journal
https://read.qxmd.com/read/37740147/resting-and-re-emergent-jaw-tremor-as-the-presenting-symptom-of-parkinson-s-disease
#1
LETTER
Halil Onder, Selcuk Comoglu
No abstract text is available yet for this article.
September 23, 2023: Neurological Sciences
https://read.qxmd.com/read/37736852/treatment-modalities-for-infantile-spasms-current-considerations-and-evolving-strategies-in-clinical-practice
#2
REVIEW
Payton P Hollenshead, Corrie N Jackson, Jordan V Cross, Taylor E Witten, Ahmed I Anwar, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye
Infantile spasms, newly classified as infantile epileptic spasm syndrome (IESS), occur in children under 2 years of age and present as an occur as brief, symmetrical, contractions of the musculature of the neck, trunk, and extremities. When infantile spasms occur with a concomitant hypsarrhythmia on electroencephalogram (EEG) and developmental regression, it is known as West Syndrome. There is no universally accepted mainstay of treatment for this condition, but some options include synthetic adrenocorticotropic hormone (ACTH), repository corticotropin injection (RCI/Acthar Gel), corticosteroids, valproic acid, vigabatrin, and surgery...
September 22, 2023: Neurological Sciences
https://read.qxmd.com/read/37736851/alternating-unilateral-blepharospasm-with-apraxia-of-eyelid-opening-in-a-patient-with-progressive-supranuclear-palsy
#3
LETTER
Halil Onder, Selcuk Comoglu
No abstract text is available yet for this article.
September 22, 2023: Neurological Sciences
https://read.qxmd.com/read/37735306/a-rare-case-of-listeria-rhombencephalitis-with-a-sudden-onset-and-unusual-brain-mri-features
#4
LETTER
Federica Garrì, Marco Puthenparampil, Davide Simonato, Francesca Rinaldi, Paolo Gallo
No abstract text is available yet for this article.
September 22, 2023: Neurological Sciences
https://read.qxmd.com/read/37733251/a-review-and-meta-analysis-of-stem-cell-therapies-in-stroke-patients-effectiveness-and-safety%C3%A2-evaluation
#5
REVIEW
L Hovhannisyan, S Khachatryan, A Khamperyan, S Matinyan
PURPOSE: Stem cells have been extensively used during the last decade to improve clinical outcomes after stroke. The dramatic increase in trials in this field has led us to perform a systematic review and meta-analysis to understand the safety, effectiveness, and relative limitations of this type of intervention. METHOD: This review summarizes the current evidence pooled from PubMed (Medline), EMBASE, EBSCOhost, https://clinicaltrials.gov , Scopus (Elsevier), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science (Science Citation Index Expanded) databases for the use of stem cell therapies in stroke patients without combinations with other treatment modalities...
September 21, 2023: Neurological Sciences
https://read.qxmd.com/read/37730935/parkinson-als-with-a-novel-mapt-variant
#6
JOURNAL ARTICLE
Camilla Ferrari, Assunta Ingannato, Sabrina Matà, Silvia Ramat, Luca Caremani, Silvia Bagnoli, Valentina Bessi, Sandro Sorbi, Benedetta Nacmias
The mutations on microtubule associated protein tau (MAPT) gene manifest clinically with behavioural frontotemporal dementia (FTD), parkinsonism, such as progressive supranuclear palsy and corticobasal degeneration, and rarely with amyotrophic lateral sclerosis (ALS). FTD-parkinsonism and FTD-ALS are clinical overlaps included in the spectrum of MAPT mutation's phenotypes. The mutations on MAPT gene cause the dysfunction of tau protein determining its accumulation in neurofibrillary tangles. Recent data describe frequently the co-occurrence of the aggregation of tau protein and α-synuclein in patients with parkinsonism and Parkinson disease (PD), suggesting an interaction of the two proteins in determining neurodegenerative process...
September 20, 2023: Neurological Sciences
https://read.qxmd.com/read/37728663/vessel-wall-enhancement-in-unruptured-infectious-intracranial-aneurysm-using-mr-contrast-enhanced-3dt1-black-blood-sequence
#7
LETTER
Monique Boukobza, Jean-Pierre Laissy
No abstract text is available yet for this article.
September 20, 2023: Neurological Sciences
https://read.qxmd.com/read/37728662/can-the-use-of-telemedicine-facilitate-online-prescribing-for-multiple-sclerosis-treatment
#8
JOURNAL ARTICLE
Giuseppina Miele, Roberta Lanzillo, Luigi Lavorgna
No abstract text is available yet for this article.
September 20, 2023: Neurological Sciences
https://read.qxmd.com/read/37725194/repeated-intravenous-thrombolysis-in-early-recurrent-ischemic-stroke-a-case-report-of-an-elderly-low-weight-female
#9
LETTER
Feifei Chen, Xiangting Chen, Qian Zhang, Siyuan Wen, Changqing Zhou
No abstract text is available yet for this article.
