journal
Journals Pancreatology : Official Journ...

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

https://read.qxmd.com/read/38749803/morbidity-and-mortality-in-patients-with-stage-iv-pancreatic-adenocarcinoma-and-acute-cholangitis-outcomes-and-risk-prognostication
#21
JOURNAL ARTICLE
Isha Singh, Joanne F Chou, Marinela Capanu, Jennifer Park, Kenneth H Yu, Anna M Varghese, Wungki Park, Alice Zervoudakis, Fergus Keane, Vineet Syan Rolston, Hans Gerdes, Alice C Wei, Pari Shah, Anne Covey, Mark Schattner, Eileen M O'Reilly
BACKGROUND: Acute cholangitis (AC) is a common complication of pancreatic ductal adenocarcinoma (PDAC). Herein, we evaluated outcomes after the first AC episode and predictors of mortality and AC recurrence in patients with stage IV PDAC. METHODS: We conducted a single-center, retrospective observational study using institutional databases. Clinical data and outcomes for patients with stage IV PDAC and at least one documented episode of AC, were assessed. Overall survival (OS) was estimated using the Kaplan-Meier method, and Cox regression model was employed to identify predictors of AC recurrence and mortality...
May 7, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38704341/the-epidemiology-of-acute-pancreatitis-in-tasmania-over-a-12-year-period-is-this-a-disease-of-disadvantage
#22
JOURNAL ARTICLE
Richard C Turner, Sauro Salomoni, Rachel E Neale, Amanda Neil, Savio G Barreto, Chee Y Ooi, Daniel Croagh, Jeremy S Wilson, Tony Pang, Minoti Apte
BACKGROUND: The global incidence of acute pancreatitis (AP) is increasing, but little information exists about trends in Australia. This study aimed to describe incidence trends, along with clinical and socio-demographic associations, in the state of Tasmania over a recent 12-year period. METHODS: The study cohort was obtained by linking clinical and administrative datasets encompassing the whole Tasmanian population between 2007 and 2018, inclusive. Pancreatitis case definition was based on relevant ICD-10 hospitalization codes, or elevated serum lipase or amylase in pathology data...
April 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38702207/implications-of-pregnancy-on-mcn-of-the-pancreas-a-multicentric-case-control-study
#23
JOURNAL ARTICLE
Alessandro Fogliati, Stefano Crippa, Giovanni Marchegiani, Giulio Belfiori, Antonio Pea, Rondell P Graham, Guido Fiorentini, Giorgia Tomasoni, Francesca Aleotti, Michael L Kendrick, Roberto Salvia, Massimo Falconi, Mark J Truty
BACKGROUND: Mucinous cystic neoplasms (MCN) of the pancreas express estrogen and progesterone receptors. Several case reports describe MCN increasing in size during gestation. The aim of this study is to assess if pregnancy is a risk factor for malignant degeneration of MCN. METHODS: All female patients who underwent pancreatic resection of a MCN between 2011 and 2021 were included. MCN resected or diagnosed within 12 months of gestation were defined perigestational...
April 27, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38719756/expression-of-versican-isoforms-v0-v1-by-pancreatic-cancer-associated-fibroblasts-increases-fibroblast-proliferation
#24
JOURNAL ARTICLE
Sufyan Elhashani, Mark Glenn, Meirion Raymant, Michael C Schmid, Ainhoa Mielgo
BACKGROUND: Versican is a large extracellular matrix (ECM) proteoglycan with four isoforms V0-3. Elevated V0/V1 levels in breast cancer and glioma regulate cell migration and proliferation, but the role of versican in pancreatic ductal adenocarcinoma (PDAC) remains unclear. METHODS: In this study, we evaluated the expression levels of versican isoforms, as well as their cellular source and interacting partners, in vivo, in human and mouse primary and metastatic PDAC tumours and in vitro, in pancreatic tumour cells and fibroblasts using immunostaining, confocal microscopy and qPCR techniques...
April 26, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38693041/k-ras-mutation-detected-by-peptide-nucleic-acid-clamping-polymerase-chain-reaction-ki-67-s100p-and-smad4-expression-can-improve-the-diagnostic-accuracy-of-inconclusive-pancreatic-eus-fnb-specimens
#25
JOURNAL ARTICLE
Bo-Hyung Kim, Minji Kwon, Donghwan Lee, Se Woo Park, Eun Shin
OBJECTIVES: We aimed to assess the diagnostic utility of an immunohistochemical panel including calcium-binding protein P, p53, Ki-67, and SMAD family member 4 and K-ras mutation for diagnosing pancreatic solid lesion specimens obtained by endoscopic ultrasound-guided fine-needle biopsy and to confirm their usefulness in histologically inconclusive cases. METHODS: Immunohistochemistry and peptide nucleic acid-clamping polymerase chain reaction for K-ras mutation were performed on 96 endoscopic ultrasound-guided fine-needle biopsy specimens...
