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Modern Rheumatology

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https://read.qxmd.com/read/31084231/development-and-exacerbation-of-pulmonary-non-tuberculous-mycobacterial-infection-in-patients-with-systemic-autoimmune-rheumatic-diseases
#1
Sayaka Takenaka, Takehisa Ogura, Hisaji Oshima, Keisuke Izumi, Ayako Hirata, Hideki Ito, Kennosuke Mizushina, Yuki Inoue, Takaharu Katagiri, Norihide Hayashi, Hideto Kameda
OBJECTIVES: To examine the development and exacerbation of pulmonary non-tuberculous mycobacterial (NTM) infection in patients with systemic autoimmune rheumatic diseases (SARD). METHODS: We conducted a case-control study. Seventeen of 7013 patients with SARD fulfilling the criteria for pulmonary NTM infection were enrolled in the NTM group. The control group was matched for age, sex, and SARD at a ratio of 2:1. RESULTS: Eight patients with rheumatoid arthritis, 4 with systemic vasculitis, 3 with Sjögren's syndrome, and 1 each with dermatomyositis and systemic lupus erythematosus were included in the NTM group...
May 14, 2019: Modern Rheumatology
https://read.qxmd.com/read/31062630/correction
#2
(no author information available yet)
No abstract text is available yet for this article.
May 7, 2019: Modern Rheumatology
https://read.qxmd.com/read/30964353/correction
#3
(no author information available yet)
No abstract text is available yet for this article.
April 9, 2019: Modern Rheumatology
https://read.qxmd.com/read/30947583/comparison-of-median-nerve-stiffness-with-and-without-rheumatoid-arthritis-by-ultrasound-real-time-tissue-elastography-a-propensity-score-matching-study
#4
Shohei Anno, Tadashi Okano, Kenji Mamoto, Yuko Sugioka, Setsuko Takeda, Ayumi Hashimoto, Emi Yamashita, Rika Morinaka, Hatsue Ueda, Kentaro Inui, Tatsuya Koike, Hiroaki Nakamura
OBJECTIVES: This study aimed to compare median nerve stiffness measured by ultrasound real-time tissue elastography in patients with and without rheumatoid arthritis (RA and non-RA groups, respectively). METHODS: Altogether, 402 hands of 201 RA group and 222 hands of 111 non-RA group were included in the study. Ultrasonography was performed to evaluate the circumference, cross-sectional area (CSA) and strain ratio as an elasticity of the median nerve at the inlet level of the carpal tunnel and the proximal portion of the carpal tunnel inlet...
April 5, 2019: Modern Rheumatology
https://read.qxmd.com/read/30942638/expressions-of-circadian-clock-genes-represent-disease-activities-of-ra-patients-treated-with-biological-dmards
#5
Kenta Kaneshiro, Kohsuke Yoshida, Kanta Morii, Yuto Oketani, Koto Uchida, Arisa Yaekura, Ikumi Okumura, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Yoshitada Sakai, Akira Hashiramoto
OBJECTIVE: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. Clock genes have been reported to affect on the pathogenesis of RA, however, the detailed relation between clock genes and disease activities of RA has remained unclear. METHODS: In this study, 15 RA patients treated with bDMARDs were enrolled (TNF inhibitor, 5; IL-6 inhibitor, 5; CTLA4-IgG, 5)...
