journal
https://read.qxmd.com/read/38418976/development-of-preoperative-and-postoperative-models-to-predict-recurrence-in-postoperative-glioma-patients-a-longitudinal-cohort-study
#1
JOURNAL ARTICLE
Wanyu Qiao, Yi Wang, Chen Luo, Jinsong Wu, Guoyou Qin, Jie Zhang, Ye Yao
BACKGROUND: Glioma recurrence, subsequent to maximal safe resection, remains a pivotal challenge. This study aimed to identify key clinical predictors influencing recurrence and develop predictive models to enhance neurological diagnostics and therapeutic strategies. METHODS: This longitudinal cohort study with a substantial sample size (n = 2825) included patients with non-recurrent glioma who were pathologically diagnosed and had undergone initial surgical resection between 2010 and 2018...
February 28, 2024: BMC Cancer
https://read.qxmd.com/read/38409035/inhibition-of-growth-of-hepatocellular-carcinoma-by-co-delivery-of-anti-pd-1-antibody-and-sorafenib-using-biomimetic-nano-platelets
#2
JOURNAL ARTICLE
Xuanbo Da, Bangping Cao, Jiantao Mo, Yukai Xiang, Hai Hu, Chen Qiu, Cheng Zhang, Beining Lv, Honglei Zhang, Chuanqi He, Yulong Yang
BACKGROUND: Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. MATERIALS AND METHODS: Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408985/protect-the-recurrent-laryngeal-nerves-in-us-guided-microwave-ablation-of-thyroid-nodules-at-zuckerkandl-tubercle-a-pilot-study
#3
JOURNAL ARTICLE
Ziyue Hu, Lu Wang, Man Lu, Wei Yang, Xiaobo Wu, Jinshun Xu, Min Zhuang, Shishi Wang
BACKGROUND: To evaluate the safety and efficacy of US-guided microwave ablation in patients with thyroid nodules at Zuckerkandl tubercle. METHODS: 103 consecutive patients with thyroid nodules at Zuckerkandl tubercle (ZTTN) were enrolled in this study from November 2017 to August 2021. Prior to the surgery or US-guided microwave ablation (MWA), preoperative ultrasound visualization of the recurrent laryngeal nerve (RLN) and ZTTN was performed, the size and the position relationship between them were observed...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408977/assessing-the-causal-relationship-between-731-immunophenotypes-and-the-risk-of-lung-cancer-a-bidirectional-mendelian-randomization-study
#4
JOURNAL ARTICLE
Ming Xu, Chengkai Li, Liyan Xiang, Siyue Chen, Lin Chen, Gongxia Ling, Yanqing Hu, Lan Yang, Xiang Yuan, Xiaodong Xia, Hailin Zhang
BACKGROUND: Previous studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors. However, the causal relationship between them remains unclear. METHODS: Bidirectional Mendelian randomization (MR) was performed on publicly available genome-wide association study (GWAS) summary statistics to analyze the causal relationships between 731 immunophenotypes and lung cancer. Sensitivity analyses were conducted to verify the robustness, heterogeneity, and potential horizontal pleiotropy of our findings...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408960/comprehensive-machine-learning-based-preoperative-blood-features-predict-the-prognosis-for-ovarian-cancer
#5
JOURNAL ARTICLE
Meixuan Wu, Sijia Gu, Jiani Yang, Yaqian Zhao, Jindan Sheng, Shanshan Cheng, Shilin Xu, Yongsong Wu, Mingjun Ma, Xiaomei Luo, Hao Zhang, Yu Wang, Aimin Zhao
PURPOSE: Significant advancements in improving ovarian cancer (OC) outcomes have been limited over the past decade. To predict prognosis and improve outcomes of OC, we plan to develop and validate a robust prognosis signature based on blood features. METHODS: We screened age and 33 blood features from 331 OC patients. Using ten machine learning algorithms, 88 combinations were generated, from which one was selected to construct a blood risk score (BRS) according to the highest C-index in the test dataset...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408959/egr1-mediates-mdr1-transcriptional-activity-regulating-gemcitabine-resistance-in-pancreatic-cancer
#6
JOURNAL ARTICLE
Zhe Yang, Feiran Chen, Dafu Wei, Fengping Chen, Haixing Jiang, Shanyu Qin
BACKGROUND: Gemcitabine is a cornerstone drug for the treatment of all stages of pancreatic cancer and can prolong the survival of patients with pancreatic cancer, but resistance to gemcitabine in pancreatic cancer patients hinders its efficacy. The overexpression of Early growth response 1(EGR1) in pancreatic ductal adenocarcinoma as a mechanism of gemcitabine chemoresistance in pancreatic cancer has not been explored. The major mechanisms of gemcitabine chemoresistance are related to drug uptake, metabolism, and action...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408958/pancreatic-adenocarcinoma-third-line-systemic-treatments-a-retrospective-cohort-study
