journal
https://read.qxmd.com/read/38890558/how-germ-granules-promote-germ-cell-fate
#1
REVIEW
Melissa C Pamula, Ruth Lehmann
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble membraneless germ granules. These specialized RNA and protein complexes are hallmarks of germ cells throughout their life cycle: as embryonic germ granules in late oocytes and zygotes, Balbiani bodies in immature oocytes, and nuage in maturing gametes. Decades of developmental, genetic and biochemical studies have identified protein and RNA constituents unique to germ granules and have implicated these in germ cell identity, genome integrity and gamete differentiation...
June 18, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38886216/brca1-and-friends-30-years-on
#2
JOURNAL ARTICLE
William D Foulkes
No abstract text is available yet for this article.
June 17, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38886215/dna-packaging-by-molecular-motors-from-bacteriophage-to-human-chromosomes
#3
REVIEW
Bram Prevo, William C Earnshaw
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the cells that contain it. Organisms, therefore, use sophisticated machineries to package their genomes. These systems range across kingdoms from a single ultra-powerful rotary motor that spools the DNA into a bacteriophage head, to hundreds of thousands of relatively weak molecular motors that coordinate the compaction of mitotic chromosomes in eukaryotic cells. Recent technological advances, such as DNA proximity-based sequencing approaches, polymer modelling and in vitro reconstitution of DNA loop extrusion, have shed light on the biological mechanisms driving DNA organization in different systems...
June 17, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38877133/next-generation-data-filtering-in-the-genomics-era
#4
REVIEW
William Hemstrom, Jared A Grummer, Gordon Luikart, Mark R Christie
Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology, evolution and human health. However, these datasets often contain noise or errors and are missing information that can affect the accuracy and reliability of subsequent computational analyses and conclusions. A key step in genomic data analysis is filtering - removing sequencing bases, reads, genetic variants and/or individuals from a dataset - to improve data quality for downstream analyses. Researchers are confronted with a multitude of choices when filtering genomic data; they must choose which filters to apply and select appropriate thresholds...
June 14, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38866919/from-mendel-s-laws-to-non-mendelian-inheritance
#5
JOURNAL ARTICLE
Laura Ross
No abstract text is available yet for this article.
June 12, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38839917/mini-colons-unlock-tumour-development-outside-the-body
#6
JOURNAL ARTICLE
L Francisco Lorenzo-Martín, Matthias P Lutolf
No abstract text is available yet for this article.
June 5, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38816646/scent-defines-non-coding-disease-mechanisms-using-single-cell-multi-omics
#7
JOURNAL ARTICLE
Saori Sakaue
No abstract text is available yet for this article.
May 30, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38806721/gene-environment-interactions-in-human-health
#8
REVIEW
Esther Herrera-Luis, Kelly Benke, Heather Volk, Christine Ladd-Acosta, Genevieve L Wojcik
Gene-environment interactions (G × E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits and diseases. Statistically, G × E can be assessed by determining the deviation from expectation of predictive models based solely on the phenotypic effects of genetics or environmental exposures. Despite the unprecedented, widespread and diverse use of G × E analytical frameworks, heterogeneity in their application and reporting hinders their applicability in public health...
May 28, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38778132/nuclear-receptors-studying-genes-to-understand-hormones
#9
JOURNAL ARTICLE
Jessica Tollkuhn
No abstract text is available yet for this article.
May 22, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38750154/banksy-scalable-cell-typing-and-domain-segmentation-for-spatial-omics
#10
JOURNAL ARTICLE
Vipul Singhal, Nigel Chou
No abstract text is available yet for this article.
May 15, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38740873/miller-spreads-and-the-power-of-observation
#11
JOURNAL ARTICLE
Mustafa Mir
No abstract text is available yet for this article.
May 13, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38740872/dysregulation-of-epigenetically-induced-cancers
#12
JOURNAL ARTICLE
Henry Ertl
No abstract text is available yet for this article.
May 13, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38724711/genetics-of-glycosylation-in-mammalian-development-and-disease
#13
REVIEW
Pamela Stanley
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells and model organisms have been key to defining glycosylation pathways and the biological functions of glycans. More recently, applications of genome sequencing have revealed the breadth of rare congenital disorders of glycosylation in humans and the influence of genetics on the synthesis of glycans relevant to infectious diseases, cancer progression and diseases of the immune system...
May 9, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38720023/tandem-repeat-variation-of-human-centromeres
#14
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
May 8, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38714860/the-emerging-role-of-tandem-repeats-in-complex-traits
#15
JOURNAL ARTICLE
Michael Lamkin, Melissa Gymrek
No abstract text is available yet for this article.
May 7, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38684857/the-hidden-world-of-transient-enhancers
#16
JOURNAL ARTICLE
Renée Beekman
No abstract text is available yet for this article.
April 29, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38684856/rapid-pathogen-surveillance-field-ready-sequencing-solutions
#17
JOURNAL ARTICLE
Kirstyn Brunker
No abstract text is available yet for this article.
April 29, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38684855/prime-editing-sensors-enable-multiplexed-genome-editing
#18
JOURNAL ARTICLE
Samuel I Gould
No abstract text is available yet for this article.
April 29, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38658741/targeted-genome-modification-tools-and-their-advanced-applications-in-crop-breeding
#19
REVIEW
Boshu Li, Chao Sun, Jiayang Li, Caixia Gao
Crop improvement by genome editing involves the targeted alteration of genes to improve plant traits, such as stress tolerance, disease resistance or nutritional content. Techniques for the targeted modification of genomes have evolved from generating random mutations to precise base substitutions, followed by insertions, substitutions and deletions of small DNA fragments, and are finally starting to achieve precision manipulation of large DNA segments. Recent developments in base editing, prime editing and other CRISPR-associated systems have laid a solid technological foundation to enable plant basic research and precise molecular breeding...
April 24, 2024: Nature Reviews. Genetics
https://read.qxmd.com/read/38658740/what-tubulin-can-teach-us-about-gene-regulation
#20
JOURNAL ARTICLE
Olivia S Rissland
No abstract text is available yet for this article.
April 24, 2024: Nature Reviews. Genetics
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