journal
https://read.qxmd.com/read/38528450/the-effect-of-early-mobilisation-%C3%A2-14%C3%A2-days-on-pathophysiological-and-functional-outcomes-in-animals-with-induced-spinal-cord-injury-a-systematic-review-with-meta-analysis
#1
JOURNAL ARTICLE
Natalie Gray, Junaid Shaikh, Alison Cowley, Vicky Goosey-Tolfrey, Pip Logan, Nasir Quraishi, Vicky Booth
INTRODUCTION: The optimum time to mobilise (standing, walking) following spinal cord injury (SCI) is unknown but may have implications for patient outcomes. There are no high-quality experimental studies that examine this issue, with a paucity of guidance for clinicians. Pre-clinical studies lead research in this field and can contribute to knowledge and support future clinical practice. OBJECTIVE: to evaluate the effect of early compared to no mobilisation on pathophysiological and functional outcomes in animals with induced SCI...
March 25, 2024: BMC Neuroscience
https://read.qxmd.com/read/38515045/neuroscience-of-taste-unlocking-the-human-taste-code
#2
REVIEW
Göran Hellekant
Since antiquity human taste has been divided into 4-5 taste qualities. We realized in the early 1970s that taste qualities vary between species and that the sense of taste in species closer to humans such as primates should show a higher fidelity to human taste qualities than non-primates (Brouwer et al. in J Physiol 337:240, 1983). Here we present summary results of behavioral and single taste fiber recordings from the distant South American marmoset, through the Old World rhesus monkey to chimpanzee, the phylogenetically closest species to humans...
March 21, 2024: BMC Neuroscience
https://read.qxmd.com/read/38491350/auditory-brainstem-responses-are-resistant-to-pharmacological-modulation-in-sprague-dawley-wild-type-and-neurexin1%C3%AE-knockout-rats
#3
JOURNAL ARTICLE
Samuel Marashli, Philipp Janz, Roger L Redondo
Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited understanding of ABRs as tools to assess the effect of pharmacological interventions. Therefore, we set out to understand how pharmacological agents that target key transmitter systems of the auditory brainstem circuitry affect ABRs in rats. Given previous studies, demonstrating that Nrxn1α KO Sprague Dawley rats show substantial auditory processing deficits and altered sensitivity to GABAergic modulators, we used both Nrxn1α KO and wild-type littermates in our study...
March 15, 2024: BMC Neuroscience
https://read.qxmd.com/read/38475688/serum-interleukin-17%C3%A2-a-and-homocysteine-levels-in-children-with-autism
#4
JOURNAL ARTICLE
Hui Li, Yunhao Dang, Ying Yan
BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that typically emerges early in childhood. This study aimed to explore the potential link between serum levels of vitamin B12 and homocysteine (Hcy) and the severity of ASD symptoms in children. METHODS: In this study, 50 children diagnosed with ASD comprised the observation group, while 50 healthy children constituted the control group. Serum levels of IL-17 A, Hcy, folate, and vitamin B12 were compared between the study group and control group, as well as among children with different degrees of ASD severity...
March 12, 2024: BMC Neuroscience
https://read.qxmd.com/read/38468222/administration-methods-and-dosage-of-poly-lactic-acid-glycol-intervention-to-myelin-oligodendrocyte-glycoprotein-induced-experimental-autoimmune-encephalitis-mice
#5
JOURNAL ARTICLE
Amy E Wright, Shuhei Nishiyama, Patrick Han, Philip Kong, Michael Levy
BACKGROUND: Myelin oligodendrocyte glycoprotein-associated disorders (MOGAD) is an autoimmune central nervous system disease. Antigen-specific immune tolerance using nanoparticles such as Polylactic-co-glycolic acid (PLGA) have recently been used as a new therapeutic tolerization approach for CNS autoimmune diseases. We examined whether MOG1-125 conjugated with PLGA could induce MOG-specific immune tolerance in an experimental autoimmune encephalitis (EAE) mouse model. EAE was induced in sixty C57BL/6 J wild-type mice using MOG1-125 peptide with complete Freund's Adjuvant...
