journal
https://read.qxmd.com/read/38018212/soluble-factors-associated-with-denervation-induced-skeletal-muscle-atrophy
#21
JOURNAL ARTICLE
Marianny Portal, Claudio Cabello-Verrugio
Skeletal muscle tissue has the critical function of mechanical support protecting the body. In addition, its functions are strongly influenced by the balanced synthesis and degradation processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation of catabolism generally determines a pathological state or condition called muscle atrophy, a reduction in muscle mass that results in partial or total loss of function. It has been established that many pathophysiological conditions can cause a decrease in muscle mass...
November 24, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37990433/development-and-challenges-of-cyclic-peptides-for-immunomodulation
#22
JOURNAL ARTICLE
Xianqiong Jiang, Li Gao, Zhilong Li, Yan Shen, Zhi-Hua Lin
Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation...
November 21, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37937553/emerging-role-of-non-collagenous-bone-proteins-as-osteokines-in-extraosseous-tissues
#23
JOURNAL ARTICLE
Kenda Jawich, Rana Hadakie, Souhaib Jamal, Rana Habeeb, Sahar Al Fahoum, Alberto Ferlin, Luca De Toni
Bone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have highlighted the importance of specific bone proteins, named "osteokines", possessing endocrine functions and exerting effects on nonosseous tissues...
November 1, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37909438/diabetic-wound-pathophysiology-complications-and-treatment-strategies
#24
JOURNAL ARTICLE
Sunita Chauhan, Monika Gulia, Rahul Pratap Singh, Vikas Jhawat
Diabetic wound healing is expected to affect 25% of all diabetics, resulting in less severe external factors, economic costs, and less trauma. Topical formulations have been continually improved to achieve a range of amazing properties and have had a significant impact on the management of diabetic wounds. Topical insulin has become one of the most attractive and convenient wound healing techniques due to its excellent biocompatibility, water retention, and therapeutic properties. Multiple versatile topical insulins have been identified and have shown promise over the past few years as they greatly facilitate the management of diabetic wounds as we understand their etiology...
October 31, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37909437/biological-significance-of-ephb4-expression-in-cancer
#25
JOURNAL ARTICLE
Asmat Ullah, Anam Razzaq, Chuanzan Zhou, Najeeb Ullah, Somia Shehzadi, Tariq Aziz, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Haroon Iqbal
Eph receptors and their Eph receptor-interacting (ephrin) ligands comprise a vital cell communication system with several functions. In cancer cells, there was evidence of bilateral Eph receptor signaling with both tumor-suppressing and tumor-promoting actions. As a member of the Eph receptor family, EphB4 has been linked to tumor angiogenesis, growth, and metastasis, which makes it a viable and desirable target for drug development in therapeutic applications. Many investigations have been conducted over the last decade to elucidate the structure and function of EphB4 in association with its ligand ephrinB2 for its involvement in tumorigenesis...
October 31, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37921168/bioconjugation-techniques-for-enhancing-stability-and-targeting-efficiency-of-protein-and-peptide-therapeutics
#26
JOURNAL ARTICLE
Tanuja Bisht, Anupriya Adhikari, Shivanand Patil, Shivang Dhoundiyal
Bioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strategies for covalent attachment and site-specific conjugation approaches...
October 25, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37921167/design-and-simulation-of-the-microcantilever-biosensor-for-mitf-antigen-and-d5-monoclonal-antibody-%C3%A4-nteraction-finite-element-analysis-and-experimental
#27
JOURNAL ARTICLE
Pelin Akcalı, Kübra Kelleci, Sevil Ozer
BACKGROUND: Biosensors and MEMS have witnessed rapid development and enormous interest over the past decades. Constant advancement in diagnostic, medical, and chemical applications has been demonstrated in several platforms and tools. In this study, the analytical and FEA of the microcantilever used in biomolecular analyses were compared with the experimental analysis results. METHODS: In this study, MITF antigen, which is a melanoma biomarker, and anti-MITF antibody (D5) were selected as biomolecules...
October 25, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37885106/a-novel-peptide-cox52-69-inhibits-high-glucose-induced-insulin-secretion-by-modulating-bk-channel-activity
#28
JOURNAL ARTICLE
Qian Lin, Jingtao Liu, Hengling Chen, Wenwu Hu, Weiqiong Lei, Meijie Wang, Xianguang Lin, Yongning Zhang, Huiting Ai, Su Chen, Chenhong Li
BACKGROUND: Excessive insulin is the leading cause of metabolic syndromes besides hyperinsulinemia. Insulin-lowering therapeutic peptides have been poorly studied and warrant urgent attention. OBJECTIVE: The main purpose of this study, was to introduce a novel peptide COX52-69 that was initially isolated from the porcine small intestine and possessed the ability to inhibit insulin secretion under high-glucose conditions by modulating large conductance Ca2+-activated K+ channels (BK channels) activity...