September 19, 2023: Neurological Sciences
https://read.qxmd.com/read/37723372/letter-to-the-editors-development-of-malignant-melanoma-and-squamous-cell-carcinoma-in-a-patient-receiving-fingolimod-treatment
#10
LETTER
Merve Karabas, Nermin Tepe, Figen Esmeli
No abstract text is available yet for this article.
September 19, 2023: Neurological Sciences
https://read.qxmd.com/read/37723371/the-role-of-plasma-neurofilament-light-chain-and-glial-fibrillary-acidic-protein-in-subjective-cognitive-decline-and-mild-cognitive-impairment
#11
JOURNAL ARTICLE
Salvatore Mazzeo, Assunta Ingannato, Giulia Giacomucci, Silvia Bagnoli, Arianna Cavaliere, Valentina Moschini, Juri Balestrini, Carmen Morinelli, Giulia Galdo, Filippo Emiliani, Diletta Piazzesi, Chiara Crucitti, Daniele Frigerio, Cristina Polito, Valentina Berti, Sonia Padiglioni, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
INTRODUCTION AND AIM: NfL and GFAP are promising blood-based biomarkers for Alzheimer's disease. However, few studies have explored plasma GFAP in the prodromal and preclinical stages of AD. In our cross-sectional study, our aim is to investigate the role of these biomarkers in the earliest stages of AD. MATERIALS AND METHODS: We enrolled 40 patients (11 SCD, 21 MCI, 8 AD dementia). All patients underwent neurological and neuropsychological examinations, analysis of CSF biomarkers (Aβ42 , Aβ42 /Aβ40 , p-tau, t-tau), Apolipoprotein E (APOE) genotype analysis and measurement of plasma GFAP and NfL concentrations...
September 19, 2023: Neurological Sciences
https://read.qxmd.com/read/37723370/marchiafava-bignami-disease-mbd-involving-bilateral-handknob-area-neuroimages
#12
JOURNAL ARTICLE
He Li, MinLing Zeng, Wei Tang
Marchiafava-Bignami disease (MBD) is a metabolic disease of the nervous system. It mainly involves the Corpus callosum, but the handknob area is rarely involved. This article reports a MBD case involving the bilateral handknob area. The involvement of the bilateral handknob area contributes to the clinical presentation of convulsions of both hands. Through this case, more clinicians realize the bilateral handknob area involvement in MBD, which is helpful for the identification and diagnosis of MBD. To our knowledge, this is the first report on MBD involving the bilateral handknob area...
September 19, 2023: Neurological Sciences
https://read.qxmd.com/read/37721572/glucocorticoid-dependent-multiple-sclerosis-overlapping-anti-nmda-receptor-encephalitis-a-case-report-and-literature-review-update
#13
REVIEW
Bo Yang, Nengwei Yu
BACKGROUND: Previous studies suggest a relationship between central nervous system inflammatory demyelinating diseases and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Also, the overlap between anti-NMDAR encephalitis and multiple sclerosis (MS) has been reported. However, the pathogenesis and clinical characteristics are still obscure. CASE PRESENTATION: A 33-year-old woman presented with diplopia and sensory ataxia at the onset. The cerebrospinal fluid (CSF) anti-NMDAR antibodies were positive (1:3...
September 18, 2023: Neurological Sciences
https://read.qxmd.com/read/37721571/is-headache-a-risk-factor-for-dementia-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Aurora Cermelli, Fausto Roveta, Lia Giorgis, Silvia Boschi, Alberto Grassini, Fabio Ferrandes, Chiara Lombardo, Andrea Marcinnò, Elisa Rubino, Innocenzo Rainero
OBJECTIVE: In this systematic review and meta-analysis, we critically evaluate available evidence regarding the association between primary headaches and subsequent decline of cognitive function and dementia. BACKGROUND: Recent studies suggested that headache disorders may increase the risk for dementia. However, available studies are conflicting. METHODS: To identify qualifying studies, we searched scientific databases, including Pubmed, Scopus, Web of Science, Science Direct and BMC, screening for relevant papers...
September 18, 2023: Neurological Sciences
https://read.qxmd.com/read/37718350/diagnostic-value-of-plasma-sirt1-levels-and-whole-brain-gray-matter-volume-in-parkinson-s-disease-patients-with-cognitive-impairment
#15
REVIEW
Xiaohuan Li, Dawei Yang, Jianjun Ma, Wei Wei, Jinhua Zheng, Yongyan Fan, Keke Liang, Xiaoxue Shi, Dongsheng Li, Zonghan She, Xuelin Qi, Siyuan Chen
OBJECTIVE: This study was designed to investigate the diagnostic value of plasma SIRT1 levels and whole-brain gray matter (GM) volume in Parkinson's disease (PD) patients with cognitive impairment. METHODS: Automated enzymatic analysis was performed to measure plasma SIRT1 levels in 80 healthy controls and 77 PD patients. Motor symptoms and nonmotor symptoms in PD patients were assessed using the corresponding scales. A Siemens MAGNETOM Prisma 3 T MRI scanner was used to acquire images in 35 of 77 PD patients...