#7
JOURNAL ARTICLE
A Gueiderikh, A Tarabay, M Abdelouahab, C Smolenschi, M L Tanguy, M Valery, D Malka, T Pudlarz, A Fuerea, V Boige, A Hollebecque, M Ducreux, A Boilève
BACKGROUND: Chemotherapy for metastatic pancreatic adenocarcinoma (PDAC) primarily relies on FOLFIRINOX (LV5FU- irinotecan - Oxaliplatine) and Gemcitabine - Nab-Paclitaxel in the first-line setting. However, second-lines remain less well-defined and there is limited data regarding third-line treatments. The objective of our study was to determine the proportion of patients advancing to third line chemotherapy, to outline the various third-line chemotherapy regimens used in routine practice and to evaluate their respective efficacy...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408930/alpha-fetoprotein-predicts-the-treatment-efficacy-of-immune-checkpoint-inhibitors-for-gastric-cancer-patients
#8
JOURNAL ARTICLE
Jingjing Zhang, Lei Wang, Shasha Zhang, Ruijie Cao, Yufei Zhao, Yue Zhao, Yanrong Song, Zhanjun Guo
BACKGROUND: Immune checkpoint inhibitors (ICIs) are commonly used in conjunction with chemotherapy to improve treatment outcomes for patients with gastric cancer. Since AFP could influence immunity by both inhibiting natural killer (NK) cells and regulating negatively the function of dendritic cells, we evaluated the influence of baseline serum alpha-fetoprotein (AFP) levels on the curative effect of ICIs in advanced gastric cancer (AGC) patients. METHODS: A retrospective analysis was conducted on 158 AGC patients who underwent ICI treatment...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38408928/quantification-of-preexisting-lung-ground-glass-opacities-on-ct-for-predicting-checkpoint-inhibitor-pneumonitis-in-advanced-non-small-cell-lung-cancer-patients
#9
JOURNAL ARTICLE
Xinyue Wang, Jinkun Zhao, Ting Mei, Wenting Liu, Xiuqiong Chen, Jingya Wang, Richeng Jiang, Zhaoxiang Ye, Dingzhi Huang
BACKGROUND: Immune checkpoint inhibitors (ICIs) can lead to life-threatening pneumonitis, and pre-existing interstitial lung abnormalities (ILAs) are a risk factor for checkpoint inhibitor pneumonitis (CIP). However, the subjective assessment of ILA and the lack of standardized methods restrict its clinical utility as a predictive factor. This study aims to identify non-small cell lung cancer (NSCLC) patients at high risk of CIP using quantitative imaging. METHODS: This cohort study involved 206 cases in the training set and 111 cases in the validation set...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38403626/ct-guided-radioactive-125-i-seeds-brachytherapy-for-lung-oligometastases-from-colorectal-cancer-initial-results
#10
JOURNAL ARTICLE
Mengyao Song, Xueliang Zhou, Rongna Hou, Milan Sigdel, Yiming Liu, Chengzhi Zhang, Kaihao Xu, Xinwei Han, Dechao Jiao
OBJECTIVES: To evaluate the safety and effectiveness of computed tomography (CT)-guided radioactive 125 I seeds brachytherapy (RISB) for lung oligometastases (LO) from colorectal cancer (CRC). METHODS: Data for 144 LOs from 70 CRC patients who underwent CT-guided RISB were retrospectively analyzed. The primary endpoints were progression-free survival (PFS) and overall survival (OS), and the secondary endpoints were technical success, local control rate (LCR), and complications...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38402399/efficacy-of-adding-levofloxacin-to-gemcitabine-and-nanoparticle-albumin-binding-paclitaxel-combination-therapy-in-patients-with-advanced-pancreatic-cancer-study-protocol-for-a-multicenter-randomized-phase-2-trial-t-core2201
#11
JOURNAL ARTICLE
Hiroo Imai, Yasuhiro Sakamoto, Shin Takahashi, Hiroyuki Shibata, Atsushi Sato, Kazunori Otsuka, Kenji Amagai, Masanobu Takahashi, Takuhiro Yamaguchi, Chikashi Ishioka
BACKGROUND: Advanced pancreatic cancer is one of the leading causes of cancer-related deaths. For patients with advanced pancreatic cancer, gemcitabine and nanoparticle albumin-binding paclitaxel (nabPTX) combination (GEM/nabPTX) therapy is one of the recommended first-line treatments. Several retrospective studies have suggested that the addition of levofloxacin improves the efficacy of GEM/nabPTX therapy in patients with advanced pancreatic cancer. This prospective study aims to evaluate whether the addition of antibiotics improves the treatment efficacy of GEM/nabPTX as a first-line chemotherapy in patients with advanced pancreatic cancer...
