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BMC Cardiovascular Disorders

Jiangrong Wang, Zhan Li, Juanjuan Du, Jianhua Li, Yong Zhang, Jing Liu, Yinglong Hou
BACKGROUND: Structural remodeling is critical to the initiation and maintenance of atrial fibrillation (AF). IGF1, insulin like growth factor 1, has been recognized as contributor to fibrosis. However, the roles and mechanisms of IGF1 in structural remodeling during AF is still unclear. METHODS: We investigated the transcriptional expression profiles of left atria in AF and non-AF rat models by using microarray analysis. And quantitative real-time polymerase chain reaction (qRT-PCR) was performed to validate the accuracy...
February 15, 2019: BMC Cardiovascular Disorders
M A Baturova, A Lindgren, Y V Shubik, J Carlson, P G Platonov
BACKGROUND: Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predicted all-cause mortality during 10 years after ischemic stroke. METHODS: The study sample comprised 235 patients (median age 74 (interquartile range 25-75% 65-81) years, 95 female) included in the Lund Stroke Register in 2001-2002, who had sinus rhythm ECGs at stroke admission...
February 11, 2019: BMC Cardiovascular Disorders
Junjie Yang, Guanhua Dou, Christian Tesche, Carlo N De Cecco, Brian E Jacobs, U Joseph Schoepf, Yundai Chen
BACKGROUND: The heterogeneity of risk in patients with diabetes mellitus (DM) is acknowledged in new guidelines promulgating different treatment recommendations for diabetics at low cardiac risk. We performed a retrospective longitudinal follow-up study to evaluate coronary plaque progression and its impact on cardiac events in asymptomatic diabetic patients. METHODS: Data of 197 asymptomatic patients (63.1 ± 17 years, 60% males) with DM and suspected coronary artery disease (CAD) who underwent clinically indicated dual-source cardiac computed tomography (CT) were retrospectively analyzed...
February 11, 2019: BMC Cardiovascular Disorders
Stephanie R Reading, Mary Helen Black, Daniel E Singer, Alan S Go, Margaret C Fang, Natalia Udaltsova, Teresa N Harrison, Rong X Wei, In-Lu Amy Liu, Kristi Reynolds
BACKGROUND: Atrial fibrillation (AF) patients are routinely prescribed medications to prevent and treat complications, including those from common co-occurring comorbidities. However, adherence to such medications may be suboptimal. Therefore, we sought to identify risk factors for general medication non-adherence in a population of patients with atrial fibrillation. METHODS: Data were collected from a large, ethnically-diverse cohort of Kaiser Permanente Northern and Southern California adult members with incident diagnosed AF between January 1, 2006 and June 30, 2009...
February 11, 2019: BMC Cardiovascular Disorders
Zheng-Rong Xu, Jun Chen, Yuan-Hui Liu, Yong Liu, Ning Tan
BACKGROUND: Percutaneous coronary intervention (PCI) has been associated with contrast-induced nephropathy (CIN) at a rate that varies depending on the patient's risk factors. This study was conducted to evaluate the predictive value of the renal resistive index (RRI) for CIN in patients with acute coronary syndrome (ACS) undergoing PCI. METHODS: This prospective study enrolled 146 consecutive patients with ACS. Renal Doppler ultrasound examinations to measure RRI were performed pre-PCI and at 1 h and 24 h after PCI...
February 11, 2019: BMC Cardiovascular Disorders
Uma Chandrasekaran, Daniel Burkhoff, Kiyotake Ishikawa, Lija Swain, Kenji Sunagawa, Jacob Møller, Carlos Santos-Gallego, Shiva Annamalai, James Udelson, Ralf Westenfeld, Navin Kapur, Xiaoying Qiao, Julian Wiora, Andreas Schäfer, Alexander Bernhardt, Ajar Kochar, Robert Kloner, Haroon Faraz
No abstract text is available yet for this article.
