journal
https://read.qxmd.com/read/38544827/a-novel-methylation-based-model-for-prognostic-prediction-in-lung-adenocarcinoma
#1
JOURNAL ARTICLE
Manyuan Li, Xufeng Deng, Dong Zhou, Xiaoqing Liu, Jigang Dai, Quanxing Liu
OBJECTIVES: Specific methylation sites have shown promise in the early diagnosis of lung adenocarcinoma (LUAD). However, their utility in predicting LUAD prognosis remains unclear. This study aimed to construct a reliable methylation-based predictor for accurately predicting the prognosis of LUAD patients. METHODS: DNA methylation data and survival data from LUAD patients were obtained from the TCGA and a GEO series. A DNA methylation-based signature was developed using univariate least absolute shrinkage and selection operators and multivariate Cox regression models...
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38544826/analysis-of-the-expression-of-prdx6-in-patients-with-hepatocellular-carcinoma-and-its-effect-on-the-phenotype-of-hepatocellular-carcinoma-cells
#2
JOURNAL ARTICLE
Runhong Mu, Mingzhu Chang, Chuanbo Feng, Yunhe Cui, Tingyu Li, Chang Liu, Yilin Wang, Xiao Guo
OBJECTIVES: This research aimed to study the expression of PRDX6 mRNA in hepatocellular carcinoma (HCC) and its effect on the prognosis of HCC. Moreover, the effect of PRDX6 gene knockdown on the proliferation, migration, and invasion of HepG2 cells mediated by lentivirus was also examined. This study offers a theoretical and experimental basis for further research on the mechanism of PRDX6 in liver cancer and new methods for clinical diagnosis and treatment. METHODS: RNA sequence data of 369 HCC patients were screened through the TCGA database, and the expression and clinical characteristics of PRDX6 mRNA were analyzed based on high-throughput RNA sequencing data...
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38544825/molecular-determination-of-tumor-necrosis-factor-alpha-interleukin-8-interleukin-10-and-c-x-c-chemokine-receptor-2-genetic-variations-and-their-association-with-disease-susceptibility-and-mortality-in-covid-19-patients
#3
JOURNAL ARTICLE
Badr A Alsayed, Rashid Mir, Mohammad M Mir, Tarig M S Alnour, Shereen Fawzy, Mesaik M Ahmed, Dnyanesh Amle
BACKGROUND: Altered cytokine levels have been associated with poor outcomes among COVID-19 patients. TNF-α, IL-8 and IL-10 are key cytokines in COVID-19 pathogenesis, and CXCR-2 is a major chemokine receptor involved in inflammatory response. Polymorphisms in the genes of these proteins are proposed to influence disease outcomes. In this study, we aimed to find out the association of genetic polymorphisms in TNF-α, IL-8, IL-10 and CXCR-2 genes with susceptibility to and mortality of COVID-19...
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38544824/preface-25-years-of-current-genomics
#4
EDITORIAL
Fabio Coppedè
No abstract text is available yet for this article.
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38544823/exploring-the-role-of-non-synonymous-and-deleterious-variants-identified-in-colorectal-cancer-a-multi-dimensional-computational-scrutiny-of-exomes
#5
JOURNAL ARTICLE
Chandrashekar Karunakaran, Vidya Niranjan, Anagha S Setlur, Dhanya Pradeep, Jitendra Kumar
INTRODUCTION: Colorectal cancers are the world's third most commonly diagnosed type of cancer. Currently, there are several diagnostic and treatment options to combat it. However, a delay in detection of the disease is life-threatening. Additionally, a thorough analysis of the exomes of cancers reveals potential variation data that can be used for early disease prognosis. METHODS: By utilizing a comprehensive computational investigation, the present study aimed to reveal mutations that could potentially predispose to colorectal cancer...
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38327653/oxford-nanopore-technology-and-its-application-in-liquid-biopsies
#6
REVIEW
Mariya Levkova, Trifon Chervenkov, Lyudmila Angelova, Deyan Dzenkov
Advanced medical technologies are transforming the future of healthcare, in particular, the screening and detection of molecular-genetic changes in patients suspected of having a neoplasm. They are based on the assumption that neoplasms release small amounts  of  various  neoplasm-specific molecules, such as tumor DNA, called circulating DNA (cirDNA), into the extracellular space and subsequently into the blood. The detection of tumor-specific molecules and specific molecular changes in body fluids in a noninvasive or minimally invasive approach is known as "liquid biopsy...
