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Current Pharmaceutical Biotechnology

https://read.qxmd.com/read/38385486/anti-seizure-effects-and-mechanisms-of-berberine-a-systematic-review
#21
JOURNAL ARTICLE
Nahid Jivad, Saeid Heidari-Soureshjani, Hesamaldin Bagheri, Catherine Mt Sherwin, Sahar Rostamian
BACKGROUND: Epilepsy is one of the most common in all age groups and disabling neurologic disorders around the world. OBJECTIVES: This systematic review was to explore whether berberine (BBR) has any anti-seizure or anti-epileptic effects and also reviewed this possible mechanism. METHODS: The EMBASE, Scopus, Cochrane Library, PubMed, and Web of Science databases were searched before Sep 2023. All types of studies that investigated the effects of BBR on epilepsy or chemical-induced seizures were eligible for inclusion...
February 21, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38375837/icariin-attenuates-human-renal-tubular-epithelial-cell-senescence-by-targeting-pak2-via-mir-23b-3p
#22
JOURNAL ARTICLE
Suqin Zhang, Yanbin Li, Qiuyue Wang
BACKGROUND: Renal tubular epithelial cells (RTECs) senescence is crucial in kidney diseases. Icariin is shown to have protective effects against renal fibrosis, acute kidney injury, and proteinuria. We aimed to explore the role of icariin in protecting RTECs from senescence and the underlying mechanism involved. METHODS: An in vitro model of RTEC senescence was established by incubating HK-2 cells with urine exosomes from patients with diabetic kidney disease. Stimulated cells were treated with icariin at various doses to evaluate the compound's therapeutic effects...
February 16, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38357950/the-use-of-lipid-based-nanocarriers-to-improve-ovarian-cancer-treatment-an-overview-of-recent-developments
#23
JOURNAL ARTICLE
Junaid Tantray, Akhilesh Patel, Bhupendra G Prajapati, Sourabh Kosey, Sankha Bhattacharya
Ovarian cancer poses a formidable health challenge for women globally, necessitating innovative therapeutic approaches. This review provides a succinct summary of the current research status on lipid-based nanocarriers in the context of ovarian cancer treatment. Lipid-based nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), offer a promising solution for delivering anticancer drugs with enhanced therapeutic effectiveness and reduced adverse effects...
February 14, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38357951/the-role-of-nad-in-myocardial-ischemia-induced-heart-failure-in-sprague-dawley-rats-and-beagles
#24
JOURNAL ARTICLE
Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wang
INTRODUCTION: Nicotinamide adenine dinucleotide (NAD+) participates in various processes that are dysregulated in cardiovascular diseases. Supplementation with NAD+ may be cardioprotective. However, whether the protective effect exerted by NAD+ in heart failure (HF) is more effective before acute myocardial infarction (MI) or after remains unclear. The left anterior descending arteries of male Sprague Dawley rats and beagles that developed HF following MI were ligated for 1 week, following which the animals were treated for 4 weeks with low, medium, and high doses of NAD+ and LCZ696...
February 13, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347797/determination-of-ideal-factors-for-early-adoption-and-standardization-of-metagenomic-next-generation-sequencing-for-respiratory-system-infections
#25
JOURNAL ARTICLE
Lei Zhao, Cole R Formslag, Qing Zhang, Braydon C Cowan, Trenton G Mayberry, Aaron R Barnhill, Yongsheng Wang, Yujiang Fang
BACKGROUND: Metagenomic next-generation sequencing (mNGS) demonstrates great promise as a diagnostic tool for determining the cause of pathogenic infections. The standard diagnostic procedures (SDP) include smears and cultures and are typically viewed as less sensitive and more time-consuming when compared to mNGS. There are concerns about the logistics and ease of transition from SDP to mNGS. mNGS lacks standardization of collection processes, databases, and sequencing. Additionally, there is the burden of training clinicians on interpreting mNGS results...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347796/implementation-of-silver-nanoparticles-green-synthesized-with-leaf-extract-of-coccinia-grandis-as-antimicrobial-agents-against-head-and-neck-infection-mdr-pathogens
#26
JOURNAL ARTICLE
Smarita Lenka, Debasmita Dubey, Santosh Kumar Swain, Goutam Rath, Ajit Mishra, Ajit Kumar Bishoyi, Gopal Krishna Purohit
BACKGROUND: Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. OBJECTIVES: This study aimed to identify the bacteria and Candidal isolates and implement the silver nanoparticles green synthesized with leaf extract of Coccinia grandis (Cg-AgNPs) as a therapeutic approach against HNI pathogens. METHODS: The Cg-AgNPs were characterized by the UV-visible spectrophotometer, FT-IR analysis, Zeta particle size, Zeta potential, and field emission scanning electron microscope (FESEM) analysis to validate the synthesis of nanoparticles...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347795/rna-based-therapeutics-past-present-and-future-prospects-challenges-in-cancer-treatment
