journal
https://read.qxmd.com/read/38581672/patient-characteristics-diagnostic-testing-and-initial-treatment-profiles-of-patients-with-connective-tissue-disease-associated-pulmonary-arterial-hypertension-ctd-pah-using-a-japanese-claims-database
#21
JOURNAL ARTICLE
Natsuko Tokushige, Yasuhiro Hayashi, Junichi Omura, Tatsunori Jinnai, Tatsuya Atsumi
OBJECTIVES: To investigate the diagnostic and therapeutic landscape for patients with connective tissue disease (CTD) and CTD-associated pulmonary arterial hypertension (CTD-PAH) in acute-care general hospitals in Japan. METHODS: We conducted a retrospective cohort study by analysing the Medical Data Vision (MDV) database from April 2008 and September 2020. CTD patients who prescribed immunosuppressants were included in cohort 1, and CTD-PAH patients extracted from cohort 1 were included in cohort 2...
April 6, 2024: Modern Rheumatology
https://read.qxmd.com/read/38581664/interferons-dominate-damage-and-activity-in-juvenile-scleroderma
#22
JOURNAL ARTICLE
Hulya Kose, Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Ferdi Ozturk, Sukru Cekic, Ferah Budak, Hayriye Sarıcaoglu, Sara Sebnem Kilic
UNLABELLED: Juvenile scleroderma is a heterogeneous group of diseases associated with sclerotic skin lesions, grouped as juvenile systemic sclerosis systemic sclerosis) and juvenile localized scleroderma. This study aims to measure the cytokine and chemokine levels involved in interferon signaling in patients with juvenile scleroderma and determine their correlation with disease severity. METHOD: Twenty-nine juvenile localized scleroderma five juvenile systemic sclerosis, and nine healthy controls were included in the study...
April 6, 2024: Modern Rheumatology
https://read.qxmd.com/read/38801704/relationship-between-lymphocyte-count-and-risk-of-infection-in-japanese-rheumatoid-arthritis-patients-treated-with-tofacitinib
#23
JOURNAL ARTICLE
Yoshiya Tanaka, Tsutomu Takeuchi, Hernan Valdez, Mark Collinge, Samuel H Zwillich, Shigeyuki Toyoizumi, Kenneth Kwok, Tomohiro Hirose
OBJECTIVES: We characterised changes in absolute lymphocyte counts (ALCs) and lymphocyte subset counts (LSCs), and their relationship to incidence of serious infection events (SIEs) and herpes zoster (HZ) events in Japanese patients with moderate to severe rheumatoid arthritis enrolled in the tofacitinib clinical programme. METHODS: Data included 765 patients receiving tofacitinib in Phase 2, Phase 3, and long-term extension studies. ALCs/LSCs and incidence rates (patients with events/100 patient-years) of SIEs and HZ were analysed over 75 months...
April 1, 2024: Modern Rheumatology
https://read.qxmd.com/read/38590079/the-association-of-beh%C3%A3-et-s-disease-on-the-quality-of-life-for-children-and-their-parents
#24
JOURNAL ARTICLE
Nihal Şahin, Yunus E Bayrak, Hafize E Sönmez, Betül Sözeri
Background and Aim Chronic diseases profoundly impact people's quality of life (QoL). Behçet's Disease (BD) is a multisystemic chronic disease characterized by vasculitis of various vessels. We aimed to assess QoL in pediatric BD patients and their parents. Methods We included pediatric BD patients meeting the pediatric BD classification criteria in a cross-sectional study conducted from June to December 2022. We recorded patients' clinical characteristics and assessed their QoL using PedsQL. Parents' QoL was evaluated using WHOQOL-Bref...
April 1, 2024: Modern Rheumatology
https://read.qxmd.com/read/38619380/safety-and-effectiveness-of-certolizumab-pegol-in-japanese-patients-with-rheumatoid-arthritis-up-to-3-year-results-from-a-postmarketing-surveillance-study
#25
JOURNAL ARTICLE
Hideto Kameda, Keiichiro Nishida, Toshihiro Nanki, Akira Watanabe, Yukiya Oshima, Shigeki Momohara
OBJECTIVES: To report up to 3-year safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a postmarketing surveillance study. METHODS: Patients enrolled previously completed 24 weeks of CZP in the 24-week postmarketing surveillance study. Adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes were 28-joint Disease Activity Score with erythrocyte sedimentation rate and European Alliance of Associations for Rheumatology response...
