journal

BMC Dermatology

journal
https://read.qxmd.com/read/32008574/osteomyelitis-complicating-secondarily-infected-atopic-eczema-two-case-reports-and-a-narrative-literature-review
#1
Josiah T Masuka, Katherine Troisi, Zamambo Mkhize
BACKGROUND: Atopic eczema is a relapsing, itchy chronic cutaneous inflammatory disease that commonly affects children. The disease is often complicated by cutaneous infections such as eczema herpeticum, eczema vaccinatum and a varied number of bacterial infections - impetigo, cellulitis and erysipelas. However, rare case reports of infective endocarditis, otitis media and osteo-articular infections have been associated with atopic eczema. These associations possibly represent the extracutaneous infectious complications of atopic eczema...
February 3, 2020: BMC Dermatology
https://read.qxmd.com/read/31918687/madurella-mycetomatis-infection-of-the-foot-a-case-report-of-a-neglected-tropical-disease-in-a-non-endemic-region
#2
Basma Karrakchou, Ibtissam Boubnane, Karima Senouci, Badreddine Hassam
BACKGROUND: Mycetoma is an uncommon chronic granulomatous infection of cutaneous and subcutaneous tissues that can be caused by filamentous bacteria (actinomycetoma) or fungi (eumycetoma). It is the prerogative of young men between the third and fourth decade and is transmitted through any trauma causing an inoculating point. The classic clinical triad associates a painless hard and swelling subcutaneous mass, multiple fistulas, and the pathognomonic discharge of grains. Although endemic in many tropical and subtropical countries, mycetoma can also be found in non-endemic areas as in Morocco, and causes then diagnosis problems leading to long lasting complications...
January 10, 2020: BMC Dermatology
https://read.qxmd.com/read/31787085/a-rare-case-of-sweet-syndrome-secondary-to-melioidosis
#3
Sahathevan Vithoosan, Balendran Thanushah, Paramarajan Piranavan, Dayal Gamlaksha, Harindra Karunatilake, Ananda Jayanaga
BACKGROUND: Melioidosis is an emerging infection in South Asia caused by Burkholderia pseudomallei with various clinical presentations that include pneumonia, bacteraemia, arthritis, and deep-seated abscesses. Various cutaneous manifestations have been described in association with melioidosis. However Sweet Syndrome secondary to melioidosis has not been reported in the literature. Herein we describe the first case of Sweet syndrome secondary to melioidosis. CASE PRESENTATION: A 53-year-old previously healthy Sri Lankan female presented with high-grade fever, painful oral ulcers, odynophagia and multiple bilateral cervical lymphadenopathies for 1 month...
December 2, 2019: BMC Dermatology
https://read.qxmd.com/read/31690295/validation-of-the-atopic-dermatitis-control-tool-adct%C3%A2-using-a-longitudinal-survey-of-biologic-treated-patients-with-atopic-dermatitis
#4
Eric Simpson, Laurent Eckert, Abhijit Gadkari, Usha G Mallya, Min Yang, Lauren Nelson, Michelle Brown, Matt Reaney, Puneet Mahajan, Isabelle Guillemin, Mark Boguniewicz, David Pariser
BACKGROUND: The Atopic Dermatitis Control Tool (ADCT©) is a brief patient self-administered instrument designed and validated to assess atopic dermatitis (AD) control; six AD symptoms and impacts are evaluated over the past week, including overall severity of symptoms, days with intense episodes of itching, intensity of bother, problem with sleep, impact on daily activities, and impact on mood or emotions. This study assessed the reliability, validity, and responsiveness of the ADCT in a longitudinal context, and provided thresholds to identify meaningful within-person change...
November 6, 2019: BMC Dermatology
https://read.qxmd.com/read/31647007/high-efficacy-of-a-dimeticone-based-pediculicide-following-a-brief-application-in-vitro-assays-and-randomized-controlled-investigator-blinded-clinical-trial
#5
Jorg Heukelbach, Doerte Wolf, John Marshall Clark, Hans Dautel, Kristina Roeschmann
BACKGROUND: Increasing resistance of head lice against neurotoxic agents and safety concerns have led to the search for treatment alternatives. Dimeticones with a physical mode of action are safe, and bear a reduced risk for the development of resistance. METHODS: We performed in vitro bioassays to assess pediculicidal and ovicidal activities of a new dimeticone-based product, and a randomized controlled clinical trial to assess efficacy, following 10 min application...