February 24, 2024: BMC Cancer
https://read.qxmd.com/read/38402391/does-transanal-drainage-tubes-placement-have-an-impact-on-the-incidence-of-anastomotic-leakage-after-rectal-cancer-surgery-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Yating Liu, Xuhua Hu, Yu Huang, Xu Yin, Pengfei Zhang, Yaoguang Hao, Hongyan Li, Guiying Wang
BACKGROUND: Whether Transanal drainage tubes (TDTs) placement reduces the occurrence of anastomotic leakage (AL) after rectal cancer (RC) surgery remains controversial. Most existing meta-analyses rely on retrospective studies, while the prospective studies present an inadequate level of evidence. METHODS: A systematic review and meta-analysis of prospective studies on TDTs placement in RC patients after surgery was conducted. The main analysis index was the incidence of AL, Grade B AL, and Grade C AL, while secondary analysis index was the incidence of anastomotic bleeding, incision infection, and anastomotic stenosis...
February 24, 2024: BMC Cancer
https://read.qxmd.com/read/38402385/gut-microbiota-in-patients-with-prostate-cancer-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Haotian Huang, Yang Liu, Zhi Wen, Caixia Chen, Chongjian Wang, Hongyuan Li, Xuesong Yang
BACKGROUND: Increasing evidence indicates that gut microbiota are closely related to prostate cancer. This study aims to assess the gut microbiota composition in patients with prostate cancer compared to healthy participants, thereby advancing understanding of gut microbiota's role in prostate cancer. METHODS: A systematic search was conducted across PubMed, Web of Science, and Embase databases, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
February 24, 2024: BMC Cancer
https://read.qxmd.com/read/38402382/advanced-gastrointestinal-stromal-tumor-reliable-classification-of-imatinib-plasma-trough-concentration-via-machine-learning
#14
JOURNAL ARTICLE
Pan Ran, Tao Tan, Jinjin Li, Hao Yang, Juan Li, Jun Zhang
AIM: Patients with advanced gastrointestinal stromal tumors (GISTs) exhibiting an imatinib plasma trough concentration (IM Cmin ) under 1100 ng/ml may show a reduced drug response rate, leading to the suggestion of monitoring for IM Cmin . Consequently, the objective of this research was to create a customized IM Cmin classification model for patients with advanced GISTs from China. METHODS: Initial data and laboratory indicators from patients with advanced GISTs were gathered, and the above information was segmented into a training set, validation set, and testing set in a 6:2:2 ratio...
February 24, 2024: BMC Cancer
https://read.qxmd.com/read/38402173/multicenter-randomized-trial-of-deferred-cytoreductive-nephrectomy-in-synchronous-metastatic-renal-cell-carcinoma-receiving-checkpoint-inhibitors-the-nordic-sun-trial
#15
JOURNAL ARTICLE
Laura Iisager, Johanne Ahrenfeldt, Frede Donskov, Börje Ljungberg, Axel Bex, Lars Lund, Iben Lyskjær, Niels Fristrup
BACKGROUND: Primary tumor removal by cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma patients has been investigated in the context of various treatment regimens. Two randomized controlled trials investigated the role and timing of cytoreductive nephrectomy in the era of targeted therapy and demonstrated that upfront nephrectomy should no longer be performed when patients require systemic therapy. Superiority of checkpoint immunotherapy agents has led to a paradigm change from targeted therapies to immunotherapy-based first-line treatment in patients with primary metastatic disease; thus, deferred cytoreductive nephrectomy needs to be verified in the immunotherapy setting...
