Journals Journal of Microbiology Immuno...

Journal of Microbiology Immunology and Infection
Maria J Citores, Aranzazu Caballero-Marcos, Valentín Cuervas-Mons, Roberto Alonso-Fernández, Javier Graus-Morales, Ana Arias-Milla, Maricela Valerio, Patricia Muñoz, Magdalena Salcedo
PURPOSE: Long-term immunity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunosuppressed patients is not well characterized. We aimed to explore the long-term natural immunity against SARS-CoV-2 in liver transplant (LT) recipients compared to the non-transplanted population (control group). METHODS: Fifteen LT recipients and 15 controls matched according to variables associated with disease severity were included at 12 months following the coronavirus disease 2019 (COVID-19) onset...
March 17, 2023: Journal of Microbiology Immunology and Infection
Ho Yin Pekkle Lam, Wen-Jui Wu, Ting-Ruei Liang, Hui-Chun Li, Kai-Chih Chang, Shih-Yi Peng
BACKGROUND: In most developing or undeveloped countries, patients are often co-infected with multiple pathogens rather than a single pathogen. While different pathogens have their impact on morbidity and mortality, co-infection of more than one pathogen usually made the disease outcome different. Many studies reported the co-infection of Schistosoma with Salmonella in pandemic areas. However, the link or the underlying mechanism in the pathogenesis caused by Schistosoma-Salmonella co-infection is still unknown...
March 13, 2023: Journal of Microbiology Immunology and Infection
Jiun-Ji Lai, L Kristopher Siu, Feng-Yee Chang, Jung-Chung Lin, Ching-Mei Yu, Rui-Xin Wu, Ching-Hsun Wang
BACKGROUND/PURPOSE: The study was to assess the relationship between antibiotic therapy and the outcome in intensive care unit (ICU) patients with Stenotrophomonas maltophilia bloodstream infection (BSI). METHODS: ICU patients with monomicrobial S. maltophilia BSI from January 2004 to December 2019 were included and divided into two groups-those with- and without appropriate antibiotic therapy after BSI-for comparison. The primary outcome was the relationship between appropriate antibiotic therapy and 14-day mortality...
March 13, 2023: Journal of Microbiology Immunology and Infection
Aroon Supramaniam, Yaman Tayyar, Daniel T W Clarke, Gabrielle Kelly, Dhruba Acharya, Kevin V Morris, Nigel A J McMillan, Adi Idris
RNA interference (RNAi) is an emerging and promising therapy for a wide range of respiratory viral infections. This highly specific suppression can be achieved by the introduction of short-interfering RNA (siRNA) into mammalian systems, resulting in the effective reduction of viral load. Unfortunately, this has been hindered by the lack of a good delivery system, especially via the intranasal (IN) route. Here, we have developed an IN siRNA encapsulated lipid nanoparticle (LNP) in vivo delivery system that is highly efficient at targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) lung infection in vivo...
March 8, 2023: Journal of Microbiology Immunology and Infection
Te-Yao Hsueh, Kai-Hsiang Chen, Wang-Da Liu, Chien-Ching Hung
No abstract text is available yet for this article.
March 7, 2023: Journal of Microbiology Immunology and Infection
Ying-Chun Chien, Yu-Tsung Huang, Chun-Hsing Liao, Jung-Yien Chien, Po-Ren Hsueh
No abstract text is available yet for this article.
March 3, 2023: Journal of Microbiology Immunology and Infection
Po-Sung Chen, Ju Lee, Hui-Ping Pan, Yuh-Jyh Lin, Yung-Chieh Lin, Yu-Shan Chang, Yen-Ju Chen, Chia-Liang Yen, Ching-Wei Lin, Chih-An Chen, Chi-Chang Shieh
From 2011, 37 children were referred to a hospital due to low levels of T cell receptor excision circles (TRECs) from newborn screening. Among them, three children were immunologically characterized and followed up to show that postnatal corticosteroid usage may be among the causes of false positivity in TRECs screening.
February 28, 2023: Journal of Microbiology Immunology and Infection
Dengyu Wu, Chenguang Zhang, Yanli Liu, Junhu Yao, Xiaojun Yang, Shengru Wu, Juan Du, Xin Yang
Intestinal microbiota, which contains bacteria, archaea, fungi, protists, and viruses including bacteriophages, is symbiotic and evolves together with humans. The balanced intestinal microbiota plays indispensable roles in maintaining and regulating host metabolism and health. Dysbiosis has been associated with not only intestinal diseases but other diseases such as neurology disorders and cancers. Faecal microbiota transplantation (FMT) or faecal virome or bacteriophage transplantation (FVT or FBT), transfers faecal bacteria or viruses, with a focus on bacteriophage, from one healthy individual to another individual (normally unhealthy condition), and aims to restore the balanced gut microbiota and assist in subduing diseases...
