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Nature Reviews. Molecular Cell Biology

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https://read.qxmd.com/read/30770903/the-unusual-saspects
#1
Paulina Strzyz
No abstract text is available yet for this article.
February 15, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30760883/may-the-force-be-with-your-lipids
#2
Grant Otto
No abstract text is available yet for this article.
February 13, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30745579/haematopoietic-stem-cell-activity-and-interactions-with-the-niche
#3
REVIEW
Sandra Pinho, Paul S Frenette
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to emergencies and injury. Improved methods for HSC isolation, driven by advances in single-cell and molecular technologies, have led to a better understanding of their behaviour, heterogeneity and lineage fate and of the niche cells and signals that regulate their function...
February 11, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30733604/breaking-the-chains-deubiquitylating-enzyme-specificity-begets-function
#4
REVIEW
Michael J Clague, Sylvie Urbé, David Komander
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases) maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from proteins. In light of the many cellular functions of ubiquitin, DUBs occupy key roles in almost all aspects of cell behaviour. Many DUBs show selectivity for particular ubiquitin linkage types or positions within ubiquitin chains. Others show chain-type promiscuity but can select a distinct palette of protein substrates via specific protein-protein interactions established through binding modules outside of the catalytic domain...
February 7, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30733603/detouring-the-roadblocks-in-gene-expression
#5
Jan Philipp Junker
No abstract text is available yet for this article.
February 7, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30733602/the-proteostasis-network-and-its-decline-in-ageing
#6
REVIEW
Mark S Hipp, Prasad Kasturi, F Ulrich Hartl
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark of many age-related diseases is the dysfunction in protein homeostasis (proteostasis), leading to the accumulation of protein aggregates. In healthy cells, a complex proteostasis network, comprising molecular chaperones and proteolytic machineries and their regulators, operates to ensure the maintenance of proteostasis. These factors coordinate protein synthesis with polypeptide folding, the conservation of protein conformation and protein degradation...
February 7, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30728477/publisher-correction-regulation-of-microrna-biogenesis-and-its-crosstalk-with-other-cellular-pathways
#7
Thomas Treiber, Nora Treiber, Gunter Meister
The legend of Figure 2 neglected to acknowledge that part b was adapted with permission from ref.46 , Elsevier and that part d, third panel from the left was reproduced from ref.62 , Springer Nature Limited. The change has been made in the HTML and PDF versions of the manuscript.
February 6, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30710120/forcing-through-barriers
#8
Paulina Strzyz
No abstract text is available yet for this article.
February 1, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30700812/telomere-crisis-activates-autophagic-death
#9
Eytan Zlotorynski
No abstract text is available yet for this article.
January 30, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30683908/how-cells-keep-scale
#10
Paulina Strzyz
No abstract text is available yet for this article.
January 25, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30659282/spatial-proteomics-a-powerful-discovery-tool-for-cell-biology
#11
REVIEW
Emma Lundberg, Georg H H Borner
Protein subcellular localization is tightly controlled and intimately linked to protein function in health and disease. Capturing the spatial proteome - that is, the localizations of proteins and their dynamics at the subcellular level - is therefore essential for a complete understanding of cell biology. Owing to substantial advances in microscopy, mass spectrometry and machine learning applications for data analysis, the field is now mature for proteome-wide investigations of spatial cellular regulation. Studies of the human proteome have begun to reveal a complex architecture, including single-cell variations, dynamic protein translocations, changing interaction networks and proteins localizing to multiple compartments...
January 18, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30655609/regulation-of-apoptosis-in-health-and-disease-the-balancing-act-of-bcl-2-family-proteins
#12
REVIEW
Rumani Singh, Anthony Letai, Kristopher Sarosiek
The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including neurological and infectious diseases as well as environmental and medical toxicities. Conversely, the abnormal survival and accumulation of damaged or superfluous cells drive prominent human pathologies such as cancers and autoimmune diseases. Apoptosis is an evolutionarily conserved cell death pathway that is responsible for the programmed culling of cells during normal eukaryotic development and maintenance of organismal homeostasis...
January 17, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30647472/enhancers-and-promoters-regulate-burst-kinetics
#13
Grant Otto
No abstract text is available yet for this article.
January 15, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30635659/crosstalk-between-metabolism-and-circadian-clocks
#14
REVIEW
Hans Reinke, Gad Asher
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest (sleep) phases that differ largely in their metabolic requirements. The circadian clock evolved as an autonomous timekeeping system that aligns behavioural patterns with the solar day and supports the body functions by anticipating and coordinating the required metabolic programmes. The key component of this synchronization is a master clock in the brain, which responds to light-darkness cues from the environment...
January 11, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30626975/mitochondrial-proteins-from-biogenesis-to-functional-networks
#15
REVIEW
Nikolaus Pfanner, Bettina Warscheid, Nils Wiedemann
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial functions in bioenergetics, metabolism and signalling and have been associated with numerous diseases. Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. Protein machineries with diverse functions such as protein translocation, respiration, metabolite transport, protein quality control and the control of membrane architecture interact with each other in dynamic networks...
January 9, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30610207/adipogenesis-and-metabolic-health
#16
REVIEW
Alexandra L Ghaben, Philipp E Scherer
Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). Notably, adipocyte expansion through adipogenesis can offset the negative metabolic effects of obesity, and the mechanisms and regulators of this adaptive process are now emerging...
January 4, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30610206/lipid-give-and-take
#17
Grant Otto
No abstract text is available yet for this article.
January 4, 2019: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30575802/freedom-of-expression-in-methylated-regions
#18
Eytan Zlotorynski
No abstract text is available yet for this article.
December 21, 2018: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30573906/mitochondria-unite
#19
Paulina Strzyz
No abstract text is available yet for this article.
December 20, 2018: Nature Reviews. Molecular Cell Biology
https://read.qxmd.com/read/30546055/hippo-yap-taz-signalling-in-organ-regeneration-and-regenerative-medicine
#20
REVIEW
Iván M Moya, Georg Halder
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and regeneration. Remarkably, experimental activation of YAP/TAZ in the mouse can promote regeneration in organs with poor or compromised regenerative capacity, such as the adult heart and the liver and intestine of old or diseased mice. However, therapeutic YAP/TAZ activation may cause serious side effects...
December 13, 2018: Nature Reviews. Molecular Cell Biology
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