February 24, 2024: BMC Cancer
https://read.qxmd.com/read/38395854/surrogacy-of-one-year-survival-for-overall-survival-in-advanced-hepatocellular-carcinoma
#16
JOURNAL ARTICLE
Yuzhi Jin, Hui Ren, Qianhua Yue, Wei Wu, Chuan Liu, Yixuan Guo, Peng Zhao
BACKGROUND: The increasing number of sequential treatments complicates the evaluation of overall survival (OS) in clinical trials for hepatocellular carcinoma (HCC), therefore, reliable surrogate endpoints (SEs) are required. This study aimed to evaluate the surrogacy of progression-free survival (PFS) and one-year (1-yr) milestone survival for OS in HCC trials. METHODS: We systematically searched databases for randomized clinical trials that evaluated systemic treatments for advanced HCC...
February 23, 2024: BMC Cancer
https://read.qxmd.com/read/38395845/oncological-risk-of-proximal-gastrectomy-for-proximal-advanced-gastric-cancer-after-neoadjuvant-chemotherapy
#17
JOURNAL ARTICLE
Yonghe Chen, Xiaojiang Chen, Yi Lin, Shenyan Zhang, Zhiwei Zhou, Junsheng Peng
PURPOSE: This study assesses the metastasis rate of the key distal lymph nodes (KDLN) that are not routinely dissected in proximal gastrectomy, aiming to explore the oncological safety of proximal gastrectomy for upper gastric cancer who underwent neoadjuvant chemotherapy. METHODS: We analyzed a cohort of 150 patients with proximal locally advanced gastric cancer (cT3/4 before chemotherapy) from two high-volume cancer centers in China who received preoperative neoadjuvant chemotherapy (NAC) and total gastrectomy with lymph node dissection...
February 23, 2024: BMC Cancer
https://read.qxmd.com/read/38395838/endostar-acts-as-a-pneumonitis-protectant-in-patients-with-locally-advanced-non-small-cell-lung-cancer-receiving-concurrent-chemoradiotherapy
#18
JOURNAL ARTICLE
Kuifei Chen, Shuling Li, Meng Chen, Zhicheng Jin, Xuefeng Sun, Suna Zhou, Haihua Yang
BACKGROUND: CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of Endostar in the occurrence of grade≥2 RP and clinical curative effect in LA-NSCLC patients. METHODS: This study retrospectively analyzed 122 patients with stage III NSCLC who received CCRT from December 2008 to December 2017, or Endostar intravenous drip concurrently with chemoradiotherapy (Endostar + CCRT group)...
February 23, 2024: BMC Cancer
https://read.qxmd.com/read/38395832/real-world-outcomes-of-third-line-immune-checkpoint-inhibitors-versus-irinotecan-based-chemotherapy-in-patients-with-advanced-gastric-cancer-a-korean-multicenter-study-kcsg-st22-06
#19
MULTICENTER STUDY
Sung Hee Lim, Keun-Wook Lee, Jae-Joon Kim, Hyeon-Su Im, In-Ho Kim, Hye Sook Han, Dong-Hoe Koo, Jang Ho Cho, Chi Hoon Maeng, Min-Young Lee, Hyo Jin Lee, Jwa Hoon Kim, Sang Gon Park, Joo Young Jung, Seong-Hoon Shin, Ki Hyang Kim, Hyeyeong Kim, So Yeon Oh, Minsu Kang, Minkyu Jung, Sun Young Rha
BACKGROUND: Immune checkpoint inhibitor (ICI) or irinotecan-based chemotherapy is frequently used after failure of second-line paclitaxel plus ramucirumab treatment for patients with locally advanced unresectable or metastatic advanced gastric cancer (AGC). This study aimed to compare the efficacy between ICI and irinotecan-based chemotherapy as third-line treatment in patients with AGC. METHODS: We retrospectively reviewed patients with AGC, whose third-line treatment started between July 2019 and June 2021 at 17 institutions in Korea...
February 23, 2024: BMC Cancer
https://read.qxmd.com/read/38395827/a-nomogram-based-on-peripheral-lymphocyte-for-predicting-8-year-survival-in-patients-with-prostate-cancer-a-single-center-study-using-lasso-cox-regression
#20
JOURNAL ARTICLE
Jiayi Chen, Feng Yu, Ganyuan He, Wenke Hao, Wenxue Hu
PURPOSE: The purpose of this study was to develop a functional clinical nomogram for predicting 8-year overall survival (OS) of patients with prostate cancer (PCa) primary based on peripheral lymphocyte. PATIENTS AND METHODS: Using data from a single-institutional registry of 94 patients with PCa in China, this study identified and integrated significant prognostic factors for survival to build a nomogram. The discriminative ability was measured by concordance index (C-index) and ROC curves (Receiver Operating Characteristic Curves)...
February 23, 2024: BMC Cancer
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