journal
https://read.qxmd.com/read/38124101/regulatory-effect-of-bacterial-melanin-on-the-isoforms-of-new-superoxide-producing-associates-from-rat-tissues-in-rotenone-induced-parkinson-s-disease
#21
JOURNAL ARTICLE
Margarita Danielyan, Kristina Nebogova, Ruzan Simonyan, Anichka Hovsepyan, Zubeida Avetisyan, Karen Simonyan, Gegham Simonyan, Vahagn Khachatryan, Kristine Karapetyan
According to recent research, selective neuronal vulnerability in Parkinson's disease (PD) results from several phenotypic traits, including calcium-dependent, feed-forward control of mitochondrial respiration leading to elevated reactive oxygen species and cytosolic calcium concentration, an extensive axonal arbor, and a reactive neurotransmitter. Therefore, antioxidant therapy is a promising direction in the treatment of PD. In vitro studies have indicated the survival-promoting activity of bacterial melanin (BM) on midbrain dopaminergic neuron cultures...
December 20, 2023: BMC Neuroscience
https://read.qxmd.com/read/38110905/exercise-combined-with-postbiotics-treatment-results-in-synergistic-improvement-of-mitochondrial-function-in-the-brain-of-male-transgenic-mice-for-alzheimer-s-disease
#22
JOURNAL ARTICLE
Attila Kolonics, Zoltán Bori, Ferenc Torma, Dora Abraham, János Fehér, Zsolt Radak
BACKGROUND: It has been suggested that exercise training and postbiotic supplement could decelerate the progress of functional and biochemical deterioration in double transgenic mice overexpresses mutated forms of the genes for human amyloid precursor protein (APPsw ) and presenilin 1 (m146L) (APP/PS1TG ). Our earlier published data indicated that the mice performed better than controls on the Morris Maze Test parallel with decreased occurrence of amyloid-β plaques in the hippocampus...
December 18, 2023: BMC Neuroscience
https://read.qxmd.com/read/38097940/behavioral-photosensitivity-of-multi-color-blind-medaka-enhanced-response-under-ultraviolet-light-in-the-absence-of-short-wavelength-sensitive-opsins
#23
JOURNAL ARTICLE
Kiyono Mizoguchi, Mayu Sato, Rina Saito, Mayu Koshikuni, Mana Sakakibara, Ran Manabe, Yumi Harada, Tamaki Uchikawa, Satoshi Ansai, Yasuhiro Kamei, Kiyoshi Naruse, Shoji Fukamachi
BACKGROUND: The behavioral photosensitivity of animals could be quantified via the optomotor response (OMR), for example, and the luminous efficiency function (the range of visible light) should largely rely on the repertoire and expression of light-absorbing proteins in the retina, i.e., the opsins. In fact, the OMR under red light was suppressed in medaka lacking the red (long-wavelength sensitive [LWS]) opsin. RESULTS: We investigated the ultraviolet (UV)- or blue-light sensitivity of medaka lacking the violet (short-wavelength sensitive 1 [SWS1]) and blue (SWS2) opsins...
December 14, 2023: BMC Neuroscience
https://read.qxmd.com/read/38093175/cognitive-dysfunction-in-systemic-lupus-erythematosus-is-associated-with-disease-activity-and-oxidative-stress-a-comparative-study-with-rheumatoid-arthritis-for-identifying-biomarkers
#24
JOURNAL ARTICLE
Daniela Cabral de Sousa, Emmanuelle Silva Tavares Sobreira, Werbety Lucas Queiroz Feitosa, Ticiana Maria Pinto Moreira Aires, Leticia Pastuszka Paz Araújo, Andressa Laura Castro Silva, Caroline Brandão Joventino, Nathalia Maria Tomaz Silveira, Adriano José Maia Chaves-Filho, Danielle Silveira Macêdo, Pedro Braga-Neto
BACKGROUND: The prevalence and pathophysiological mechanisms of cognitive deficits (CD) Systemic Lupus Erythematosus (SLE) and Rheumatoid arthritis (RA) are very heterogeneous and poorly understood. We characterized CD in patients with SLE compared with RA patients and healthy controls. We compared the neuropsychological profile of SLE and RA with patients' oxidative/inflammatory biomarkers for CD. METHODS: We performed a cross-sectional study, including 50 SLE patients, 29 RA patients, and 32 healthy controls...
