Dana Gates, Abu Zayed Md Badruddoza, Md Ikhtiar Zahid, Thean Yeoh, Jaymin Shah, Taylor Walsh, Md Nurunnabi
Recently, vast efforts towards sustainability have been made in the pharmaceutical industry. In conventional oil-in-water (O/W) cream formulations, various petroleum-based excipients, namely mineral oil and petrolatum, are commonly used. Natural or synthetic excipients, derived from vegetable sources, were explored as alternatives to petroleum-based excipients in prototype topical creams, with 1% (w/w) lidocaine. A conventional cream comprised of petroleum-derived excipients was compared to creams containing sustainable excipients in terms of key quality and performance attributes, physicochemical properties, and formulation performance...
March 27, 2024: AAPS PharmSciTech