September 18, 2023: Neurological Sciences
https://read.qxmd.com/read/37718349/do-stroke-services-still-show-sex-differences-a-multicenter-study
#16
JOURNAL ARTICLE
Nevine El Nahas, Hossam Shokri, Tamer Roushdy, Noha Dawood, Amr Zaki, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Amal Al Hashmi, Waldemar Brola, Krystian Kosno, Cristian Falup-Pecurariu, Bogdan Ciopleias, Joan Montaner, Soledad Pérez-Sánchez, Manoj Mittal, Kandis Dowd, Annie Banke, Nicholas Vigilante, James Siegler, Atilla Ozcan Ozdemir, Ozlem Aykac, Zehra Uysal Kocabas, Donoband Melgarejo, Analia Cardozo, Lorena Peralta, Hany Aref, Valeria Caso
BACKGROUND: The issue of sex differences in stroke has gained concern in the past few years. However, multicenter studies are still required in this field. This study explores sex variation in a large number of patients and compares stroke characteristics among women in different age groups and across different countries. METHODS: This multicenter retrospective cross-sectional study aimed to compare sexes regarding risk factors, stroke severity, quality of services, and stroke outcome...
September 18, 2023: Neurological Sciences
https://read.qxmd.com/read/37710144/understanding-the-interplay-between-apo-e-polymorphism-and-cognition-in-the-italian-oldest-old-results-from-the-mugello-study
#17
JOURNAL ARTICLE
Gemma Lombardi, Silvia Pancani, Silvia Bagnoli, Federica Vannetti, Benedetta Nacmias, Sandro Sorbi, Francesca Cecchi, Claudio Macchi
INTRODUCTION: Recent data suggest that the deleterious effect on general health and cognition of ε4 allele of Apolipoprotein E (ApoE) observed in the elderly population, may attenuate in extreme aging. This study aimed to describe the ApoE genotype distribution and its relationship with cognition in a group of nonagenarians living in the Mugello area, Italy. MATERIAL AND METHODS: Cognition was evaluated using the Mini-Mental-State-Examination (MMSE). DNA was extracted from blood samples to determine ApoE genotyping...
September 15, 2023: Neurological Sciences
https://read.qxmd.com/read/37707604/current-status-and-value-of-testing-antiphospholipid-antibody-in-patients-with-acute-ischemic-stroke-a-retrospective-single-center-study-in-china
#18
JOURNAL ARTICLE
Qiqi Wang, Guangsong Han, Yuhui Sha, Mingyu Tang, Ziang Pan, Yicheng Zhu, Lixin Zhou, Jun Ni
BACKGROUND AND PURPOSE: Testing for antiphospholipid antibodies (aPL) is useful to determine the cause of ischemic stroke in young and female patients. However, the clinical relevance of aPL in older patients with ischemic stroke remains unclear. We aimed to explore the status and diagnostic value of initial aPL testing in all patients with acute ischemic stroke. METHODS: We retrospectively analyzed patients with acute ischemic stroke who were consecutively hospitalized in our hospital between June 2012 and January 2022 and investigated the factors associated with performing aPL screening in real-world clinical practice...
September 14, 2023: Neurological Sciences
https://read.qxmd.com/read/37702830/regular-assessment-of-serum-vascular-endothelial-growth-factor-levels-to-monitor-poems-syndrome
#19
JOURNAL ARTICLE
Francesco Gentile, Fabrizia Terenghi, Pietro Emiliano Doneddu, Alberto De Lorenzo, Claudia Giannotta, Andrea Giordano, Rita Mazza, Andrea Nozza, Eduardo Nobile-Orazio
BACKGROUND: To investigate the utility of regular serum VEGF (sVEGF) levels assessment in the monitoring of POEMS syndrome. METHODS: We retrospectively reviewed data of 30 patients with POEMS syndrome whose sVEGF was tested regularly every 6 months. sVEGF levels after treatment were measured and correlated with disability (Overall Neuropathy Limitations Scale, ONLS), clinical impairment (measured with the modified Clinical Response Evaluation Scale, mCRES), and relapse-free survival...
September 13, 2023: Neurological Sciences
https://read.qxmd.com/read/37702829/can-mobile-health-apps-with-smartphones-and-tablets-be-the-new-frontier-of-cognitive-rehabilitation-in-older-individuals-a-narrative-review-of-a-growing-field
#20
REVIEW
Maria Grazia Maggio, Antonina Luca, Rocco Salvatore Calabrò, Filippo Drago, Alessandra Nicoletti
INTRODUCTION: A recent interesting field of application of telemedicine/e-health involved smartphone apps. Although research on mHealth began in 2014, there are still few studies using these technologies in healthy elderly and in neurodegenerative disorders. Thus, the aim of the present review was to summarize current evidence on the usability and effectiveness of the use of mHealth in older adults and patients with neurodegenerative disorders. METHODS: This review was conducted by searching for recent peer-reviewed articles published between June 1, 2010 and March 2023 using the following databases: Pubmed, Embase, Cochrane Database, and Web of Science...
September 13, 2023: Neurological Sciences
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