April 3, 2019: Modern Rheumatology
https://read.qxmd.com/read/30938551/clinical-features-and-human-t-cell-leukemia-virus-type-1-htlv-1-proviral-load-in-htlv-1-positive-patients-with-rheumatoid-arthritis-baseline-data-in-a-single-center-cohort-study
#6
Katsumi Eguchi, Masako Iwanaga, Kaoru Terada, Toshiyuki Aramaki, Yoshiko Tuji, Shouta Kurushima, Kanako Kojima, Kazuhiko Arima, Naoki Iwamoto, Kunihiko Ichinose, Atushi Kawakami, Naoyuki Hirakata, Yukitaka Ueki
OBJECTIVE: Recently, Human T-cell leukemia virus type-1 proviral load (HTLV-1 PVL) has been evaluated as an important predictor of adult T-cell leukemia/lymphoma (ATL) in HTLV-1 carriers. We aimed to evaluate whether HTLV-1 PVL is also important for the development of ATL among HTLV-1-positive patients with rheumatoid arthritis (RA). METHODS: We established a cohort of 82 HTLV-1-positive RA patients between 2017 - 2018. Of those, 27 (32.9%) were treated with biological disease-modifying anti-rheumatic drugs (bDMARDs) with/without methotrexate...
April 2, 2019: Modern Rheumatology
https://read.qxmd.com/read/30938197/correction
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2, 2019: Modern Rheumatology
https://read.qxmd.com/read/30932727/pharmaceutical-immunoglobulins-reduce-neutrophil-extracellular-trap-formation-and-ameliorate-the-development-of-mpo-anca-associated-vasculitis
#8
Ryo Uozumi, Risa Iguchi, Sakiko Masuda, Yuka Nishibata, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu
Objectives Intravenous immunoglobulin (IVIG) therapy is effective against some autoimmune diseases. Although its efficacy on peripheral neuropathy due to eosinophilic granulomatosis with polyangiitis-one of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis (MPO-AAV)-has been established, that on other MPO-AAV remains undetermined. We examined the effects of pharmaceutical immunoglobulins on the formation of neutrophil extracellular traps (NETs) related to MPO-ANCA production and the development of MPO-AAV...
April 1, 2019: Modern Rheumatology
https://read.qxmd.com/read/30929541/association-between-preexisting-lung-involvements-and-the-risk-of-diffuse-alveolar-hemorrhage-in-patients-with-microscopic-polyangiitis-a-multi-center-retrospective-cohort-study
#9
Takashi Kida, Tadashi Tanaka, Isao Yokota, Keiichi Tamagaki, Tomoya Sagawa, Masatoshi Kadoya, Takahiro Yamada, Kazuki Fujioka, Makoto Wada, Masataka Kohno, Noriya Hiraoka, Atsushi Omoto, Wataru Fukuda, Yutaka Kawahito
OBJECTIVES: To identify the factors associated with the risk of diffuse alveolar hemorrhage (DAH) in patients with microscopic polyangiitis (MPA), focusing on other preexisting lung involvements such as interstitial lung disease (ILD) and airway disease. METHODS: In this retrospective cohort study, we analyzed consecutive patients with myeloperoxidase-antineutrophil cytoplasmic antibody-positive MPA who had undergone chest computed tomography (CT) before starting treatment between 2006 and 2016...
April 1, 2019: Modern Rheumatology
https://read.qxmd.com/read/30924705/danaparoid-is-effective-and-safe-for-patients-with-obstetric-antiphospholipid-syndrome
#10
Hiroyuki Yoshihara, Mayumi Sugiura-Ogasawara, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki
OBJECTIVE: The objective is to evaluate whether danaparoid is effective in improving the live birth rate in patients with obstetric antiphospholipid syndrome (oAPS). METHODS: This prospective study included 91 pregnancies of 60 patients with oAPS diagnosed according to criteria of the International Congress on APS. Live birth rates, adverse pregnancies and perinatal outcomes were compared among patients treated with danaparoid and low dose aspirin (danaparoid group, LDA), unfractionated heparin (UFH) and LDA (UFH group) and LDA and/or prednisolone (LDA group)...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30924699/effects-of-range-of-motion-exercise-of-the-metatarsophalangeal-joint-from-2-weeks-after-joint-preserving-rheumatoid-forefoot-surgery
#11
Makoto Hirao, Hideki Tsuboi, Naotaka Tasaki, Kohei Kushimoto, Kosuke Ebina, Hideki Yoshikawa, Jun Hashimoto
