Journals Kaohsiung Journal of Medical S...

Kaohsiung Journal of Medical Sciences
Shih-Wei Wang, Ling-Feng Wang, Tzu-Yen Huang, Chih-Feng Tai
No abstract text is available yet for this article.
November 29, 2023: Kaohsiung Journal of Medical Sciences
Hu-Jun Xu, Xian-Peng Li, Li-Ye Han
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway. We administrated esketamine, along with lipopolysaccharide or anisomycin, to the aged POCD mouse models. We assessed their cognitive function using the Morris water maze test. Additionally, we evaluated histopathological changes/neuronal apoptosis in the mouse hippocampal CA1 area through HE/TUNEL stainings...
November 29, 2023: Kaohsiung Journal of Medical Sciences
Jia-Xi Zhu, Yu Dun, Wei Wu, Jie Shen, Feng Zhang, Lin Zhang
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening condition with no effective treatment currently available. Curcumin (CCM), a polyphenol compound in Curcuma Longa, reportedly has positive effects against intestinal I/R injury. However, the mechanism underlying the protective effect of CCM against intestinal I/R injury has not been fully clarified. To determine whether the protective effect of CCM was mediated by epigenetic effects on Wnt/β-catenin signaling, the effect of CCM was examined in vivo and in vitro...
November 27, 2023: Kaohsiung Journal of Medical Sciences
Chi-Ming Tai, Ming-Lung Yu
With the introduction of direct-acting antivirals, elimination of hepatitis C virus (HCV) infection is becoming possible. People who inject drugs (PWID) represent a population with a high risk for HCV infection, which has been reported as high as 90% in Taiwanese PWID. To reach the goal of HCV elimination, PWID is a key population deserving special attention. Barriers in HCV care cascade still exist in PWID, and interventions to promote access to HCV diagnosis, link-to-care, treatment, and prevention for PWID are warranted...
November 27, 2023: Kaohsiung Journal of Medical Sciences
Chao Zhang, Wei Wang, Biao Wu
Liver cancer is the most prevalent fatal malignancy across the globe. The present study aims to explore the molecular mechanism of E3 ligase WWP1 in liver cancer cell proliferation and invasion/migration. RT-qPCR and Western blot were performed to detect WWP1, KLF14, and VEPH1 expressions in liver cancer cell lines. Furthermore, WWP1 expression was silenced in cells, followed by the detection of cell viability, proliferation, and invasion/migration by CCK-8, colony formation, and Transwell assays, respectively...
November 23, 2023: Kaohsiung Journal of Medical Sciences
Shuang Luo, Xi-Han Chen
This study aimed to investigate the expression levels of tissue and serum miR-149-3p and miR-149-5p in hospitalized patients with inflammatory bowel disease (IBD). A total of 35 ulcerative colitis (UC) patients, 12 Crohn's disease (CD) patients, and 25 healthy controls were included in the study. The miRNAs expressions were measured in tissue and serum samples using quantitative real-time polymerase chain reaction (qRT-PCR). Inflammatory biomarkers were measured, including serum albumin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), and fecal calprotectin...
November 23, 2023: Kaohsiung Journal of Medical Sciences
Shuai Huang, Hong-Liang Wang
This study was to probe the protective effects and mechanisms of salvianolic acid A (SAA) on cerebral ischemia-reperfusion injury (CIRI). The middle cerebral artery occlusion model (MCAO) was established in rats. Rats' behavior, neurological deficits, brain injury, inflammation, and apoptosis in the brain tissue were evaluated. The inflammatory response and apoptosis of PC12 cells induced by oxygen glucose deprivation/reperfusion (OGD/R) were detected. SAA-mediated changes in miR-212-3p, SOX7, and Wnt/β-catenin pathway were determined, and the targeting relationship between miR-212-3p and SOX7 was clarified...
November 21, 2023: Kaohsiung Journal of Medical Sciences
Zhen-Hao Quan, Fei-Peng Xu, Zhe Huang, Ri-Hong Chen, Qing-Wen Xu, Lin Lin
Long noncoding RNA MYLK antisense RNA 1 (MYLK-AS1) is the crux in multiple diseases. Therefore, the purpose of this study was to investigate the possible mechanism of MYLK-AS1. A total of 62 colon cancer (CC) specimens and paired adjacent normal tissues were collected, and the expression of MYLK-AS1, microRNA (miR)-101-5p/cell division cycle 42 (CDC42) was detected. CC cell lines were transfected with MYLK-AS1, miR-101-5p, CDC42-related plasmids, and the biological functions and markers of epithelial-mesenchymal transition (EMT) were analyzed...