March 29, 2024: Modern Rheumatology
https://read.qxmd.com/read/38564330/risk-factors-for-serious-infections-and-infection-related-mortality-in-patients-with-microscopic-polyangiitis-multicentre-reveal-cohort-study
#26
JOURNAL ARTICLE
Atsushi Manabe, Keiichiro Kadoba, Ryosuke Hiwa, Takuya Kotani, Mikihito Shoji, Mirei Shirakashi, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Wataru Yamamoto, Ayana Okazaki, Shogo Matsuda, Takaho Gon, Ryu Watanabe, Motomu Hashimoto, Akio Morinobu
OBJECTIVE: Infections are a critical concern for patients with microscopic polyangiitis (MPA). This study aimed to identify the risk factors associated with serious infections (SIs) and infection-related mortality in patients with MPA, as well as the effect of glucocorticoid (GC) dose tapering on these outcomes. METHODS: This multicentre, retrospective, and observational study utilised data from a cohort of patients with MPA in Japan [Registry of Vasculitis Patients to Establish REAL World Evidence (REVEAL) cohort]...
March 29, 2024: Modern Rheumatology
https://read.qxmd.com/read/38482606/significant-association-of-hla-a26-with-uveitis-and-gastrointestinal-involvement-in-patients-with-beh%C3%A3-et-s-disease-in-a-multicenter-study
#27
JOURNAL ARTICLE
Tomoya Nakajima, Hideaki Tsuji, Ryuta Inaba, Rintaro Saito, Keisuke Nishimura, Akio Morinobu
OBJECTIVES: Specific HLA haplotypes are associated with Behçet's disease (BD). Because the effects of HLA-A26 and its combination with HLA-B51 on organ involvement in BD have not been well demonstrated, we aimed to examine them. METHODS: This multicenter, cross-sectional, observational study enrolled patients with BD who visited Kyoto University Hospital between 2018 and 2021 or Kurashiki Central Hospital between 2006 and 2016 (n = 200). Disease severity was evaluated using the Krause score...
March 14, 2024: Modern Rheumatology
https://read.qxmd.com/read/38471963/prevalence-of-high-and-low-serum-alkaline-phosphatase-levels-and-the-associated-factors-in-patients-with-rheumatoid-arthritis-results-from-the-iorra-cohort-study
#28
JOURNAL ARTICLE
Takefumi Furuya, Eisuke Inoue, Eiichi Tanaka, Hisashi Yamanaka, Masayoshi Harigai
No abstract text is available yet for this article.
March 13, 2024: Modern Rheumatology
https://read.qxmd.com/read/38459899/correction-to-long-term-safety-and-efficacy-of-belimumab-in-japanese-patients-with-sle-a-7-year-open-label-continuation-study
#29
(no author information available yet)
No abstract text is available yet for this article.
March 9, 2024: Modern Rheumatology
https://read.qxmd.com/read/38450776/disease-modifying-anti-rheumatic-drug-selection-in-japanese-patients-with-rheumatoid-arthritis-treated-with-biologics-or-jak-inhibitors-without-methotrexate-a-retrospective-hospital-based-administrative-claims-database-study
#30
JOURNAL ARTICLE
Naohisa Miyakawa, Katsuki Tsuritani, Bruno Casaes Teixeira, Keishi Fujio
OBJECTIVES: We evaluated the medication selection and clinical characteristics of rheumatoid arthritis (RA) patients who started treatment with/without methotrexate (using biologic disease-modifying antirheumatic drugs or Janus kinase inhibitors [JAKi] instead) in Japan. METHODS: Using a Japanese hospital-based administrative claims database, RA patients who received treatment (abatacept, interleukin-6 receptor inhibitor [IL-6Ri], tumor necrosis factor inhibitor, or JAKi) between 1/January/2015 and 31/December/2019 were enrolled...
March 7, 2024: Modern Rheumatology
https://read.qxmd.com/read/38450541/osteoporosis-and-osteopenia-in-patients-with-psoriatic-arthritis-a-single-center-retrospective-study
#31
JOURNAL ARTICLE
Kenji Takami, Mari Higashiyama, Shigeyoshi Tsuji
OBJECTIVE: It is known that fracture risk is increased in patients with psoriatic arthritis (PsA), however, there is no consensus on the association with osteoporosis. The purpose of this study was to elicit the rate of osteoporosis and the risk factors of osteoporosis in patients with PsA at our institution. METHODS: The data in this study were extracted from 163 patients with PsA. Osteoporosis and osteopenia were defined based on the WHO definition. Osteoporosis was also diagnosed when a fragility vertebral compression fracture was observed...