March 11, 2024: BMC Neuroscience
https://read.qxmd.com/read/38443782/discrimination-of-the-moving-direction-is-improved-depending-on-the-pattern-of-the-mechanical-tactile-stimulation-intervention
#6
JOURNAL ARTICLE
Yuki Maruyama, Sho Kojima, Hideaki Onishi
BACKGROUND: The mechanical tactile stimulation, such as plastic pins and airflow-driven membrane, induces cortical activity. The cortical activity depends on the mechanical tactile stimulation pattern. Therefore, the stimulation pattern of mechanical tactile stimuli intervention may influence its effect on the somatosensory function. However, the effect of the mechanical tactile stimulation input pattern on the somatosensory function has not yet been investigated at the behavioral level...
March 5, 2024: BMC Neuroscience
https://read.qxmd.com/read/38438999/resistance-training-modifies-of-serum-levels-of-matrix-metalloproteinase-2-and-tissue-inhibitor-of-matrix-metalloproteinases-in-multiple-sclerosis-women-a-randomized-controlled-trail
#7
RANDOMIZED CONTROLLED TRIAL
Nasrin Niazi Nezhad, Abdolhossein Parnow, Kianoosh Khamoushian, Rasoul Eslami, Julien S Baker
The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT20120912010824N3, 07.09.2023), twenty-five MS-W were randomly divided into sedentary (MS) and resistance exercise (12 weeks/3 times per week/ 60-80% of 1RM) (MS + RT) groups. Fifteen healthy aged-matched women participated as a control group (HCON)...
March 4, 2024: BMC Neuroscience
https://read.qxmd.com/read/38438989/defined-co-cultures-of-glutamatergic-and-gabaergic-neurons-with-a-mutation-in-disc1-reveal-aberrant-phenotypes-in-gabaergic-neurons
#8
JOURNAL ARTICLE
Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
BACKGROUND: Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used animal models or rather heterogeneous populations of iPSC-derived neurons, generated by undirected differentiation, to study the effects of DISC1 disruption. Since major hypotheses to explain neurodevelopmental, psychiatric disorders rely on altered neuronal connectivity observed in patients, an ideal iPSC-based model requires accurate representation of the structure and complexity of neuronal circuitries...
March 4, 2024: BMC Neuroscience
https://read.qxmd.com/read/38438964/prodromal-parkinson-disease-signs-are-predicted-by-a-whole-blood-inflammatory-transcriptional-signature-in-young-pink1-rats
#9
JOURNAL ARTICLE
Sarah A Lechner, David G S Barnett, Stephen C Gammie, Cynthia A Kelm-Nelson
BACKGROUND: Parkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly understood; as such, there are no specific prognostic or diagnostic tests. A validated Pink1 genetic knockout rat was used to model early-onset and progressive PD. Male Pink1-/- rats exhibit progressive declines in ultrasonic vocalizations as well as hindlimb and forelimb motor deficits by mid-to-late adulthood. Previous RNA-sequencing work identified upregulation of genes involved in disease pathways and inflammation within the brainstem and vocal fold muscle...
March 4, 2024: BMC Neuroscience
https://read.qxmd.com/read/38438838/state-transition-dynamics-of-resting-state-functional-magnetic-resonance-imaging-data-model-comparison-and-test-to-retest-analysis
#10
JOURNAL ARTICLE
Saiful Islam, Pitambar Khanra, Johan Nakuci, Sarah F Muldoon, Takamitsu Watanabe, Naoki Masuda
Electroencephalogram (EEG) microstate analysis entails finding dynamics of quasi-stable and generally recurrent discrete states in multichannel EEG time series data and relating properties of the estimated state-transition dynamics to observables such as cognition and behavior. While microstate analysis has been widely employed to analyze EEG data, its use remains less prevalent in functional magnetic resonance imaging (fMRI) data, largely due to the slower timescale of such data. In the present study, we extend various data clustering methods used in EEG microstate analysis to resting-state fMRI data from healthy humans to extract their state-transition dynamics...