February 7, 2019: BMC Cardiovascular Disorders
Li Wang, Jiamei Li, Ya Gao, Ruohan Li, Jingjing Zhang, Dan Su, Tao Wang, Guang Yang, Xiaochuang Wang
BACKGROUND: Previous studies have found a connection between left coronary artery dominance and worse prognoses in patient with acute coronary syndrome, which remains a predominant cause of morbidity and mortality globally. The aim of this study was to investigate whether coronary dominance is associated with the incidence of acute inferior myocardial infarction (MI). METHODS: Between January 2011 and November 2014, 265 patients with acute inferior MI and 530 age-matched and sex-matched controls were recruited for a case-control study in the Second Affiliated Hospital of Xi'an Jiaotong University in Xi'an, China...
February 4, 2019: BMC Cardiovascular Disorders
R Chaban, A Kornberger, N Branski, K Buschmann, N Stumpf, A Beiras-Fernandez, C F Vahl
February 4, 2019: BMC Cardiovascular Disorders
Ilais Moreno Velásquez, Ashwini Gajulapuri, Karin Leander, Anita Berglund, Ulf de Faire, Bruna Gigante
BACKGROUND: The aim of this study is to investigate if IL8 levels were associated with incident cardiovascular (CV) events (CVE) and mortality (all-cause, CV, and cancer) in a cohort of 60 years old men and women from Stockholm (60YO). METHODS: The 60YO comprises 4232 participants; baseline period: 1997-1999. The cohort is matched annually to population registries to record deaths and incident CVE. Serum IL8 was measured in 4011 participants and categorized in quartiles...
February 4, 2019: BMC Cardiovascular Disorders
L Pleva, P Kukla, K Vítková, V Procházka
BACKGROUND: Heart failure (HF) is a major chronic illness and results in high morbidity and mortality. The most frequent cause of HF with reduced ejection fraction (HFREF) is coronary artery disease (CAD). Although revascularisation of ischemic myocardium lead to improvements in myocardial contractility and systolic function, it cannnot restore the viability of the already necrotic myocardium. METHODS/DESIGN: The aim of our prospective randomised study is to assess the efficacy of the retrograde application of non-selected bone marrow autologous cells concentrate (BMAC) in patients with HFREF of ischemic aetiology...
January 31, 2019: BMC Cardiovascular Disorders
Buchuan Tan, Qian Liu, Liping Yang, Yushuang Yang, Dongna Liu, Long Liu, Fanbo Meng
BACKGROUND: Protein arginine methyltransferases (PRMTs) can catalyse the methylation of arginine and participate in many important cellular reaction processes. The purpose of this research is to determine whether the expression levels of the PRMT5 gene in peripheral blood can be used as a biomarker for predicting the risk of Acute Myocardial Infarction (AMI). METHODS: In this research, peripheral blood was collected from 91 patients with AMI and 87 patients with stable coronary artery disease (CAD)...
January 31, 2019: BMC Cardiovascular Disorders
Esteban Londoño Agudelo, Armando Rodríguez Salvá, Addys Díaz Piñera, René García Roche, Pol De Vos, Tullia Battaglioli, Patrick Van der Stuyft
BACKGROUND: To determine the prevalence of hypertension treatment and control among hypertensive patients in the Cuban municipalities of Cardenas and Santiago and to explore the main associated predictors. METHODS: Cross-sectional study, with multistage cluster sampling, conducted between February 2012 and January 2013 in two Cuban municipalities. We interviewed and measured blood pressure in 1333 hypertensive patients aged 18 years or older. Hypertension control was defined as blood pressure lower than 140/90 mmHg...
January 30, 2019: BMC Cardiovascular Disorders
Abdonas Tamosiunas, Janina Petkeviciene, Ricardas Radisauskas, Gailute Bernotiene, Dalia Luksiene, Mindaugas Kavaliauskas, Irena Milvidaitė, Dalia Virviciute
BACKGROUND: This study aimed to assess the trends in the prevalence of electrocardiographic (ECG) abnormalities from 1986 to 2015 and impact of ECG abnormalities on risk of death from cardiovascular diseases (CVD) in the Lithuanian population aged 40-64 years. METHODS: Data from four surveys carried out in Kaunas city and five randomly selected municipalities of Lithuania were analysed. A resting ECG was recorded and CVD risk factors were measured in each survey...