OBJECTIVES: Joint-preserving rheumatoid forefoot surgery improves clinical outcomes, but postoperative range of motion (ROM) of the metatarsophalangeal (MTP) joint remains an issue. The objective of this study was to evaluate the effect of ROM exercise from the early period after lesser toe MTP joint-preserving surgery Methods: A retrospective, observational study of 22 rheumatoid arthritis patients who underwent modified metatarsal shortening offset osteotomy was completed. Lesser toe scales were administered using the Japanese Society for Surgery of the Foot (JSSF) standard rating system, and the maximum distance of continuous walking was checked to evaluate clinical outcomes...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30924382/measurement-of-equivalence-between-the-web-and-paper-versions-of-the-japanese-orthopaedic-association-hip-disease-evaluation-questionnaire
#12
Yasuhiko Takegami, Taisuke Seki, Yoshitoshi Higuchi, Yusuke Osawa, Naoki Ishiguro
OBJECTIVES: Digitised patient-reported outcome may be beneficial for physicians and patients. The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) can only be completed with paper and pencil (pJHEQ). We newly developed a web version of the JHEQ (wJHEQ). This study aimed to determine whether the scores obtained with the wJHEQ are equivalent to those from the pJHEQ, how much the wJHEQ would decrease missing answers, and which JHEQ the participants preferred to use...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30924379/impact-of-comorbidity-rates-of-lumbar-spondylosis-knee-osteoarthritis-and-osteoporosis-on-physical-qol-and-risk-factors-for-poor-physical-qol-in-middle-aged-and-elderly-people
#13
Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Taisuke Seki, Takashi Hamada, Masaaki Machino, Kyotaro Ota, Satoshi Tanaka, Masayoshi Morozumi, Shunsuke Kanbara, Sadayuki Ito, Naoki Ishiguro, Yukiharu Hasegawa
PURPOSE: To examine effects of combined osteoporosis (P), knee osteoarthritis (K-OA), and lumbar spondylosis (L-OA) on quality of life (QOL), and identify risk factors for poor QOL. METHODS: 1,021 subjects (440 males, 581 females, mean age: 63.4 years) were prospectively included. Osteoporosis (%YAM ≤70%), K-OA (Kellgren-Lawrence grade ≥2), and L-OA (Nathan class ≥3) were defined. Subjects were divided into groups 0 to 3 based on the number of comorbid diseases, and into groups P, K, and L (one disease), PK, PL, and KL (two diseases), and PKL (three diseases)...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30924376/recognition-of-alpha-mannan-by-dectin-2-is-essential-for-onset-of-kawasaki-disease-like-murine-vasculitis-induced-by-candida-albicans-cell-wall-polysaccharide
#14
Toshiaki Oharaseki, Yuki Yokouchi, Yasunori Enomoto, Wakana Sato, Kenichi Ishibashi, Noriko Miura, Naohito Ohno, Kei Takahashi
OBJECTIVES: Using a murine model of systemic Kawasaki disease (KD)-like vasculitis induced by Candida albicans cell-wall-derived mannan•β-glucan•protein complexes, the objective was to elucidate the relationships of β-glucan receptor dectin-1 (D1) and α-mannan receptor dectin-2 (D2) to the onset of that vasculitis. METHODS: The incidence and histological severity of vasculitis were compared among mice lacking the genes for D1 or D2 (i.e., D1-/- and D2-/- ) and wild-type (WT) mice...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30922195/high-melatonin-levels-are-related-to-spinal-ossification-in-patients-with-ankylosing-spondylitis
#15
Yanshan Li, Xiaomeng Cui, Zunzhong Li, Qian Jia, Li Jiang, Zhenchun Zhang, Qing Lu, Jibo Wang, Lindi Jiang
OBJECTIVES: To investigate associations of serum melatonin with spinal ossification and cytokines in ankylosing spondylitis (AS). METHODS: Serum was obtained from 52 AS patients and 25 healthy controls. Melatonin was measured by ELISA kit; Bone morphogenetic protein (BMP)-2, dickkopf-related protein (Dkk)-1, IL-1β, IL-6, IL-17 and TNF-α concentrations were assayed using Luminex multiplex bead system. Osteocalcin and β isomer of C-terminal telopeptide of type I collagen (β-CTX) was measured using electrochemiluminescence immunoassay...
