journal
https://read.qxmd.com/read/38532359/sirt5-promote-malignant-advancement-of-chordoma-by-regulating-the-desuccinylation-of-c-myc
#1
JOURNAL ARTICLE
Minghui Jiang, Zheng Huang, Li Chen, Ting Deng, Junpeng Liu, Yue Wu
Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT)5 plays pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found. This study was performed to investigate the regulatory effects of SIRT5 on cell proliferation, migration, and invasion and the underlying mechanism in chordoma. A xenograft tumor mouse model was established to assess tumor growth. Reverse transcription-quantitative polymerase chain reaction was used to analyze the mRNA levels of SIRT5 and c-myc...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532345/reductive-prodrug-and-aie-copolymer-nanoparticle-for-monitoring-and-chemotherapy
#2
JOURNAL ARTICLE
Zigui Wang, Guilin Li, Qiaohui Zhao, Guangyu Fu, Zengli Yang, Guojun Zhang
Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately controlling drug and probe release from the nanoparticles and determining the loading content of drug and probe. To address these issues, we have developed a reduction-responsive Pt(IV) prodrug-based polymeric delivery system that can be dynamically monitored using aggregation-induced emission luminogens (AIE) based bioprobes...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532338/carbon-ion-radiotherapy-for-hepatocellular-carcinoma-with-major-vascular-invasion-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada, Masaru Miyazaki
BACKGROUND: Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI. METHODS: This retrospective cohort study evaluated HCC patients with MVI treated using C-ion RT with a dose of 45...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532314/reproductive-factors-and-risk-of-lung-cancer-among-300-000-chinese-female-never-smokers-evidence-from-the-china-kadoorie-biobank-study
#4
JOURNAL ARTICLE
Marwa M A Elbasheer, Bastian Bohrmann, Yiping Chen, Jun Lv, Dianjianyi Sun, Xia Wu, Xiaoming Yang, Daniel Avery, Liming Li, Zhengming Chen, Christiana Kartsonaki, Ka Hung Chan, Ling Yang
BACKGROUND: Lung cancer is the leading cause of cancer mortality among Chinese females despite the low smoking prevalence among this population. This study assessed the roles of reproductive factors in lung cancer development among Chinese female never-smokers. METHODS: The prospective China Kadoorie Biobank (CKB) recruited over 0.5 million Chinese adults (0.3 million females) from 10 geographical areas in China in 2004-2008 when information on socio-demographic/lifestyle/environmental factors, physical measurements, medical history, and reproductive history collected through interviewer-administered questionnaires...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532312/high-expression-of-rtel1-predicates-worse-progression-in-gliomas-and-promotes-tumorigenesis-through-jnk-elk1-cascade
#5
JOURNAL ARTICLE
Guanjie Wang, Xiaojuan Ren, Jianying Li, Rongrong Cui, Xumin Zhao, Fang Sui, Juan Liu, Pu Chen, Qi Yang, Meiju Ji, Peng Hou, Ke Gao, Yiping Qu
Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of glioma. In order to investigate the biological role of RTEL1 in glioma. Relative telomere length (RTL) and RTEL1 mRNA was explored and regression analysis was performed to further examine the relationship of the RTL and the expression of RTEL1 with clinicopathological characteristics of glioma patients. We observed that high expression of RTEL1 is positively correlated with telomere length in glioma tissue, and serve as a poor prognostic factor in TERT wild-type patients...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38528547/evaluation-of-the-diagnostic-performance-of-colposcopy-in-the-detection-of-cervical-high-grade-squamous-intraepithelial-lesions-among-women-with-transformation-zone-type-3
#6
JOURNAL ARTICLE
Xiaoxiao Li, Yunzhi Zhao, Fenfen Xiang, Xinpei Zhang, Zixi Chen, Mengzhe Zhang, Xiangdong Kang, Rong Wu
BACKGROUND: Inaccurate colposcopy diagnosis may lead to inappropriate management and increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic accuracy of colposcopy in the detection of histologic cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women with transformation zone type 3 (TZ3). METHODS: Records from 764 patients with TZ3 who underwent colposcopy-directed biopsy and/or endocervical curettage in Putuo Hospital China between February 2020 and March 2023 were retrospectively collected...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38528507/the-radiological-characteristics-tertiary-lymphoid-structures-and-survival-status-associated-with-egfr-mutation-in-patients-with-subsolid-nodules-like-stage-i-ii-luad
#7
JOURNAL ARTICLE
Mei Xie, Jie Gao, Xidong Ma, Jialin Song, Chongchong Wu, Yangyu Zhou, Tianjiao Jiang, Yiran Liang, Chen Yang, Xinyu Bao, Xin Zhang, Jie Yao, Ying Jing, Jianlin Wu, Jianxin Wang, Xinying Xue
BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as subsolid nodules. MATERIALS AND METHODS: The inclusion of patients exhibiting clinical staging of IA-IIB subsolid nodules...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528489/correction-effect-of-educational-intervention-on-the-knowledge-attitude-and-practice-of-breast-self-examination-among-female-students-at-a-private-university-in-southern-nigeria
#8
Rejoice Oritsemoyowa Uruntie, Chime Helen Oputa, Esegbue Peters, Agofure Otovwe
No abstract text is available yet for this article.
