H J Kwon, B K Sung, J W Kim, J H Lee, N D Kim, M A Yoo, H S Kang, H S Baek, S J Bae, J S Choi, R Takahashi, S Goto, H Y Chung
Oxidative stress is thought to be a causative factor for age-related damage in a wide variety of cellular constituents that can lead to dysfunction and various pathological conditions, including the inflammatory process. At the molecular level, the redox-sensitive transcription factor, NF-κB plays a key role in the regulation of the inflammatory process, along with cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). We studied the mechanism underlying the modulation of the inflammatory reaction with age by investigating NF-κB activation and the expression of COX-2, iNOS, and cytokines genes in hepatic tissues isolated from young and old rats...
October 2001: Journal of the American Aging Association