journal
https://read.qxmd.com/read/38977859/neurogenic-exacerbation-of-psoriasis
#1
JOURNAL ARTICLE
Darran Yates
No abstract text is available yet for this article.
July 8, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38956369/predicting-natural-behaviour-by-perturbation
#2
JOURNAL ARTICLE
Jake Rogers
No abstract text is available yet for this article.
July 2, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38956368/mapping-the-cell-type-specific-effects-of-ageing-in-the-human-cortex
#3
JOURNAL ARTICLE
Katherine Whalley
No abstract text is available yet for this article.
July 1, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38951687/indirect-neurogenesis-in-space-and-time
#4
REVIEW
Stefan Thor
During central nervous system (CNS) development, neural progenitor cells (NPCs) generate neurons and glia in two different ways. In direct neurogenesis, daughter cells differentiate directly into neurons or glia, whereas in indirect neurogenesis, neurons or glia are generated after one or more daughter cell divisions. Intriguingly, indirect neurogenesis is not stochastically deployed and plays instructive roles during CNS development: increased generation of cells from specific lineages; increased generation of early or late-born cell types within a lineage; and increased cell diversification...
July 1, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38951686/wrapping-up-reward
#5
JOURNAL ARTICLE
Sian Lewis
No abstract text is available yet for this article.
July 1, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38937655/why-so-slow-models-of-parkinsonian-bradykinesia
#6
REVIEW
David Williams
Bradykinesia, or slowness of movement, is a defining feature of Parkinson disease (PD) and a major contributor to the negative effects on quality of life associated with this disorder and related conditions. A dominant pathophysiological model of bradykinesia in PD has existed for approximately 30 years and has been the basis for the development of several therapeutic interventions, but accumulating evidence has made this model increasingly untenable. Although more recent models have been proposed, they also appear to be flawed...
June 27, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38937654/timescales-of-learning-in-prefrontal-cortex
#7
REVIEW
Jacob A Miller, Christos Constantinidis
The lateral prefrontal cortex (PFC) in humans and other primates is critical for immediate, goal-directed behaviour and working memory, which are classically considered distinct from the cognitive and neural circuits that support long-term learning and memory. Over the past few years, a reconsideration of this textbook perspective has emerged, in that different timescales of memory-guided behaviour are in constant interaction during the pursuit of immediate goals. Here, we will first detail how neural activity related to the shortest timescales of goal-directed behaviour (which requires maintenance of current states and goals in working memory) is sculpted by long-term knowledge and learning - that is, how the past informs present behaviour...
June 27, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38902514/the-power-of-direct-observation-discovery-of-rem-sleep
#8
JOURNAL ARTICLE
Danqian Liu
No abstract text is available yet for this article.
June 20, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38902513/causal-prominence-for-neuroscience
#9
LETTER
Philip Tseng, Tony Cheng
No abstract text is available yet for this article.
June 20, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38902512/reply-to-causal-prominence-for-neuroscience
#10
LETTER
Lauren N Ross, Dani S Bassett
No abstract text is available yet for this article.
June 20, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38898231/gene-therapy-for-cns-disorders-modalities-delivery-and-translational-challenges
#11
REVIEW
Jingjing Gao, Swetharajan Gunasekar, Ziting Judy Xia, Kiruba Shalin, Christopher Jiang, Hao Chen, Dongtak Lee, Sohyung Lee, Nishkal D Pisal, James N Luo, Ana Griciuc, Jeffrey M Karp, Rudolph Tanzi, Nitin Joshi
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of recently approved gene therapies for the treatment of spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and active cerebral adrenoleukodystrophy are encouraging further development of this approach. However, most attempts to translate gene therapy to the clinic have failed to make it to market. There is an urgent need not only to tailor the genes that are targeted to the pathology of interest but to also address delivery challenges and thereby maximize the utility of genetic tools...
June 19, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38862665/lessons-on-predictive-learning-from-the-honeybee
#12
JOURNAL ARTICLE
Sabine Krabbe
No abstract text is available yet for this article.
June 11, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38858580/reply-to-fear-anxiety-and-the-functional-architecture-of-the-human-central-extended-amygdala
#13
LETTER
Liping Wang, Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Sheng He
No abstract text is available yet for this article.
June 10, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38858579/fear-anxiety-and-the-functional-architecture-of-the-human-central-extended-amygdala
#14
LETTER
Alexander J Shackman, Shannon E Grogans, Andrew S Fox
No abstract text is available yet for this article.
June 10, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38839948/a-pas-de-deux-between-the-hippocampus-and-the-cortex-during-sleep
#15
JOURNAL ARTICLE
Adrien Peyrache
No abstract text is available yet for this article.
June 5, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38831132/pattern-recognition-using-action-potential-timing
#16
JOURNAL ARTICLE
Izumi Fukunaga
No abstract text is available yet for this article.
June 3, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38806946/common-principles-for-odour-coding-across-vertebrates-and-invertebrates
#17
REVIEW
Kara A Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta
The olfactory system is an ideal and tractable system for exploring how the brain transforms sensory inputs into behaviour. The basic tasks of any olfactory system include odour detection, discrimination and categorization. The challenge for the olfactory system is to transform the high-dimensional space of olfactory stimuli into the much smaller space of perceived objects and valence that endows odours with meaning. Our current understanding of how neural circuits address this challenge has come primarily from observations of the mechanisms of the brain for processing other sensory modalities, such as vision and hearing, in which optimized deep hierarchical circuits are used to extract sensory features that vary along continuous physical dimensions...
May 28, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38789516/the-neuropathobiology-of-multiple-sclerosis
#18
REVIEW
Marcel S Woo, Jan Broder Engler, Manuel A Friese
Chronic low-grade inflammation and neuronal deregulation are two components of a smoldering disease activity that drives the progression of disability in people with multiple sclerosis (MS). Although several therapies exist to dampen the acute inflammation that drives MS relapses, therapeutic options to halt chronic disability progression are a major unmet clinical need. The development of such therapies is hindered by our limited understanding of the neuron-intrinsic determinants of resilience or vulnerability to inflammation...
May 24, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38783147/network-state-transitions-during-cortical-development
#19
REVIEW
Michelle W Wu, Nazim Kourdougli, Carlos Portera-Cailliau
Mammalian cortical networks are active before synaptogenesis begins in earnest, before neuronal migration is complete, and well before an animal opens its eyes and begins to actively explore its surroundings. This early activity undergoes several transformations during development. The most important of these is a transition from episodic synchronous network events, which are necessary for patterning the neocortex into functionally related modules, to desynchronized activity that is computationally more powerful and efficient...
May 23, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38760459/brain-functional-networks-and-psychiatric-disorders
#20
JOURNAL ARTICLE
Isobel Leake
No abstract text is available yet for this article.
May 17, 2024: Nature Reviews. Neuroscience
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