journal
https://read.qxmd.com/read/38772757/we-are-what-we-eat-macrophages-and-efferocytosis
#1
JOURNAL ARTICLE
Kyle T Cunningham, Rick M Maizels
Liebold et al. recently revealed how the identity of dying cells drives distinct changes to the macrophages which engulf and clear them, a process known as efferocytosis. During infection with the helminth Schistosoma mansoni, liver macrophages recapitulate these phenotypes, mediated by Axl/MerTK receptors and regulating egg burdens.
May 20, 2024: Trends in Parasitology
https://read.qxmd.com/read/38762372/to-kill-a-tachyzoite-assault-and-battery
#2
JOURNAL ARTICLE
Azadeh Nasuhidehnavi, George S Yap
Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.
May 17, 2024: Trends in Parasitology
https://read.qxmd.com/read/38760258/genetic-surveillance-of-insecticide-resistance-in-african-anopheles-populations-to-inform-malaria-vector-control
#3
REVIEW
Penelope A Hancock, Eric Ochomo, Louisa A Messenger
Insecticide resistance in malaria vector populations poses a major threat to malaria control, which relies largely on insecticidal interventions. Contemporary vector-control strategies focus on combatting resistance using multiple insecticides with differing modes of action within the mosquito. However, diverse genetic resistance mechanisms are present in vector populations, and continue to evolve. Knowledge of the spatial distribution of these genetic mechanisms, and how they impact the efficacy of different insecticidal products, is critical to inform intervention deployment decisions...
May 16, 2024: Trends in Parasitology
https://read.qxmd.com/read/38760257/next-generation-sequencing-technologies-for-helminth-diagnostics-and-surveillance-in-ruminants-shifting-diagnostic-barriers
#4
REVIEW
Alistair Antonopoulos, John S Gilleard, Johannes Charlier
Helminth infections in grazing ruminants are a major issue for livestock farming globally, but are unavoidable in outdoor grazing systems and must be effectively managed to avoid deleterious effects to animal health, and productivity. Next-generation sequencing (NGS) technologies are transforming our understanding of the genetic basis of anthelmintic resistance (AR) and epidemiological studies of ruminant gastrointestinal parasites. They also have the potential to not only help develop and validate molecular diagnostic tests but to be directly used in routine diagnostics integrating species-specific identification and AR into a single test...
May 16, 2024: Trends in Parasitology
https://read.qxmd.com/read/38760256/curing-mosquitoes-with-genetic-approaches-for-malaria-control
#5
REVIEW
Mary Kefi, Victor Cardoso-Jaime, Sally A Saab, George Dimopoulos
Malaria remains a persistent global public health challenge because of the limitations of current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria, in conjunction with existing methods, holds promise for achieving elimination of malaria and preventing its reintroduction. In this context, population modification involves the spread of engineered genetic elements through mosquito populations that render them incapable of malaria transmission. Significant progress has been made in this field over the past decade in revealing promising targets, optimizing genetic tools, and facilitating the transition from the laboratory to successful field deployments, which are subject to regulatory scrutiny...
May 16, 2024: Trends in Parasitology
https://read.qxmd.com/read/38755024/a-decade-of-invasive-anopheles-stephensi-sequence-based-identification-toward-a-global-standard
#6
REVIEW
Elizabeth Waymire, Jeanne N Samake, Isuru Gunarathna, Tamar E Carter
Anopheles stephensi is an invasive malaria vector in Africa that has been implicated in malaria outbreaks in the Horn of Africa. In 10 years, it has been detected as far east as Djibouti and as far west as Ghana. Early detections were mostly incidental, but now active surveillance in Africa has been updated to include An. stephensi. Morphological identification of An. stephensi from native vectors can be challenging, thus, sequence-based assays have been used to confirm identification during initial detections...
May 15, 2024: Trends in Parasitology
https://read.qxmd.com/read/38749866/the-biology-and-pathogenesis-of-vivax-malaria
#7
REVIEW
Nicholas M Anstey, Wai-Hong Tham, G Dennis Shanks, Jeanne R Poespoprodjo, Bruce M Russell, Steven Kho
Plasmodium vivax contributes significantly to global malaria morbidity. Key advances include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent reticulocytes, crucial for vaccine development. Humanized mouse models and hepatocyte culture systems have enhanced understanding of hypnozoite biology. The spleen has emerged as a major reservoir for asexual vivax parasites, replicating in an endosplenic life cycle, and contributing to recurrent and chronic infections, systemic inflammation, and anemia...
May 14, 2024: Trends in Parasitology
https://read.qxmd.com/read/38744542/new-paradigms-in-the-prevention-of-canine-vector-borne-diseases
#8
REVIEW
Domenico Otranto, Jairo A Mendoza-Roldan, Frederic Beugnet, Gad Baneth, Filipe Dantas-Torres
The prevention of canine vector-borne diseases (CVBDs) is pivotal for the health and welfare of dogs as well as for reducing their zoonotic risk to humans. Scientific knowledge gained in recent years contributed to the development of new strategies for the control of these diseases in different social and cultural contexts. Here, we discuss recent advances in the prevention of vector-borne pathogens (VBPs) affecting dogs with a focus on those of zoonotic relevance.
May 13, 2024: Trends in Parasitology
https://read.qxmd.com/read/38734575/spirocerca-lupi
#9
JOURNAL ARTICLE
Paula Alfaro-Segura, Gad Baneth, Alicia Rojas
No abstract text is available yet for this article.
