Oony-Iye Eepho, Al-Amin M Bashir, Adesola A Oniyide, Ayodeji Aturamu, Olutunmise V Owolabi, Isaac O Ajadi, Adedamola A Fafure, Mary B Ajadi, Stephanie E Areloegbe, Kehinde S Olaniyi
Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various neurodegenerative conditions. Hence, this study investigates the impact of butyrate in reversing hypothalamic-related disorder, possibly through γ aminobutyric acid (GABA) in a rat model of PCOS. Eight-week-old female Wistar rats were allotted into four groups (n = 5), which include control, butyrate, letrozole, and letrozole + butyrate groups...
November 23, 2023: BMC Neuroscience