journal
https://read.qxmd.com/read/37752361/mucoadhesive-fluconazole-loaded-nanogels-complexed-with-sulfhydryl-%C3%AE-cyclodextrin-for-oral-thrush-treatment
#1
JOURNAL ARTICLE
Farwa Muskan Khalid, Muhammad Ijaz, Arshad Mahmood, Muhammad Khurram Waqas, Talib Hussain, Mulazim Hussain Asim, Nadeem Ahmad, Shumaila Arshad, Masood Ur Rehman, Imran Nazir
The objective of this study was to generate fluconazole-loaded mucoadhesive nanogels to address the problem of hydrophobicity of fluconazole (FL). An inclusion complex was formulated with sulfhydryl-β-CD (SH-β-CD) followed by nanogels formation by a Schiff base reaction of carbopol 940 (CA-940) and gelatin (GE). For characterization, PXRD, FT-IR analysis, drug content, and phase solubility studies were performed. Similarly, nanogels were assessed for particle size, zeta potential, organoleptic, and spreadability studies...
September 26, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37740105/viability-of-lactobacillus-acidophilus-in-thin-film-freeze-dried-powders-filled-in-delayed-release-vegetarian-capsules-in-a-simulated-gastric-fluid
#2
JOURNAL ARTICLE
Jie-Liang Wang, Benjamin Southard, Miguel O Jara, Yu-Sheng Yu, Haiyue Xu, Justin Kalafat, Robert O Williams, Zhengrong Cui
Previously, we have shown that thin-film freeze-drying can be applied to prepare dry powders of bacteria such as Lactobacillus acidophilus. Herein, we tested the viability of L. acidophilus in thin-film freeze-dried powders (TFF powders) filled in delayed-release vegetarian capsules in a simulated gastric fluid (SGF) consisting of 0.1N hydrochloric acid and sodium chloride. Initially, we determined the water removal rate from frozen thin films on relatively larger scales (i.e., 10-750 g). We then prepared and characterized two TFF powders of L...
September 22, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37726590/co-administration-of-thymoquinone-and-propolis-in-liposomal-formulations-as-a-potential-approach-for-treatment-of-acetic-acid-induced-ulcerative-colitis-physiological-and-histopathological-analysis
#3
JOURNAL ARTICLE
Eman Alaaeldin, Hesham Refaat, Entesar Ali Saber, Neven Makram Aziz, Nehad M Reda Abdel-Maqsoud, Mohammed Mustafa Abd El Aleem, Maha Yehia Kamel, Fatma M Mady
A severe form of autoimmune-mediated inflammatory bowel disease (IBD) is termed as ulcerative colitis (UC) which ultimately results in significant mucosal damage and ulceration. Herbal remedies may be employed as an alternative for treatment of UC instead of conventional medications such as Sulfasalazine. Promising natural remedies for the treatment of IBD, including colitis, are propolis extract (PP) and thymoquinone (TQ). This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects...
September 19, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37726576/new-insights-into-the-applications-of-3d-printed-biomaterial-in-wound-healing-and-prosthesis
#4
REVIEW
Aayushi Pandey, Pragya, Jovita Kanoujia, Poonam Parashar
Recently three-dimensional bioprinting (3D-bioP) has emerged as a revolutionary technique for numerous biomedical applications. 3D-bioP has facilitated the printing of advanced and complex human organs resulting in satisfactory therapeutic practice. One of the important biomedical applications of 3D-bioP is in tissue engineering, wound healing, and prosthetics. 3D-bioP is basically aimed to restore the natural extracellular matrix of human's damage due to wounds. The relevant search was explored using various scientific database, viz...
September 19, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37726536/design-and-evaluation-of-continentalic-acid-encapsulated-transfersomal-gel-and-profiling-of-its-anti-arthritis-activity
#5
JOURNAL ARTICLE
Muhammad Waseem Akram, Danish Mazhar, Iqra Afzal, Ahmad Zeb, Qurat Ul Ain, Salman Khan, Hussain Ali
Rheumatoid arthritis restricts the physical ability of patients and increases the disease burden; therefore, research has always been focused on evaluating better therapeutic options. The present research aimed to design Continentalic acid (CA)-loaded transfersomes (CA-TF) embedded in Carbopol gel containing permeation enhancer (PE) for the treatment of rheumatoid arthritis. CA-TF was developed via a modified thin film hydration method and incorporated into Carbopol 934 gel containing Eucalyptus oil (EO) as PE...