April 25, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38724419/exploring-the-prognostic-value-of-circular-rnas-in-pancreatic-ductal-adenocarcinoma-using-genome-wide-expression-profiling
#26
JOURNAL ARTICLE
Siri Vreim Ørbeck, Theresa Jakobsen, Juan Luis García-Rodríguez, Mark Burton, Lukas Gammelgaard Rasmussen, Jesper Dupont Ewald, Claus Wilki Fristrup, Per Pfeiffer, Michael Bau Mortensen, Lasse Sommer Kristensen, Sönke Detlefsen
BACKGROUND/OBJECTIVES: Median survival of pancreatic ductal adenocarcinoma (PDAC) is around eight months and new prognostic tools are needed. Circular RNAs (circRNAs) have gained interest in different types of cancer. However, only a few studies have evaluated their potential in PDAC. We aimed to identify the most differentially expressed circRNAs in PDAC compared to controls and to explore their potential as prognostic markers. METHODS: Using frozen specimens with PDAC and controls, we performed RNA sequencing and identified 20,440 unique circRNAs...
April 24, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38714387/contrast-enhanced-endoscopic-ultrasound-likely-does-not-improve-diagnostic-adequacy-during-endoscopic-ultrasound-guided-tissue-acquisition-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Marie Anne Engh, Brigitta Teutsch, Alexander Schulze Wenning, Yael Hadani, Omer Almog, Dániel Sándor Veres, Péter Hegyi, Bálint Erőss
BACKGROUND AND AIMS: Solid pancreatic masses are sampled through tissue acquisition by endoscopic ultrasound (EUS). Inadequate samples may significantly delay diagnosis, increasing costs and carrying risks to the patients. AIM: assess the diagnostic adequacy of tissue acquisition using contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) compared to conventional EUS. METHODS: Five databases (PubMed, Embase, CENTRAL, Scopus and Web of Science) were searched in November 2023...
April 24, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38693038/the-effect-of-steroid-therapy-on-pancreatic-exocrine-function-in-autoimmune-pancreatitis
#28
JOURNAL ARTICLE
Nicolò de Pretis, Luigi Martinelli, Enrico Palmeri, Federico Caldart, Salvatore Crucillà, Alberto Zorzi, Alessandro Brillo, Stefano Francesco Crinò, Maria Cristina Conti Bellocchi, Laura Bernardoni, Giulia De Marchi, Antonio Amodio, Pietro Campagnola, Rachele Ciccocioppo, Armando Gabbrielli, Alessandro Marcon, Luca Frulloni
BACKGROUND/OBJECTIVES: Autoimmune pancreatitis (AIP) is a steroid-responsive inflammatory disease of the pancreas. Few studies investigated pancreatic exocrine function (PEF) in patients suffering from AIP and no definitive data are available on the effect of steroids in PEF recovery. Aim of the study is the evaluation of severe pancreatic insufficiency (sPEI) prevalence in AIP at clinical onset and after steroid treatment. METHODS: 312 Patients with diagnosis of AIP between January 1st, 2010 and December 31st, 2020 were identified in our prospectively maintained register...
April 24, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38693039/development-of-clinical-screening-tool-for-exocrine-pancreatic-insufficiency-in-patients-with-definite-chronic-pancreatitis
#29
JOURNAL ARTICLE
Mohamed O Othman, Christopher Forsmark, Dhiraj Yadav, Vikesh K Singh, Luis F Lara, Walter Park, Zuoyi Zhang, Jun Yu, Jens J Kort
BACKGROUND/OBJECTIVES: No simple, accurate diagnostic tests exist for exocrine pancreatic insufficiency (EPI), and EPI remains underdiagnosed in chronic pancreatitis (CP). We sought to develop a digital screening tool to assist clinicians to predict EPI in patients with definite CP. METHODS: This was a retrospective case-control study of patients with definite CP with/without EPI. Overall, 49 candidate predictor variables were utilized to train a Classification and Regression Tree (CART) model to rank all predictors and select a parsimonious set of predictors for EPI status...
