever, headache for 21 days and left limb weakness for 2 days. The blood cell counts (11...
September 30, 2023: BMC Neurology
https://read.qxmd.com/read/37770846/effects-of-functional-performance-and-national-health-insurance-cost-on-length-of-hospitalization-for-postacute-care-in-stroke-a-retrospective-observational-study
#5
JOURNAL ARTICLE
Hsiang-Yun Chou, Shang-Chun Ma, Ya-Wen Tsai, Chia-Li Shih, Chieh-Ting Yeh
BACKGROUND: The postacute care for cerebrovascular disease (PAC-CVD) program was launched in Taiwan nearly a decade ago. However, no clear regulations regarding length of stay (LOS) in the program and extension standards exist. Thus, the allocation of limited medical resources such as hospital beds is a major issue. METHODS: This novel study retrospectively investigated the effects of functional performance and national health insurance (NHI) costs on PAC-CVD LOS...
September 29, 2023: BMC Neurology
https://read.qxmd.com/read/37770834/treatment-of-idiopathic-facial-paralysis-bell-s-palsy-and-secondary-facial-paralysis-with-extracellular-vesicles-a-pilot-safety-study
#6
JOURNAL ARTICLE
Paul A Dreschnack, Ina Belshaku
BACKGROUND: Paralysis of the facial nerve (CN VII) is one of the most debilitating issues that any patient can encounter. Bell's palsy is the most commonly seen mononeuropathy. Although usually self-limited, symptomatology can persist for decades in persistent cases. The non-surgical alternative therapies discussed in this study are successful without reconstruction and are regenerative. OBJECTIVE AND DESIGN: We sought to determine a safe new treatment could be developed to restore facial nerve function using extracellular vesicles (EVs) in patients who have been unable to return to normal under a variety of conditions...
September 28, 2023: BMC Neurology
https://read.qxmd.com/read/37759178/multidomain-interventions-for-non-pharmacological-enhancement-mine-program-in-chinese-older-adults-with-mild-cognitive-impairment-a-multicenter-randomized-controlled-trial-protocol
#7
JOURNAL ARTICLE
Xiaochu Wu, Tianyao Zhang, Yanhao Tu, Xueling Deng, A Sigen, Yuxiao Li, Xiaofan Jing, Lixuan Wei, Ning Huang, Ying Cheng, Linghui Deng, Shuli Jia, Jun Li, Ning Jiang, Birong Dong
BACKGROUND: Dementia is characterized by progressive neurodegeneration and therefore early intervention could have the best chance of preserving brain health. There are significant differences in health awareness, living customs, and daily behaviors among Chinese older adults compared to Europeans and Americans. Because the synergistic benefits of multidomain non-pharmacological interventions are consistent with the multifactorial pathogenicity of MCI, such interventions are more appealing, easier to adhere to, and more relevant to daily life than single-mode interventions...
September 28, 2023: BMC Neurology
https://read.qxmd.com/read/37752429/obstructive-sleep-apnea-a-major-risk-factor-for-covid-19-encephalopathy
#8
JOURNAL ARTICLE
Gautier Breville, François Herrmann, Dan Adler, Christine Deffert, Giulia Bommarito, Patrick Stancu, Alice Accorroni, Marjolaine Uginet, Frederic Assal, Renaud Tamisier, Patrice H Lalive, Jean-Louis Pepin, Karl-Olof Lövblad, Gilles Allali
BACKGROUND: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). METHODS: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis of COVID-19 AE. They were divided in two groups depending on the presence or absence of high risk for OSA based on the modified NOSAS score (mNOSAS, respectively ≥ 8 and < 8)...
September 27, 2023: BMC Neurology
https://read.qxmd.com/read/37752420/effect-of-virtual-reality-combined-with-repetitive-transcranial-magnetic-stimulation-on-musculoskeletal-pain-and-motor-development-in-children-with-spastic-cerebral-palsy-a-protocol-for-a-randomized-controlled-clinical-trial
#9
JOURNAL ARTICLE
Xin Li, Zefan Huang, Tijiang Lu, Juping Liang, Haibin Guo, Lixia Wang, Zhengquan Chen, Xuan Zhou, Qing Du
PURPOSE: This trial aims to investigate the efficacy and safety of virtual reality (VR) combined with repetitive transcranial magnetic stimulation (rTMS) for improving musculoskeletal pain and motor development in children with unilateral spastic cerebral palsy (CP). METHODS: This study protocol is for a randomized controlled trial consisting of 2 treatment sessions (3 days/week for 4 weeks in each session, with a 1-week interval between sessions). We will recruit children aged 3-10 years with unilateral spastic CP (Gross Motor Function Classification System level I or II)...