September 19, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37726501/formulation-and-development-of-flurbiprofen-colon-specific-eudragit-coated-matrix-tablets-use-of-a-novel-crude-banana-peel-powder-as-a-time-dependent-polymer
#6
JOURNAL ARTICLE
Sateesh Kumar Vemula, Bhaskar Daravath, Sridhar Babu Gummadi, Michael Repka
The rationale for the current investigation is to study the crude banana peel (CBP) powder efficiency as a novel natural time-dependent polymer along with a pH-sensitive polymer to develop flurbiprofen colon-specific tablets. The direct compression method is utilized to prepare the flurbiprofen-CBP matrix tablets using 9 mm punches on the rotary tableting machine and subsequently coated with Eudragit® S 100 by a dip coating method. The tablets were evaluated for various tableting properties and in vitro drug release studies...
September 19, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37715004/emerging-applications-of-hydroxypropyl-methylcellulose-acetate-succinate-different-aspects-in-drug-delivery-and-its-commercial-potential
#7
REVIEW
Manisha Choudhari, Shantanu Damle, Ranendra Narayan Saha, Sunil Kumar Dubey, Gautam Singhvi
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are beneficial while developing formulations...
September 15, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37700215/development-of-delayed-release-oral-formulation-comprising-esomeprazole-spray-dried-dispersion-utilizing-design-of-experiment-as-an-optimization-strategy
#8
JOURNAL ARTICLE
Kaushika Patel, Jaymin Patel, Shreeraj Shah
Solid dispersion (SD) technology is one of the most widely preferred solubility enhancement methods, especially for Biopharmaceutics classification system class II and IV drugs. Since the last decade, its application for the dual purpose of solubility hike and modified release using novel carriers has been in demand for its added advantages. Spray drying is a commercially accepted technique with high aspects of scalability and product characteristics. The current study used spray-dried dispersion to design delayed release capsule for the proton pump inhibitor esomeprazole...
September 12, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37700198/metronidazole-loaded-camphor-based-in-situ-forming-matrix-for-periodontitis-treatment
#9
JOURNAL ARTICLE
Kritamorn Jitrangsri, Nutdanai Lertsuphotvanit, Ngamsil Kabthong, Thawatchai Phaechamud
Periodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulations were evaluated...
September 12, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37700110/percutaneous-absorption-and-skin-accumulation-of-lorazepam-diphenhydramine-haloperidol-carbopol-gel-in-porcine-ear-skin
#10
JOURNAL ARTICLE
Rabin Neupane, Sai H S Boddu, Moawia M Al-Tabakha, Shery Jacob, R Jayachandra Babu, Amit K Tiwari
This study presents the formulation and evaluation of an ABH Carbopol gel containing lorazepam (Ativan®), diphenhydramine hydrochloride (Benadryl®), and haloperidol (Haldol®) for treating chemotherapy-induced nausea and vomiting (CINV) in hospice patients. ABH PLO gel is widely used for this purpose due to its low cost and presumed efficacy. However, previous studies, including one conducted by the authors, have reported insufficient drug absorption from the ABH PLO gel. Here we hypothesized that the ABH Carbopol gel would provide superior percutaneous absorption of the drugs...