February 26, 2023: Journal of Microbiology Immunology and Infection
Chih-Hao Kuo, Wei-Feng Lin, Chia-Jui Liu, Zhe-Chong Wang, Ting-Yi Liu, Hwei-Ling Peng
BACKGROUND: CpxAR is a two-component system that allows bacteria to reorganize envelope structures in response to extracellular stimuli. CpxAR negatively affects type 1 fimbriae expression in Klebsiella pneumoniae CG43, a hypervirulent strain. The involvement of CpxAR in the regulation of type 3 fimbriae expression was investigated. METHODS: cpxAR, cpxA, and cpxR gene-specific deletion mutants were generated. The deletion effects on the expression of type 1 and type 3 fimbriae were analyzed via measuring the promoter activity, mannose sensitive yeast agglutination activity, biofilm formation, and the production of the major pilins FimA and MrkA respectively...
February 25, 2023: Journal of Microbiology Immunology and Infection
Shu-Huey Chen, James S Miser, Phui-Ly Liew, Bo-Jung Chen, Yen-Lin Liu
No abstract text is available yet for this article.
February 24, 2023: Journal of Microbiology Immunology and Infection
Ya-Chen Yang, Chi-Jung Wu, Ming-I Hsieh, Yi-Ju Wu, Yi-Chun Chen
No abstract text is available yet for this article.
February 24, 2023: Journal of Microbiology Immunology and Infection
Tu-Hsuan Chang, Po-Ren Hsueh, Yu-Tsung Huang, Po-Yu Chen, Hung-Jen Tang, Jong-Min Chen
BACKGROUND: Streptococcus gallolyticus subsp. pasteurianus (SGSP) is a commensal in the intestinal tract and a potential pathogen of neonatal sepsis. During an 11-month period, four consecutive cases of SGSP sepsis were identified in one postnatal care unit (unit A) without evidence of vertical transmission. Therefore, we initiated this study to investigate the reservoir and mode of transmission of SGSP. METHOD: We performed cultures of stool samples from healthcare workers in unit A and unit B (another unit without SGSP sepsis)...
February 24, 2023: Journal of Microbiology Immunology and Infection
Mei Zeng, Jun Xia, Zhiyong Zong, Yi Shi, Yuxing Ni, Fupin Hu, Yijian Chen, Chao Zhuo, Bijie Hu, Xiaoju Lv, Jiabin Li, Zhengyin Liu, Jing Zhang, Wenjie Yang, Fan Yang, Qiwen Yang, Hua Zhou, Xin Li, Jianhua Wang, Yimin Li, Jian'an Ren, Baiyi Chen, Dechang Chen, Anhua Wu, Xiangdong Guan, Jieming Qu, Depei Wu, Xiaojun Huang, Haibo Qiu, Yingchun Xu, Yunsong Yu, Minggui Wang
The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug-resistant, resulting in limited antimicrobial treatment options and high mortality. A multidisciplinary guideline development group covering clinical infectious diseases, clinical microbiology, clinical pharmacology, infection control, and guideline methodology experts jointly developed the present clinical practice guidelines based on best available scientific evidence to address the clinical issues regarding laboratory testing, antimicrobial therapy, and prevention of CRGNB infections...
February 18, 2023: Journal of Microbiology Immunology and Infection
Ching-Chu Lo, Wei-Yi Lei, Ying-Che Huang, Jow-Jyh Hwang, Chen-Yu Lo, Chien-Hung Lin, Hsu-Sheng Cheng, Yee-Tam Liao, Po-Cheng Liang, Meng-Jau Chiou, Ming-Jong Bair, Chia-Yen Dai, Ming-Lung Yu
INTRODUCTION: Taiwan has several hepatitis C virus (HCV) hyper-endemic areas. We aimed to evaluate the effectiveness and safety of a collaborative HCV care system with an outreach decentralized strategy among the resource-constrained rural/remote areas of Taiwan. METHODS: The pilot study was conducted in four high HCV-endemic townships in the rural/remote areas of Taoyuan, Alishan, Zhuoxi and Xiulin. Registered residents who worked or lived in the four areas and were aged 30-75 years were invited to participate in this program...
