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Journal of Toxicology and Environmental Health. Part A

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https://read.qxmd.com/read/30755151/maternal-bisphenol-a-exposure-disrupts-spermatogenesis-in-adult-rat-offspring
#1
Patricia De Campos, Isabela M Oliveira, Janaina Sena de Souza, Rodrigo Rodrigues Da Conceição, Gisele Giannocco, Maria I Chiamolera, Magnus R Dias-Da Silva, Marco A Romano, Renata Marino Romano
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that is widely used in the manufacturing of plastics and inner linings of food cans. Previously, it was reported that BPA disturbed the sexual dimorphic nucleus of the hypothalamus and delaying the onset of puberty attributed to an estrogenic action. In addition, BPA during the perinatal period increased LH serum concentrations in male offspring of dams at doses below the reproductive NOAEL (No Observable Adverse Effect Level) based upon World Health Organization guidelines...
February 12, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30755101/the-influence-of-maternal-and-perinatal-high-fat-diet-on-ozone-induced-pulmonary-responses-in-offspring
#2
Samantha J Snow, Pamela M Phillips, Allen Ledbetter, Andrew F M Johnstone, Mette C Schladweiler, Christopher J Gordon, Urmila P Kodavanti
There is growing interest in understanding how maternal diet might affect the sensitivity of offspring to environmental exposures. Previous studies demonstrated that adult rat offspring (approximately 6-months-old) from dams given a high-fat diet (HFD) prior to, during, and after pregnancy displayed elevated pulmonary responses to an acute ozone (O3 ) exposure. The aim of this study was to examine the influence of maternal and perinatal HFD on pulmonary and metabolic responses to O3 in male and female young-adult offspring (approximately 3-month old)...
February 12, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30744511/effects-of-cross-fostering-and-developmental-exposure-to-mixtures-of-environmental-contaminants-on-hepatic-gene-expression-in-prepubertal-21-days-old-and-adult-male-sprague-dawley-rats
#3
D Desaulniers, N Khan, C Cummings-Lorbetskie, K Leingartner, G-H Xiao, A Williams, C L Yauk
The notion that adverse health effects produced by exposure to environmental contaminants (EC) may be modulated by the presence of non-chemical stressors is gaining attention. Previously, our lab demonstrated that cross-fostering (adoption of a litter at birth) acted as a non-chemical stressor that amplified the influence of developmental exposure to EC on the glucocorticoid stress-response in adult rats. Using liver from the same rats, the aim of the current study was to investigate whether cross-fostering might also modulate EC-induced alterations in hepatic gene expression profiles...
February 11, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30741125/toxicological-aspects-of-campomanesia-xanthocarpa-berg-associated-with-its-phytochemical-profile
#4
Joubert Aires De Sousa, Lismare da Silva Prado, Bárbara Lopes Alderete, Fernanda Brião Menezes Boaretto, Mariangela C Allgayer, Fabiano Moraes Miguel, Jayne Torres De Sousa, Norma Possa Marroni, Maria Luísa Brodt Lemes, Dione Silva Corrêa, Alexandre de Barros Falcão Ferraz, Jaqueline Nascimento Picada
Campomanesia xanthocarpa leaves are used as tea to treat diarrhea, inflammation, and hypercholesterolemia. Some pharmacological studies noted its beneficial uses of C. xanthocarpa; however, few investigations examined the toxicological profile of this plant. The aim of this study was to determine the chemical composition, genotoxic, and mutagenic potential of an aqueous extract of C. xanthocarpa leaves (CxAE), and potential protective effects against oxidative damage. Phytochemical constituents were determined using HPLC, and antioxidant effect in vitro was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay...
February 10, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30741122/perspectives-on-trace-chemical-safety-and-chemophobia-risk-communication-and-risk-management
#5
Byung-Mu Lee, Seok Kwon, Yun Mi Cho, Kyu-Bong Kim, Kyungwon Seo, Choong Sik Min, Kyoungeun Kim
Safety issues regarding consumer products contaminated with trace amounts of chemicals are of great concern to consumers, with the degree of concern occasionally escalating to the psychological syndrome, chemophobia (i.e., the fear of chemicals). Hazardous substances frequently implicated in safety concerns include heavy metals (arsenic, mercury, cadmium, and lead), volatile organic compounds (VOC) such as benzene and o-toluidine, pesticides, carcinogens, radioactive substances, and endocrine disrupting chemicals (EDC) such as bisphenol A and phthalates...