November 11, 2023: Kaohsiung Journal of Medical Sciences
Tyng-Yuan Jang, Chi-Chang Ho, Po-Cheng Liang, Chih-Da Wu, Yu-Ju Wei, Pei-Chien Tsai, Po-Yao Hsu, Ming-Yen Hsieh, Yi-Hung Lin, Meng-Hsuan Hsieh, Chih-Wen Wang, Jeng-Fu Yang, Ming-Lun Yeh, Chung-Feng Huang, Wan-Long Chuang, Jee-Fu Huang, Ya-Yun Cheng, Chia-Yen Dai, Pau-Chung Chen, Ming-Lung Yu
We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti-HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter ≤2...
November 10, 2023: Kaohsiung Journal of Medical Sciences
Chung-Feng Huang, Tyng-Yuan Jang, Shun-Chieh Yu, Shin-Chung Huang, Shao-Lun Ho, Ming-Lun Yeh, Chih-Wen Wang, Po-Cheng Liang, Yu-Ju Wei, Po-Yao Hsu, Ching-I Huang, Ming-Yen Hsieh, Yi-Hung Lin, Sung-Lin Yu, Pey-Fang Wu, Yu-Han Chen, Shin-Chi Chien, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Tso-Jen Wang, Ming-Lung Yu
Patients with serious mental illness have a higher risk of hepatitis C virus (HCV) infection but suboptimal HCV care. The current study aimed to facilitate HCV treatment uptake by implementing an integrated outreach care model. Multidisciplinary outreach screening followed by HCV reflex testing and onsite treatment for schizophrenia patients was accomplished through the coordination of nongovernmental organizations, remote specialists, and local care providers. The objective was microelimination effectiveness, defined as the multiplication of the rates of anti-HCV antibodies screening, accurate HCV RNA diagnosis, treatment allocation, treatment completion, and sustained virological response (SVR12; no detectable HCV RNA throughout 12 weeks in the post-treatment follow-up period)...
November 9, 2023: Kaohsiung Journal of Medical Sciences
Hsin-Yi Huang, Rwei-Ling Yu, Wei-Fang Tsai, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chun-Hsiang Tan
Elevated levels of interleukin 1β (IL-1β) have been identified in patients with chronic viral hepatitis and have been associated with depressive symptoms. Given the high prevalence of depression in this patient population, this study sought to explore the potential influence of IL-1β genetic variations on the severity of depressive symptoms. In a cohort of 181 Taiwanese patients with chronic viral hepatitis, we investigated the impact of five common IL-1β single nucleotide polymorphisms (SNPs), including rs16944, rs1143627, rs1143630, rs1143643, and rs3136558, on depressive symptoms using the Beck's Depression Inventory-II...
November 8, 2023: Kaohsiung Journal of Medical Sciences
Jia Zhou, Jun-Yi Du, Rui Xu, Xiao-Juan Wu, Guo-Yue Zhang
Airway mucous cell metaplasia and mucous hypersecretion is one of the key characteristic pathophysiological status of chronic obstructive pulmonary disease (COPD). micro(mi)RNAs are acknowledged as non-encoding RNA molecules playing important roles in gene expression regulation. In this study, we searched the Gene Expression Omnibus (GEO) database for the differentially expressed miRNAs between COPD and non-COPD controls with bioinformatics analysis. Finally, we focused on miR-513a-5p and investigated the potential mechanism by which miR-513a-5p regulates airway mucous hypersecretion and goblet cell metaplasia...
November 2, 2023: Kaohsiung Journal of Medical Sciences
Yeong-Shiau Pu, Chao-Yuan Huang, Hung-Lin Wu, Jyun-Hong Wu, Ying-Fang Su, Chang-Tze Ricky Yu, Chi-Yu Lu, Wen-Jeng Wu, Shu-Pin Huang, Ying-Tang Huang, Tzyh-Chyuan Hour
Docetaxel-based chemotherapy has generally been considered as one of the effective treatments for castration-resistant prostate cancer (PCa). However, clinical treatment with docetaxel often encounters a number of undesirable effects, including drug resistance. Tubulin isoforms have been previously examined for their resistance to docetaxel in many cancers, but their real mechanisms remained unclear. In this study, a series of docetaxel-resistant PC/DX cell sublines were established by chronically exposing PC3 to progressively increased concentrations of docetaxel...
November 2, 2023: Kaohsiung Journal of Medical Sciences
Fang Zou, Zhi-Hua Zhang, Shuang-Shuang Zou, Zhong-Bao Zhuang, Qiang Ji, Rui Chang, Jia-Huan Cao, Bu Wang
Lung cancer (LCa), the most frequent malignancy worldwide, causes millions of mortalities each year. Overexpression of the long noncoding RNA MIR210HG in LCa has been established; however, a more comprehensive investigation into its biological role within LCa is imperative. This study aimed to validate the MIR210H levels in LCa tissues and cells. The expression of indicated genes was evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) and/or Western blotting. The viability, proliferation, migration, and invasion of LCa cells were measured using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), colony formation, wound healing, and transwell assays, respectively...
