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Current Pharmaceutical Biotechnology

Ritu Kataria, Anurag Khatkar
Bacterial ureases have been the cause of various human and animal pathogenicity including hepatic encephalopathy, hepatic coma urolithiasis, gastric and peptic ulcers, pyelonephritis, and urinary catheter encrustation by production of ammonia. Hence in view of the side effects of existing drugs, there is a strong need to discover, more safe, effective and potent compounds for treatment of infections caused by urease. For this purpose, several natural phenolic compounds have been screened by molecular modelling techniques...
April 9, 2019: Current Pharmaceutical Biotechnology
Jhonatas Emílio Ribeiro da Cruz, Joyce Ferreira da Costa Guerra, Marcos de Souza Gomes, Guilherme Ramos Oliveira E Freitas, Enyara Rezende Morais
BACKGROUND: Currently, the treatment of infectious diseases has not always been successful due to the emergence of microbial resistance worldwide. OBJECTIVES: This study aimed to evaluate the antioxidant activity, content of total phenolic compounds and flavonoids, antifungal potential and antibacterial action of six medicinal plants found in the Cerrado, leaf extracts of Boldo (Peumus boldus), Goiaba (Psidium guajava), Assa-Peixe (Vernonia polysphaera), Abacate (Persea americana), Eucalipto (Eucalyptus citriodora) and raw sap of Bálsamo (Jatropha multifida)...
April 8, 2019: Current Pharmaceutical Biotechnology
Marcin Oplawski, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Krzysztof Januszyk, Dariusz Dąbruś, Dariusz Boroń
BACKGROUND: EDIL3 is an extracellular matrix protein that plays a key role in angiogenesis. Changes in the pattern of its expression also affect cellular processes and the tumor microenvironment. Elevated level of EDIL3 is considered an unfavorable prognostic marker of survival. OBJECTIVE: The aim of this study was to evaluate the changes in EDIL3 expression in endometrial cancer at various degrees of its differentiation (G1-G3) and to discuss its potential role as a molecular diagnostic marker and therapeutic target...
April 8, 2019: Current Pharmaceutical Biotechnology
Víctor Manuel Muñoz-Pérez, Mario I Ortiz, Raquel Cariño-Cortés, Eduardo Fernández-Martínez, Leticia Rocha-Zavaleta, Mirandeli Bautista-Ávila
Worldwide the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries with socioeconomic differences, which have considered implementing alternative healthcare strategies to prevent and reduce preterm births. Currently, there is no widely effective strategy to prevent preterm birth...
April 8, 2019: Current Pharmaceutical Biotechnology
Fawzeh A Al-Salmi, Reham Z Hamza, Nahla S El-Shenawy
BACKGROUND: Zinc oxide nanoparticles (ZnO NPs) are increasingly utilized in both industrial and medical applications. Therefore, the study was aimed to investigate the effect one of green nanoparticle complex (green tea extract/ zinc oxide nanoparticles complex, GTE / ZnO NPs) on oxidative stress induced by monosodium glutamate (MSG) on the liver of rats. METHODS: Wistar male rats (n=64) weighing between 200-250 g were divided randomly into eight groups: control that was given physiological saline (1 mg/kg), two groups were treated with two different doses of MSG (MSG-LD, MSG-HD; 6 and 17...
April 8, 2019: Current Pharmaceutical Biotechnology
Peter Amadi, Charity Ogunka-Nnoka, Bene Abbey
BACKGROUND: In this study, local sustainable enzyme sources involving excised digestive juice of African land snail and yeast were to achieve the simultaneous saccharification and fermentation (SSF) of plantain pseudo stem (PPS) waste, and afterwards examined their effects on terpenoids using gas chromatograpy coupled to a fluorescent ionization detector (GC-FID). RESULTS: The most abundant terpenoids were found in the order α-pinene > borneol > camphor > humulene > β-caryophellene, while the least in abundance were cis ocimene (8...
April 8, 2019: Current Pharmaceutical Biotechnology
Guglielmo Giraldi, Marzietta Montesano, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti, Christian Napoli, Giovanni Battista Orsi
BACKGROUND: The increasing antimicrobial resistance poses a challenge for surveillance systems and raises concerns about the impact of multidrug-resistant organisms on patient safety. OBJECTIVE: To estimate extra hospital stay and economic burden of infections due to alert organisms - mostly multidrug-resistant - in a teaching hospital. METHODS: The present retrospective matched cohort study was conducted through the analysis of hospital admissions at Sant'Andrea Teaching Hospital in Rome from April to December 2015...