September 26, 2023: BMC Neurology
https://read.qxmd.com/read/37749503/wnt-pathway-in-focal-cortical-dysplasia-compared-to-perilesional-nonlesional-tissue-in-refractory-epilepsies
#10
JOURNAL ARTICLE
Daniel R Marinowic, Gabriele G Zanirati, Fernando A C Xavier, Fábio Jean Varella, Sofia Prates da Cunha Azevedo, Isadora Machado Ghilardi, Normando G Pereira-Neto, Marco Antônio Eduardo Koff, Eliseu Paglioli, André Palmini, José Garcia Abreu, Denise C Machado, Jaderson C da Costa
BACKGROUND: Focal cortical dysplasia (FCD) is a malformation of cortical development that causes medical refractory seizures, and one of the main treatments may be surgical resection of the affected area of the brain. People affected by FCD may present with seizures of variable severity since childhood. Despite many medical treatments available, only surgery can offer cure. The pathophysiology of the disease is not yet understood; however, it is known that several gene alterations may play a role...
September 26, 2023: BMC Neurology
https://read.qxmd.com/read/37749518/diagnosis-and-management-of-neuro-beh%C3%A3-et-disease-with-isolated-intracranial-hypertension-a-case-report-and-literature-review
#11
REVIEW
Yali Wu, Wei Yin, Shufang Liu, Shasha Wang, Yan Ding
BACKGROUND: Neuro-Behçet's disease (NBD), characterized by isolated intracranial hypertension, is a rarely encountered condition, especially in children. In this study, we describe the treatment of a pediatric patient with NBD, who exhibited isolated intracranial pressure elevation as indicated by the initial manifestation of diplopia and physical examination finding of papilledema. CASE PRESENTATION: An 8-year-old boy was admitted to the hospital with a confirmed diagnosis of Behçet's disease (BD) over eight months...
September 25, 2023: BMC Neurology
https://read.qxmd.com/read/37749508/neutrophil-to-lymphocyte-ratio-is-an-independent-predictor-for-neurological-disability-in-patients-with-idiopathic-transverse-myelitis
#12
JOURNAL ARTICLE
Je Hong Min, Sung-Yeon Sohn, Seung Yeon Lee, Sang Hyun Seo, Shin Yeop Kim, Bumhee Park, Seung Il Kim, In Soo Joo
INTRODUCTION: The neutrophil-to-lymphocyte ratio (NLR) has been found to be useful in the prognostication of immune-mediated neurological disorders because it roughly reflects the systemic innate immune response compared to the adaptive immune response. However, studies on the validity of NLR in demyelinating disorders of the central nervous system have shown conflicting results. Therefore, we aimed to investigate NLR in the idiopathic transverse myelitis (ITM) cohort. METHODS: We retrospectively analyzed the cohort data of patients with ITM between January 2006 and February 2020...
September 25, 2023: BMC Neurology
https://read.qxmd.com/read/37749496/stroke-epidemiology-and-outcomes-of-stroke-patients-in-nepal-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Raju Paudel, Christine Tunkl, Shakti Shrestha, Ram Chandra Subedi, Ayush Adhikari, Lekhjung Thapa, Bikram Prasad Gajurel, Avinash Chandra, Ghanashyam Kharel, Pankaj Jalan, Subash Phuyal, Babu Ram Pokharel, Subi Acharya, Kanchan Bogati, Pinky Jha, Naresh Kharbuja, Christoph Gumbinger
BACKGROUND: With an increasing burden of stroke, it is essential to minimize the incidence of stroke and improve stroke care by emphasizing areas that bring out the maximum impact. The care situation remains unclear in the absence of a national stroke care registry and a lack of structured hospital-based data monitoring. We conducted this systematic review and meta-analysis to assess the status of stroke care in Nepal and identify areas that need dedicated improvement in stroke care. METHODS: A systematic literature review was conducted to identify all studies on stroke epidemiology or stroke care published between 2000 and 2020 in Nepal...
September 25, 2023: BMC Neurology
https://read.qxmd.com/read/37737161/clinical-presentations-and-treatment-outcomes-of-hashimoto-encephalopathy-at-siriraj-hospital-thailand-s-largest-national-tertiary-referral-center
#14
JOURNAL ARTICLE
Chaisak Dumrikarnlert, Smathorn Thakolwiboon, Vorapun Senanarong
BACKGROUND: Hashimoto encephalopathy has multiple clinical presentations, and other than the presence of thyroid antibody, laboratory and imaging investigations are all non-specific. Data specific to the clinical presentations and treatment outcomes of patients with Hashimoto encephalopathy in Thailand remain scarce. OBJECTIVES: To retrospectively investigate the clinical presentations and treatment outcomes of patients with Hashimoto encephalopathy at Siriraj Hospital...
