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BMC Ophthalmology

Flavio S Lopes, Igor Matsubara, Izabela Almeida, Syril K Dorairaj, Roberto M Vessani, Augusto Paranhos Jr, Tiago S Prata
BACKGROUND: To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters. METHODS: We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co...
February 15, 2019: BMC Ophthalmology
Isabella Herrera, Yong Kam, Thomas J Whittaker, Mary Champion, Radwan S Ajlan
BACKGROUND: To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy. CASE PRESENTATION: A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. She has a past medical history of chronic inflammatory demyelinating polyneuropathy, Sjogren's syndrome, and systemic lupus erythematosus that have been controlled with immunosuppressive therapy for three years...
February 14, 2019: BMC Ophthalmology
Jehn-Yu Huang, Chien-Chia Su, Tsing-Hong Wang, I-Ju Tsai
BACKGROUND: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Thus, in the present study, we investigated the risk for open angle glaucoma (OAG) in migraineurs using a 10-year follow-up study that employed a nationwide population-based dataset in Taiwan...
February 13, 2019: BMC Ophthalmology
Nicole M Putnam, Balamurali Vasudevan, Andre Juarez, Cam Tu Le, Kristine Sam, Pablo de Gracia, Allissun Hoppert
BACKGROUND: Many patients voice concerns regarding poor night vision, even when they see 20/20 or better in the exam room. During mesopic and scotopic conditions the pupil size increases, increasing the effects on visual performance of uncorrected (residual) refractive errors. The i.Scription refraction method claims to optimize traditional refractions for mesopic and scotopic conditions, by using the information that the Zeiss i.Profilerplus gathers of ocular aberrations (low and high order)...
February 12, 2019: BMC Ophthalmology
Shan Li, Bin Feng, Yabo Feng, Zaiying Pang, Youting Lin
BACKGROUND: Painful ophthalmoplegia can be caused by various etiologies, and broad differential diagnosis is needed. Carotid-cavernous fistula (CCF) is a rare cause of painful ophthalmoplegia, and early diagnosis is quite difficult. CASE PRESENTATION: Here, we present a case of paroxysmal painful ophthalmoplegia caused by CCF. The episodic symptoms were nonstereotypical and lasted minutes to hours. Magnetic resonance imaging (MRI) and computed tomography angiography (CTA) results were normal, which confounded efforts to determine a diagnosis...
February 11, 2019: BMC Ophthalmology
Samia Al Jabri, Jamie Kirkham, Fiona J Rowe
BACKGROUND: Core Outcome Sets (COS) are defined as the minimum sets of outcomes that should be measured and reported in all randomised controlled trials to facilitate combination and comparability of research. The aim of this review is to produce an item bank of previously reported outcome measures from published studies in amblyopia, strabismus and ocular motility disorders to initiate the development of COS. METHODS: A review was conducted to identify articles reporting outcome measures for amblyopia, strabismus and ocular motility disorders...
February 8, 2019: BMC Ophthalmology
Qin Qin, Lianyun Bao, Liping Yang, Zifang He, Zhenping Huang
BACKGROUND: This study sought to compare the visual quality between intraocular collamer lens (EVO-ICL) implantation and small-incision lenticule extraction (SMILE) and determine the appropriate surgical method to treat patients with high myopia (- 6.25 to - 10 D). METHODS: A total of 48 eyes underwent EVO-ICL implantation and another 48 eyes underwent SMILE. The uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BCVA) and equivalent spherical degree were compared across the SMILE (- 6...
February 8, 2019: BMC Ophthalmology
Lin Fu, Yau Kei Chan, Li Nie, Qi Dai, Zhenbin Qian, Kendrick Co Shih, Jimmy Shiu Ming Lai, Rong Huang, Weihua Pan
BACKGROUND: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation. METHODS: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included...
February 6, 2019: BMC Ophthalmology
Wenbo Zhang, Yadi Zhang, Lei Kang, Xiaopeng Gu, Hailong Wu, Liu Yang
BACKGROUND: A study was conducted to evaluate the choroidal thickness (CT) and retinal thickness (RT) in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome (NS). We also studied the correlation between the subfoveal choroidal thickness (SFCT) and serum protein concentration. METHODS: This was a cross-sectional study. Fifty-one paediatric patients with hypoalbuminaemia caused by NS and 41 normal subjects were included in the study. Enhanced depth imaging optical coherence tomography (EDI-OCT) was performed to measure the RT and CT...
February 6, 2019: BMC Ophthalmology
Ahmed A M Gad, Bahaa-Eldin Hasan Abdulhalim, Ayman Lotfy, Ayman Mohamed Abdelrahman, Ahmed Samir Ahmed
BACKGROUND: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma. METHODS: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes)...
February 6, 2019: BMC Ophthalmology
Xiaodi Qiu, Xianfang Rong, Jin Yang, Yi Lu
BACKGROUND: To compare the protective effects of the histone deacetylase inhibitors (HDACis) β-hydroxybutyrate (βOHB), trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human lens epithelial cells(HLECs) following ultraviolet-B (UVB) exposure. METHODS: HLECs were divided into subgroups: four HDACi groups, a control group, a UVB-treated group and a DMSO group (cells treated with DMSO and UVB irradiation). In the HDACi groups, HLECs were cultured with different concentrations of HDACis 12 h prior to UVB irradiation...