March 4, 2024: BMC Neuroscience
https://read.qxmd.com/read/38424488/current-state-of-neuroprotective-therapy-using-antibiotics-in-human-traumatic-brain-injury-and-animal-models
#11
REVIEW
Katharina Ritter, Pawit Somnuke, Lingjiao Hu, Eva-Verena Griemert, Michael K E Schäfer
TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves patient mortality and outcome is an ongoing matter of debate. In contrast, results from animal models of TBI suggest translational perspectives and support the hypothesis that antibiotics, independent of their anti-microbial activity, alleviate secondary injury and improve neurological outcomes...
February 29, 2024: BMC Neuroscience
https://read.qxmd.com/read/38383317/a-flowchart-for-adequate-controls-in-virus-based-monosynaptic-tracing-experiments-identified-cre-independent-leakage-of-the-tva-receptor-in-r%C3%AE-gt-mice
#12
JOURNAL ARTICLE
Anna Velica, Klas Kullander
BACKGROUND: A pseudotyped modified rabies virus lacking the rabies glycoprotein (G-protein), which is crucial for transsynaptic spread, can be used for monosynaptic retrograde tracing. By coupling the pseudotyped virus with transgene expression of the G-protein and the avian leukosis and sarcoma virus subgroup A receptor (TVA), which is necessary for cell entry of the virus, researchers can investigate specific neuronal populations. Responder mouse lines, like the RΦGT mouse line, carry the genes encoding the G-protein and TVA under Cre-dependent expression...
February 21, 2024: BMC Neuroscience
https://read.qxmd.com/read/38350864/multimodal-evaluation-of-the-effects-of-low-intensity-ultrasound-on-cerebral-blood-flow-after-traumatic-brain-injury-in-mice
#13
LETTER
Huiling Yi, Shuo Wu, Xiaohan Wang, Lanxiang Liu, Wenzhu Wang, Yan Yu, Zihan Li, Yinglan Jin, Jian Liu, Tao Zheng, Dan Du
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide, and destruction of the cerebrovascular system is a major factor in the cascade of secondary injuries caused by TBI. Laser speckle imaging (LSCI)has high sensitivity in detecting cerebral blood flow. LSCI can visually show that transcranial focused ultrasound stimulation (tFUS) treatment stimulates angiogenesis and increases blood flow. To study the effect of tFUS on promoting angiogenesis in Controlled Cortical impact (CCI) model...
February 13, 2024: BMC Neuroscience
https://read.qxmd.com/read/38317077/modulation-of-long-term-potentiation-following-microdoses-of-lsd-captured-by-thalamo-cortical-modelling-in-a-randomised-controlled-trial
#14
JOURNAL ARTICLE
Robin J Murphy, Kate Godfrey, Alexander D Shaw, Suresh Muthukumaraswamy, Rachael L Sumner
BACKGROUND: Microdosing psychedelics is a phenomenon with claimed cognitive benefits that are relatively untested clinically. Pre-clinically, psychedelics have demonstrated enhancing effects on neuroplasticity, which cannot be measured directly in humans, but may be indexed by non-invasive electroencephalography (EEG) paradigms. This study used a visual long-term potentiation (LTP) EEG paradigm to test the effects of microdosed lysergic acid diethylamide (LSD) on neural plasticity, both acutely while on the drug and cumulatively after microdosing every third day for six weeks...
February 5, 2024: BMC Neuroscience
https://read.qxmd.com/read/38308250/tmem119-expression-is-downregulated-in-a-subset-of-brain-metastasis-associated-microglia
#15
JOURNAL ARTICLE
Weili Ma, Jack Oswald, Angela Rios Angulo, Qing Chen
Under pathological conditions, the immune-specialized brain microenvironment contains both resident microglia and bone marrow-derived myeloid cells recruited from peripheral circulation. Due to largely overlapping phenotypic similarities between these ontogenically distinct myeloid populations, studying their individual functions in central nervous system diseases has been challenging. Recently, transmembrane protein 119 (Tmem119) has been reported as a marker for resident microglia which is not expressed by bone marrow-derived myeloid cells...
