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Journals Current Pharmaceutical Biotech...

Current Pharmaceutical Biotechnology

https://read.qxmd.com/read/38867525/oleogels-for-the-promotion-of-healthy-skin-care-products-synthesis-and-characterization-of-allantoin-containing-moringa-based-oleogel
#1
JOURNAL ARTICLE
Nazia Yaqoob, Fazeelat Imtiaz, Nusrat Shafiq, Saima Rehman, Huma Munir, Mohammed Bourhia, Khalid S Almaary, Hiba-Allah Nafidi
BACKGROUND: Oleogelation is an efficient and emerging approach for obtaining biocompatible and biodegradable elastic semisolid crystals to be used in various cosmetic and pharmaceutical formulations. Recently, drug incorporation in oil structuring has been a promising strategy under consideration due to the effectiveness of this method. Plant oils have very beneficial characteristics for skin care and wound healing due to the presence of certain antioxidants. METHODS: In this study, the oleogels of Moringa oleifera seed oil with natural polysaccharides, including pectin, chitosan, and xanthan gum, were prepared using the emulsion template method...
June 11, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38859783/phytoactive-molecules-and-nanodelivery-approaches-for-breast-cancer-treatment-current-and-future-perspectives
#2
JOURNAL ARTICLE
Evren Algın Yapar, Merve Nur Ozdemir, Simona Cavalu, Özlem Akbal Dagıstan, Yıldız Ozsoy, Murat Kartal
One of the most common malignancies in women, breast cancer accounts for nearly 25% of all cancer cases. Breast cancer is a diverse cancer form that exhibits variability in both morphology and molecular characteristics, and is linked to numerous risk factors. Although various approaches and research are ongoing in the treatment and prevention of breast cancer, medication resistance in the current breast cancer treatment contributes to the disease's relapse and recurrence. Phytoactive molecules are the subject of growing research in both breast cancer prevention and treatment but currently used conventional medicines and techniques limit their application...
June 7, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38847163/genome-editing-approaches-using-zinc-finger-nucleases-zfns-for-the-treatment-of-motor-neuron-diseases
#3
JOURNAL ARTICLE
Medisetti Manikishore, Sandeep Kumar Maurya, Sunny Rathee, Umesh Kumar Patil
Motor neuron disorders are diseases that can be passed through generations by heredity or they occur due to spontaneous mutations in the gene. These are the disorders that weaken the connection between motor neurons and the muscles, due to this the coordination between the neurons and muscles gets disturbed and thereby the actions become abnormal, every year millions of people around the world suffer from these different types of motor neuron disorders. Till now there is no proper known treatment for this type of disorder, there is active research work going on to treat these diseases permanently...
June 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38847162/integrated-serum-pharmacochemistry-network-pharmacology-and-molecular-docking-to-study-the-mechanism-of-rhubarb-against-atherosclerosis
#4
JOURNAL ARTICLE
Zhi-Yan Cai, Shu-Jiao Li, Yu-Qing Wang
BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipids, the formation of lesion plaques, and the narrowing of arterial lumens. Rhubarb has significant effects against AS, but there is a lack of analysis and exploration of the mechanism of action of the transitional components in serum containing rhubarb. OBJECTIVE: This work aims to combine serum pharmacochemistry, network pharmacology, and molecular docking to explore active ingredients and mechanism of rhubarb against AS...
June 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38847161/methicillin-resistant-staphylococcus-aureus-infection-and-its-health-perspective-a-review
#5
JOURNAL ARTICLE
Abisha Thomas, Nagarjuna Palathoti, Mohammed Afzal Azam
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a potential threat globally since it is associated with high morbidity and mortality. In addition, the ability of MRSA to develop resistance and adapt to various environments makes it exceptional from other bacterial strains. Effective management is best determined by the site of infection. OBJECTIVES: This study aims to summarize and assess the epidemiology of MRSA, resistance, detection of MRSA in humans, animals, and food products, treatment employed, and combination therapy...
June 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38847160/artificial-intelligence-in-cancer-diagnosis-a-game-changer-in-healthcare
#6
JOURNAL ARTICLE
Pramit Sahoo, Meghoparna Kundu, Jeenatara Begum
Early cancer identification is essential for increasing survival rates and lowering the disease's burden in today's society. Artificial intelligence [AI]--based algorithms may help in the early detection of cancer and resolve problems with current diagnostic methods. This article gives an overview of the prospective uses of AI in early cancer detection. The authors go over the possible applications of Artificial Intelligence algorithms used for screening risk of malignancy in asymptomatic patients, investigating as well as prioritising symptomatic individuals, and more accurately diagnosing cancer recurrence...