#27
JOURNAL ARTICLE
Anjana Goel, Amisha Rastogi, Mansi Jain, Kinjal Niveriya
It is becoming more and harder in today's climate to disregard the impact of cancer on social health. Even though a significant amount of money is spent annually on cancer research, it still ranks as the second leading cause of death worldwide. Additionally, only about half of the patients suffering from complex forms of cancer survive a year after receiving traditional cancer therapies. A method for silencing genes is called RNA interference (RNAi). Such a method is very effective in focusing on genes linked to cancer...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347794/naringenin-nanoformulations-for-neurodegenerative-diseases
#28
JOURNAL ARTICLE
Liza Sahoo, Nigam Sekhar Tripathy, Fahima Dilnawaz
Glioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary metabolite byproduct of the flavanone subgroup. NRG can cross the blood-brain barrier and deliver drugs into the central nervous system when conjugated with appropriate nanocarriers and can overcome the challenges associated with gliomas through naringenin-loaded nanoformulations...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347793/traditional-chinese-medicine-based-treatment-in-cardiovascular-disease-potential-mechanisms-of-action
#29
JOURNAL ARTICLE
Lanlan Li, Yutong Ran, Jiao Wen, Yirui Lu, Shunmei Liu, Hong Li, Min Cheng
Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide and has become a global public health problem. Traditional Chinese medicine (TCM) has been used in China to treat CVD and achieved promising results. Therefore, TCM has aroused significant interest among pharmacologists and medical practitioners. Previous research showed that TCM can regulate the occurrence and development of atherosclerosis (AS), ischemic heart disease, heart failure, myocardial injury, and myocardial fibrosis by inhibiting vascular endothelial injury, inflammation, oxidant stress, ischemia-reperfusion injury, and myocardial remodeling...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38347792/unconventional-remedies-for-squamous-cell-carcinoma-a-journey-into-alternative-treatments
#30
JOURNAL ARTICLE
Elen Deng, Amor Kachemoune
Squamous cell carcinoma (SCC) is the second most common form of skin cancer and is typically found on sun-exposed skin. Risk factors include ultraviolet radiation exposure, older age, fairer complexion, smoking, and immunosuppression. SCC is a slow-growing tumor with the possibility of metastasis if not treated. The clinical presentation can range from a dry, scaly erythematous patch or plaque to a firm hyperkeratotic papule, plaque, or nodule, depending on the histological type via biopsy. The first-line therapies for SCC removal are standard excision and Mohs microscopic surgery; however, there are novel and alternative non-surgical options being considered for the treatment of SCC...
February 12, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38321900/long-non-coding-rna-dleu1-promotes-progression-of-osteoarthritis-via-mir-492-tlr8-axis
#31
JOURNAL ARTICLE
Chenzhe Ni, Wanglin Zhang, Sai Qiu, Hao Cheng, Chunhui Ma
BACKGROUND: Long non-coding RNAs (LncRNAs) are generally reported to participate in the development of Osteoarthritis (OA) by acting as competing endogenous RNAs (ceRNAs). However, the molecular mechanism is largely unknown. This study aimed to investigate the possible mechanisms contributing to osteoarthritis (OA). METHODS: Four gene expression profiles from patients with OA were downloaded from a public database and integrated to screen important RNAs associated with OA...
February 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38321899/biodistribution-and-tumor-targeted-accumulation-of-anti-cea-loaded-iron-nanoparticles
#32
JOURNAL ARTICLE
Thais Silva Correa, William Gustavo Lima, Aline Beatriz do Couto Campos, Alexsandro Sobreira Galdino, Emilia Celma de Oliveira Lima, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Mariana Campos-da-Paz
INTRODUCTION: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals. METHOD: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium-99m (99mTc) and intravenously injected in CEA-positive 4T1 tumor-bearing mice to perform biodistribution studies...
February 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38288793/recent-advances-in-pharmaceutical-design-unleashing-the-potential-of-novel-therapeutics
#33
JOURNAL ARTICLE
Ram Narayan Prajapati, Bharat Bhushan, Kuldeep Singh, Himansu Chopra, Shivendra Kumar, Mehak Agrawal, Devender Pathak, Dilip Kumar Chanchal, Laxmikant
Pharmaceutical design has made significant advancements in recent years, leading to the development of novel therapeutics with unprecedented efficacy and safety profiles. This review highlights the potential of these innovations to revolutionize healthcare and improve patient outcomes. The application of cutting-edge technologies like artificial intelligence, machine learning, and data mining in drug discovery and design has made it easier to find potential drug candidates. Combining big data and omics has led to the discovery of new therapeutic targets and personalized medicine strategies...