March 29, 2019: Modern Rheumatology
https://read.qxmd.com/read/30912459/correction
#16
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2019: Modern Rheumatology
https://read.qxmd.com/read/30880555/the-correlation-between-interleukin-34-and-bone-erosion-under-ultrasound-in-rheumatoid-arthritis
#17
Na Li, Li Jiang, Yehua Cai, Jia Yan Liu, Tianyi Zhao, Ning Kong, Yiyun Yu, Dan Dan Xuan, Hejian Zou, Yu Xue, Weiguo Wan
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthropathy characterized by excessive synovial hyperplasia and progressive joint destruction. Pro-inflammatory cytokines play major roles in the regulation of synovial inflammation. The contribution of interleukin-34 (IL-34) in RA pathogenesis has been strongly suggested in clinical studies. AIM: To investigate the correlation between plasma IL-34 and disease parameters in RA patients including disease activity score (DAS28), receptor activator of NF-κB ligand (RANKL) concentration, synovitis and bone erosions under ultrasound...
March 17, 2019: Modern Rheumatology
https://read.qxmd.com/read/30843747/differences-of-articular-and-extra-articular-involvement-in-polymyalgia-rheumatica-a-comparison-by-whole-body-fdg-pet-ct
#18
Koichiro Kaneko, Eiichi Suematsu, Tomoya Miyamura, Hisakazu Ishioka
OBJECTIVES: To clarify differences in incidences of articular and extra-articular involvement in patients with polymyalgia rheumatica (PMR) using FDG-PET/CT. METHODS: Twenty PMR patients were enrolled in this retrospective study. We compared frequency, degree, and patterns (diffuse or non-diffuse) of abnormal FDG accumulation in the proximal and distal articular structures (PAS, DAS), and extra-articular synovial structures (ESS). Regional analyses were performed for the large joints (shoulder, hip, and knee)...
March 7, 2019: Modern Rheumatology
https://read.qxmd.com/read/30836801/radiographic-and-clinical-outcomes-following-etanercept-monotherapy-in-japanese-methotrexate-na%C3%A3-ve-patients-with-active-rheumatoid-arthritis
#19
Tsutomu Takeuchi, Nobuyuki Miyasaka, Ron Pedersen, Noriko Sugiyama, Tomohiro Hirose
OBJECTIVES: Compare outcomes with methotrexate (MTX) or etanercept (ETN) monotherapy in Japanese patients with active rheumatoid arthritis (RA) who were MTX-naïve or with intolerance or inadequate response to prior MTX (MTX-IR). METHODS: Post hoc analysis of a phase 3 study comparing MTX, ETN 10 mg twice weekly, and ETN 25 mg twice weekly in Japanese patients with RA. Disease activity was evaluated using American College of Rheumatology (ACR) scores and 28-joint Disease Activity Score (DAS28), radiographic progression evaluated using van der Heijde's modified Total Sharp Score (mTSS), and functional status evaluated using Health Assessment Questionnaire Disability Index (HAQ-DI)...
March 6, 2019: Modern Rheumatology
https://read.qxmd.com/read/30836050/prevalence-and-clinical-characteristics-of-overactive-bladder-in-systemic-sclerosis
#20
Sei-Ichiro Motegi, Akiko Sekiguchi, Yoshitaka Sekine, Hiroshi Nakayama, Kazuhiro Suzuki, Osamu Ishikawa
OBJECTIVES: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients with OAB. METHODS: OAB was diagnosed by OAB symptom score (OABSS) in 104 Japanese SSc patients (93 women and 11 men). Differential diseases of OAB was conducted by urologists...
March 5, 2019: Modern Rheumatology
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