March 7, 2024: Modern Rheumatology
https://read.qxmd.com/read/38564322/cluster-analysis-defines-four-groups-of-japanese-patients-with-adult-onset-still-s-disease
#32
JOURNAL ARTICLE
Yuri Shirahama, Ayako Kokuzawa, Yusuke Yamauchi, Yohei Kirino, Hideto Nagai, Yasushi Inoue, Toshiyuki Ota, Yutaka Chifu, Hiroki Mitoma, Mitsuteru Akahoshi, Mariko Sakai, Akihito Maruyama, Akihide Ohta, Masahiro Iwamoto, Yoshifumi Tada
OBJECTIVES: To define groups and characterize differences in the prognosis of patients with adult-onset Still's disease (AOSD). METHODS: We performed a retrospective cohort study. Patients with AOSD were grouped using hierarchical unsupervised cluster analysis according to age, sex, clinical features, and laboratory data. The primary endpoints were overall survival and drug-free remission rate. RESULTS: A total of 153 patients with AOSD were placed into four clusters...
March 6, 2024: Modern Rheumatology
https://read.qxmd.com/read/38491996/comparison-of-effectiveness-of-methotrexate-in-patients-with-late-onset-versus-younger-onset-rheumatoid-arthritis-real-world-data-from-an-inception-cohort-in-japan-nicer-j
#33
JOURNAL ARTICLE
Shuji Asai, Mochihito Suzuki, Ryota Hara, Yuji Hirano, Satomi Nagamine, Tetsuya Kaneko, Takahito Suto, Tadashi Okano, Yutaka Yoshioka, Makoto Hirao, Hiroki Wakabayashi, Takayoshi Fujibayashi, Tatsuo Watanabe, Yuya Takakubo, Hajime Ishikawa, Yoshihisa Nasu, Toki Takemoto, Takefumi Kato, Eiji Torikai, Kensuke Koyama, Hideki Takagi, Toshifumi Fujiwara, Yasumori Sobue, Yoshifumi Ohashi, Tsuyoshi Nishiume, Kenya Terabe, Masayo Kojima, Toshihisa Kojima, Shiro Imagama
OBJECTIVE: To compare the effectiveness of methotrexate (MTX) as initial therapy in patients with late-onset and younger-onset rheumatoid arthritis (LORA and YORA). METHODS: Of 114 patients with YORA and 96 patients with LORA, defined as RA occurring at ≥65 years of age, enrolled in a multicentre RA inception cohort study, 71 and 66 patients who had been followed up to 6 months after starting MTX treatment were included in this study. RESULTS: Proportions of patients on MTX treatment at 6 months were 96% and 92% in the YORA and LORA groups, respectively...
March 6, 2024: Modern Rheumatology
https://read.qxmd.com/read/38445746/systematic-review-for-the-treatment-of-older-rheumatoid-arthritis-patients-informing-the-2024-update-of-the-japan-college-of-rheumatology-clinical-practice-guidelines-for-the-management-of-rheumatoid-arthritis
#34
JOURNAL ARTICLE
Takahiko Sugihara, Yutaka Kawahito, Yuko Kaneko, Eiichi Tanaka, Ryo Yanai, Nobuyuki Yajima, Masayo Kojima, Masayoshi Harigai
OBJECTIVES: To update an evidence base informing the 2024 JCR clinical practice guidelines (CPGs) for the management of rheumatoid arthritis (RA) in older adults. METHODS: Four clinical questions (CQs) regarding efficacy and safety of drug treatment were evaluated, with CQ1 addressing methotrexate (MTX), CQ2 biological disease-modifying antirheumatic drugs (bDMARDs), CQ3 Janus kinase (JAK) inhibitors, and CQ4 glucocorticoids (GCs). Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system...
March 6, 2024: Modern Rheumatology
https://read.qxmd.com/read/38516944/comparison-of-safety-and-effectiveness-between-etanercept-biosimilar-lbec0101-and-reference-in-patients-with-rheumatoid-arthritis-in-real-world-data-using-the-kurama-cohort
#35
JOURNAL ARTICLE
Tomoya Kawakami, Sho Masui, Akira Onishi, Hideo Onizawa, Takayuki Fujii, Kosaku Murakami, Koichi Murata, Masao Tanaka, Takashi Shimada, Shunsaku Nakagawa, Shuichi Matsuda, Akio Morinobu, Tomohiro Terada, Atsushi Yonezawa
OBJECTIVES: Biosimilars are anticipated to be widely used in the treatment of rheumatoid arthritis (RA), owing to their cost efficiency; LBEC0101 was the first etanercept (ETN) biosimilar approved in Japan. However, there are limited real-world data comparing its safety and effectiveness with those of a reference product. METHODS: This study used data from the Kyoto University Rheumatoid Arthritis Management Alliance cohort, including patients with RA who received ETN therapy-ETN reference product (ETN-RP) or LBEC0101-between 2015 and 2021...