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528488/decision-making-and-autonomy-among-participants-in-early-phase-cancer-immunotherapy-trials-a-qualitative-study
#9
JOURNAL ARTICLE
Jonathan Avery, Jennifer A H Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim, Lynda G Balneaves
BACKGROUND: Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influence patients' decisions about participating in early-phase cancer immunotherapy CTs through the ethical lens of relational autonomy. METHODS: Using an interpretive descriptive design, interviews were conducted with 21 adult patients with advanced cancer who had enrolled in an early-phase CT...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528486/comment-on-a-novel-super-enhancer-related-gene-signature-predicts-prognosis-and-immune-microenvironment-for-breast-cancer
#10
LETTER
Matin Chehelgerdi, Milad Khorramian-Ghahfarokhi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi
The primary aim of this study is to critically evaluate and comment on the research presented in the article titled "A Novel Super-Enhancer-Related Gene Signature Predicts Prognosis and Immune Microenvironment for Breast Cancer" by Wu et al. Our specific objectives include assessing the methodology employed by the authors, particularly in regard to the utilization of a super-enhancer-related gene signature for breast cancer prognosis prediction. We propose the necessity of subgroup analysis to effectively address the heterogeneity in breast cancer subtypes, which is crucial for the applicability of the SERGs across diverse breast cancer cases...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528478/a-lack-of-association-between-bmi-and-chemoimmunotherapy-efficacy-in-advanced-non-small-cell-lung-cancer-secondary-analysis-of-the-impower150-and-impower130-clinical-trials
#11
JOURNAL ARTICLE
Lee X Li, Mark A Socinski, Ganessan Kichenadasse, Christos S Karapetis, Adel Shahnam, Ross A McKinnon, Andrew Rowland, Ashley M Hopkins, Michael J Sorich
BACKGROUND: Multiple studies have indicated that patients with high body mass index (BMI) may have favourable survival outcomes following treatment with an immune checkpoint inhibitor (ICI). However, this evidence is limited by several factors, notably the minimal evidence from randomised controlled trials (RCTs), the use of categorised BMI with inconsistent cut point definitions, and minimal investigation of contemporary combination ICI therapy. Moreover, whether overweight and obese patients gain a larger benefit from contemporary frontline chemoimmunotherapy in non-small cell lung cancer (NSCLC) is unclear...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528468/accuracy-of-endometrial-sampling-in-the-diagnosis-of-endometrial-cancer-a-multicenter-retrospective-analysis-of-the-jago-noggo
#12
JOURNAL ARTICLE
Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine KunzYoung Academy Of Gynecologic Oncology, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer, Jalid Sehouli, Klaus Pietzner
BACKGROUND: Accurate preoperative molecular and histological risk stratification is essential for effective treatment planning in endometrial cancer. However, inconsistencies between pre- and postoperative tumor histology have been reported in previous studies. To address this issue and identify risk factors related to inaccurate histologic diagnosis after preoperative endometrial evaluation, we conducted this retrospective analysis. METHODS: We conducted a retrospective analysis involving 375 patients treated for primary endometrial cancer in five different gynaecological departments in Germany...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528462/single-cell-transcriptional-signature-based-drug-repurposing-and-in-vitro-evaluation-in-colorectal-cancer
#13
JOURNAL ARTICLE
Roohallah Mahdi-Esferizi, Zahra Shiasi, Razieh Heidari, Ali Najafi, Issa Mahmoudi, Fatemeh Elahian, Shahram Tahmasebian
BACKGROUND: The need for intelligent and effective treatment of diseases and the increase in drug design costs have raised drug repurposing as one of the effective strategies in biomedicine. There are various computational methods for drug repurposing, one of which is using transcription signatures, especially single-cell RNA sequencing (scRNA-seq) data, which show us a clear and comprehensive view of the inside of the cell to compare the state of disease and health. METHODS: In this study, we used 91,103 scRNA-seq samples from 29 patients with colorectal cancer (GSE144735 and GSE132465)...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528459/positivity-rates-trends-and-experiences-of-health-workers-on-human-papillomavirus-screened-using-genexpert-in-uganda-a-three-year-retrospective-cohort-study
#14
JOURNAL ARTICLE
Harriet Nakigozi, Paul Mukama Ategyeka, Susan Nabadda, Rawlance Ndejjo
