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BMC Pediatrics

Yu-Tang Chang, Ming-Yii Huang, Hsiang-Hung Shih, Chun-Chieh Wu, Tzu-Ying Lu, Pei-Chin Lin
BACKGROUND: Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 40% of primary gastric lymphoma. Gastric MALT lymphoma reaches its peak incidence between 50 to 60 years of age, therefore, it is rarely encountered in pediatric population. The presenting symptoms of gastric MALT lymphoma are usually nonspecific and primary perforation of gastric MALT lymphoma is uncommon...
February 19, 2019: BMC Pediatrics
Faten Moassas, Mohamad Sayah Nweder, Hossam Murad
BACKGROUND: Beta thalassemia (β-thal) is an inherited hemoglobin disorder characterized by reduced synthesis of the hemoglobin that results in microcytic hypochromic anemia. β-Thalassemia intermedia (TI) is a clinical term of intermediate gravity between the carrier state and β-thalassemia major (β -TM). CASE PRESENTATION: We describe a 12-year-old male proband originating from Al-Quneitra province - southwest Syria. Hematological investigations revealed, pallor and anemia (Hb 9 g/dl)...
February 18, 2019: BMC Pediatrics
Ti-Long Huang, Bao-Hua Sang, Qing-Ling Lei, Chun-Yan Song, Yun-Bi Lin, Yu Lv, Chun-Hui Yang, Na Li, Yue-Huang Yang, Xian-Wen Zhang, Xin Tian
BACKGROUND: Hereditary spherocytosis (HS) is a type of hemolytic anemia caused by abnormal red cell membrane skeletal proteins with few unique clinical manifestations in the neonate and infant. An ANK1 gene mutation is the most common cause of HS. CASE PRESENTATION: The patient was a 11-month-old boy who suffered from anemia and needed a regular transfusion therapy at an interval of 2-3 months. Hematological investigations showed moderate anemia (Hb80 g/L). Red cells displayed microcytosis (MCV76...
February 18, 2019: BMC Pediatrics
Ameyalli M Rodríguez-Cano, Jennifer Mier-Cabrera, Cinthya Muñoz-Manrique, Arturo Cardona-Pérez, Gicela Villalobos-Alcázar, Otilia Perichart-Perera
BACKGROUND: Body composition in infancy plays a central role in the programming of metabolic diseases. Fat mass (FM) is determined by personal and environmental factors. Anthropometric measurements allow for estimations of FM in many age groups; however, correlations of these measurements with FM in early stages of life are scarcely reported. The aim of this study was to evaluate anthropometric and clinical correlates of FM in healthy term infants at 6 months of age. METHODS: Healthy term newborns (n = 102) from a prospective cohort...
February 18, 2019: BMC Pediatrics
Ying-Fu Chen, Lan Hu, Feng Xu, Cheng-Jun Liu, Jing Li
BACKGROUND: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. CASE PRESENTATION: We report a rare case of HFMD in a 16-year-old male teenager residing in Chonqing, China. The clinical presentation was typical of HFMD and included vesicular lesions and oral mucosal ulcers, macular and vesicular lesions on palms and soles...
February 13, 2019: BMC Pediatrics
Anne Kerling, Okan Toka, André Rüffer, Hanna Müller, Sheeraz Habash, Christel Weiss, Sven Dittrich, Julia Moosmann
BACKGROUND: Postoperative fluid management in critically ill neonates and infants with capillary leak syndrome (CLS) and extensive volume overload after cardiac surgery on cardiopulmonary bypass is challenging. CLS is often resistant to conventional diuretic therapy, aggravating the course of weaning from invasive ventilation, increasing length of stay on ICU and morbidity and mortality. METHODS: Tolvaptan (TLV, vasopressin type 2 receptor antagonist) was used as an additive diuretic in neonates and infants with CLS after cardiac surgery...
February 12, 2019: BMC Pediatrics
Pasqua Piemontese, Domenica Mallardi, Nadia Liotto, Chiara Tabasso, Camilla Menis, Michela Perrone, Paola Roggero, Fabio Mosca
BACKGROUND: Donor human milk (DHM) is the best alternative for preterm infants when their own mother's milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influence the macronutrient content. The aim of this study was to investigate the effect of Holder pasteurization (HoP) on DHM macronutrient content. METHODS: Protein, lactose, lipids (g/100 ml) and energy (kcal/100 ml) of DHM pools were analysed before and after HoP (62...
