Farwa Muskan Khalid, Muhammad Ijaz, Arshad Mahmood, Muhammad Khurram Waqas, Talib Hussain, Mulazim Hussain Asim, Nadeem Ahmad, Shumaila Arshad, Masood Ur Rehman, Imran Nazir
The objective of this study was to generate fluconazole-loaded mucoadhesive nanogels to address the problem of hydrophobicity of fluconazole (FL). An inclusion complex was formulated with sulfhydryl-β-CD (SH-β-CD) followed by nanogels formation by a Schiff base reaction of carbopol 940 (CA-940) and gelatin (GE). For characterization, PXRD, FT-IR analysis, drug content, and phase solubility studies were performed. Similarly, nanogels were assessed for particle size, zeta potential, organoleptic, and spreadability studies...
September 26, 2023: AAPS PharmSciTech