May 10, 2024: Trends in Parasitology
https://read.qxmd.com/read/38734574/the-drug-design-development-seminar-2024-combining-efforts-towards-human-and-animal-parasitic-diseases
#10
JOURNAL ARTICLE
Richard J Marhöfer, Sandra Noack, Paul M Selzer
No abstract text is available yet for this article.
May 10, 2024: Trends in Parasitology
https://read.qxmd.com/read/38714463/hepatocytes-and-the-art-of-killing-plasmodium-softly
#11
REVIEW
Camila Marques-da-Silva, Clyde Schmidt-Silva, Samarchith P Kurup
The Plasmodium parasites that cause malaria undergo asymptomatic development in the parenchymal cells of the liver, the hepatocytes, prior to infecting erythrocytes and causing clinical disease. Traditionally, hepatocytes have been perceived as passive bystanders that allow hepatotropic pathogens such as Plasmodium to develop relatively unchallenged. However, now there is emerging evidence suggesting that hepatocytes can mount robust cell-autonomous immune responses that target Plasmodium, limiting its progression to the blood and reducing the incidence and severity of clinical malaria...
May 6, 2024: Trends in Parasitology
https://read.qxmd.com/read/38704297/phlebotomus-perniciosus
#12
JOURNAL ARTICLE
Tarcísio de Freitas Milagres, Carla Maia
No abstract text is available yet for this article.
May 3, 2024: Trends in Parasitology
https://read.qxmd.com/read/38704296/ornithodoros-hermsi
#13
JOURNAL ARTICLE
Lucas C de Sousa-Paula, Tom G Schwan, Lucas Tirloni
No abstract text is available yet for this article.
May 3, 2024: Trends in Parasitology
https://read.qxmd.com/read/38702267/the-first-cryptosporidium-meeting-a-concerted-effort-to-fight-cryptosporidiosis
#14
JOURNAL ARTICLE
Wes van Voorhis, Joyce Siwila, Jessica C Kissinger, Natalia Bayona Vásquez, Guy Robinson, Rodrigo Baptista, Asis Khan, Amandine Guérin, Yi-Wei Chang, Zannatun Noor, N Bishara Marzook, Sumiti Vinayak, Sam Arnold, Chelsea Marie, Robert K M Choy, Mattie C Pawlowic, Rajiv S Jumani
No abstract text is available yet for this article.
May 2, 2024: Trends in Parasitology
https://read.qxmd.com/read/38677926/ixodes-scapularis-blacklegged-tick
#15
JOURNAL ARTICLE
Sarah M Short, Risa Pesapane
No abstract text is available yet for this article.
April 26, 2024: Trends in Parasitology
https://read.qxmd.com/read/38677925/hookworm-genomics-dusk-or-dawn
#16
REVIEW
Vladislav Ilík, Erich M Schwarz, Eva Nosková, Barbora Pafčo
Hookworms are parasites, closely related to the model nematode Caenorhabditis elegans, that are a major economic and health burden worldwide. Primarily three hookworm species (Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum) infect humans. Another 100 hookworm species from 19 genera infect primates, ruminants, and carnivores. Genetic data exist for only seven of these species. Genome sequences are available from only four of these species in two genera, leaving 96 others (particularly those parasitizing wildlife) without any genomic data...
April 26, 2024: Trends in Parasitology
https://read.qxmd.com/read/38637184/apicomplexa-micropore-history-function-and-formation
#17
REVIEW
Jiong Yang, Shaojun Long, Geoff Hide, Zhao-Rong Lun, De-Hua Lai
The micropore, a mysterious structure found in apicomplexan species, was recently shown to be essential for nutrient acquisition in Plasmodium falciparum and Toxoplasma gondii. However, the differences between the micropores of these two parasites questions the nature of a general apicomplexan micropore structure and whether the formation process model from Plasmodium can be applied to other apicomplexans. We analyzed the literature on different apicomplexan micropores and found that T. gondii probably harbors a more representative micropore type than the more widely studied ones in Plasmodium...
April 17, 2024: Trends in Parasitology
https://read.qxmd.com/read/38614866/cystoisospora-suis
#18
JOURNAL ARTICLE
Anna Sophia Feix, Anja Joachim
No abstract text is available yet for this article.
April 12, 2024: Trends in Parasitology
https://read.qxmd.com/read/38609741/regulation-of-host-metabolic-health-by-parasitic-helminths
#19
REVIEW
Suchandan Sikder, Doris Pierce, Eti R Sarkar, Connor McHugh, Kate G R Quinlan, Paul Giacomin, Alex Loukas
Obesity is a worldwide pandemic and major risk factor for the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). T2D requires lifelong medical support to limit complications and is defined by impaired glucose tolerance, insulin resistance (IR), and chronic low-level systemic inflammation initiating from adipose tissue. The current preventative strategies include a healthy diet, controlled physical activity, and medication targeting hyperglycemia, with underexplored underlying inflammation. Studies suggest a protective role for helminth infection in the prevention of T2D...
April 11, 2024: Trends in Parasitology
https://read.qxmd.com/read/38609740/mam-2024-malaria-in-a-changing-world
#20
JOURNAL ARTICLE
Rhea J Longley, Josephine Malinga, Eva Hesping, Edwin Sutanto, Sophia M DonVito, Michal Kucharski, Damian A Oyong, Julie M J Verhoef, Esrah Du, Elizabeth Villasis, Kioko Mwikali
No abstract text is available yet for this article.
April 11, 2024: Trends in Parasitology
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