October 18, 2019: BMC Dermatology
https://read.qxmd.com/read/31510998/comparative-efficacy-of-three-pediculicides-to-treat-head-lice-infestation-in-primary-school-girls-a-randomised-controlled-assessor-blind-trial-in-rural-iran
#6
Hadi Kalari, Aboozar Soltani, Kourosh Azizi, Hossein Faramarzi, Mohammad Djaefar Moemenbellah-Fard
BACKGROUND: Head lice infestation (Pediculosis) is one of the most important health challenges particularly in primary school-aged children. It is often present among 6-11-year-old students in various tropical and temperate regions of the world. The aim of this study was to examine epidemiologic indices and comparative analysis of two pyrethroid-based and one non-chemical pediculicide products on head lice treatment of primary school girls in a rural setting of Fars province, south Iran, as part of a randomized controlled assessor blind trial...
September 12, 2019: BMC Dermatology
https://read.qxmd.com/read/31401977/ainhum-a-rare-mutilating-dermatological-disease-in-a-female-cameroonian-a-case-report
#7
Diego Nitcheu Tchouakam, Joel Noutakdie Tochie, Marc Leroy Guifo, Simeon Pierre Choukem
BACKGROUND: Ainhum is an idiopathic dermatological disease characterized by a progressive constricting ring usually on the fifth toe, which may lead to spontaneous auto-amputation of the affected toe. Timely diagnosis and treatment are the key elements to avert amputations with resultant mutilating deformities, permanent handicaps and psychological sequelae. Though common in African descents, this pathology has not been described in the Cameroonian literature. Herein, we report the case of an adult Cameroonian woman presenting with ainhum...
August 12, 2019: BMC Dermatology
https://read.qxmd.com/read/31337387/gluteal-hidradenitis-suppurativa-presenting-pemphigus-like-findings-case-report
#8
Yuichi Kurihara, Masutaka Furue
BACKGROUND: Hidradenitis suppurativa is one member of the follicular occlusion triad: acne conglobata, hidradenitis suppurativa, and dissecting cellulitis of the scalp. The presence of acantholysis and desmoglein autoantibodies in hidradenitis suppurativa is rare. CASE PRESENTATION: We report a case of 68-year-old male with a diagnosis of gluteal hidradenitis suppurativa co-presenting pemphigus-like findings including acantholysis and positive desmoglein autoantibodies...
July 23, 2019: BMC Dermatology
https://read.qxmd.com/read/31291927/a-seven-year-retrospective-analysis-of-patch-test-data-in-a-cohort-of-patients-with-contact-dermatitis-in-sri-lanka
#9
B S D P Keragala, H M M T B Herath, T S Keragala, M A M H Malavi, Chaturaka Rodrigo, C N Gunasekera
BACKGROUND: Patch testing with a baseline series is a common tool employed when the sensitizing agent in contact dermatitis is unclear. However, for Asian countries, there are no locally validated baseline series to utilize in screening. METHODS: We completed a retrospective analysis of all patients that had undergone patch testing with the European Baseline series, Shoe Series or Comprehensive International Baseline series, over 7 years from 2012 to 2018 in a tertiary care reference dermatology clinic in Sri Lanka to evaluate the suitability of these investigations to identify causes for contact dermatitis in the local study population...
July 10, 2019: BMC Dermatology
https://read.qxmd.com/read/31262288/diaper-dermatitis-a-survey-of-risk-factors-in-thai-children-aged-under-24-months
#10
Chonnakarn Sukhneewat, Jitjira Chaiyarit, Leelawadee Techasatian
BACKGROUND: To identify the prevalence and risk factors associated with diaper dermatitis in Thai children aged 1-24 months. METHODS: This was a cross-sectional study of 1153 participants using structural questionnaires, which was conducted at Khon Kaen University Faculty of Medicine Pediatric department in Thailand. Univariate and multivariate logistic regression analyses were used to test the association between diaper dermatitis and its possible risk factors...