June 6, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38847261/table-development-and-characterization-of-polymeric-based-biomaterial-from-agro-food-waste-a-sustainable-and-eco-friendly-approach-towards-plastic-pollution
#7
JOURNAL ARTICLE
Rabbia Hussain, Athar Aziz, Rashid Amin, Asma Khurshid
INTRODUCTION: Commercial plastics are potentially hazardous and can be carcinogenic due to the incorporation of chemical additives along with other additional components utilized as brominated flame retardants and phthalate plasticizers during production that excessively produce large numbers of gases, litter, and toxic components resulting in environmental pollution. METHOD: Biodegradable plastic derived from natural renewable resources is the novel, alternative, and innovative approach considered to be potentially safe as a substitute for traditional synthetic plastic as they decompose easily without causing any harm to the ecosystem and natural habitat...
June 5, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38840396/revealing-the-curative-possibilities-a-comprehensive-exploration-of-caffeic-acid
#8
JOURNAL ARTICLE
Ahsas Goyal, Vishwa Deep Singh, Kunal Solanki, Aanchal Verma
Caffeic acid, a phenolic compound of the hydroxycinnamic acid family, is abundant in various plant-based foods, such as fruits, vegetables, and coffee, alongside other biologically active compounds. Recognizing its potential to address various health issues and its widespread presence in commonly consumed foods underscores the importance of comprehending and harnessing the benefits of caffeic acid for human nutrition and well-being. This versatile substance, characterized by acrylic and phenolic functional groups, plays a pivotal role in the food and pharmaceutical industries...
June 4, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38840395/biotechnological-advances-in-enzymatic-hydrolysis-and-fermentation-for-edible-insects-functionality-acceptability-and-safety
#9
JOURNAL ARTICLE
Ravi K Mittal, Gaurav Krishna, Vikram Sharma
OBJECTIVE: This review paper examines biotechnological methods for enhancing edible insects using enzymatic hydrolysis and fermentation. Evaluations involve improving functionality, analyzing consumer acceptability elements, guaranteeing safety and quality, negotiating regulatory frameworks, and suggesting field breakthroughs and applications. METHODS: Our method comprises a thorough literature analysis and academic database searches for edible insect enzymatic hydrolysis and fermentation investigations...
June 4, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38818911/synthetic-and-natural-radioprotective-agents-recent-status-and-their-underlying-mechanism-of-action
#10
JOURNAL ARTICLE
Juhi Mishra, Neelam Poonia, Viney Lather, Dhruv Kumar Nishad, Deepti Pandita
Various substances possessing radiation scavenging properties, known as radioprotectors, play a crucial role in shielding organisms from the harmful effects of ionizing radiation (IR) by preventing cellular damage caused by free radicals. Initially, synthetic radioprotectors were developed using thiol synthetic compounds. However, among these, only amifostine (WR-2721) underwent clinical testing as a radioprotector. Various composites with different chemical structures other than thiol compounds were also investigated...
May 30, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38818910/the-effects-of-probiotics-prebiotics-and-synbiotics-on-wound-infection-a-systematic-review
#11
JOURNAL ARTICLE
Marzie Mahdizade Ari, Soheila Shahroodian, Roghayeh Afifirad, Parisa Asadollahi, Arezoo Asadi, Talihe Darbandi, Roya Ghanavati, Atieh Darbandi
INTRODUCTION: This systematic review aimed to summarize the currently available evidence on the effect of oral probiotic therapy on infected wound healing among patients who underwent surgery. MATERIALS AND METHODS: An electronic search was conducted for articles published during 2010- 2022 in Embase, PubMed/Medline, Scopus, Web of Science, and Google Scholar using the keywords "probiotics," "prebiotics," "synbiotics," and "wound infection." The titles and abstracts of 2625 articles were screened, and 22 publications that fulfilled the inclusion criteria were included...
May 30, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38808712/computational-strategies-in-drug-discovery-leveraging-subtractive-genomic-analysis-for-target-identification
#12
JOURNAL ARTICLE
Vivek Patil, Sharav Desai, Vipul Patel, Vrushali Somase
The utilization of In-silico subtractive genomic analysis has emerged as an important and essential method in modern drug discovery and development since it significantly improves the process of identifying and validating potential targets for discovering novel therapeutic compounds to treat severe infections caused by Antimicrobial-resistant (AMR) - pathogenic species. This review provides a complete overview of the methodology, advantages, disadvantages, and prospects, associated with subtractive genomic research in the context of drug discovery and development...
May 28, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38808711/recent-nanosolutions-based-on-green-propolis-presenting-useful-medical-applications
#13
JOURNAL ARTICLE
Fernanda Maria Policarpo Tonelli, Flávia Cristina Policarpo Tonelli, Vitória de Oliveira Lourenço, Geicielly da Costa Pinto
Nanotechnology has the potential to offer elegant solutions to problems experienced in the medical field, such as poor drug delivery efficiency and microbial resistance. In this sense, it is interesting to associate nanomaterials with substances that also offer desirable properties to favor human health. Green propolis is an example of a material that contains some of these useful substances. The phenolic acids present in this type of propolis have already been proven to present, for example, antimicrobial, immunostimulant, and antioxidant activities...