February 10, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30729860/embryonic-arsenic-exposure-reduces-intestinal-cell-proliferation-and-alters-hepatic-igf-mrna-expression-in-killifish-fundulus-heteroclitus
#6
Kaleigh C Sims, Katey L Schwendinger, Dana B Szymkowicz, Jonathan R Swetenberg, Lisa J Bain
Arsenic (As) is a toxicant found in food and water throughout the world, and studies suggested that exposure early in life reduces growth. Thus, the goal of this study was to examine mechanisms by which As impacted organismal growth. Killifish (Fundulus heteroclitus) were exposed to 0, 10, 50, or 200 ppb As as embryos and, after hatching, were reared in clean water for up to 40 weeks. Metabolism studies revealed that killifish biotransform As such that monomethylated and dimethylated arsenicals account for 15-17% and 45-61%, respectively, of the total metal...
February 7, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30722754/ethnic-differences-in-risk-experiences-medical-needs-and-access-to-care-after-hurricane-sandy-in-new-jersey
#7
Joanna Burger, Michael Gochfeld, Clifton Lacy
This survey investigation assessed an economically challenged and largely minority population regarding concerns, evacuation status, medical needs and access to care during, and after, Hurricane Sandy by ethnicity status for patients using New Jersey's Federally Qualified Health Centers (FQHC). Data obtained contribute to understanding risk from disasters, and improving environmental justice for vulnerable populations following disasters. FQHCs provide medical and dental services for 5% of New Jersey 's population; 95% of those served are uninsured, underinsured, or live below the poverty level...
February 5, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30704354/role-of-nf-%C3%AE%C2%BAb-activation-in-mouse-bone-marrow-stromal-cells-exposed-to-900-mhz-radiofrequency-fields-rf
#8
Lin Zong, Zhen Gao, Wen Xie, Jian Tong, Yi Cao
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a primary transcription factor which plays a key role in several cellular processes including proliferation and survival. It is well known that exposure to non-ionizing radiofrequency fields (RFs), which are ubiquitous, resulted in interaction with cellular components. The aim of the study was thus to examine whether exposure of mouse bone marrow stromal cells (BMSC) to RF also resulted in cellular interactions. BMSC were exposed to 900 MHz RF at 120 μW/cm2 power intensity for 4 hr/day for 5 consecutive days...
January 31, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30669952/preliminary-results-on-the-uptake-and-biochemical-response-to-water-exposure-of-tamiflu%C3%A2-oseltamivir-phosphate-in-two-marine-bivalves
#9
Sara Dallarés, Nicola Montemurro, Sandra Pérez, Neus Rodríguez-Sanchez, Montserrat Solé
Tamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Bivalves are reliable sentinels of chemical exposure due to their low metabolism; however, biotransformation of drugs does occur in these aquatic invertebrates...
January 22, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30663538/role-of-nf-%C3%AE%C2%BAb-activation-in-mouse-bone-marrow-stromal-cells-exposed-to-900-mhz-radiofrequency-fields-rf
#10
Lin Zong, Zhen Gao, Wen Xie, Jian Tong, Yi Cao
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a primary transcription factor which plays a key role in several cellular processes including proliferation and survival. It is well-known that exposure to non-ionizing radiofrequency fields (RF), which are ubiquitous, interact with cellular components. The aim of the study was thus to examine whether exposure of mouse bone marrow stromal cells (BMSC) to RF also resulted in cellular interactions. BMSC were exposed to 900 MHz RF at 120 μW/cm2 power intensity for 4 hr/day for 5 consecutive days...
