journal
https://read.qxmd.com/read/36914776/genomic-transformations-of-eurasian-hunter-gatherer-populations-during-the-last-ice-age
#1
JOURNAL ARTICLE
Linda Koch
No abstract text is available yet for this article.
March 13, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36864178/methods-and-applications-for-single-cell-and-spatial-multi-omics
#2
REVIEW
Katy Vandereyken, Alejandro Sifrim, Bernard Thienpont, Thierry Voet
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease. In less than a decade, the field has seen tremendous technological revolutions that enable crucial new insights into the interplay between intracellular and intercellular molecular mechanisms that govern development, physiology and pathogenesis. In this Review, we highlight advances in the fast-developing field of single-cell and spatial multi-omics technologies (also known as multimodal omics approaches), and the computational strategies needed to integrate information across these molecular layers...
March 2, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36854803/engineering-transgenerational-epigenetic-inheritance-in-mammals
#3
JOURNAL ARTICLE
Darren J Burgess
No abstract text is available yet for this article.
February 28, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36829055/simultaneous-sequencing-of-genome-and-epigenome
#4
JOURNAL ARTICLE
Linda Koch
No abstract text is available yet for this article.
February 24, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36814001/sex-and-age-affect-circadian-gene-expression
#5
JOURNAL ARTICLE
Dorothy Clyde
No abstract text is available yet for this article.
February 22, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36806206/mendelian-inheritance-revisited-dominance-and-recessiveness-in-medical-genetics
#6
REVIEW
Johannes Zschocke, Peter H Byers, Andrew O M Wilkie
Understanding the consequences of genotype for phenotype (which ranges from molecule-level effects to whole-organism traits) is at the core of genetic diagnostics in medicine. Many measures of the deleteriousness of individual alleles exist, but these have limitations for predicting the clinical consequences. Various mechanisms can protect the organism from the adverse effects of functional variants, especially when the variant is paired with a wild type allele. Understanding why some alleles are harmful in the heterozygous state - representing dominant inheritance - but others only with the biallelic presence of pathogenic variants - representing recessive inheritance - is particularly important when faced with the deluge of rare genetic alterations identified by high throughput DNA sequencing...
February 20, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36801929/understanding-soft-sweeps-a-signature-of-rapid-adaptation
#7
JOURNAL ARTICLE
Nandita R Garud
No abstract text is available yet for this article.
February 17, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36747004/the-finngen-study-disease-insights-from-a-bottlenecked-population
#8
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
February 6, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36747003/regulatory-promoter-architectures-in-the-hands-of-thermodynamic-modelling
#9
JOURNAL ARTICLE
Julio Collado-Vides
No abstract text is available yet for this article.
February 6, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36737647/human-specific-genetics-new-tools-to-explore-the-molecular-and-cellular-basis-of-human-evolution
#10
REVIEW
Alex A Pollen, Umut Kilik, Craig B Lowe, J Gray Camp
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled humans to colonize diverse habitats, develop extraordinary technologies and reshape the biosphere. Understanding the genetic, developmental and molecular bases for these changes will provide insights into how we became human. Connecting human-specific genetic changes to species differences has been challenging owing to an abundance of low-effect size genetic changes, limited descriptions of phenotypic differences across development at the level of cell types and lack of experimental models...
February 3, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36732640/how-hi-c-ignited-the-era-of-3d-genome-biology
#11
JOURNAL ARTICLE
Magda Bienko
No abstract text is available yet for this article.
February 2, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36732639/chromatin-organization-in-red-triangles
#12
JOURNAL ARTICLE
Elisa Oricchio
No abstract text is available yet for this article.
February 2, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36717624/molecular-mechanisms-of-environmental-exposures-and-human-disease
#13
REVIEW
Haotian Wu, Christina M Eckhardt, Andrea A Baccarelli
A substantial proportion of disease risk for common complex disorders is attributable to environmental exposures and pollutants. An appreciation of how environmental pollutants act on our cells to produce deleterious health effects has led to advances in our understanding of the molecular mechanisms underlying the pathogenesis of chronic diseases, including cancer and cardiovascular, neurodegenerative and respiratory diseases. Here, we discuss emerging research on the interplay of environmental pollutants with the human genome and epigenome...
January 30, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36717623/exon-junction-complex-modulates-m-6-a-distribution
#14
JOURNAL ARTICLE
Dorothy Clyde
No abstract text is available yet for this article.
January 30, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36707729/pharmacogenomics-current-status-and-future-perspectives
#15
REVIEW
Munir Pirmohamed
Inter-individual variability in drug response, be it efficacy or safety, is common and likely to become an increasing problem globally given the growing elderly population requiring treatment. Reasons for this inter-individual variability include genomic factors, an area of study called pharmacogenomics. With genotyping technologies now widely available and decreasing in cost, implementing pharmacogenomics into clinical practice - widely regarded as one of the initial steps in mainstreaming genomic medicine - is currently a focus in many countries worldwide...
January 27, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36697957/stem-cell-derived-organoid-models-defying-the-hayflick-limit
#16
JOURNAL ARTICLE
Meritxell Huch
No abstract text is available yet for this article.
January 25, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36697956/optical-filament-recording-of-cellular-events
#17
JOURNAL ARTICLE
Darren J Burgess
No abstract text is available yet for this article.
January 25, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36653550/navigating-the-pitfalls-of-mapping-dna-and-rna-modifications
#18
REVIEW
Yimeng Kong, Edward A Mead, Gang Fang
Chemical modifications to nucleic acids occur across the kingdoms of life and carry important regulatory information. Reliable high-resolution mapping of these modifications is the foundation of functional and mechanistic studies, and recent methodological advances based on next-generation sequencing and long-read sequencing platforms are critical to achieving this aim. However, mapping technologies may have limitations that sometimes lead to inconsistent results. Some of these limitations are technical in nature and specific to certain types of technology...
January 18, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36646844/mapping-the-minutiae-of-the-human-methylome
#19
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
January 16, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/36639513/prioritizing-the-detection-of-rare-pathogenic-variants-in-population-screening
#20
JOURNAL ARTICLE
Paul Lacaze, Ranjit Manchanda, Robert C Green
No abstract text is available yet for this article.
January 13, 2023: Nature Reviews. Genetics
journal
journal
35149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.