July 2, 2019: BMC Dermatology
https://read.qxmd.com/read/31226985/rationale-objectives-and-design-of-pure-a-prospective-registry-of-patients-with-moderate-to-severe-chronic-plaque-psoriasis-in-canada-and-latin-america
#11
Kim A Papp, Melinda Gooderham, Jennifer Beecker, Charles W Lynde, Isabelle Delorme, Ignacio Dei-Cas, Lorne Albrecht, Emmanouil Rampakakis, John S Sampalis, Antonio Vieira, Shamiza Hussein, Olivier Chambenoit, Lenka Rihakova
BACKGROUND: Treatment options for the management of moderate to severe plaque psoriasis include phototherapy, oral systemic agents, and biologic therapy. Secukinumab, a fully human monoclonal antibody that selectively targets IL-17A, is the first IL-17 antagonist approved for this patient population. Long-term observational data are required for establishing the true population-based benefit-risk ratio of approved treatments. PURE is a multinational registry that will assess the real-world safety and effectiveness of secukinumab and other approved therapies in the management of patients with moderate to severe psoriasis...
June 21, 2019: BMC Dermatology
https://read.qxmd.com/read/31174539/a-multi-item-physician-global-assessment-scale-to-assess-psoriasis-disease-severity-validation-based-on-four-phase-iii-tofacitinib-studies
#12
Kristina Callis Duffin, Andrew G Bushmakin, Joseph C Cappelleri, Lotus Mallbris, Carla Mamolo
BACKGROUND: Several different Physician Global Assessment (PGA) versions have been used in clinical studies as a co-primary end point to evaluate psoriasis severity. Tofacitinib is an oral Janus kinase inhibitor. We performed an analysis of the PGA using data from studies of tofacitinib in moderate to severe chronic plaque psoriasis. METHODS: Data from 3641 patients with moderate to severe chronic plaque psoriasis, enrolled in one of four phase III tofacitinib studies (OPT Pivotal 1 and 2, OPT Compare and OPT Retreatment), were used to evaluate a three-item PGA scale...
June 7, 2019: BMC Dermatology
https://read.qxmd.com/read/31096980/sofosbuvir-induced-leucocytoclasic-vasculitis-a-case-report
#13
Elena Campione, Annunziata Dattola, Monia Di Prete, Daniele Di Paolo, Amedeo Ferlosio, Augusto Orlandi, Luca Bianchi
BACKGROUND: We describe a case of leucocytoclasic vasculitis induced by Sofosbuvir and its disappearence after the end of the therapy. The hepatitis C virus, firstly described in 1989, is a major global health problem, with high morbidity and mortality. We observed a temporal relationship between the treatment and the onset of vasculitis. We emphasize the multidisciplinary approach to the patients with liver disease to improve the quality of life of these patients. CASE PRESENTATION: A 53-year-old Caucasian man with a history of hepatitis C virus genotype 1 infection was examined at our Department of Dermatology for the occurrence of palpable purpura...
May 17, 2019: BMC Dermatology
https://read.qxmd.com/read/30961561/pattern-of-skin-diseases-in-children-attending-a-dermatology-clinic-in-a-referral-hospital-in-wolaita-sodo-southern-ethiopia
#14
Abraham Getachew Kelbore, Philip Owiti, Anthony J Reid, Efa Ambaw Bogino, Lantesil Wondewosen, Blen Kassahun Dessu
BACKGROUND: Epidemiological studies to determine the pattern of skin diseases among children are important for proper health care planning and management. The purpose of this study was to describe the pattern of skin diseases among pediatric patients seen at a dermatology outpatient clinic of Wolaita Sodo Teaching and Referral Hospital, southern Ethiopia. METHOD: We conducted a retrospective hospital-based, cross-sectional study between January 2016 and December 2017 at a teaching and referral hospital dermatology outpatient department...