September 22, 2023: BMC Neurology
https://read.qxmd.com/read/37735648/clinical-characteristics-and-prognosis-of-temporary-miller-fisher-syndrome-following-covid-19-vaccination-a-systematic-review-of-case-studies
#15
JOURNAL ARTICLE
Dorsa Alijanzadeh, Afsaneh Soltani, Fatemeh Afra, Fardis Salmanpour, Amir Hossein Loghman, Noosha Samieefar, Nima Rezaei
BACKGROUND: Miller Fisher syndrome (MFS) is a subtype of Guillain-Barré syndrome (GBS) which is characterized by the three components of ophthalmoplegia, ataxia, and areflexia. Some studies reported MFS as an adverse effect of the COVID-19 vaccination. We aimed to have a detailed evaluation on demographic, clinical, and para-clinical characteristics of subjects with MFS after receiving COVID-19 vaccines. MATERIALS AND METHODS: A thorough search strategy was designed, and PubMed, Web of Science, and Embase were searched to find relevant articles...
September 21, 2023: BMC Neurology
https://read.qxmd.com/read/37735638/neutrophil-to-lymphocyte-ratio-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Samaneh Hosseini, Nasim Shafiabadi, Monireh Khanzadeh, Arshin Ghaedi, Raziyeh Ghorbanzadeh, Amir Azarhomayoun, Aida Bazrgar, Jalil Pezeshki, Hanieh Bazrafshan, Shokoufeh Khanzadeh
BACKGROUND: The goal of this research was to explore the role of Neutrophil to lymphocyte ratio (NLR) in Parkinson's disease (PD). METHODS: From inception to 4 June 2023, PubMed, Web of Science, and ProQuest were searched for papers comparing NLR in PD to healthy individuals. Standardized mean difference (SMD) with a confidence interval (CI) of 95% were calculated. RESULTS: A random-effect model revealed that PD patients had elevated NLR values compared to healthy individuals (SMD = 0...
September 21, 2023: BMC Neurology
https://read.qxmd.com/read/37723424/retinal-functional-and-structural-changes-in-patients-with-parkinson-s-disease
#17
JOURNAL ARTICLE
Rehab Elanwar, Hatem Al Masry, Amna Ibrahim, Mona Hussein, Sahar Ibrahim, Mohammed M Masoud
BACKGROUND: Visual dysfunction have been well reported as one of the non-motor symptoms in Parkinson's disease (PD). The aim of this study was to evaluate the functional and structural changes in the retina in patients with PD, and to correlate these changes with disease duration and motor dysfunction. METHODS: For this case-control study, we recruited patients fulfilling the diagnostic criteria for idiopathic PD according to British Brain Bank criteria, aged between 50 and 80 years...
September 18, 2023: BMC Neurology
https://read.qxmd.com/read/37723414/simoa-based-analysis-of-plasma-nfl-levels-in-mci-and-ad-patients-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Hadi Sahrai, Ali Norouzi, Sina Hamzehzadeh, Alireza Majdi, Rana Kahfi-Ghaneh, Saeed Sadigh-Eteghad
BACKGROUND: The single-molecule array assay (SIMOA)-based detection of neurofilament light (NFL) chain could be useful in diagnosing mild cognitive impairment (MCI) and Alzheimer's disease (AD). This meta-analysis aimed to evaluate the circulating concentration of NFL in AD and MCI patients compared with healthy controls using the SIMOA technique. METHODS: To this end, Google Scholar, PubMed, Scopus, Web of Science, and the reference lists of relevant articles were systematically searched for studies reporting serum NFL chain levels in healthy controls, MCI, and AD patients...
September 18, 2023: BMC Neurology
https://read.qxmd.com/read/37715128/a-unique-case-of-a-fulminant-clonal-cd8-positive-t-cell-lymphoproliferative-disorder-with-cns-involvement
#19
JOURNAL ARTICLE
Lia Mesbah-Oskui, Jarrah Alabkal, Waleed Alduaij, Priya S Dhawan
BACKGROUND: This is a unique case that describes the presentation, investigations, and disease trajectory of a fatal, clonal CD8-positive T-cell lymphoproliferative disorder in an otherwise healthy and immunocompetent patient with Epstein-Barr virus seronegative status. Central nervous system involving T-cell lymphoproliferative disorders are rare and typically encountered in the setting of immunocompromise. These disorders are often associated with aggressive cytomorphological features and characteristic magnetic resonance imaging patterns, which were not seen in this case...
September 15, 2023: BMC Neurology
https://read.qxmd.com/read/37715122/leptomeningeal-neuraxis-relapse-in-glioblastoma-is-an-uncommon-but-not-rare-event-associated-with-poor-outcome
#20
JOURNAL ARTICLE
Eric Wegener, Patrick Horsley, Helen Wheeler, Dasantha Jayamanne, Marina Kastelan, Linxin Guo, Chris Brown, Michael Back
BACKGROUND: Spinal neuraxis leptomeningeal metastasis (LM) relapse in glioblastoma is an uncommon event that is challenging to manage. This study aims to determine the incidence, associated factors, and outcome of LM relapse in patients with glioblastoma managed with radical intent. METHODS: Patients managed for glioblastoma using the EORTC-NCIC (Stupp) Protocol from 2007 to 2019 were entered into a prospective ethics-approved database. Follow-up included routine cranial MRI surveillance with further imaging as clinically indicated...
September 15, 2023: BMC Neurology
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