September 12, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37700072/quantitative-determination-of-r-3-hydroxybutyl-r-3-hydroxybutyrate-ketone-ester-and-its-metabolites-beta-hydroxybutyrate-1-3-butanediol-and-acetoacetate-in-human-plasma-using-lc-ms
#11
JOURNAL ARTICLE
Nimishraj Panse, Matthew Halquist, Phillip M Gerk
Ketone ester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) has gained popularity as an exogenous means to achieve ketosis. Regarding its potential as a therapeutic prodrug, it will be necessary to study its pharmacokinetic profile and its proximal metabolites (beta-hydroxybutyrate, 1,3-butanediol, and acetoacetate) in humans. Here we develop and validate two LC-MS methods for quantifying KE and its metabolites in human plasma. The first assay uses a C18 column to quantitate ketone ester, beta-hydroxybutyrate, and 1,3-butanediol, and the second assay uses a hydrophilic interaction liquid chromatography (HILIC) column for the quantitation of acetoacetate...
September 12, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37700066/deep-eutectic-solvents-based-on-l-arginine-and-2-hydroxypropyl-%C3%AE-cyclodextrin-for-drug-carrier-and-penetration-enhancement
#12
JOURNAL ARTICLE
Jianhua Lv, Pan Wu, Yaru Fang, Wenchang Zhang, Dongwen Liu, Mi Wu, Lei Shang, Huaiguo Li, Yan Zhao
By selecting L-arginine as the hydrogen bond acceptor (HBA) and 2-hydroxypropyl-β-cyclodextrin (2HPβCD) as the hydrogen bond donor (HBD), deep eutectic solvents (DESs) with various water content were prepared at the 4:1 mass ratio of L-arginine to 2HPβCD with 40 to 60% of water, and were studied for its application in transdermal drug delivery system (TDDS). The hydrogen bond networks and internal chemistry structures of the DESs were measured by attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1 H-nuclear magnetic resonance spectroscopy (1 H-NMR), which demonstrated the successful synthesis of DESs...
September 12, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37697172/a-traditional-chinese-medicine-tcm-inspired-doxorubicin-resistance-reversing-strategy-preparation-characterization-and-application-of-a-co-loaded-ph-sensitive-liposome
#13
JOURNAL ARTICLE
Xueyan Zhang, Hua Liu, Na Li, Jiayang Li, Meng Wang, Xiaoliang Ren
In this study, nano-strategy for combined medication of active compounds from traditional Chinese medicine herbs was proposed to achieve the synergistic effects of inhibiting the doxorubicin (DOX) resistance, reducing the cardio-toxicity, and improving the treatment efficacy simultaneously. Dihydroartemisinin (DHA) and tetrandrine (TET) were co-delivered for the first time to treat DOX resistance of breast cancer with multi-pathway mechanism. Tumor micro-environment sensitivity prescription was adopted to enhance the reversal effect of DOX resistance nearly 50 times (resistance index, RI was 46...
September 11, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37697137/curcumin-fusidic-acid-bitherapy-loaded-mixed-micellar-nanogel-for-acne-vulgaris-treatment-in-vitro-and-in-vivo-studies
#14
JOURNAL ARTICLE
Raghda Abdel-Monem, Eman S El-Leithy, Ahmed Adel Alaa-Eldin, Rania S Abdel-Rashid
The combination of herbal drugs with a topical antibacterial for managing a chronic disease like acne vulgaris has emerged lately to settle side effects and bacterial multidrug resistance. Mixed micelles (MMs) incorporated into nanogel were explored for hybrid delivery of curcumin (Cur) and fusidic acid (FA) combination presenting a multi-strategic treatment. Curcumin-fusidic acid-loaded mixed micelles (Cur-FA-MMs) were assessed for size, surface charge, compatibility, in vitro release, and encapsulation. The selected formula was further loaded into nanogel and investigated for viscosity, ex vivo permeation, and in vivo potential...
September 11, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37697085/exploring-sorafenib-and-simvastatin-combination-for-ferroptosis-induced-cancer-treatment-cytotoxicity-screening-in-vivo-efficacy-and-safety-assessment
#15
JOURNAL ARTICLE
Kaushik Kuche, Vivek Yadav, Meet Patel, Rohan Ghadi, Sanyog Jain
Ferroptosis, a pathway dependent on oxygen and iron catalysts, holds promise as a therapeutic approach for cancer treatment due to its manageable regulation, direct control, and immunogenic properties. The sensitivity of cancer cells to ferroptosis induction varies based on their metabolic, genetic, and signalling pathways, prompting the use of combination therapy. In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity...