April 16, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38580492/pancreatic-anastomosis-training-models-current-status-and-future-directions
#30
REVIEW
Kunal Joshi, Daniel M Espino, Duncan Et Shepherd, Nasim Mahmoodi, Keith J Roberts, Nikolaos Chatzizacharias, Ravi Marudanayagam, Robert P Sutcliffe
Postoperative pancreatic fistula (POPF) is a major cause of morbidity and mortality after pancreatoduodenectomy (PD), and previous research has focused on patient-related risk factors and comparisons between anastomotic techniques. However, it is recognized that surgeon experience is an important factor in POPF outcomes, and that there is a significant learning curve for the pancreatic anastomosis. The aim of this study was to review the current literature on training models for the pancreatic anastomosis, and to explore areas for future research...
June 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38508910/revealing-the-role-of-early-peripancreatic-bacterial-contamination-and-enterococcus-faecalis-in-pancreatic-fistula-development-after-pancreaticoduodenectomy-implications-for-useful-antibiotic-prophylaxis-an-observational-cohort-study
#31
JOURNAL ARTICLE
Norihisa Kimura, Keinosuke Ishido, Taiichi Wakiya, Hayato Nagase, Tadashi Odagiri, Yusuke Wakasa, Kenichi Hakamada
BACKGROUND: Peripancreatic bacterial contamination (PBC) is a critical factor contributing to the development of clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD). Controlling pathogenic bacteria is essential in preventing CR-POPF; however, the precise relationship between specific bacteria and CR-POPF remains unclear. This study aimed to investigate the relationship between PBC and CR-POPF after PD, with a focus on identifying potentially causative bacteria...
June 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38519395/streamlining-ipmn-follow-up-embracing-a-standardized-and-abbreviated-mri-protocol
#32
LETTER
Nicolò Brandi, Matteo Renzulli
No abstract text is available yet for this article.
May 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38443232/natural-history-and-growth-prediction-model-of-pancreatic-serous-cystic-neoplasms
#33
JOURNAL ARTICLE
Jenny H Chang, Breanna C Perlmutter, Chase Wehrle, Robert Naples, Kathryn Stackhouse, John McMichael, Tu Chao, Samer Naffouje, Toms Augustin, Daniel Joyce, Robert Simon, R Matthew Walsh
OBJECTIVE: Serous cystic neoplasms (SCN) are benign pancreatic cystic neoplasms that may require resection based on local complications and rate of growth. We aimed to develop a predictive model for the growth curve of SCNs to aid in the clinical decision making of determining need for surgical resection. METHODS: Utilizing a prospectively maintained pancreatic cyst database from a single institution, patients with SCNs were identified. Diagnosis confirmation included imaging, cyst aspiration, pathology, or expert opinion...
May 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38383175/tumor-location-clinicopathological-features-and-perioperative-and-prognostic-outcomes-in-patients-who-underwent-pancreatic-resection-following-neoadjuvant-chemoradiotherapy-for-resectable-pancreatic-cancer-a-retrospective-study
#34
JOURNAL ARTICLE
Hironobu Suto, Hiroyuki Matsukawa, Takuro Fuke, Mina Nagao, Yasuhisa Ando, Minoru Oshima, Hiroki Yamana, Hideki Kamada, Hideki Kobara, Hiroyuki Okuyama, Kensuke Kumamoto, Keiichi Okano
BACKGROUND: /Objective: Preoperative treatment of resectable pancreatic ductal adenocarcinoma (PDAC) is gaining popularity worldwide. However, the characteristics of tumors located in the pancreatic head (Ph), or those in the body or tail (Pbt), after surgery following neoadjuvant chemoradiotherapy (NACRT) remain unclear. This study aimed to evaluate and compare the clinicopathological features, perioperative outcomes, and prognosis of patients with resectable PDAC who underwent NACRT followed by curative pancreatic resection, focusing on distinguishing between Ph and Pbt PDACs...
May 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38637234/letter-to-editor-clinical-outcomes-of-acute-pancreatitis-in-covid-19-hospitalizations-in-the-united-states
#35
LETTER
Adishwar Rao, Akriti Agrawal, Hassam Ali, Manesh Kumar Gangwani, Saurabh Chandan, Dushyant Singh Dahiya
No abstract text is available yet for this article.
