Carla Vizzotti, Jennifer B Harris, Analía Aquino, Carolina Rancaño, Cristian Biscayart, Romina Bonaventura, Andrea Pontoriero, Elsa Baumeister, Maria Cecilia Freire, Mirta Magariños, Blanca Duarte, Gavin Grant, Susan Reef, Janeen Laven, Kathleen A Wannemuehler, Alba Maria Ropero Alvarez, J Erin Staples
BACKGROUND: In yellow fever (YF) endemic areas, measles, mumps, and rubella (MMR), and YF vaccines are often co-administered in childhood vaccination schedules. Because these are live vaccines, we assessed potential immune interference that could result from co-administration. METHODS: We conducted an open-label, randomized non-inferiority trial among healthy 1-year-olds in Misiones Province, Argentina. Children were randomized to one of three groups (1:1:1): Co-administration of MMR and YF vaccines (MMR1 YF1 ), MMR followed by YF vaccine four weeks later (MMR1 YF2 ), or YF followed by MMR vaccine four weeks later (YF1 MMR2 )...
March 17, 2023: BMC Infectious Diseases