October 25, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37849226/advancements-of-the-crispr-cas9-system-in-the-treatment-of-liver-cancer
#29
JOURNAL ARTICLE
Zhuoyu Li, Ziming Han
In recent years, the CRISPR/Cas9 system has become a rapidly advancing gene editing technology with significant advantages in various fields, particularly biomedicine. Liver cancer is a severe malignancy that threatens human health and is primarily treated with surgery, radiotherapy, and chemotherapy. However, surgery may not be suitable for advanced cases of liver cancer with distant metastases. Moreover, radiotherapy and chemotherapy have low specificity and numerous side effects that limit their effectiveness; therefore, more effective and safer treatments are required...
October 17, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37815184/plant-bzip-proteins-potential-use-in-agriculture-a-review
#30
JOURNAL ARTICLE
Cláudia de Souza, Cleyson Serrão, Nicolle Barros, Sávio Reis, Deyvid Marques
With global climate changes and the increased demand for food due to expected world population growth, genetic improvement programs have aimed at producing crops with increased yield and tolerance to environmental stresses, such as drought, salinity, and pathogens. On the other hand, genetic improvement programs via biotechnology require candidate genes that confer traits of interest to be incorporated into improved crops. In this regard, genes encoding transcription factors (TFs) can be promising since they are proteins that transcriptionally regulate the expression of target genes related to the most diverse roles in the plant, including defense against stresses...
October 5, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37718516/arl15-and-its-multiple-disease-associations-emerging-functions-and-potential-therapeutic-applications
#31
JOURNAL ARTICLE
Manisha Saini, Varnita Anand, Aditya Sharma, Anuj Pandey, B K Thelma, Suman Kundu
ARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in this gene to be statistically associated with numerous traits and complex diseases. Here, we provided the unique features of ARL15 small G protein, its association with varied metabolic and lifestyle diseases, its function in vesicular and lipid trafficking, and its binding partners...
September 15, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37694793/purification-characterization-and-evaluation-of-the-anticoagulant-effect-of-an-uncompetitive-trypsin-inhibitor-obtained-from-bauhinia-pulchella-benth-seeds
#32
JOURNAL ARTICLE
Renato R Roma, Lucas P Dias, Ana L E Santos, Romério R S Silva, Maria H C Santos, Bruno A M Rocha, Rômulo F Carneiro, Celso S Nagano, Alexandre H Sampaio, Maria L V Oliva, Cláudio G L Silva, Racquel O S Souza, Claudener S Teixeira
INTRODUCTION: Trypsin inhibitors (TIs) have the ability to competitively or non-competitively bind to trypsin and inhibit its action. These inhibitors are commonly found in plants and are used in protease inhibition studies involved in biochemical pathways of pharmacological interest. OBJECTIVE: This work aimed to purify a trypsin inhibitor from Bauhinia pulchella seeds (BpuTI), describing its kinetic mechanism and anticoagulant effect. METHODOLOGY: Affinity chromatography, protein assay, and SDS-PAGE were used to purify the inhibitor...
September 8, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37670708/research-progress-on-hcnt3-structure-function-and-nucleoside-anticancer-drugs
#33
JOURNAL ARTICLE
Xinru Yue, Jianping Hu, Xun Zhang, Derong Zhang, Lingkai Tang, Zuoxin Ou, Zhigang Zhang, Yujie Cao, Jing Li, Li Liang, Wei Liu, Ying Li
Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs, including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then delivered to the lesion site for their therapeutic effects. hCNT3 is highly conserved during the evolution from lower to higher vertebrates, which contains scaffold and transport domains in structure and delivers substrates by coupling with Na+ and H+ ions in function...
September 5, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37653631/pi3k-signaling-pathways-as-a-molecular-target-for-glioblastoma-multiforme
#34
JOURNAL ARTICLE
Andressa Letícia Lopes da Silva, Thiago Pina Goes de Araújo, Shakira Cavalcante de Albuquerque Ferreira, Anderson Brandão Leite, João Kaycke Sarmento da Silva, Lilyana Waleska Nunes Albuquerque, Ana Rachel Vasconcelos de Lima, Herbert Charles Silva Barros, Leandro Rocha Silva, Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior, Vivaldo Moura Neto, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira
Glioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical research aims to improve this prognosis by proposing the search for new drugs that effectively eliminate cancer cells, circumventing problems such as resistance to treatment...