April 7, 2019: Current Pharmaceutical Biotechnology
Giuseppe Davide Albano, Giuseppe Bertozzi, Francesca Maglietta, Angelo Montana, Giulio Di Mizio, Massimiliano Esposito, Pietro Mazzeo, Stefano D'Errico, Monica Salerno
Healthcare-associated infections are one of the most serious Public Health concern, as they prolong length of hospitalization, reduce quality of life, and increase morbidity and mortality. Despite they are not completely avoidable, the number of healthcare-associated infections related negligence claims has risen over the last years, contributing to remarkable economic and reputation losses of Healthcare System. In this regard, several studies suggested a key role of medical records quality in determining medical care process, risk management and preventing liability...
April 7, 2019: Current Pharmaceutical Biotechnology
Vittorio Gatto, Matteo Scopetti, Raffaele La Russa, Alessandro Santurro, Luigi Cipolloni, Rocco Valerio Viola, Mariantonia Di Sanzo, Paola Frati, Vittorio Fineschi
BACKGROUND: Healthcare Associated Infections (HAIs) represent a crucial issue in health and patient safety management due to the persistent nature, economic impact and possible preventability of the phenomenon. Compensation claims for damages resulting from HAI could provide insights that improve the understanding of suboptimal steps in the therapeutic process, enable an estimate of costs related to infectious complications, and guide the development of planning tools for implementation of the quality of care...
April 7, 2019: Current Pharmaceutical Biotechnology
Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia, Emanuela Turillazzi
The phenomenon of clinical negligence claims has rapidly spread to United States, Canada and Europe assuming the dimensions and the severity of a pandemia. Consequently, the issues related to medical malpractice need to be studied from a transnational perspective since they raise similar problems in different legal systems. Over the last two decades, medical liability has become a prominent issue in healthcare policy and a major concern for healthcare economics in Italy. The failures of the liability system and the high cost of healthcare have led to considerable legislative activity concerning medical malpractice liability, and a law was enacted in 2012 (Law no...
April 7, 2019: Current Pharmaceutical Biotechnology
Gil Bub, Matthew J Daniels
In 1791 Galvani established that electricity activated excitable cells. In the two centuries that followed, electrode stimulation of neuronal, skeletal and cardiac muscle became the adjunctive method of choice in experimental, electrophysiological, and clinical arenas. This approach underpins breakthrough technologies like implantable cardiac pacemakers that we currently take for granted. However, the contact dependence, and field stimulation that electrical depolarization delivers brings inherent limitations to the scope and experimental scale that can be achieved...
April 5, 2019: Current Pharmaceutical Biotechnology
Benedetto Caroleo, Pasquale Malandrino, Aldo Liberto, Dario Condorelli, Federico Patanè, Aniello Maiese, Filomena Casella, Diego Geraci, Pietrantonio Ricci, Giulio Di Mizio
Catheter-related bloodstream infections (CRBSIs) pathogenesis is complex and multifactorial mostly due to cutaneous microorganisms migration through the catheter insertion site and catheter tip colonization. Ochrobactrum anthropi is a gram-negative bacteria belonging to the Brucellaceae and related infections are especially observed in immunocompromised patients. Therefore, O. anthropi infection prevention and surveillance is a relevant issue for healthcare system and risk management, in order to improve healthcare quality and patient safety...
April 5, 2019: Current Pharmaceutical Biotechnology
Charalampia Dimou, Haralabos C Karantonis, Dimitrios Skalkos, Antonios E Koutelidakis
Owning to the increase in the world population as well as the consumer's awareness on the health benefits of consumption of fruits, the demand for both fresh and processed fruits has been increased. The by-product and waste streams generated from fruit processing industries are extremely diverse, owning mainly to different fruits varieties and the wide range of the processes employed towards the production of the end fruit-based products. Due to the increasing production and processing of fruits, disposal of waste and by-product streams is a very significant issue, since these materials are prone to microbial spoilage...
April 5, 2019: Current Pharmaceutical Biotechnology
Nabil N Al-Hashimi, Amjad H El-Sheikh, Rania F Qawariq, Majed H Shtaiwi, Rowan AlEjielat
The efficient analytical method for analysis of nonsteroidal anti-inflammatory drugs (NSAIDs) in biological fluid are important for determining the toxicological aspects of such long-term used therapies. In the present work, multi-walled carbon nanotubes reinforced into hollow fiber by chitosan sol-gel assisted-solid/ liquid phase microextraction (MWCNTs-HF-CA-SLPME) method followed by high performance liquid chromatography-diode array detection (HPLC-DAD) was developed for determination of three NSAIDs, ketoprofen, diclofenac, and ibuprofen in human urine samples...
