journal
https://read.qxmd.com/read/38012269/swi-snf-function-compensated-by-another-chromatin-remodeller
#1
JOURNAL ARTICLE
Henry Ertl
No abstract text is available yet for this article.
November 27, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/38012268/translating-genomic-advances-into-biodiversity-conservation
#2
REVIEW
Carolyn J Hogg
A key action of the new Global Biodiversity Framework is the maintenance of genetic diversity in all species to safeguard their adaptive potential. To achieve this goal, a translational mindset, which aims to convert results of basic research into direct practical benefits, needs to be applied to biodiversity conservation. Despite much discussion on the value of genomics to conservation, a disconnect between those generating genomic resources and those applying it to biodiversity management remains. As global efforts to generate reference genomes for non-model species increase, investment into practical biodiversity applications is critically important...
November 27, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/38001317/context-specific-functions-of-chromatin-remodellers-in-development-and-disease
#3
REVIEW
Sai Gourisankar, Andrey Krokhotin, Wendy Wenderski, Gerald R Crabtree
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate remarkable biological specificity and dosage sensitivity of the thirty-two adenosine triphosphate (ATP)-dependent chromatin remodellers encoded in the human genome. Mutations in remodellers produce many human developmental disorders and cancers, motivating efforts to investigate their distinct functions in biologically relevant settings. Exquisitely specific biological functions seem to be an emergent property in mammals, and in many cases are based on the combinatorial assembly of subunits and the generation of stable, composite surfaces...
November 24, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37993610/weaponized-genomics-potential-threats-to-international-and-human-security
#4
JOURNAL ARTICLE
Subhayan Chattopadhyay, Tony Ingesson, Alberto Rinaldi, Oscar Larsson, J J Widen, Jessica Almqvist, David Gisselsson
No abstract text is available yet for this article.
November 22, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37993609/mouse-genome-rewriting-with-human-dna-for-disease-modelling
#5
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
November 22, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37993608/including-diverse-populations-enhances-the-discovery-of-type-2-diabetes-loci
#6
JOURNAL ARTICLE
Segun Fatumo
No abstract text is available yet for this article.
November 22, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37985791/interrogating-epigenetic-mechanisms-with-chemically-customized-chromatin
#7
REVIEW
Nir Hananya, Shany Koren, Tom W Muir
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated in the epigenetic regulation of DNA-templated processes such as transcription. However, achieving a mechanistic understanding of how these molecules interact with chromatin to elicit a functional output is non-trivial, owing to the tremendous complexity of the biochemical networks involved. Advances in protein engineering have enabled the reconstitution of 'designer' chromatin containing customized post-translational modification patterns, which, when used in conjunction with sophisticated biochemical and biophysical methods, allow many mechanistic questions to be addressed...
November 20, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37968332/non-coding-rnas-in-disease-from-mechanisms-to-therapeutics
#8
REVIEW
Kinga Nemeth, Recep Bayraktar, Manuela Ferracin, George A Calin
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and tissues, and their dysregulation has been implicated in disease. Notably, much research has focused on the link between microRNAs (miRNAs) and human cancers, although other ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as relevant contributors to human disease...
November 15, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37950000/wnt-regulator-controls-stripe-patterning
#9
JOURNAL ARTICLE
Henry Ertl
No abstract text is available yet for this article.
November 10, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37938738/scrambling-the-genome-in-cancer-causes-and-consequences-of-complex-chromosome-rearrangements
#10
REVIEW
Ksenia Krupina, Alexander Goginashvili, Don W Cleveland
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome rearrangement is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event. Chromothripsis can be initiated by mitotic errors that produce a micronucleus encapsulating a single chromosome or chromosomal fragment. Rupture of the unstable micronuclear envelope exposes its chromatin to cytosolic nucleases and induces chromothriptic shattering...
November 8, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37914910/a-genetic-atlas-of-the-human-blood-proteome
#11
JOURNAL ARTICLE
Michael Attwaters
No abstract text is available yet for this article.
November 1, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37884793/de-novo-genes-from-non-genic-to-genic
#12
JOURNAL ARTICLE
Li Zhao
No abstract text is available yet for this article.
October 26, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37872242/controlling-organoid-gene-expression-with-light
#13
JOURNAL ARTICLE
Henry Ertl
No abstract text is available yet for this article.
October 23, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37863940/genomics-for-monitoring-and-understanding-species-responses-to-global-climate-change
#14
REVIEW
Louis Bernatchez, Anne-Laure Ferchaud, Chloé Suzanne Berger, Clare J Venney, Amanda Xuereb
All life forms across the globe are experiencing drastic changes in environmental conditions as a result of global climate change. These environmental changes are happening rapidly, incur substantial socioeconomic costs, pose threats to biodiversity and diminish a species' potential to adapt to future environments. Understanding and monitoring how organisms respond to human-driven climate change is therefore a major priority for the conservation of biodiversity in a rapidly changing environment. Recent developments in genomic, transcriptomic and epigenomic technologies are enabling unprecedented insights into the evolutionary processes and molecular bases of adaptation...
October 20, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37863939/inborn-errors-of-immunity-an-expanding-universe-of-disease-and-genetic-architecture
#15
REVIEW
Yemsratch T Akalu, Dusan Bogunovic
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy and/or cancer. Here, we discuss evidence that IEIs need not be rare disorders or exclusively affect the immune system. Namely, an increasing number of patients with IEIs present with severe dysregulations of the central nervous, digestive, renal or pulmonary systems. Current challenges in the diagnosis of IEIs that result from the segregated practice of specialized medicine could thus be mitigated, in part, by immunogenetic approaches...
October 20, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37821682/predicting-variant-pathogenicity-with-alphamissense
#16
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
October 11, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37803176/nuclear-genome-influences-mitochondrial-dna
#17
JOURNAL ARTICLE
Henry Ertl
No abstract text is available yet for this article.
October 6, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37794181/author-correction-transposable-elements-mcclintock-s-legacy-revisited
#18
Cédric Feschotte
No abstract text is available yet for this article.
October 4, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37749210/genomic-surveillance-for-antimicrobial-resistance-a-one-health-perspective
#19
REVIEW
Steven P Djordjevic, Veronica M Jarocki, Torsten Seemann, Max L Cummins, Anne E Watt, Barbara Drigo, Ethan R Wyrsch, Cameron J Reid, Erica Donner, Benjamin P Howden
Antimicrobial resistance (AMR) - the ability of microorganisms to adapt and survive under diverse chemical selection pressures - is influenced by complex interactions between humans, companion and food-producing animals, wildlife, insects and the environment. To understand and manage the threat posed to health (human, animal, plant and environmental) and security (food and water security and biosecurity), a multifaceted 'One Health' approach to AMR surveillance is required. Genomic technologies have enabled monitoring of the mobilization, persistence and abundance of AMR genes and mutations within and between microbial populations...
September 25, 2023: Nature Reviews. Genetics
https://read.qxmd.com/read/37749209/the-evolutionary-tale-of-lactase-persistence-in-humans
#20
JOURNAL ARTICLE
Luis B Barreiro
No abstract text is available yet for this article.
September 25, 2023: Nature Reviews. Genetics
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