September 11, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37658977/development-and-in-vitro-evaluation-of-crizotinib-loaded-lipid-polymer-hybrid-nanoparticles-using-box-behnken-design-in-non-small-cell-lung-cancer
#16
JOURNAL ARTICLE
Pelinsu Korucu Aktas, Ipek Baysal, Samiye Yabanoglu-Ciftci, Betul Arica
The goal of the study was to produce, optimize, characterize, and compare crizotinib-loaded lipid-polymer hybrid nanoparticles (CL-LPHNPs), representing a novel contribution to the existing literature, and to determine their anticancer activity in non-small cell lung cancer cells (NSCLC). Box-Behnken design was used to investigate the effect of three independent variables: polymer amount (X1 ), soy phosphatidylcholine (X2 ), and DSPE-PEG (X3 ), on three responses: particle size (Y1 ), polydispersity index (Y2 ), and zeta potential (Y3 )...
September 2, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37658972/nanovesicular-mediated-intranasal-drug-therapy-for-neurodegenerative-disease
#17
REVIEW
Shalu Singh, Rahul Shukla
Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's, amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant concerns of global health. Formulation-related issues, physiological and anatomical barriers, post-administration obstacles, physical challenges, regulatory limitations, environmental hurdles, and health and safety issues have all hindered successful delivery and effective outcomes despite a variety of treatment options. In the current review, we covered the intranasal route, an alternative strategic route targeting brain for improved delivery across the BBB...
September 2, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37639081/quality-by-design-based-development-of-rivaroxaban-loaded-liquisolid-compact-tablets-with-improved-biopharmaceutical-attributes
#18
JOURNAL ARTICLE
Pranav Shah, Heta Desai, Bhavin Vyas, Manisha Lalan, Madhur Kulkarni
Rivaroxaban (RXN) finds use in the management of pulmonary embolism and deep vein thrombosis. Its poor solubility (5-7 µg/mL) and P-gp-mediated efflux from intestinal lining limits the oral application of RXN. This work assessed the impact of liquisolid compact technique in augmenting the solubility and bioavailability of RXN. PEG 400, Avicel PH 200, and Aerosil 200 were used as non-volatile liquid, carrier, and coating material, respectively, to formulate RXN liquid-solid compacts (RXN LSCs). A 32 -factor factorial design was used in the optimisation to assess the impacts of factors (load factor and carrier:coating ratio) on the responses (angle of repose and Q30 min )...
August 28, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37639072/development-of-a-novel-histatin-5-mucoadhesive-gel-for-the-treatment-of-oral-mucositis-in-vitro-characterization-and-in-vivo-evaluation
#19
JOURNAL ARTICLE
Shiva Golshani, Alireza Vatanara, Saeed Balalaie, Zeinab Kadkhoda, Mohammad Abdollahi, Mohsen Amin
Antimicrobial peptides have appeared to be promising candidates for therapeutic purposes due to their broad antimicrobial activity and non-toxicity. Histatin-5 (Hst-5) is a notable salivary antimicrobial peptide that exhibited therapeutic properties in the oral cavity. Oral mucositis is an acute inflammation of the oral cavity, following cancer therapy. The current treatment methods of oral mucositis have low effectiveness. The aim of this study was to design, formulate and characterize a mucoadhesive gel delivery system for Hst-5 usage in the treatment of oral mucositis...
August 28, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/37603110/effects-of-additives-on-the-physical-stability-and-dissolution-of-polymeric-amorphous-solid-dispersions-a-review
#20
REVIEW
Jinghan Li, Yihan Wang, Dongyue Yu
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the solubility of poorly water-soluble drugs. However, achieving both physical stability and dissolution performance in an ASD prepared with a single polymer can be challenging. Therefore, a secondary excipient can be added. In this paper, we review three classes of additives that can be added internally to ASDs: (i) a second polymer, to form a ternary drug-polymer-polymer ASD, (ii) counterions, to facilitate in situ salt formation, and (iii) surfactants...
August 21, 2023: AAPS PharmSciTech
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