Linlin Zhao, Jinming Zhao, Yingying Zhang, Lele Wang, Longyan Zuo, Airu Niu, Wei Zhang, Xia Xue, Suhong Zhao, Chao Sun, Kailin Li, Jue Wang, Zhimin Bian, Xiaogang Zhao, Dieter Saur, Barbara Seidler, Chuanxin Wang, Tonggang Qi
BACKGROUND: Our previous study have shown that the PSMD11 protein was an important survival factor for cancer cells except for its key role in regulation of assembly and activity of the 26S proteasome. To further investigate the role of PSMD11 in carcinogenesis, we constructed a conditional exon 5 floxed allele of PSMD11 (PSMD11flx ) in mice. RESULTS: It was found that homozygous PSMD11 flx/flx mice showed normal and exhibited a normal life span and fertility, and showed roughly equivalent expression of PSMD11 in various tissues, suggesting that the floxed allele maintained the wild-type function...
February 1, 2021: BMC Developmental Biology