March 5, 2024: Modern Rheumatology
https://read.qxmd.com/read/38441892/pregnancy-related-issues-from-the-perspective-of-patients-with-inflammatory-rheumatic-diseases-results-from-a-survey-of-the-members-of-the-national-association-for-inflammatory-rheumatic-diseases
#36
JOURNAL ARTICLE
Atsuko Murashima, Kayoko Kaneko, Hiroshi Oguro, Yukiko Mori, Mikako Goto, Shuko Mishima, Tatsuhiko Anzai, Kunihiko Takahashi
OBJECTIVES: This study aimed to clarify the issues related to pregnancy in patients with inflammatory rheumatic diseases (RDs) and to provide useful information for developing medical services from patients' perspectives. METHODS: A survey involving approximately 5,000 members of the Patients Association for Collagen Vascular Diseases Japan was conducted using a questionnaire that was sent and returned by mail. The questionnaire items included age at the time of the survey, types of RDs, association of RDs with pregnancy/childbirth outcomes, and pregnancy-related supports and hindrances...
March 5, 2024: Modern Rheumatology
https://read.qxmd.com/read/38441307/evaluation-of-medication-withdrawal-in-patients-with-non-systemic-juvenile-idiopathic-arthritis-in-japan-using-a-web-based-survey
#37
JOURNAL ARTICLE
Takasuke Ebato, Takayuki Kishi, Keiji Akamine, Tomo Nozawa, Tomoyuki Imagawa, Yuki Bando, Takako Miyamae
OBJECTIVE: Although treatments for juvenile idiopathic arthritis (JIA) have seen considerable advancements, there remains a lack of clear guidelines on withdrawing medications. This study aimed to investigate the current strategies for discontinuing non-systemic JIA treatment. METHODS: A web-based questionnaire was distributed to Pediatric Rheumatology Association of Japan members. RESULTS: According to 126 responses, the most significant factors influencing JIA treatment tapering were the duration of clinically inactive disease, medication toxicity, and a history of arthritis flares...
March 5, 2024: Modern Rheumatology
https://read.qxmd.com/read/38441253/lncrna-oip5-as1-promotes-mitophagy-to-alleviate-osteoarthritis-by-up-regulating-ppar-%C3%AE-to-activate-ampk-akt-mtor-pathway
#38
JOURNAL ARTICLE
Zhilu Sun, Jie Tang, Ting You, Bihong Zhang, Yu Liu, Jing Liu
BACKGROUND: Osteoarthritis (OA) is the most common chronic joint degenerative disease. Mitophagy is closely related to OA pathogenesis. Herein, we investigated the role of lncRNA OIP5-AS1 in regulating mitophagy during OA. METHODS: RT-qPCR and Western blotting were utilized to analyze gene and protein levels. RIP and RNA pull down verified the relationship between OIP5-AS1, FUS and PPAR-γ. CCK-8 assay detected cells viability. ELISA evaluated the secretion of inflammatory cytokines...
March 5, 2024: Modern Rheumatology
https://read.qxmd.com/read/38511322/consensus-statement-on-the-management-of-late-onset-rheumatoid-arthritis
#39
JOURNAL ARTICLE
Masayo Kojima, Takahiko Sugihara, Yutaka Kawahito, Toshihisa Kojima, Yuko Kaneko, Hajime Ishikawa, Asami Abe, Kazuo Matsui, Shintaro Hirata, Mitsumasa Kishimoto, Eiichi Tanaka, Akio Morinobu, Motomu Hashimoto, Isao Matsushita, Toshihiko Hidaka, Toshihiro Matsui, Keiichiro Nishida, Shuji Asai, Hiromu Ito, Ryozo Harada, Masayoshi Harigai
OBJECTIVES: Late-onset rheumatoid arthritis (LORA), which has been increasing in recent years, lacks evidence for initial treatment. Japanese rheumatology experts recognized this gap and addressed it by developing consensus statements on the first clinical application of LORA. METHODS: These statements were created following an introductory discussion about treatment fundamentals, which included a review of existing literature and cohort data. The steering committee created a draft, which was refined using a modified Delphi method that involved panel members reaching a consensus...
February 28, 2024: Modern Rheumatology
https://read.qxmd.com/read/38430527/short-term-efficacy-and-limitations-of-foot-care-in-patients-with-rheumatoid-arthritis
#40
JOURNAL ARTICLE
Koichiro Yano, Katsunori Ikari, Emiko Shiraki, Mitsuki Midorikawa, Masami Maeda, Kazuya Kubo, Yasushi Kuwahara, Ken Okazaki
OBJECTIVES: Foot and ankle impairments are major issues in patients with rheumatoid arthritis (RA). Foot deformities often lead to skin disorders, such as callosities, ingrown toenails, and interdigital tinea pedis. This study was aimed at investigating the efficacy and limitations of foot care by experts in patients with RA. METHODS: Thirty-one patients with RA who began receiving foot care from nurses at our institution between September 2020 and February 2023 were included...
February 27, 2024: Modern Rheumatology
journal
journal
35092
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.