February 2, 2024: BMC Neuroscience
https://read.qxmd.com/read/38291397/norepinephrine-protects-against-cochlear-outer-hair-cell-damage-and-noise-induced-hearing-loss-via-%C3%AE-2a-adrenergic-receptor
#16
JOURNAL ARTICLE
Chaoyong Tian, Yang Yang, Renfeng Wang, Yao Li, Fei Sun, Jun Chen, Dingjun Zha
BACKGROUND: The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIHL. In this study, we aimed at investigating the effects of a superior cervical ganglionectomy (SCGx) on NIHL in Sprague-Dawley rats. METHODS: We explored the effects of unilateral and bilateral Superior Cervical Ganglion (SCG) ablation in the eight-ten weeks old Sprague-Dawley rats of both sexes on NIHL...
January 30, 2024: BMC Neuroscience
https://read.qxmd.com/read/38216918/degree-of-covid-19-severity-and-mortality-in-stroke-correlation-of-clinical-and-laboratory-parameters
#17
JOURNAL ARTICLE
Abdul Gofir, Irawan Satriotomo, Yossy Catarina Budi Nur Syamsah, Mawaddah Ar Rochmah, Tommy Rachmat Setyawan, Adika Mianoki, Raymond Aris Nimrod Alvonsius Silalahi, Dhite Bayu Nugroho
BACKGROUND: Stroke is one of the neurological manifestations of COVID-19, leading to a significant risk of morbidity and mortality. Clinical manifestations and laboratory parameters were investigated to determine mortality predictors in this case. METHOD: The case control study was conducted at Dr. Sardjito General Hospital,Yogyakarta, Indonesia, with data collected between July 2020 and August 2021. All recorded clinical and laboratory data from acute stroke patients with confirmed COVID-19 were collected...
January 13, 2024: BMC Neuroscience
https://read.qxmd.com/read/38195391/ventral-tegmental-area-dopaminergic-circuits-participates-in-stress-induced-chronic-postsurgical-pain-in-male-mice
#18
JOURNAL ARTICLE
Weizhen Liu, Wang Wang, Ziliang Wang, Ying Xing
BACKGROUND: Chronic postsurgical pain (CPP) markedly impairs patients' quality of life. Research has shown that chronic stress may extend incisional nociception in male mice. Dopaminergic (DAergic) neurons in the ventral tegmental area (VTA) are integral to stress-related mental disorders (including major depressive disorder, anxiety disorders, and PTSD) and pain. However, the impact of chronic social defeat stress (CSDS) on mesolimbic dopamine (DA) transmission in the development of CPP is yet to be established...
January 9, 2024: BMC Neuroscience
https://read.qxmd.com/read/38166747/graph-neural-network-and-machine-learning-analysis-of-functional-neuroimaging-for-understanding-schizophrenia
#19
JOURNAL ARTICLE
Gayathri Sunil, Smruthi Gowtham, Anurita Bose, Samhitha Harish, Gowri Srinivasa
BACKGROUND: Graph representational learning can detect topological patterns by leveraging both the network structure as well as nodal features. The basis of our exploration involves the application of graph neural network architectures and machine learning to resting-state functional Magnetic Resonance Imaging (rs-fMRI) data for the purpose of detecting schizophrenia. Our study uses single-site data to avoid the shortcomings in generalizability of neuroimaging data obtained from multiple sites...
January 2, 2024: BMC Neuroscience
https://read.qxmd.com/read/38166559/sex-differences-in-response-to-obesity-and-caloric-restriction-on-cognition-and-hippocampal-measures-of-autophagic-lysosomal-transcripts-and-signaling-pathways
#20
JOURNAL ARTICLE
Sadie B Baer, Adrianah D Dorn, Danielle M Osborne
BACKGROUND: Obesity rates in the U.S. continue to increase, with nearly 50% of the population being either obese or morbidly obese. Obesity, along with female sex, are leading risk factors for sporadic Alzheimer's Disease (AD) necessitating the need to better understand how these variables impact cellular function independent of age or genetic mutations. Animal and clinical studies both indicate that autophagy-lysosomal pathway (ALP) dysfunction is among the earliest known cellular systems to become perturbed in AD, preceding cognitive decline, yet little is known about how obesity and sex affects these cellular functions in the hippocampus, a brain region uniquely susceptible to the negative effects of obesity...
January 2, 2024: BMC Neuroscience
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