April 8, 2019: BMC Dermatology
https://read.qxmd.com/read/30704477/a-novel-elastin-gene-frameshift-mutation-in-a-russian-family-with-cutis-laxa-a-case-report
#15
E G Okuneva, A A Kozina, N V Baryshnikova, A Yu Krasnenko, K Yu Tsukanov, O I Klimchuk, E I Surkova, V V Ilinsky
BACKGROUND: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive. The X-linked form is now classified in the group of copper transport diseases. Autosomal dominant CL is characterized by wrinkled, redundant and sagging, inelastic skin and in some cases is associated with internal organ involvement. CASE PRESENTATION: We report a familial case of autosomal dominant CL, which includes a 33-year-old woman and her 11-year-old son with dry, thin and wrinkled skin that appeared prematurely aged...
January 31, 2019: BMC Dermatology
https://read.qxmd.com/read/30674299/mucous-membrane-pemphigoid-associated-paronychia-with-onychomadesis
#16
Salim Alkeraye, Sarah F Alsukait
BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare. CASE PRESENTATION: We report on a 58 years old man with severe MMP who presented with onychomadesis. CONCLUSION: To our knowledge, mucous membrane pemphigoid associated paronychia and onychomadesis have not been reported before. We believe it is important for dermatologists to be aware of this entity...
January 23, 2019: BMC Dermatology
https://read.qxmd.com/read/30670022/proderm-technology-a-water-based-lipid-delivery-system-for-dermatitis-that-penetrates-viable-epidermis-and-has-antibacterial-effects
#17
Alexandra Charruyer, Mats Silvander, Melinda Caputo-Janhager, Isabelle Raymond, Ruby Ghadially
BACKGROUND: A defective skin barrier and bacterial colonization are two important factors in maintenance and progression of atopic dermatitis and chronic allergic/irritant hand dermatitis. A water-based lipid delivery system containing physiologic lipids was previously shown to be a useful adjunct in the treatment of hand dermatitis. We tested the ability of this formulation to penetrate into the viable epidermis and in addition assessed its antibacterial properties. METHODS: Epidermal penetration of the product was assessed by fluorescence microscopy...
January 22, 2019: BMC Dermatology
https://read.qxmd.com/read/30611259/differences-in-microrna-expression-between-melanoma-and-healthy-adjacent-skin
#18
Mariya Aksenenko, Nadezhda Palkina, Anna Komina, Liubov Tashireva, Tatiana Ruksha
BACKGROUND: The tumor microenvironment is composed of cancer-associated fibroblasts, tumor-associated macrophages, endothelial cells, immune cells, signaling molecules and extracellular matrix structures, which closelycommunicate with the tumor via multiple mechanisms. MicroRNAs are paracrine regulators that provide a direct interaction between the microenvironment and cancer cells. In the presentstudy, we aimed to identify the microRNA expression profile in melanoma compared with thatin healthy adjacent skin, with a further assessment of altered microRNA signaling pathways and target genes...
January 5, 2019: BMC Dermatology
https://read.qxmd.com/read/30541516/interdisciplinary-and-multiprofessional-outpatient-secondary-individual-prevention-of-work-related-skin-diseases-in-the-metalworking-industry-1-year-follow-up-of-a-patient-cohort
#19
Annika Wilke, Günther Gediga, Andreas Goergens, Andreas Hansen, Anja Hübner, Swen Malte John, Kathrin Nordheider, Marc Rocholl, Sabine Weddeling, Britta Wulfhorst, Dorothée Nashan
BACKGROUND: In Germany, work-related skin diseases are predominant within the spectrum of reported occupational diseases. Metal workers are among the high-risk professions. Offering effective prevention programs to affected patients is of utmost importance to avoid deterioration of the disease and job loss. We conducted a 1-year follow-up in patients who participated in a multidisciplinary, complex outpatient prevention program representing a standard procedure of patient care by the respective statutory accident insurance...
December 12, 2018: BMC Dermatology
https://read.qxmd.com/read/30509232/assessing-skin-disease-and-associated-health-related-quality-of-life-in-a-rural-lao-community
#20
C I Wootton, S Bell, A Philavanh, K Phommachack, M Soukavong, S Kidoikhammouan, S L Walker, M Mayxay
BACKGROUND: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI)...
December 4, 2018: BMC Dermatology
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