December 28, 2023: Current Genomics
https://read.qxmd.com/read/38327652/identification-of-two-novel-pathogenic-variants-of-the-atm-gene-in-the-iranian-azeri-turkish-ethnic-group-by-applying-whole-exome-sequencing
#7
JOURNAL ARTICLE
Amir-Reza Dalal Amandi, Neda Jabbarpour, Shadi Shiva, Mortaza Bonyadi
BACKGROUND: The ATM gene encodes a multifunctional kinase involved in important cellular functions, such as checkpoint signaling and apoptosis, in response to DNA damage. Bi-allelic pathogenic variants in this gene cause Ataxia Telangiectasia (AT), while carriers of ATM pathogenic variants are at increased risk of cancer depending on the pathogenicity of the variant they carry. Identifying pathogenic variants can aid in the management of the disease in carriers. METHODS: Whole-exome sequencing (WES) was performed on three unrelated patients from the Iranian-Azeri Turkish ethnic group referred to a genetic center for analysis...
December 28, 2023: Current Genomics
https://read.qxmd.com/read/38327651/aberrant-expressions-of-psmd14-in-tumor-tissue-are-the-potential-prognostic-biomarkers-for-hepatocellular-carcinoma-after-curative-resection
#8
JOURNAL ARTICLE
Yi-Mei Xiong, Fang Zhou, Jia-Wen Zhou, Fei Liu, Si-Qi Zhou, Bo Li, Zhong-Jian Liu, Yang Qin
INTRODUCTION: Hepatocellular carcinoma (HCC) has a high mortality rate, with curative resection being the primary treatment. However, HCC patients have a large possibility of recurrence within 5 years after curative resection. METHODS: Thus, identifying biomarkers to predict recurrence is crucial. In our study, we analyzed data from CCLE, GEO, and TCGA, identifying eight oncogenes associated with HCC. Subsequently, the expression of 8 genes was tested in 5 cases of tumor tissues and the adjacent non-tumor tissues...
December 28, 2023: Current Genomics
https://read.qxmd.com/read/38327650/epigenetic-diversity-underlying-seasonal-and-annual-variations-in-brown-planthopper-bph-populations-as-revealed-by-methylation-sensitive-restriction-assay
#9
JOURNAL ARTICLE
Ayushi Gupta, Suresh Nair
BACKGROUND: The brown planthopper (BPH) is a monophagous sap-sucking insect pest of rice that is responsible for massive yield loss. BPH populations, even when genetically homogenous, can display a vast range of phenotypes, and the development of effective pest-management strategies requires a good understanding of what generates this phenotypic variation. One potential source could be epigenetic differences. METHODS: With this premise, we explored epigenetic diversity, structure and differentiation in field populations of BPH collected across the rice-growing seasons over a period of two consecutive years...
December 28, 2023: Current Genomics
https://read.qxmd.com/read/38235355/current-advances-in-genetic-testing-for-spinal-muscular-atrophy
#10
REVIEW
Yulin Zhou, Yu Jiang
Spinal muscular atrophy (SMA) is one of the most common genetic disorders worldwide, and genetic testing plays a key role in its diagnosis and prevention. The last decade has seen a continuous flow of new methods for SMA genetic testing that, along with traditional approaches, have affected clinical practice patterns to some degree. Targeting different application scenarios and selecting the appropriate technique for genetic testing have become priorities for optimizing the clinical pathway for SMA. In this review, we summarize the latest technological innovations in genetic testing for SMA, including MassArray® , digital PCR (dPCR), next-generation sequencing (NGS), and third-generation sequencing (TGS)...