INTRODUCTION: Cervical cancer is a major public health issue in Uganda, with high incidence due to limited screening especially in rural areas. In 2019, HPV DNA testing using GeneXpert was rolled out to improve screening access. Assessing progress and challenges since its introduction is important. AIM: To determine genotype distribution and explore health worker experiences with HPV screening using GeneXpert in Uganda. METHODS: We conducted a retrospective cohort study where HPV screening data from 66 GeneXpert labs from March 2021-May 2023 country wide was analyzed...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528456/roar-a-re-optimization-based-online-adaptive-radiotherapy-of-anal-cancer-a-prospective-phase-ii-trial-protocol
#15
JOURNAL ARTICLE
Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen
BACKGROUND: Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region. This increases the irradiated volume and radiation dose to the surrounding normal tissue and thereby toxicity...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528446/correction-a-real-world-study-of-the-effectiveness-and-safety-of-apatinib-based-regimens-in-metastatic-triple-negative-breast-cancer
#16
Weiwei Huang, Chenxi Wang, Yangkun Shen, Qi Chen, Zhijian Huang, Jian Liu, Xiaoyan Lin, Lili Wang, Fan Wu, Xinhua Chen, Nani Li, Yi Hong, Mulan Chen, Jieyu Li, Chuanzhong Huang
No abstract text is available yet for this article.
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528445/investigator-choice-of-standard-therapy-versus-sequential-novel-therapy-arms-in-the-treatment-of-relapsed-follicular-lymphoma-refract-study-protocol-for-a-multi-centre-open-label-randomised-phase-ii-platform-trial
#17
JOURNAL ARTICLE
Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F Barrington, Ingo Ringshausen, Alan G Ramsay, Maria Calaminici, Kim Linton, Mark Bishton
BACKGROUND: Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined. METHODS: The REFRACT trial is an investigator-initiated, UK National Cancer Research Institute, open-label, multi-centre, randomised phase II platform trial aimed at accelerating clinical development of novel therapies by addressing evidence gaps...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38519974/development-and-validation-of-a-radiopathomics-model-based-on-ct-scans-and-whole-slide-images-for-discriminating-between-stage-i-ii-and-stage-iii-gastric-cancer
#18
JOURNAL ARTICLE
Yang Tan, Li-Juan Feng, Ying-He Huang, Jia-Wen Xue, Zhen-Bo Feng, Li-Ling Long
OBJECTIVE: This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological staging of gastric cancer (stage I-II and stage III). METHODS: This study included a total of 202 gastric cancer patients with confirmed pathological staging (training cohort: n = 141; validation cohort: n = 61). Pathological histological features were extracted from HE slides, and pathological models were constructed using logistic regression (LR), support vector machine (SVM), and NaiveBayes...
March 22, 2024: BMC Cancer
https://read.qxmd.com/read/38519889/cd13-expression-affects-glioma-patient-survival-and-influences-key-functions-of-human-glioblastoma-cell-lines-in-vitro
#19
JOURNAL ARTICLE
Wenying Zhang, Anne Blank, Irina Kremenetskaia, Anja Nitzsche, Güliz Acker, Peter Vajkoczy, Susan Brandenburg
CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients obtained by TCGA and CGGA databases were used to evaluate the survival rate and prognostic value of CD13 expression level. Protein expression of CD13 was confirmed by immunofluorescence staining of fresh patient tissues. Eight human glioblastoma cell lines were studied by RT-PCR, Western Blot, immunofluorescence staining and flow cytometry to define CD13 expression...
March 22, 2024: BMC Cancer
https://read.qxmd.com/read/38515096/clinical-characteristics-and-mri-based-radiomics-nomograms-can-predict-ipfs-and-short-term-efficacy-of-third-generation-egfr-tki-in-egfr-mutated-lung-adenocarcinoma-with-brain-metastases
#20
JOURNAL ARTICLE
Haoran Qi, Yichen Hou, Zhonghang Zheng, Mei Zheng, Qiang Qiao, Zihao Wang, Xiaorong Sun, Ligang Xing
BACKGROUND: Predicting short-term efficacy and intracranial progression-free survival (iPFS) in epidermal growth factor receptor gene mutated (EGFR-mutated) lung adenocarcinoma patients with brain metastases who receive third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy was of great significance for individualized treatment. We aimed to construct and validate nomograms based on clinical characteristics and magnetic resonance imaging (MRI) radiomics for predicting short-term efficacy and intracranial progression free survival (iPFS) of third-generation EGFR-TKI in EGFR-mutated lung adenocarcinoma patients with brain metastases...
March 21, 2024: BMC Cancer
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