Paramita Baruah, Jennifer Marshall, Philip N Jones, Triin Major, Valentina Pucino, John D O'Neil, Meriam Nefla, Helen McGettrick, Peter Monksfield, Richard Irving, Christopher D Buckley
BACKGROUND AND AIM: Vestibular schwannomas (VSs), despite being histologically benign, cause significant morbidity because of their challenging intracranial location and the propensity for growth. The role of the stroma and particularly fibroblasts, in the progression of VS, is not completely understood. This study examines the profile of fibroblasts in VS. METHODS: Seventeen patients undergoing surgical excision of VS were recruited into the study. Reverse transcription with quantitative polymerase chain reaction (RT-qPCR) was performed on VS tissue samples and fibroblast-associated molecules examined...
September 15, 2023: Otology & Neurotology