January 21, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30663519/perspectives-on-trace-chemical-safety-and-chemophobia-risk-communication-and-risk-management
#11
Byung-Mu Lee, Seok Kwon, Yun Mi Cho, Kyu-Bong Kim, Kyungwon Seo, Choong Sik Min, Kyoungeun Kim
Safety issues regarding consumer products contaminated with trace amounts of chemicals are of great concern to consumers, with the degree of concern occasionally escalating to the psychological syndrome, chemophobia, i.e., the fear of chemicals. Hazardous substances frequently implicated in safety concerns include heavy metals (arsenic, mercury, cadmium, and lead), volatile organic compounds (VOC) such as benzene and o-toluidine, pesticides, carcinogens, radioactive substances, and endocrine disrupting chemicals (EDC) such as bisphenol A and phthalates...
January 21, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30652531/metal-bashing-iron-deficiency-and-manganese-overexposure-impact-on-peripheral-nerves
#12
Robyn M Amos-Kroohs, Vanina Usach, Gonzalo Piñero, Charles V Vorhees, Rocío Martinez Vivot, Paula A Soto, Michael T Williams, Patricia Setton-Avruj
Iron (Fe) deficiency (FeD) and manganese (Mn) overexposure (MnOE) may result in several neurological alterations in the nervous system. Iron deficiency produces unique neurological deficits due to its elemental role in central nervous system (CNS) development and myelination, which might persist after normalization of Fe in the diet. Conversely, MnOE is associated with diverse neurocognitive deficits. Despite these well-known neurotoxic effects on the CNS, the influence of FeD and MnOE on the peripheral nervous system (PNS) remains poorly understood...
January 17, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30626254/multi-platform-analysis-of-methylation-regulated-genes-in-human-lung-adenocarcinoma
#13
Jin Wang, Xiao-Fan Yu, Nan OUYang, Qiu-Lin Luo, Shi-Yu Zhao, Xi-Fei Guan, Tao Chen, Jian-Xiang Li
Lung adenocarcinoma (LUAD) is the most frequent pathological type of lung cancer that has a poor prognosis and high mortality rate. DNA methylation plays a critical role in various biological processes during development, while dysregulation results in pathological consequences. Thus, this study aimed to identify DNA methylation-regulated genes involved in LUAD occurrence. Initially, 300 downregulated and 168 upregulated mRNA expression levels were identified in two databases: Gene Expression Omnibus (GEO) and The Cancer Genome Atlas...
January 9, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30582425/toxicity-and-expression-of-oxidative-stress-genes-in-tribolium-castaneum-induced-by-toluene-xylene-and-thinner
#14
Nerlis Pajaro-Castro, Karina Caballero-Gallardo, Jesus Olivero-Verbel
Thinner is a solvent that contains toluene, xylene, and other substances. The aim of this study was to examine the toxicity of thinner, xylene, and toluene on adult red flour beetles, Tribolium castaneum (Herbst), as well as the effects of thinner and toluene on gene expression. The major compounds identified in the thinner with peak area >2% were p-xylene (6%), toluene (4%), 2,4-dimethylheptane (3%), methylcyclohexane (2.75%), 2-methylheptane (2%), cyclohexanone (2.6%), and nonane (2.1%). Insects were exposed to solvents at 0-240 µl/L air for 4-48 hr...
December 24, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30526399/functional-and-structural-liver-abnormalities-in-former-pcb-exposed-workers-analyses-from-the-helpcb-cohort
#15
Andrea Kaifie, Thomas Schettgen, Monika Gube, Patrick Ziegler, Thomas Kraus, André Esser
The effects of polychlorinated biphenyls (PCB) on liver function and structure are still under debate. Although higher transaminase activity and tumor promoting the potential of PCB reported for animal and human studies was suggested, these studies were not able to provide definitive evidence on the ability of these chemicals to affect liver function and contribution to tumor development. The aim of this study was to determine the influence of PCB on liver function and morphology in a cohort of former PCB exposed workers...