January 30, 2019: BMC Cardiovascular Disorders
M Piels, T Faes, J Vainer
BACKGROUND: Obstructive coronary artery disease is found in approximately 97% of patients presenting with ST-elevation myocardial infarction and 92% of patients with non ST-elevation myocardial infarction (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al. Int J Cardiol 264: 12-17, 2018). Recent studies showed that myocardial infarction without obstructive coronary atherosclerosis (MINOCA) is also associated with a long-term risk of adverse events (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al...
January 29, 2019: BMC Cardiovascular Disorders
Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, Jochen Renner, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Frank Kletzin, Jan Roesner, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F Brandes, Martin Bauer, Andreas Kortgen, Sebastian N Stehr, Maria Wittmann, Georg Baumgarten, Rafael Struck, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Michael Sander, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Frauke Degenhardt, Andre Franke, Soeren Mucha, Lukas Tittmann, Madeline Kohlhaas, Georg Fuernau, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm
BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery...
January 24, 2019: BMC Cardiovascular Disorders
Shuangkun Chen, Jiahui Li, Qianzhen Li, Zhihuang Qiu, Xijie Wu, Liangwan Chen
BACKGROUND: Metabolic syndrome (MetS) is a prevalent risk factor for coronary artery disease progression. Past studies have shown that MetS and its components tends to increase mortality after coronary artery bypass grafting (CABG), but data on the impact of MetS on postoperative outcome in patients with a left ventricular (LV) ejection fraction (EF) < 50% are still lacking. METHODS: Out of 2300 patients who underwent CABG between 2008 and 2018 in our center, 190 patients were identified as having impaired LV systolic function (EF < 50%)...
January 23, 2019: BMC Cardiovascular Disorders
Gaurav S Gulsin, Abhishek Shetye, Jeffrey Khoo, Daniel J Swarbrick, Eylem Levelt, Florence Y Lai, Iain B Squire, Jayanth R Arnold, Gerry P McCann
Following publication of the original article [1], the author reported his name has erroneously spelled as Abishek Shetye. The correct name is Abhishek Shetye.
January 21, 2019: BMC Cardiovascular Disorders
Andrew Czarnecki, Peter C Austin, Stephen E Fremes, Jack V Tu, Harindra C Wijeysundera, Dennis T Ko
BACKGROUND: Studies have shown that patients who undergo trans-catheter aortic valve replacement (TAVR) have high rates of hospital readmission. Our objectives were to identify the causes of readmission after TAVR, determine whether transitional care factors were associated with a reduction in readmission and to identify other predictors that could be used to target quality improvement efforts. METHODS: We conducted a chart abstraction study that included all patients who underwent TAVR in Ontario, Canada between 2007 and 2013 and survived to hospital discharge...
January 18, 2019: BMC Cardiovascular Disorders
Christine Reichart, Jochen Wöhrle, Sinisa Markovic, Wolfgang Rottbauer, Julia Seeger
BACKGROUND: Data on bioresorbable vascular scaffolds (BVS) for the treatment of long lesions are limited. We studied the use of BVS-Absorb in routine clinical practice and compared the outcome of long lesions with short lesions. Implantation of drug-eluting scaffolds without PSP-technique (predilation, proper sizing and postdilation) is associated with an increased thrombotic risk. We compared the long-term outcome up to 36 months of patients with short (< 20 mm) and long (≥20 mm) coronary artery lesions after implantation of bioresorbable vascular scaffolds (BVS) via PSP-technique...
January 18, 2019: BMC Cardiovascular Disorders
Shui-Ming Li, Wan-Ting Liu, Fang Yang, Qi-Jian Yi, Shuai Zhang, Hong-Ling Jia
BACKGROUND: Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. However, few researches explored phosphorylated proteins in KD patients. METHODS: We compared phosphoprotein profiles of HCAECs stimulated by the serum of KD patients and normal children using iTRAQ technology, TiO2 enrichment phosphorylated peptide and MS analysis...
January 17, 2019: BMC Cardiovascular Disorders
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