Jacob W Vogel, Nick Corriveau-Lecavalier, Nicolai Franzmeier, Joana B Pereira, Jesse A Brown, Anne Maass, Hugo Botha, William W Seeley, Dani S Bassett, David T Jones, Michael Ewers
Neurodegenerative diseases are the most common cause of dementia. Although their underlying molecular pathologies have been identified, there is substantial heterogeneity in the patterns of progressive brain alterations across and within these diseases. Recent advances in neuroimaging methods have revealed that pathological proteins accumulate along specific macroscale brain networks, implicating the network architecture of the brain in the system-level pathophysiology of neurodegenerative diseases. However, the extent to which 'network-based neurodegeneration' applies across the wide range of neurodegenerative disorders remains unclear...
August 24, 2023: Nature Reviews. Neuroscience