December 20, 2023: Current Genomics
https://read.qxmd.com/read/38235354/high-prevalence-of-a-c-5979dupa-variant-in-the-dysferlin-gene-dysf-in-individuals-from-a-semiarid-region-of-brazil
#11
JOURNAL ARTICLE
Isabella A Motta, Maria L A Gouveia, Ana P M Braga, Rafael S Andrade, Mayra F F Montenegro, Sandra N Gurgel, Keila M F Albuquerque, Priscilla A N G Souto, Flávia P B F Cardoso, Joseane S Araujo, Mirella C L Pinheiro, Carlos E P da Silva, Pamella A S Gurgel, David Feder, Matheus M Perez, Glaucia L da Veiga, Beatriz C A Alves, Fernando L A Fonseca, Alzira A S Carvalho
BACKGROUND: Dysferlinopathies represent a group of limb girdle or distal muscular dystrophies with an autosomal-recessive inheritance pattern resulting from the presence of pathogenic variants in the dysferlin gene (DYSF). OBJECTIVE: In this work, we describe a population from a small city in Brazil carrying the c.5979dupA pathogenic variant of DYSF responsible for limb girdle muscular dystrophy type 2R and distal muscular dystrophy. METHODS: Genotyping analyses were performed by qPCR using customized probe complementary to the region with the duplication under analysis in the DYSF...
December 20, 2023: Current Genomics
https://read.qxmd.com/read/38235353/identification-of-plausible-candidates-in-prostate-cancer-using-integrated-machine-learning-approaches
#12
JOURNAL ARTICLE
Bhumandeep Kour, Nidhi Shukla, Harshita Bhargava, Devendra Sharma, Amita Sharma, Anjuvan Singh, Jayaraman Valadi, Trilok Chand Sadasukhi, Sugunakar Vuree, Prashanth Suravajhala
BACKGROUND: Currently, prostate-specific antigen (PSA) is commonly used as a prostate cancer (PCa) biomarker. PSA is linked to some factors that frequently lead to erroneous positive results or even needless biopsies of elderly people. OBJECTIVES: In this pilot study, we undermined the potential genes and mutations from several databases and checked whether or not any putative prognostic biomarkers are central to the annotation. The aim of the study was to develop a risk prediction model that could help in clinical decision-making...
December 20, 2023: Current Genomics
https://read.qxmd.com/read/38235352/pan-cancer-analysis-identifies-aimp2-as-a-potential-biomarker-for-breast-cancer
#13
JOURNAL ARTICLE
Jie Qiu, Tao Zhou, Danhong Wang, Weimin Hong, Da Qian, Xuli Meng, Xiaozhen Liu
INTRODUCTION: Aminoacyl tRNA synthetase complex interacting with multifunctional protein 2 (AIMP2) is a significant regulator of cell proliferation and apoptosis. Despite its abnormal expression in various tumor types, the specific functions and effects of AIMP2 on tumor immune cell infiltration, proliferation, and migration remain unclear. MATERIALS AND METHODS: To assess AIMP2's role in tumor immunity, we conducted a pan-cancer multi-database analysis using the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Cancer Cell Lines Encyclopedia (CCLE) datasets, examining expression levels, prognosis, tumor progression, and immune microenvironment...
December 20, 2023: Current Genomics
https://read.qxmd.com/read/38169773/modulation-of-plant-microrna-expression-its-potential-usability-in-wheat-triticum-aestivum-l-improvement
#14
REVIEW
Louie Cris Lopos, Urbashi Panthi, Igor Kovalchuk, Andriy Bilichak
Wheat, a crucial crop for the pursuit of food security, is faced with a plateauing yield projected to fall short of meeting the demands of the exponentially increasing human population. To raise global wheat productivity levels, strong efforts must be made to overcome the problems of (1) climate change-induced heat and drought stress and (2) the genotype-dependent amenability of wheat to tissue culture, which limits the success of recovering genetically engineered plants, especially in elite cultivars. Unfortunately, the mainstream approach of genetically engineering plant protein-coding genes may not be effective in solving these problems as it is difficult to map, annotate, functionally verify, and modulate all existing homeologs and paralogs within wheat's large, complex, allohexaploid genome...
December 12, 2023: Current Genomics
https://read.qxmd.com/read/38169762/complete-chloroplast-genomes-of-pterodon-emarginatus-vogel-and-pterodon-pubescens-benth-comparative-and-phylogenetic-analyses
#15
JOURNAL ARTICLE
Juliana Borges Pereira Brito, Adriana Maria Antunes, Ramilla Dos Santos Braga Ferreira, Mariana Pires de Campos Telles, Cintia Pelegrineti Targueta, Thannya Nascimento Soares
BACKGROUND: The species Pterodon emarginatus and P. pubescens , popularly known as white sucupira or faveira, are native to the Cerrado biome and have the potential for medicinal use and reforestation. They are sister species with evolutionary proximity. OBJECTIVE: Considering that the chloroplast genome exhibits a conserved structure and genes, the analysis of its sequences can contribute to the understanding of evolutionary, phylogenetic, and diversity issues...