August 30, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37649287/mechanisms-involved-in-the-therapeutic-effect-of-cannabinoid-compounds-on-gliomas-a-review-with-experimental-approach
#35
JOURNAL ARTICLE
Hugo Fernandes Oliveira Pires, Pablo Rayff da Silva, Arthur Lins Dias, Cleyton de Sousa Gomes, Natália Ferreira de Sousa, Aline Matilde Ferreira Dos Santos, Lívia Roberta Pimenta Souza, Jaislânia Lucena de Figueiredo Lima, Mayara Cecile Nascimento Oliveira, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida, Ricardo Dias de Castro, Mirian Graciela da Silva Stiebbe Salvadori, Marcus Tullius Scotti, Luciana Scotti
INTRODUCTION: Brain tumors have high morbidity and mortality rates, accounting for 1.4% of all cancers. Gliomas are the most common primary brain tumors in adults. Currently, several thera-peutic approaches are used; however, they are associated with side effects that affect pa-tients'quality of life. Therefore, further studies are needed to develop novel therapeutic protocols with a more favorable side effect profile. In this context, cannabinoid compounds may serve as potential alternatives...
August 30, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37642183/intercellular-interactions-mediated-by-hgf-and-tgf-%C3%AE-promote-the-3d-spherical-and-xenograft-growth-of-liver-cancer-cells
#36
JOURNAL ARTICLE
Zheng Peng, Xiaolan Lv, Pengfei Zhang, Qiao Chen, Hongyu Zhang, Jianlin Chen, Xingxuan Ma, Bohui Ouyang, Meng Hao, Haibo Tong, Dongwei Guo, Yi Luo, Shigao Huang
BACKGROUND: Recently, the importance of the interactions between liver cancer cells and fibroblasts has been increasingly recognized; however, many details remain to be explored. METHODS: In this work, we first studied their intercellular interactions using conditioned medium from mouse embryonic fibroblasts (MEFs), then through a previously established coculture model. RESULTS: Culturing in a conditioned medium from MEFs could significantly increase the growth, migration, and invasion of liver cancer cells...
August 25, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37641992/in-silico-and-in-vitro-analysis-of-phenolic-acids-for-identification-of-potential-dhfr-inhibitors-as-antimicrobial-and-anticancer-agents
#37
JOURNAL ARTICLE
Renu Sehrawat, Priyanka Rathee, Pooja Rathee, Sarita Khatkar, Esra Kupelli Akkol, Anurag Khatkar
BACKGROUND: DHFR is an indispensable enzyme required for the survival of almost all prokaryotic and eukaryotic cells, making it an attractive molecular target for drug design. OBJECTIVE: In this study, a combined in silico and in vitro approach was utilized to screen out potential anticancer and antimicrobial agents by using DHFR PDB IDs 2W9S (for antimicrobial) and 1U72 (for anticancer). METHODS: Computational work was performed using Maestro Schrodinger Glide software...
August 25, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37608655/unfolded-protein-response-signaling-in-hepatic-stem-cell-activation-in-liver-fibrosis
#38
JOURNAL ARTICLE
Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein Kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E Butler, Maryam Mohammad-Sadeghipour, Amirhossein Sahebkar
Frequent exposure to various external and internal adverse forces (stresses) disrupts ‎cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. ‎This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain ‎optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, ‎fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to ‎activating the hepatic stellate cells (HSCs)...
August 22, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37608654/bh3-mimetic-peptides-an-effective-strategy-to-complement-anticancer-therapy
#39
JOURNAL ARTICLE
Sundra Dhakshinamurthy Saraswathy, Arumugam Mirunalini, Kandasamy Karthikeyan, Kumpati Premkumar
Apoptosis, a natural process of programmed cell death, is a promising therapeutic target as the disruption of apoptosis evolves in many diseases including cancer. Several pieces of evidence indicate that errors in apoptotic pathways result in the imbalance between cell proliferation and death, allowing cells with genetic abnormalities to survive. The intrinsic and extrinsic pathways of apoptosis utilize different caspases to execute the event of cell death through the cleavage of hundreds of proteins. Proteins from the Bcl-2 family, a pivotal component of the mitochondrial apoptosis pathway, activate the death signal either directly or indirectly involving mitochondrial translocation of Bax/Bak, which are recognized critical elements in defective apoptosis...
August 22, 2023: Current Protein & Peptide Science
https://read.qxmd.com/read/37608653/protein-engineering-in-cyanobacterial-biotechnology-tools-and-recent-updates
#40
JOURNAL ARTICLE
Swati Tyagi, Srabani Kar, Amit Srivastava, Pratyoosh Shukla
Cyanobacteria have emerged as a microbial cell factory to produce a variety of bioproducts, including peptides and proteins. Cyanobacteria stand out among other organisms due to their photoautotrophic metabolism and ability to produce a wide range of metabolites and proteins. As photoautotrophic hosts can produce industrial compounds and proteins by using minimal resources such as sunlight, atmospheric carbon dioxide, and fewer nutrients, cyanobacteria are cost-effective industrial hosts. Therefore, the use of protein engineering tools for rational protein design, protein motifs/domains study, and the desired modification of enzyme activity has become a desirable undertaking in cyanobacterial biology...
August 22, 2023: Current Protein & Peptide Science
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