May 28, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38803172/spirulina-unveiled-a-comprehensive-review-on-biotechnological-innovations-nutritional-proficiency-and-clinical-implications
#14
JOURNAL ARTICLE
Ravi K Mittal, Gaurav Krishna, Vikram Sharma, Priyank Purohit, Raghav Mishra
This comprehensive review of Spirulina encompasses biotechnology, phycocyanin production, and purification. Bioactive compounds and vital nutrients are investigated during the study. The literature examines the potential therapeutic advantages and clinical applications of Spirulina. This analysis assesses Spirulina consumption and its associated health risks. The current review offers a comprehensive synthesis of the therapeutic applications as well as technologies utilized for the extraction and purification of phycocyanin...
May 27, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38803171/exploring-edible-insects-a-review-on-protein-diversity-extraction-techniques-and-health-benefits
#15
JOURNAL ARTICLE
Ravi K Mittal, Gaurav Krishna, Vikram Sharma
This study investigates whether edible insects may be used as a sustainable protein source. This study covers insect proteins, their defatting process and extraction, health advantages, economic and environmental impacts, safety considerations, and regulatory aspects. This review also investigates the ecological benefits of insect farming and consumer acceptance of this dietary trend. A systematic search of the pertinent literature was conductedto collect data for this review. Current research examines the effects of using edible insects as functional, sustainable reservoirs of proteins, including protein screening, extraction methods, health benefits, and social recognition...
May 27, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38797905/unveiling-fda-approved-drugs-and-formulations-in-the-management-of-bladder-cancer-a-review
#16
JOURNAL ARTICLE
Keshav Bansal, Neeraj Chaudhary, Hemant Bhati, Vanshita
Urological cancers are one of the most prevalent malignancies around the globe. Specifically, bladder cancer severely threatens the health of humans because of its heterogeneous and aggressive nature. Extensive studies have been conducted for many years in order to address the limitations associated with the treatment of solid tumors with selective substances. This article aims to provide a summary of the therapeutic drugs that have received FDA approval or are presently in the testing phase for use in the prevention or treatment of bladder cancer...
May 23, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38778618/the-effectiveness-of-listextm-p100-in-reducing-the-biofilm-of-listeria-spp-on-steel-plastic-and-galvanised-surfaces
#17
JOURNAL ARTICLE
Manaf AlMatar, Işil Var, Selin Sağlam, Osman Albarri
BACKGROUND: Eliminating and managing L. monocytogenes, L. welshimeri, and L. ivanovii biofilms is a significant problem for food safety, as listeriosis is among the worst foodborne illnesses. METHOD: The Listex P100 bacteriophage's bactericidal and inhibitory properties have been investigated in relation to varying strains of vegetative cells and biofilms of L. monocytogenes, L. welshimeri, and L. ivanovii. RESULTS: The phage concentrations of 109 and 1010 PFU/ml showed strong antibacterial activity against L...
May 21, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38778590/from-synthesis-to-solutions-hydrogels-impact-on-the-biomedical-landscape
#18
JOURNAL ARTICLE
Ravi K Mittal, Gaurav Krishna, Raghav Mishra, Rehan Uddin, Vikram Sharma
This review aims to examine the hydrogel structure concisely, approaches to hydrogel synthesis, and the most recent progressions in hydrogel technology along with its multifaceted applications within the domain of biomedicine, emphasizing its capacity to transform the delivery of drugs, tissue engineering, and diagnostics. This review employs an organized search of the literature to gather and evaluate state-of-the-art examines on hydrogel uses for biomedicine, synthesizing significant developments and breakthroughs to provide a holistic comprehension of their developing role and possible impact...
May 20, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38766821/exploring-therapeutic-frontiers-unveiling-the-potential-of-natural-diterpenoid-derivatives-in-addressing-neurological-disorders
#19
JOURNAL ARTICLE
Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Shivendra Kumar, Sunam Saha, Ashwani Sharma
Neurological disorders present a formidable challenge in healthcare, necessitating the continuous exploration of innovative therapeutic avenues. This review delves into the burgeoning field of natural diterpenoid derivatives and their promising role in addressing neurological disorders. Derived from natural sources, these compounds exhibit a diverse range of pharmacological properties, positioning them as potential agents for treating conditions such as Alzheimer's and Parkinson's disease. The review highlights recent advancements, shedding light on the multifaceted mechanisms through which diterpenoid derivatives exert their effects, from antiinflammatory to neuroprotective actions...
May 17, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38766820/the-cross-talk-of-non-coding-rnas-and-inflammation-in-human-cancer
#20
JOURNAL ARTICLE
Jiayi Li, Xiaoyong Lei, Xiaoyan Yang
Despite advanced clinical treatment, the mortality rate of cancer patients is high. Recent studies have linked the development of cancer to inflammation. Many cancers are exacerbated by the emergence of inflammatory responses, and non-coding RNAs play an important role in inflammation. Non-coding RNAs include microRNAs, circular RNAs, long-chain noncoding RNAs, etc. The non-coding RNA regulatory network composed of microRNAs, circular RNAs and long-chain non-coding RNAs is involved in the regulatory process of multiple gene expression...
May 17, 2024: Current Pharmaceutical Biotechnology
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