November 2, 2023: Kaohsiung Journal of Medical Sciences
Mohd Akram, Neha, Pinky, Mohd Saqib, Mohd Salman, Suhel Parvez
The primary objective of this study was to investigate the protective effects of ropinirole (ROP) medication given for an extended period following the induction of cognitive decline, oxidative stress, and deterioration of mitochondria in a Wistar rat model by Aβ1-42 . This study aimed to examine the neuroprotective efficacy of ROP in a stereotaxis model of AD. The Wistar rats were randomly assigned into four groups. Group I was considered as a sham, group II served as Aβ-infusion alone, Group III was Aβ1-42 + ROP (5 mg/kg/i...
October 30, 2023: Kaohsiung Journal of Medical Sciences
Tyng-Yuan Jang, Po-Cheng Liang, Dae Won Jun, Jang Han Jung, Hidenori Toyoda, Chih-Wen Wang, Man-Fung Yuen, Ka Shing Cheung, Satoshi Yasuda, Sung Eun Kim, Eileen L Yoon, Jihyun An, Masaru Enomoto, Ritsuzo Kozuka, Makoto Chuma, Akito Nozaki, Toru Ishikawa, Tsunamasa Watanabe, Masanori Atsukawa, Taeang Arai, Korenobu Hayama, Masatoshi Ishigami, Yong Kyun Cho, Eiichi Ogawa, Hyoung Su Kim, Jae-Jun Shim, Haruki Uojima, Soung Won Jeong, Sang Bong Ahn, Koichi Takaguchi, Tomonori Senoh, Maria Buti, Elena Vargas-Accarino, Hiroshi Abe, Hirokazu Takahashi, Kaori Inoue, Jee-Fu Huang, Wan-Long Chuang, Ming-Lun Yeh, Chia-Yen Dai, Chung-Feng Huang, Mindie H Nguyen, Ming-Lung Yu
Elevated serum gamma-glutamyl transferase (GGT) levels are associated with chronic hepatitis B (CHB)-related hepatocellular carcinoma. However, their role in predicting mortality in patients with CHB treated with nucleotide/nucleoside analogs (NAs) remains elusive. Altogether, 2843 patients with CHB treated with NAs were recruited from a multinational cohort. Serum GGT levels before and 6 months (Month-6) after initiating NAs were measured to explore their association with all-cause, liver-related, and non-liver-related mortality...
October 27, 2023: Kaohsiung Journal of Medical Sciences
Wei Jiao, Jie Hao, Jin-Ming Liu, Wei-Nian Gao, Jia-Jia Zhao, Yong-Jun Li
Cardiac remodeling is manifested by hypertrophy and apoptosis of cardiomyocytes, resulting in the progression of cardiovascular diseases. Long noncoding RNAs (lncRNAs) serve as modifiers of cardiac remodeling. In this study, we aimed to explore the molecular mechanism of H19 shuttled by mesenchymal stem cells (MSC)-derived extracellular vesicles (EV) in cardiac remodeling upon heart failure (HF). Using the GEO database, H19, microRNA (miR)-29b-3p, and CDC42 were screened out as differentially expressed biomolecules in HF...
October 27, 2023: Kaohsiung Journal of Medical Sciences
Song Qin, Ying-Cong Ren, Jun-Ya Liu, Wen-Bo Chen, Bao Fu, Jie Zheng, Xiao-Yun Fu
Sepsis-induced myocardial injury is one of the most difficult complications of sepsis in intensive care units. Annexin A1 (ANXA1) short peptide (ANXA1sp) protects organs during the perioperative period. However, the protective effect of ANXA1sp against sepsis-induced myocardial injury remains unclear. We aimed to explore the protective effects and mechanisms of ANXA1sp against sepsis-induced myocardial injury both in vitro and in vivo. Cellular and animal models of myocardial injury in sepsis were established with lipopolysaccharide...
October 25, 2023: Kaohsiung Journal of Medical Sciences
Xi-Xi Li, Jia-Kun Xu, Wei-Jie Su, Hong-Lin Wu, Kun Zhao, Chang-Ming Zhang, Xiang-Kun Chen, Li-Xuan Yang
Temozolomide (TMZ) resistance presents a significant challenge in the treatment of gliomas. Although lysine demethylase 4A (KDM4A) has been implicated in various cancer-related processes, its role in TMZ resistance remains unclear. This study aims to elucidate the contribution of KDM4A to TMZ resistance in glioma cells and its potential implications for glioma prognosis. We assessed the expression of KDM4A in glioma cells (T98G and U251MG) using qRT-PCR and Western blot assays. To explore the role of KDM4A in TMZ resistance, we transfected siRNA targeting KDM4A into drug-resistant glioma cells...
October 24, 2023: Kaohsiung Journal of Medical Sciences
Yi-Yun Chen, Liang-Chun Chao, Shih-Huang Tai, E-Jian Lee
No abstract text is available yet for this article.
October 24, 2023: Kaohsiung Journal of Medical Sciences
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