December 13, 2023: BMC Neuroscience
https://read.qxmd.com/read/38087196/stress-related-cellular-pathophysiology-as-a-crosstalk-risk-factor-for-neurocognitive-and-psychiatric-disorders
#25
REVIEW
Iryna S Palamarchuk, George M Slavich, Tracy Vaillancourt, Tarek K Rajji
In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that drive cognitive decline and behavioral change. First, we describe the general neurobiology of the stress response to define neurocognitive stress reactivity. Second, we review aspects of epigenetic regulation, synaptic transmission, sex hormones, photoperiodic plasticity, and psychoneuroimmunological processes that can contribute to cognitive decline and neuropsychiatric conditions...
December 12, 2023: BMC Neuroscience
https://read.qxmd.com/read/38066457/symptomatic-intracranial-hemorrhage-mediates-the-association-between-eosinophils-and-90-day-outcomes-after-mechanical-thrombectomy-for-acute-ischemic-stroke
#26
JOURNAL ARTICLE
Shuhong Yu, Xiaocui Wang, Hao Huang, Yi Luo, Zhiliang Guo
BACKGROUND: Decreased eosinophil level is associated with poor outcomes after mechanical thrombectomy in patients with acute ischemic stroke (AIS), but the underlying mechanism of this association is elusive. We aimed to assess the mediation effect of symptomatic intracranial hemorrhage (sICH) on the aforementioned association. METHODS: A total of 328 consecutive AIS patients undergoing mechanical thrombectomy between May 2017 and March 2021 were analyzed. SICH was defined as any evidence of brain hemorrhage on CT scan with neurological deterioration...
December 8, 2023: BMC Neuroscience
https://read.qxmd.com/read/38057703/effects-of-electroacupuncture-on-imaging-and-behavior-in-rats-with-ischemic-stroke-through-mir-212-5p
#27
JOURNAL ARTICLE
Sisi Li, Xiangxin Xing, Xuyun Hua, Yuwen Zhang, Jiajia Wu, Chunlei Shan, Mouxiong Zheng, He Wang, Jianguang Xu
BACKGROUND: Ischemic stroke is a serious disease leading to significant disability in humans worldwide. Increasing evidence suggests that some microRNAs (miRNAs) participate in the pathophysiology of ischemic stroke. A key role for MiR-212 has been found in neuronal function and synaptic plasticity. Ischemic stroke can be effectively treated with electroacupuncture (EA); however, there is a lack of understanding of the relevant mechanisms. In this study, we employed behavioral test and resting-state functional magnetic resonance imaging (rs-fMRI) to detect behavioral and brain function alterations in rats suffering from ischemic stroke...
December 6, 2023: BMC Neuroscience
https://read.qxmd.com/read/37996797/modulation-of-gaba-by-sodium-butyrate-ameliorates-hypothalamic-inflammation-in-experimental-model-of-pcos
#28
JOURNAL ARTICLE
Oony-Iye Eepho, Al-Amin M Bashir, Adesola A Oniyide, Ayodeji Aturamu, Olutunmise V Owolabi, Isaac O Ajadi, Adedamola A Fafure, Mary B Ajadi, Stephanie E Areloegbe, Kehinde S Olaniyi
Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various neurodegenerative conditions. Hence, this study investigates the impact of butyrate in reversing hypothalamic-related disorder, possibly through γ aminobutyric acid (GABA) in a rat model of PCOS. Eight-week-old female Wistar rats were allotted into four groups (n = 5), which include control, butyrate, letrozole, and letrozole + butyrate groups...
November 23, 2023: BMC Neuroscience
https://read.qxmd.com/read/37957605/monitoring-the-neural-activity-associated-with-praying-in-sahaja-yoga-meditation
#29
JOURNAL ARTICLE
Oscar Perez-Diaz, Alfonso Barrós-Loscertales, Uffe Schjoedt, José L González-Mora, Katya Rubia, José Suero, Sergio Elías Hernández
BACKGROUND: Sahaja Yoga Meditation draws on many religious traditions and uses a variety of techniques including Christian prayer to reach a state known as thoughtless awareness, or mental silence. While there are many studies on the neural correlates of meditation, few studies have focused on the neural correlates of praying. Thus, the aim of our research was to study the neural activity associated with the prayer practices in Sahaja Yoga Mediation, which have not been studied before, to explore effects beyond repetitive speech or "mantra effects"...