February 10, 2023: Journal of Microbiology Immunology and Infection
Ling-Ya Chen, Hsin-Yun Sun, Yu-Chung Chuang, Yu-Shan Huang, Wang-Da Liu, Kuan-Yin Lin, Hsi-Yen Chang, Yu-Zhen Luo, Pei-Ying Wu, Yi-Ching Su, Wen-Chun Liu, Chien-Ching Hung
BACKGROUND: While some evidence has suggested the benefits of co-formulated bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) in improving the quality of life of people living with HIV (PLWH), patient-reported outcome studies that focus on Asian population remain scarce. We aimed to determine the changes in HIV-related symptom burden in virally-suppressed PLWH switching to B/F/TAF in a real-world setting. METHODS: PLWH on stable antiretroviral therapy (ART) for ≥6 months with plasma HIV RNA <200 copies/mL who decided to switch to B/F/TAF were eligible for the study...
February 9, 2023: Journal of Microbiology Immunology and Infection
Kanit Assawatheptawee, Non Sowanna, Pornpit Treebupachatsakul, Anamai Na-Udom, Taradon Luangtongkum, Pannika R Niumsup
BACKGROUND: Presently, community-associated carbapenemase-producing Enterobacterales (CPE) remains largely unknown and require public attention. This study aimed to investigate the presence of CPE from outpatients in Thailand. METHODS: Non-duplicate stool (n = 886) and urine (n = 289) samples were collected from outpatients with diarrhea and urinary tract infection, respectively. Demographic data and characteristics of patients were collected...
February 8, 2023: Journal of Microbiology Immunology and Infection
Wei-Ju Su, Yu-Lun Liu, Chia-Hsuin Chang, Yen-Ching Lin, Wei-I Huang, Li-Chiu Wu, Shu-Fong Chen, Yu-Sheng Lin, Yee-Lin Hsieh, Chiao-An Yang, Chiu-Hsiang Lin, Kim-Wei Arnold Chan, Ping-Ing Lee, Jen-Hsiang Chuang, Chin-Hui Yang
BACKGROUND: An extended interval between the two primary doses may reduce the risk of myocarditis/pericarditis after COVID-19 mRNA vaccination. Taiwan has implemented a two-dose regimen with a 12-week interval for adolescents. Here we present nationwide data of myocarditis/pericarditis following COVID-19 vaccinations. METHODS: Data on adverse events of myocarditis/pericarditis were from the Taiwan Vaccine Adverse Events Reporting System between March 22, 2021, and February 9, 2022...
February 8, 2023: Journal of Microbiology Immunology and Infection
Merve Arslan Aydin, Rajendra Prasad Janapatla, Chyi-Liang Chen, Hsin-Chieh Li, Lin-Hui Su, Cheng-Hsun Chiu
BACKGROUND/PURPOSE: Serotype 3 has persisted to be an important cause of invasive pneumococcal disease in adults in the post-vaccine era. We aimed to investigate clinical and microbiological characteristics of Streptococcus pneumoniae serotype 3 infection in Taiwan and identify the risk factors associated with severe clinical outcome. METHODS: A multicenter observational study was conducted to analyze serotype 3 isolates collected between 2012 and 2021. Demographics, comorbidities, and risk categories were statistically compared with clinical outcome...
February 2, 2023: Journal of Microbiology Immunology and Infection
Meng-Hsiu Yen, Dah-Chin Yan, Chao-Jan Wang, Kuo-Chien Tsao, Yi-Chuan Huang, Shao-Wen Cheng, Cheng-Hsun Chiu, Yhu-Chering Huang, Tzou-Yien Lin
BACKGROUND: Macrolide-resistant Mycoplasma pneumoniae (MRMP) infection is increasing worldwide. However, its clinical significance is still uncertain. METHODS: The data of the Laboratory Medicine Department of Chang Gung Memorial Hospital in northern Taiwan was searched for children with molecular confirmed macrolide-susceptible Mycoplasma pneumoniae (MSMP) and MRMP infections between January 2011 and December 2018. The clinical features, laboratory data, and chest image presentations were compared between patients with MRMP and MSMP infections and between patients with good and poor macrolide response, respectively...
January 24, 2023: Journal of Microbiology Immunology and Infection
Thanus Pienthong, Watcharee Chancharoenrat, Sirinporn Sajak, Suphannee Phetsaen, Padcharadda Hanchai, Kanokporn Thongphubeth, Thana Khawcharoenporn
BACKGROUND: A risk categorization tool for healthcare workers (HCWs) exposed to COVID-19 is crucial for preventing COVID-19 transmission and requires validation and modification according to local context. METHODS: From January to December 2021, a prospective cohort study was conducted among Thai HCWs to evaluate the performance of the specifically-created risk categorization tool, which classified HCWs into low-risk (LR), intermediate-risk (IR), and high-risk (HR) groups based on types of activities, duration of exposure, and protective methods used during exposure...
January 20, 2023: Journal of Microbiology Immunology and Infection
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