February 12, 2019: BMC Pediatrics
Tzy-Chyi Yu, Chi Nguyen, Nancy Ruiz, Siting Zhou, Xian Zhang, Elaine A Böing, Hiangkiat Tan
BACKGROUND: Prevalence of hemolytic neonatal hyperbilirubinemia (NHB) is not well characterized, and economic burden at the population level is poorly understood. This study evaluated the prevalence, clinical characteristics, and economic burden of hemolytic NHB newborns receiving treatment in U.S. real-world settings. METHODS: This cohort study used administrative claims from 01/01/2011 to 08/31/2017. The treated cohort had hemolytic NHB diagnosis and received phototherapy, intravenous immunoglobulin, and/or exchange transfusions...
February 11, 2019: BMC Pediatrics
Susanne Kobel, Olivia Wartha, Jens Dreyhaupt, Sarah Kettner, Jürgen M Steinacker
BACKGROUND: The global incidence of overweight and obesity has increased dramatically among children and adolescents over the past decades. Insufficient sleep duration and physical inactivity are known risk factors for overweight and obesity in children. To engage children in a healthier lifestyle knowledge about associations of sleep duration and behavioural aspects in children are vital. Therefore, this study investigated the mentioned associations in German primary school children...
February 11, 2019: BMC Pediatrics
V Mandese, E Bigi, P Bruzzi, G Palazzi, B Predieri, L Lucaccioni, M Cellini, L Iughetti
BACKGROUND: Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crises may be involved. Aims of this study were to evaluate the growth pattern, endocrine complications, and metabolic alterations and to detect the relationship between these conditions and the SCD severity in affected children and adolescents...
February 11, 2019: BMC Pediatrics
Lijian Xie, Yun Li, Xunwei Jiang, Jian Zhao, Tingting Xiao
BACKGROUND: Abernethy malformation is an extremely rare congenital malformation characterised by an extrahepatic portosystemic shunt. Children with Abernathy malformation can develop hepatopulmonary syndrome (HPS) with pulmonary arteriovenous fistulas (PAVF) or pulmonary hypertension. PAVF manifests as central cyanosis with effort intolerance. We report a case of PAVF in a Ten-year-old Boy. Persistent symptoms identified Abernathy malformation as the cause of progressive symptoms and current understanding of this rare malformation is reviewed...
February 11, 2019: BMC Pediatrics
F H de Bitencourt, I V D Schwartz, F S L Vianna
BACKGROUND: The literature suggests that 0.9 to 6% of infants who die unexpectedly may have had a metabolic disorder. At least 43 different inborn errors of metabolism (IEMs) have been associated with sudden death (SUDI). To date, the frequency of IEM-associated SUDI has not been studied in Brazil. The present study sought to characterize infant mortality related to IEMs known to cause SUDI disaggregated by each of the regions of Brazil. METHODS: This was a descriptive, cross-sectional, population-based study of data obtained from the Brazilian Ministry of Health Mortality Information System (SIM)...
February 8, 2019: BMC Pediatrics
Saul N Faust, Maguelone Le Roy, Chitsanu Pancharoen, Miguel Angel Rodriguez Weber, Katrina Cathie, Ulrich Behre, Jolanta Bernatoniene, Matthew D Snape, Klaus Helm, Carlos Eduardo Medina Pech, Ouzama Henry, Carmen Baccarini, Michael Povey, Paul Gillard
BACKGROUND: A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous study showed that the vaccine was immunologically non-inferior to the HSA-containing vaccine and well-tolerated in toddlers; low-grade fever was numerically higher in children receiving the vaccine without HSA, but the study lacked power to conclude on this difference...
February 7, 2019: BMC Pediatrics
Thomas Waterfield, Derek Fairley, Bronagh Blackwood, James McKenna, Michael D Shields
BACKGROUND: The early recognition of meningococcal disease in children is vital. During the prodrome however, meningococcal infection presents similarly to many self-limiting viral infections. This mandates a cautious approach with many children receiving unnecessary broad-spectrum parenteral antibiotics. Advances in nucleic acid amplification techniques mean that it is now possible to test for Neisseria meningitidis DNA using Loop-mediated-isothermal AMPlification (LAMP). This technique is quicker than traditional PCR techniques and can be performed using simple equipment...