November 13, 2023: BMC Neuroscience
https://read.qxmd.com/read/37946101/cycle-dependent-sex-differences-in-expression-of-membrane-proteins-involved-in-cerebrospinal-fluid-secretion-at-rat-choroid-plexus
#30
JOURNAL ARTICLE
Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Connar Stanley James Westgate, Bjarne Styrishave, Rigmor H Jensen, Sajedeh Eftekhari
BACKGROUND: Female sex is a known risk factor of brain disorders with raised intracranial pressure (ICP) and sex hormones have been suggested to alter cerebrospinal fluid (CSF) dynamics, thus impairing ICP regulation in CSF disorders such as idiopathic intracranial hypertension (IIH). The choroid plexus (CP) is the tissue producing CSF and it has been hypothesized that altered hormonal composition could affect the activity of transporters involved in CSF secretion, thus affecting ICP...
November 9, 2023: BMC Neuroscience
https://read.qxmd.com/read/37932682/melatonin-inhibits-japanese-encephalitis-virus-replication-and-neurotoxicity-via-calcineurin-autophagy-pathways
#31
JOURNAL ARTICLE
Ji-Hong Moon, Jeong-Min Hong, Jae-Won Seol, Byung-Yong Park, Seong Kug Eo, Sang-Youel Park
BACKGROUND: Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that has no specific treatment except for supportive medical care. JEV is a neurotropic virus that affects the nervous system and triggers inflammation in the brain. METHODS: Melatonin is used as a sleep-inducing agent in neurophysiology and may serve as a protective agent against neurological and neurodegenerative diseases. Herein, we investigated the effects of melatonin and the critical roles of the serine/threonine protein phosphatase calcineurin during JEV infection in SK-N-SH neuroblastoma cells...
November 6, 2023: BMC Neuroscience
https://read.qxmd.com/read/37919674/the-molecular-architecture-of-a-complex-social-behavior-gregarious-song
#32
LETTER
Tyler J Stevenson
The medial preoptic area (mPOA) regulates the probability and intensity of singing behavior in birds. Polzin and colleagues examined the molecular changes in the mPOA that were associated with gregarious song in European starlings (Sturnus vulgaris). High-throughput transcriptome analyses identified glutamate and dopamine pathways were highly enriched with gregarious song.
November 2, 2023: BMC Neuroscience
https://read.qxmd.com/read/37907857/cytokine-levels-reflect-tic-symptoms-more-prominently-during-mild-phases
#33
JOURNAL ARTICLE
SuHyuk Chi, Young Eun Mok, June Kang, Jeong-An Gim, Changsu Han, Moon-Soo Lee
Tic disorder is a neuropsychiatric condition that affects 3% of all children and can have a significant impact on their quality of life. Cytokines, interferons, interleukins, lymphokines, and tumor necrosis factors are involved in the neuroinflammatory circuitry of tic disorders. This study aimed to identify the cytokines involved in the pathogenesis of tic disorders. We enrolled 44 patients with tic disorder and 38 healthy controls. Patients were free of psychotropic medications for at least 3 weeks. Whole blood samples were analyzed using a Luminex® human cytokine multiplex assay kit...
October 31, 2023: BMC Neuroscience
https://read.qxmd.com/read/37875799/anda-an-open-source-tool-for-automated-image-analysis-of-in-vitro-neuronal-cells
#34
JOURNAL ARTICLE
Hallvard Austin Wæhler, Nils-Anders Labba, Ragnhild Elisabeth Paulsen, Geir Kjetil Sandve, Ragnhild Eskeland
BACKGROUND: Imaging of in vitro neuronal differentiation and measurements of cell morphologies have led to novel insights into neuronal development. Live-cell imaging techniques and large datasets of images have increased the demand for automated pipelines for quantitative analysis of neuronal morphological metrics. RESULTS: ANDA is an analysis workflow that quantifies various aspects of neuronal morphology from high-throughput live-cell imaging screens of in vitro neuronal cell types...
October 24, 2023: BMC Neuroscience
https://read.qxmd.com/read/37853315/mindfulness-interventions-for-craving-reduction-in-substance-use-disorders-and-behavioral-addictions-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#35
JOURNAL ARTICLE
Anastasia Demina, Benjamin Petit, Vincent Meille, Benoit Trojak
BACKGROUND: High-quality evidence is still required to affirm the efficacy of mindfulness-based interventions (MBIs) in craving reduction. MBIs may be particularly appropriate for this purpose given the neurobiological mechanisms of addiction with automatic behavior in response to the negative affect. In this systematic review and meta-analysis, we aimed to study the efficacy of MBIs in craving reduction and to synthetize the newly published data. METHODS: We searched four databases and three clinical trial registries for randomized controlled trials (RCTs) up to August 2023, including studies with MBIs in all types of substance use disorders or behavioral addictions...