April 13, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38641487/pancreas-2000-my-journey-with-the-central-organ
#36
REVIEW
J-Matthias Löhr
The European Pancreatic Club Lifetime Achievement Award is a distinction awarded for research on the pancreas and service to European Pancreatology. It comes with the obligation to submit a review article to our society's journal, Pancreatology. It was awarded to me 2023 and I take this opportunity to highlight my journey with the central organ AKA the pancreas, that is inseparatable from "Pancreas 2000" - an educational program for future pancreatologists, inaugurated by Karolinska Institutet.
April 8, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38637233/deletion-of-myeloid-specific-orai1-calcium-channel-does-not-affect-pancreatic-tissue-damage-in-experimental-acute-pancreatitis
#37
JOURNAL ARTICLE
Wentong Mei, Xiuli Zhang, Mengya Niu, Liang Li, Xiaoyu Guo, Gang Wang, Stephen Pandol, Li Wen, Feng Cao
BACKGROUND: Store-operated Ca2+ entry (SOCE) mediated by ORAI1 channel plays a crucial role in acute pancreatitis (AP). Macrophage is an important regulator in amplifying pancreatic tissue damage, but little is known about the role of ORAI1 in macrophages. In this study, we examined the effects of macrophage-specific ORAI1 on pancreatic tissue damage in AP. METHOD: Myeloid-specific Orai1 deficient mice was generated by crossing a LysM-Cre mouse line with Orai1f/f mice...
April 5, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38599956/treatment-outcomes-of-gemcitabine-plus-nab-paclitaxel-in-pancreatic-cancer-patients-with-malignant-ascites
#38
JOURNAL ARTICLE
Kanae Inoue, Koh Fukushi, Shota Yamaguchi, Tomonao Taira, Taro Shibuki, Tomoyuki Satake, Kazuo Watanabe, Mitsuhito Sasaki, Hiroshi Imaoka, Shuichi Mitsunaga, Masafumi Ikeda
BACKGROUND: Gemcitabine plus nab-paclitaxel (GnP) therapy has been shown to improve the prognosis in patients with metastatic pancreatic cancer (PC); however, the efficacy and safety of GnP in PC patients with malignant ascites (MA) remains unknown. METHODS: We retrospectively investigated PC patients with peritoneal dissemination who had received GnP as first-line chemotherapy at our institution between March 2015 and August 2021. The following patient data were reviewed: patient characteristics, overall survival (OS), progression-free survival (PFS), objective response rate (ORR), adverse events (AEs), and relative dose intensity (RDI)...
April 4, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38584052/development-of-a-novel-ct-based-index-for-predicting-the-number-of-extracorporeal-shockwave-lithotripsy-eswl-sessions-required-for-successful-fragmentation-of-obstructing-pancreatic-duct-stones
#39
JOURNAL ARTICLE
Nikhil Bush, Praneeth Chandragiri, Nitish Ashok Gaurav, Sneh Sonaiya, Ila Lahooti, Anmol Singh, Abhinav Gupta, Elham Afghani, Georgios Papachristou, Mouen A Khashab, Peter J Lee, Rupjyoti Talukdar, Sundeep Lakhtakia, Vikesh K Singh, Samuel Han, Manu Tandan, Venkata S Akshintala
BACKGROUND & AIM: Extracorporeal shock wave lithotripsy (ESWL) is used for the treatment of pancreatic duct stones (PDS) in patients with chronic pancreatitis (CP). We aimed to develop a CT based index to predict the required number of ESWL sessions for technical success. METHODS: We retrospectively evaluated patients with PDS secondary to CP who underwent ESWL. Technical success was defined as the complete fragmentation of stones to <3 mm. CT features including PDS size, number, location, and density in Hounsfield units (HU) were noted...
March 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38693040/identification-of-pancreatic-cancer-risk-factors-from-clinical-notes-using-natural-language-processing
#40
JOURNAL ARTICLE
Dhruv Sarwal, Liwei Wang, Sonal Gandhi, Elham Sagheb Hossein Pour, Laurens P Janssens, Adriana M Delgado, Karen A Doering, Anup Kumar Mishra, Jason D Greenwood, Hongfang Liu, Shounak Majumder
OBJECTIVES: Screening for pancreatic ductal adenocarcinoma (PDAC) is considered in high-risk individuals (HRIs) with established PDAC risk factors, such as family history and germline mutations in PDAC susceptibility genes. Accurate assessment of risk factor status is provider knowledge-dependent and requires extensive manual chart review by experts. Natural Language Processing (NLP) has shown promise in automated data extraction from the electronic health record (EHR). We aimed to use NLP for automated extraction of PDAC risk factors from unstructured clinical notes in the EHR...
March 26, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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