Teresa Ravizza, Mirte Scheper, Rossella Di Sapia, Jan Gorter, Eleonora Aronica, Annamaria Vezzani
Epilepsy remains a major health concern as anti-seizure medications frequently fail, and there is currently no treatment to stop or prevent epileptogenesis, the process underlying the onset and progression of epilepsy. The identification of the pathological processes underlying epileptogenesis is instrumental to the development of drugs that may prevent the generation of seizures or control pharmaco-resistant seizures, which affect about 30% of patients. mTOR signalling and neuroinflammation have been recognized as critical pathways that are activated in brain cells in epilepsy...
March 26, 2024: Nature Reviews. Neuroscience