October 18, 2023: BMC Neuroscience
https://read.qxmd.com/read/37845642/comparison-of-efficacy-of-non-pharmacological-intervention-for-post-stroke-dysphagia-a-systematic-review-and-bayesian-network-meta-analysis
#36
REVIEW
Hao Zhu, Xinyuan Deng, Guorui Luan, Yu Zhang, Yichen Wu
Increasingly, non-pharmacological interventions are being identified and applied to post-stroke dysphagia. Nevertheless, there is insufficient evidence to assess which type of interventions are more effective. In this study, the randomized controlled trials of non-pharmacological interventions on post-stroke dysphagia were retrieved from the relevant databases. Including 96 studies and 12 non-drug treatments. Then, and the network meta-analysis is carried out by statistical software. The results show: In the aspects of videofluoroscopic swallowing study (VFSS), Standardized Swallowing Assessment (SSA), swallowing-quality of life (SWAL-QOL), Water swallow test (WST); Acupuncture + electrotherapy + rehabilitation training, acupuncture + rehabilitation training + massage, electrotherapy + rehabilitation training, acupuncture + electrotherapy + rehabilitation training, electrotherapy, acupuncture + rehabilitation training + acupoints sticking application have significant effects in post-stroke dysphagia...
October 16, 2023: BMC Neuroscience
https://read.qxmd.com/read/37845610/metabolomics-in-severe-traumatic-brain-injury-a-scoping-review
#37
JOURNAL ARTICLE
Riley Page Fedoruk, Chel Hee Lee, Mohammad Mehdi Banoei, Brent W Winston
BACKGROUND: Diagnosis and prognostication of severe traumatic brain injury (sTBI) continue to be problematic despite years of research efforts. There are currently no clinically reliable biomarkers, though advances in protein biomarkers are being made. Utilizing Omics technology, particularly metabolomics, may provide new diagnostic biomarkers for sTBI. Several published studies have attempted to determine the specific metabolites and metabolic pathways involved; these studies will be reviewed...
October 16, 2023: BMC Neuroscience
https://read.qxmd.com/read/37817064/effects-of-isoflurane-and-urethane-anesthetics-on-glutamate-neurotransmission-in-rat-brain-using-in-vivo-amperometry
#38
JOURNAL ARTICLE
Joshua A Beitchman, Gokul Krishna, Caitlin E Bromberg, Theresa Currier Thomas
BACKGROUND: Aspects of glutamate neurotransmission implicated in normal and pathological conditions are predominantly evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. Urethane and isoflurane anesthesia influence glutamate neurotransmission through different mechanisms; however, real-time outcome measures of potassium chloride (KCl)-evoked glutamate overflow and glutamate clearance kinetics have not been compared within and between regions of the brain...
October 10, 2023: BMC Neuroscience
https://read.qxmd.com/read/37749547/typical-metabolic-pattern-of-18-f-fdg-pet-in-anti-nmdar-encephalitis-in-the-acute-and-subacute-phases-and-its-correlation-with-t2-flair-mri-features
#39
JOURNAL ARTICLE
Leilei Yuan, Guangjuan Mao, Yudi Zhang, Yang Xu, Qian Chen, Baoci Shan, Tao Cui, Lin Ai
BACKGROUND/AIMS: Early diagnosis of Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis with non-invasive imaging modalities benefiting is crucial to guarantee prompt treatments decision-making and good prognosis for patients. The present study aimed to explore the correlation of MRI features with brain metabolism characteristics of 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) and to describe the metabolic patterns in Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis at acute and subacute phases...
September 25, 2023: BMC Neuroscience
https://read.qxmd.com/read/37715119/machine-learning-and-eeg-can-classify-passive-viewing-of-discrete-categories-of-visual-stimuli-but-not-the-observation-of-pain
#40
JOURNAL ARTICLE
Tyler Mari, Jessica Henderson, S Hasan Ali, Danielle Hewitt, Christopher Brown, Andrej Stancak, Nicholas Fallon
Previous studies have demonstrated the potential of machine learning (ML) in classifying physical pain from non-pain states using electroencephalographic (EEG) data. However, the application of ML to EEG data to categorise the observation of pain versus non-pain images of human facial expressions or scenes depicting pain being inflicted has not been explored. The present study aimed to address this by training Random Forest (RF) models on cortical event-related potentials (ERPs) recorded while participants passively viewed faces displaying either pain or neutral expressions, as well as action scenes depicting pain or matched non-pain (neutral) scenarios...
September 15, 2023: BMC Neuroscience
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