February 7, 2019: BMC Pediatrics
Mary Drake, Dunstan R Bishanga, Akwila Temu, Mustafa Njozi, Erica Thomas, Victor Mponzi, Lauren Arlington, Georgina Msemo, Mary Azayo, Allan Kairuki, Amunga R Meda, Kahabi G Isangula, Brett D Nelson
BACKGROUND: Newborn resuscitation is a life-saving intervention for birth asphyxia, a leading cause of neonatal mortality. Improving provider newborn resuscitation skills is critical for delivering quality care, but the retention of these skills has been a challenge. Tanzania implemented a national newborn resuscitation using the Helping Babies Breathe (HBB) training program to help address this problem. Our objective was to evaluate the effectiveness of two training approaches to newborn resuscitation skills retention implemented across 16 regions of Tanzania...
February 7, 2019: BMC Pediatrics
Freda Lennartsson, Per Nordin
BACKGROUND: The aim was to evaluate the intervention's effect on prevention and reversal of nonsynostotic plagiocephaly. METHODS: Thirty-eight intervention group nurses were educated about nonsynostotic plagiocephaly and asked to follow guidelines; 18 control group nurses were not. In a longitudinal single-blinded clinical intervention, parents brought infants to well-child visits according to the national schedule. Cranial shape was assessed in 176 intervention and 92 control group infants at 2-, 4-, and 12-month visits...
February 6, 2019: BMC Pediatrics
Abdoul-Magib Cissé, Gabrièle Laborde-Balen, Khady Kébé-Fall, Aboubacry Dramé, Halimatou Diop, Karim Diop, FatouNiasse-Traoré, Mohamed Coulibaly, Ndeye-Ngone Have, Nicole Vidal, Safiatou Thiam, Abdoulaye S Wade, Martine Peeters, Bernard Taverne, Philippe Msellati, Coumba Touré-Kane
BACKGROUND: In Senegal in 2015, an estimated 4800 children were living with HIV, with 1200 receiving ARV treatment, of whom half had follow-up care in decentralized sites outside Dakar. However, until now no studies have determined the efficacy of pediatric treatment in decentralized settings, even though the emergence of viral resistance, particularly among children in Africa, is a well-known phenomenon. This study aimed to assess the virological status of HIV-infected children in all decentralized facilities to help improve access to quality care...
February 5, 2019: BMC Pediatrics
Hani Saleh Faidah, Abdul Haseeb, Majd Yousuf Lamfon, Malak Mohammad Almatrafi, Imtinan Abdullah Almasoudi, Ejaz Cheema, Waleed Hassan Almalki, Mahmoud E Elrggal, Mahmoud M A Mohamed, Fahad Saleem, Manal Mansour Al-Gethamy, Beenish Pervaiz, Tahir Mehmood Khan, Mohamed Azmi Hassali
BACKGROUND: Excessive and inappropriate antimicrobial use in the community is one risk factor that can result in the spread of antimicrobial resistance. Upper respiratory tract infections are most frequently reported among children and mainly of viral origin and do not require antibiotics. We have conducted Knowledge, Attitude and Perception (KAP) survey of parents to explore the parent's knowledge, attitude & perception of Saudi parents. METHODS: A knowledge attitude perception questioner was adopted from a previous study conducted in Greece by Panagakou et al...
February 4, 2019: BMC Pediatrics
Carolin Donath, Marie Christine Bergmann, Sören Kliem, Thomas Hillemacher, Dirk Baier
BACKGROUND: Data on the prevalence of suicidal ideation, suicide attempts, and direct self-injurious behavior in adolescents with a migration background are scarce. There are hints that this population is at risk. The aim of the study is to investigate the epidemiology of suicidal ideation, suicide attempts, and direct self-injurious behavior in adolescents with a migration background in Germany while taking gender-specific differences into consideration. METHODS: A representative study with N = 10,638 students (mean age 14...
February 1, 2019: BMC Pediatrics
Nafsa R Marombwa, Hendry R Sawe, Upendo George, Said S Kilindimo, Nanyori J Lucumay, Kilalo M Mjema, Juma A Mfinanga, Ellen J Weber
BACKGROUND: A number of region-specific validated triage systems exist; however very little is known about their performance in resource limited settings. We compare the local triage tool and internationally validated tools among under-fives presenting to an urban emergency department in Tanzania. METHODOLOGY: Prospective descriptive study of consecutive under-fives seen at Muhimbili National Hospital (MNH), ED between November 2017 to April 2018. Patients were triaged according to Local Triage System (LTS), and the information collected were used to assign acuities in the other triage scales: Canadian Triage and Acuity Scale (CTAS), Australasian Triage Scale (ATS), Manchester Triage Scale (MTS) and South African Triage Scale (SATS)...
February 1, 2019: BMC Pediatrics
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