December 12, 2023: Current Genomics
https://read.qxmd.com/read/38169652/a-study-and-analysis-of-disease-identification-using-genomic-sequence-processing-models-an-empirical-review
#16
REVIEW
Sony K Ahuja, Deepti D Shrimankar, Aditi R Durge
Human gene sequences are considered a primary source of comprehensive information about different body conditions. A wide variety of diseases including cancer, heart issues, brain issues, genetic issues, etc . can be pre-empted via efficient analysis of genomic sequences. Researchers have proposed different configurations of machine learning models for processing genomic sequences, and each of these models varies in terms of their performance & applicability characteristics. Models that use bioinspired optimizations are generally slower, but have superior incremental-performance, while models that use one-shot learning achieve higher instantaneous accuracy but cannot be scaled for larger disease-sets...
December 12, 2023: Current Genomics
https://read.qxmd.com/read/38169628/unraveling-the-concealed-transcriptomic-landscape-of-pten-in-human-malignancies
#17
JOURNAL ARTICLE
Michaela A Boti, Panagiotis G Adamopoulos, Dido Vassilacopoulou, Andreas Scorilas
BACKGROUND: Phosphatase and tensin homolog, widely known as PTEN, is a major negative regulator of the PI3K/AKT/mTOR signaling pathway, involved in the regulation of a variety of important cellular processes, including cell proliferation, growth, survival, and metabolism. Since most of the molecules involved in this biological pathway have been described as key regulators in cancer, the study of the corresponding genes at several levels is crucial. OBJECTIVE: Although previous studies have elucidated the physiological role of PTEN under normal conditions and its involvement in carcinogenesis and cancer progression, the transcriptional profile of PTEN has been poorly investigated...
December 12, 2023: Current Genomics
https://read.qxmd.com/read/38169623/taxonomic-status-and-phylogenetic-relationship-of-the-charadriidae-family-based-on-complete-mitogenomes
#18
JOURNAL ARTICLE
Weiya Qian, Yizheng Liu, Keer Miao, Qing Chang, Chaochao Hu
BACKGROUND: The Charadriiformes provide a good source for researching evolution owing to their diverse distribution, behavior, morphology, and ecology. However, in the Charadrii, family-level relationships remain understudied, and the monophyly of Charadriidae is also a subject of controversy. METHODS: In the present study, we generated complete mitogenomes for two species, Charadrius leschenaultii and Charadrius mongolus , which were found to be 16,905 bp and 16,844 bp in length, respectively...
December 12, 2023: Current Genomics
https://read.qxmd.com/read/38178988/genome-sequencing-and-organization-of-three-geographically-different-isolates-of-nucleopolyhedrovirus-from-the-gypsy-moth-reveal-significant-genomic-differences
#19
JOURNAL ARTICLE
Donus Gencer, Cihan Inan, Zeynep Bayramoglu, Remziye Nalcacioglu, Feifei Yin, Zheng Zhu, Jun Wang, Zhihong Hu, Lillian Pavlik, Basil Arif, Zihni Demirbag, Ismail Demir
BACKGROUND: The gypsy moth ( Lymantria dispar L., Lepidoptera: Erebidae) is a worldwide pest of trees and forests. Lymantria dispar nucleopolyhedrovirus (LdMNPV) belongs to the Baculoviridae family and is an insect virus specific to gypsy moth larvae. In this study, we describe the complete genome sequences of three geographically diverse isolates, H2 (China), J2 (Japan), and T3 (Turkey), of Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV). METHODS: The genomes of isolates H2, J2, and T3 were subjected to shotgun pyrosequencing using Roche 454 FLX and assembled using Roche GS De Novo Assembler...
November 22, 2023: Current Genomics
https://read.qxmd.com/read/38178987/decoding-the-link-between-periodontitis-and-neuroinflammation-the-journey-of-bacterial-extracellular-vesicles
#20
EDITORIAL
Heon-Jin Lee, Youngkyun Lee, Su-Hyung Hong, Jin-Woo Park
No abstract text is available yet for this article.
November 22, 2023: Current Genomics
journal
journal
35108
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.