February 4, 2019: BMC Ophthalmology
Chengzhe Lu, Shasha Yu, Hui Song, Yun Zhao, Shiyong Xie, Xin Tang, Xiaoyong Yuan
BACKGROUND: To compare the influence of posterior capsule opacification (PCO) morphology and severity on intraocular stray light and visual function with different levels of contrast. METHODS: Forty-five patients diagnosed with PCO were included in this prospective consecutive case series. The Optical Quality Analysis System II (OQAS II) was adopted to assess the objective visual function including objective scatter index (OSI) and optical quality analysis system values (OVs) with 100, 20, and 9% contrast...
February 4, 2019: BMC Ophthalmology
Hirotaka Tanabe, Motoko Kawashima, Minako Kaido, Reiko Ishida, Tetsuya Kawakita, Kazuo Tsubota
BACKGROUND: To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands. METHODS: Twelve eyes of 6 subjects were all evaluated just before and after wiping lid margins using 1) tap water alone, 2) Eye Shampoo, 3) Eye Brush, or 4) both products, each during a different week. The results after using both products twice daily for 1 month were also evaluated. Wiping efficacy was determined by post-wiping scores for the remaining fluorescein-stained 0...
February 4, 2019: BMC Ophthalmology
Yaqin Jiang, Canwei Zhang, Jianli Ma, Luping Wang, Jing Gao, Jiantao Ren, Wei He, Sheng Wang, Shuai Sheng, Xudong Huang
BACKGROUND: To investigate the expression of Matrix Metalloproteinases 2 and aquaporin-1 in corneoscleral junction and explore the mechanism of trabecular damageafter angle-closure. METHODS: Thirty New Zealand white rabbits were randomly assigned into 2 groups, theexperimental group (Group 1) including twenty five rabbits and the control group (Group 2) including 5 rabbits. The rabbits in the experimental group were used to establish angle-closure models, and the rabbits in the control group were not subjected to any operation...
February 4, 2019: BMC Ophthalmology
Juanjuan Li, Yunpeng Li, Hua Li, Liwei Zhang
BACKGROUND: Multifocal choroiditis (MFC) is multi-inflammatory lesions that occur in the retinal pigment epithelium (RPE) and the choriocapillaris. Optical examinations are the major diagnostic methods to diagnose the disease. OBJECTIVE: To examine patients with different types of MFC by multiple imageological methods. To summarize the imageology features of different types of MFC to make a medical examination guideline for clinician practices. METHOD: All of the patients who included in the study received examinations of fundus color photography, infrared fundus photography, fundus auto fluorescence (FAF), fluorescein fundus angiography (FFA), and optical coherence tomography (OCT), respectively...
February 1, 2019: BMC Ophthalmology
Ipsita Sutradhar, Priyanka Gayen, Mehedi Hasan, Rajat Das Gupta, Tapash Roy, Malabika Sarker
INTRODUCTION: Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21.6% have low vision. Therefore, this paper aimed to identify the community-based prevalence and associated risk factors of eye diseases among slum dwellers of Dhaka city. METHODS: The study was carried out in two phases. In the first phase, a survey was conducted using multistage cluster sampling among 1320 households of three purposively selected slums in Dhaka city...
January 31, 2019: BMC Ophthalmology
Ryan Gise, Timothy Truong, Afshin Parsikia, Joyce N Mbekeani
PURPOSE: Pediatric ocular trauma is a major source of morbidity and blindness and the number of epidemiological studies is incommensurate with its significance. We sought to determine differences in epidemiologic patterns of pediatric ocular injuries based on intention. METHODS: A retrospective review of the National Trauma Data Bank (2008-2014) was performed and patients < 21 years old, admitted with trauma and ocular injury, were identified using ICD-9CM codes...
January 29, 2019: BMC Ophthalmology
Song Xia, Xin-Yu Zhao, Er-Qian Wang, You-Xin Chen
BACKGROUND: A few randomized controlled trials (RCTs) have evaluated face-down posturing (FDP) with the far less physically challenging nonsupine posturing (NSP) in the treatment of idiopathic full-thickness macular holes (MHs). The objective of our study was to evaluate the efficacy of postoperative posturing on the anatomical and functional outcomes of MH surgery. METHODS: The PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched from their earliest entries through December 2016 to identify the studies that had evaluated the effects of postoperative posturing with FDP or NSP for patients with MH surgery...
January 28, 2019: BMC Ophthalmology
Yi Zha, Wei Huang, Jinfei Zhuang, Jianqiu Cai
PURPOSE: To measure peripapillary retinal nerve fiber layer (RNFL) thickness and posterior pole retinal thickness in primary angle-closure suspects (PACS) by Spectral domain optical coherence tomography (SD-OCT) and to be compared with normal subjects. METHODS: Thirty five primary angle-closure suspect patients and thirty normal subjects were enrolled in this study. Peripapillary RNFL and posterior pole retinal thickness by posterior pole asymmetry analysis (PPAA) in SD-OCT were measured...
January 28, 2019: BMC Ophthalmology
Patricia J McLaughlin, Joseph W Sassani, Michelle B Titunick, Ian S Zagon
BACKGROUND: Dry eye disease (DED) is a prevalent complication of diabetes and presents as reduced tear production and/or increased corneal surface sensitivity often with secondary ocular surface changes. This study examined the safety and efficacy of a proprietary new eye drop formulation for topical treatment of DED. METHODS: Type 1 diabetes (T1D) was established in male Sprague-Dawley rats to study the efficacy and safety of the investigational compound that contained 20 μg/ml of naltrexone (NTX)...
January 28, 2019: BMC Ophthalmology
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