December 10, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30507365/exposure-to-mixtures-of-mercury-cadmium-lead-and-arsenic-alters-the-disposition-of-single-metals-in-tissues-of-wistar-rats
#16
Sarah E Orr, Mary C Barnes, Hannah S George, Lucy Joshee, Byunggwon Jeon, Austin Scircle, Oscar Black, James V Cizdziel, Betsy E Smith, Christy C Bridges
Humans throughout the world are exposed regularly to mixtures of environmental toxicants. Four of the most common heavy metal toxicants in the environment are mercury (Hg), cadmium (Cd), lead (Pb), and arsenic (As). Numerous studies have assessed the effects and disposition of individual metals in organ systems; however, humans are usually exposed to mixtures of toxicants or metals rather than to a single toxicant. Therefore, the purpose of the current study was to test the hypothesis that exposure to a mixture of toxic heavy metals alters the disposition of single metals in target organs...
December 3, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30507362/impact-of-stainless-steel-welding-fumes-on-proteins-and-non-coding-rnas-regulating-dna-damage-response-in-the-respiratory-tract-of-sprague-dawley-rats
#17
Jayaraman Krishnaraj, Abdul Basit Baba, Periasamy Viswanathan, Veeran Veeravarmal, Viswalingam Balasubramanian, Siddavaram Nagini
Substantial evidence has established the negative impact of inhalation exposure to welding fumes on respiratory functions. The aim of the present study was to investigate the effect of welding fume inhalation on expression of molecules that function as sensors, transducers and effectors of DNA damage response (DDR) in the respiratory tract of male Sprague-Dawley rats. Animals were exposed to 50 mg/m3 stainless steel welding fumes for 1 h/d for 4, 8, and 12 weeks, respectively. Histological examination demonstrated preneoplastic changes in trachea and bronchi with focal atelectasis and accumulation of chromium (Cr) in the lungs...
December 3, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30485163/protective-effect-of-schisandra-chinensis-lignans-on-hypoxia-induced-pc12-cells-and-signal-transduction
#18
Yong-Hui Zhang, Zhi-Ying Zhao, Bao-Jun Wang, Yuan-Qing Zhang, Ming Zhang, Yang-Yang Gao
It is well-known that hypoxia induces neuronal injury; however, the mechanisms underlying this observed effect remain to be determined. Schisandra chinensis lignans (SCL). The aim of this study was thus to examine the ability of Schisandra chinensis lignans (SCL) to prevent hypoxia-induced neuronal injury using a human adrenal pheochromocytoma cell line (PC12). Exposure to hypoxia significantly reduced cell survival rate in cultured PC12 cells. However, pretreatment with SCL at 10, 20 or 40 μmol/L followed by hypoxia prevented loss of cellular viability...
November 28, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30465633/rural-and-urban-differences-in-prenatal-exposure-to-essential-and-toxic-elements
#19
Jesse N Cottrell, D'Andrea S Thomas, Brenda L Mitchell, Jason E Childress, Diane M Dawley, Lawrence E Harbrecht, David A Jude, Monica A Valentovic
Excess or inadequate levels of inorganic ions may induce significant acute and long-term irreversible dysfunction in humans. The fetus and placenta are particularly vulnerable to toxins due to the immaturity of the blood-brain barrier and diminished biotransformation enzymatic activity. A comparative cross-sectional study was conducted on 172 pregnant women, 79 rural, and 93 urban. Umbilical cord blood was collected at the time of delivery and analyzed for 20 inorganic elements. Significant differences were found between urban and rural samples for two elements where copper (Cu) and molybdenum (Mo) were higher in urban samples...
November 22, 2018: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30465629/effects-of-national-smoke-free-legislation-on-the-rates-of-preterm-births-and-low-birthweights-in-taiwan
#20
Chih-Cheng Chen, Yu-Tung Huang, Chun-Yuh Yang
This study evaluated the effects of partial and complete island-wide smoking bans on perinatal outcomes in Taiwan. Trends were determined in the yearly prevalence rates for preterm births and low birth weight (LBW) for a 1978 to 1997 pre-ban period, a 1998 to 2008 Phase 1 partial ban period, and a 2009 to 2016 Phase 2 complete ban period. Poisson regression with a yearly time-series model was employed to determine alterations in trends in prevalence rates for preterm births and LBW. Compared with pre-ban period, the rate ratio (RR) for Phase 1 preterm births was 0...
November 22, 2018: Journal of Toxicology and Environmental Health. Part A
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