April 5, 2019: Current Pharmaceutical Biotechnology
Yu-Lin Tan, Han-Xiao Ou, Min Zhang, Duo Gong, Zhen-Wang Zhao, Ling-Yan Chen, Xiao-Dan Xia, Zhong-Cheng Mo, Chao-Ke Tang
Background: Tanshinone IIA (Tan IIA) and Omentin-1 have a protective role in the cardiovascular system. However, if and how Tan IIA and Omentin-1 regulate cholesterol metabolism in macrophages has not been fully elucidated. OBJECTIVE: To investigate the possible mechanisms of Tan IIA and Omentin-1 on preventing macrophage cholesterol accumulation and atherosclerosis development. METHODS: The effect of Tan IIA on the protein and mRNA levels of Omentin-1 and ATP-binding cassette transporter A1 (ABCA1) in macrophages was examined by Western blot and qRT-PCR assay, respectively...
April 4, 2019: Current Pharmaceutical Biotechnology
Ahmad Almeman, Kasem Abdulmajed, Eltayeb E Eid
BACKGROUND: Heparin is an essential drug used as an anticoagulant. Access to raw material suitable for heparin extraction is critical for creating a viable business opportunity. In Saudi Arabia, large amounts of raw material with potential for heparin extraction are wasted. OBJECTIVE: To extract heparin and low-molecular-weight heparin (LMWH) from the camel lung, and measure its potency and activity. METHODS: Heparin preparation included three steps: extraction, electrophoretic identification, and activity measurement...
April 1, 2019: Current Pharmaceutical Biotechnology
Georgakopoulou Vasiliki, Dimou Charalampia, Karantonis Christos Haralabos
BACKGROUND: The present work evaluated the in vitro antioxidant, antithrombotic, antiatherogenic and antidiabetic activities of Urtica dioica, Sideritis euboea and Cistus creticus and investigated pasta fortification with the most bioactive one. The methods employed were total phenolic content (TPC) in mg of gallic acid equivalents per g of dried-herb, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging in mg of dried-herb, cupric reducing antioxidant capacity (CUPRAC) in micromol trolox equivalent per g of dried-herb, platelet aggregation inhibition (PAF-PAI); plasma oxidation inhibition (POxI); and alpha glucosidase inhibition (a-GaseI) all in mg of dried-herb...
March 27, 2019: Current Pharmaceutical Biotechnology
Baoyu Yang, Bing Gao, Xiuli Lu, Jing Mao
BACKGROUND: Computer-assisted drug virtual screening models the process of drug screening through computer simulation technology, by docking small molecules in some of the databases to a certain protein target. There are many kinds of small molecules databases available for drug screening, including natural product databases. METHODS: Plants have been used as a source of medication for millennia. About 80% of drugs were either natural products or related analogues by 1990, and many natural products are biologically active and have favorable absorption, distribution, metabolization, excretion, and toxicology...
March 27, 2019: Current Pharmaceutical Biotechnology
Nadielle Silva Bidu, Bruno José Dumêt Fernandes, Eduardo Jorge Cavalvante Dias, Jucelino Nery Conceição Filho, Regina Eunice de Andrade Bastos, Ana Leonor Pardo Campos Godoy, Francine Johansson Azeredo, Joice Neves Reis Pedreira, Ricardo David Couto
BACKGROUND: Vancomycin is used mostly to overcome infections caused by methicillin-resistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to outside range serum concentrations. OBJECTIVE: This case series evaluates the pharmacokinetics adjustment from a vancomycin therapeutic regimen prescribed to neonates and infants with bacterial infection at a neonatal public hospital intensive-care-unit, with the primary purpose to verify cases of nephrotoxicity...
March 19, 2019: Current Pharmaceutical Biotechnology
Abdullah M Alnuqaydan, Bilal Rahb
BACKGROUND: Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in combination with other plant extracts against different ailments since immemorial. METHODS: Electronic database survey via Pubmed, Google Scholar, Researchgate, Scopus and Science Direct were used to review the scientific inputs until October 2018, by searching appropriate keywords...
March 18, 2019: Current Pharmaceutical Biotechnology
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