January 29, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38288791/the-gut-microbiota-and-major-depressive-disorder-current-understanding-and-novel-therapeutic-strategies
#34
JOURNAL ARTICLE
Mohaddeseh Bahmani, Saba Mehrtabar, Ali Jafarizadeh, Sevda Zoghi, Fatemah Sadeghpour Heravi, Amin Abbasi, Sarvin Sanaie, Sama Rahnemayan, Hamed Ebrahimzadeh Leylabadlo
Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products with the hypothalamic-pituitary-adrenal system and immune mediators can reverse depression phenotypes in vulnerable individuals...
January 29, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38310454/effects-and-mechanisms-of-fisetin-against-ischemia-reperfusion-injuries-a-systematic-review
#35
JOURNAL ARTICLE
Omid-Ali Adeli, Saeid Heidari-Soureshjani, Sahar Rostamian, Zahra Azadegan-Dehkordi, Armin Khaghani
BACKGROUND: Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. OBJECTIVES: This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. METHODS: This systematic review included studies earlier than Sep 2023 by following the PRISMA statement 2020. After determining inclusion and exclusion criteria and related keywords, bibliographic databases, such as Cochrane Library, PubMed, Web of Science, Embase, and Scopus databases, were used to search the relevant studies...
January 28, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38288794/overcoming-low-adherence-to-chronic-medications-by-improving-their-effectiveness-using-a-personalized-second-generation-digital-system
#36
JOURNAL ARTICLE
Areej Bayatra, Rima Nasserat, Yaron Ilan
INTRODUCTION: Low adherence to chronic treatment regimens is a significant barrier to improving clinical outcomes in patients with chronic diseases. Low adherence is a result of multiple factors. METHODS: We review the relevant studies on the prevalence of low adherence and present some potential solutions. RESULTS: This review presents studies on the current measures taken to overcome low adherence, indicating a need for better methods to deal with this problem...
January 26, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38288792/hydrogel-breakthroughs-in-biomedicine-recent-advances-and-implications
#37
JOURNAL ARTICLE
Ravi K Mittal, Raghav Mishra, Rehan Uddin, Vikram Sharma
The objective of this review is to present a succinct summary of the latest advancements in the utilization of hydrogels for diverse biomedical applications, with a particular focus on their revolutionary impact in augmenting the delivery of drugs, tissue engineering, along with diagnostic methodologies. Using a meticulous examination of current literary works, this review systematically scrutinizes the nascent patterns in applying hydrogels for biomedical progress, condensing crucial discoveries to offer a comprehensive outlook on their ever-changing importance...
January 26, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38284738/emerging-therapeutic-approaches-targeting-ferroptosis-in-cancer-focus-on-immunotherapy-and-nanotechnology
#38
JOURNAL ARTICLE
Zongchao Yu, Zhongcheng Mo, Yuan Qiu, Hengzhe Lu, Biao Zheng, Longfei Liu
Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung cancer, renal cell carcinoma, colorectal cancer, pancreatic cancer, and ovarian cancer. Inducing ferroptosis has shown promising results in inhibiting tumor growth and reversing tumor progression...
January 26, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38275054/recent-approaches-on-molecular-markers-treatment-and-novel-drug-delivery-system-used-for-the-management-of-colorectal-cancer-a-comprehensive-review
#39
JOURNAL ARTICLE
Sonia Chauhan, Sakshi Sharma
Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost. However, metastatic disease has an insignificant long-term diagnosis, and significant challenges remain due to last-stage diagnosis and treatment failure...
January 24, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38275053/extrusion-and-co-extrusion-a-technology-in-probiotic-encapsulation-with-alternative-materials
#40
JOURNAL ARTICLE
Aziz Homayouni-Rad, Amir M Mortazavian, Hadi Pourjafar, Saba Kamalledin Moghadam
Encapsulation, in particular extrusion and co-extrusion, is a common practice to protect probiotics from the harsh conditions of the digestive tract as well as processing. Hydrocolloids, including proteins and carbohydrates, natural or modified, are a group of ingredients used as the wall material in extrusion. Hydrocolloids, due to their specific properties, can significantly improve the probiotic survivability of the final powder during the microencapsulation process and storage. The present article will discuss the different kinds of hydrocolloids used for microencapsulation of probiotics by extrusion and co-extrusion, along with new sources of novel gums and their potential as wall material...
January 24, 2024: Current Pharmaceutical Biotechnology
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