Journals Journal of Microbiology Immuno...

Journal of Microbiology Immunology and Infection
Yu-Tzu Lin, Hsiu-Hsien Lin, Kun-Hao Tseng, Tai-Fen Lee, Yu-Tsung Huang, Po-Ren Hsueh
BACKGROUND: This study aimed to assess the performance of three commercial panels, the ERIC Carbapenem-Resistant Enterobacteriaceae Test (ERIC CRE test), the NG-Test CARBA 5 (NG CARBA 5), and the BD Phoenix CPO Detect Panel (CPO panel), for the detection of main types of carbapenemases among carbapenem-resistant Enterobacterales (CRE). METHODS: We collected 502 isolates of carbapenem-resistant Enterobacterales (CRE) demonstrating intermediate or resistant profiles to at least one carbapenem antibiotic (ertapenem, imipenem, meropenem, or doripenem)...
June 6, 2024: Journal of Microbiology Immunology and Infection
Ching-Chi Lee, Chung-Hsu Lai, Shang-Yi Lin, Nan-Yao Lee, Po-Yu Liu, Chih-Hui Yang, Yi-Han Huang, Jiun-Nong Lin
For 29 parent strains, recognized by pulsed-field gel electrophoresis, the MICs multiplied significantly in the ciprofloxacin group than levofloxacin group, following the first and third induction cycle. Ser83Arg in GyrA was the most common site of mutations. No mutation in ParC nor ParE was identified in the selected mutants.
June 3, 2024: Journal of Microbiology Immunology and Infection
Tian-Yu You, Ching-Lung Lo, Wen-Chia Tsai, Hao-En Jan, Wen-Chien Ko, Nan-Yao Lee
BACKGROUND: As limited antibiotic options are available for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections (BSIs), the optimal treatment duration for CRKP BSIs is unclear. Our objective was to investigate whether short courses (6-10 days) are as effective as prolonged courses (≥11 days) of active antibiotic therapy for CRKP BSIs. METHODS: A retrospective cohort study comprising adults with monomicrobial CRKP BSI receiving a short or prolonged course of in vitro active therapy at a medical center was conducted between 2010 and 2021...
May 30, 2024: Journal of Microbiology Immunology and Infection
Yu-Lin Lee, Szu-Min Hsieh, Yi-Tsung Lin, Shian-Sen Shie, Chia-Jui Yang, Po-Ren Hsueh
The burden of respiratory syncytial virus (RSV) infection among older adults in Taiwan is not well understood due to a scarcity of published epidemiological data. Nonetheless, the increasing proportion of older adults is anticipated to translate to increased burden of RSV infection, presenting a challenge to the healthcare system. Thus, an expert meeting was convened among a panel of infectious disease specialists from Taiwan to evaluate the existing local evidence and data gaps related to RSV infection in older adults (aged ≥50 years), and propose steps to generating evidence on disease burden among this population...
May 30, 2024: Journal of Microbiology Immunology and Infection
Ke-Min Chen, Shih-Chan Lai
BACKGROUND: Co-therapy with albendazole and steroid is commonly used in patients with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis infections. However, anthelminthics often worsen symptoms, possibly due to the inflammatory reaction to antigens released by dying worms. Therefore, the present study was to investigate the curative effects and probable mechanisms of the platelet-derived growth factor receptor-beta (PDGFR-β) inhibitor AG1296 (AG) and the phosphoinositide 3-kinase inhibitor (PI3K) LY294002 (LY) in A...
May 30, 2024: Journal of Microbiology Immunology and Infection
Li-Sang Hsu, Ing Chen, Cai-Sin Yao, Yu-Shan Huang, Jenn-Tzong Chang, Hsiao-Ping Wang, Nai-Wen Fang
BACKGROUND: Urine leukocyte count under microscopy is one of the most frequently used routine screening tests for urinary tract infection (UTI). Nevertheless, it is observed that pyuria is lacking in 10-25% of children with UTI. This study aims to determine the factors related to pyuria-negative UTI in young infants aged under four months old. METHOD: This retrospective cross-sectional study was conducted on 157 patients aged under 4 months old with UTI...
May 28, 2024: Journal of Microbiology Immunology and Infection
Jun Nishikawa, Tomohiro Fujii, Soichiro Fukuda, Shoma Yoneda, Yuta Tamura, Yuki Shimizu, Akie Yanai, Yuki Kobayashi, Koji Harada, Keisuke Kawasaki, Katsuaki Mishima, Kenji Watanabe, Yoichi Mizukami, Hironori Yoshiyama, Yutaka Suehiro, Takahiro Yamasaki, Taro Takami
BACKGROUND: Periodontal disease is the leading cause of tooth loss, and an association between periodontal disease and non-oral systemic diseases has been shown. Formation of biofilm by periodontal pathogens such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Streptococcus mutans and their resistance to antimicrobial agents are at the root of persistent and chronic bacterial infections. METHODS: The bactericidal effect of far-ultraviolet (F-UV) light irradiation at 222 nm on periodontal bacteria was assessed qualitatively and quantitatively...
May 28, 2024: Journal of Microbiology Immunology and Infection
Shan-Chi Yu, Tai-Hua Chan, Ruwen Jou
BACKGROUND: Granulomatous lymphadenitis, a histopathological diagnosis, often indicates infections, such as those caused by mycobacterial and fungal agents. METHODS: We conducted an analysis of 1098 granulomatous lymphadenitis cases, examining age distribution, lymph node locations, and laterality. Molecular detection of Bacillus Calmette-Guérin (BCG) was performed on archived formalin-fixed paraffin-embedded tissue specimens. RESULTS: Our analysis revealed a bimodal age distribution, notably with a minor peak in infants...
May 24, 2024: Journal of Microbiology Immunology and Infection
Kuan-Yu Lin, Hsin-Yun Sun, Wang-Da Liu, Chi-Ying Lin, Ming-Jui Tsai, Yu-Chung Chuang, Hung-Yuan Li, Jou-Wei Lin, Wen-Chun Liu, Pei-Ying Wu, Ling-Ya Chen, Hsi-Yen Chang, Yu-Zhen Luo, Yi-Ting Chen, Guei-Chi Li, Shyang-Rong Shih, Chien-Ching Hung
BACKGROUND: Male hypogonadism is not uncommon in people with HIV (PWH), with estimated prevalence ranging from 9% to 16%. Existing data are limited on the serum testosterone levels in PWH in Asian populations. METHODS: We enrolled HIV-positive men who have sex with men (MSM) and had been on stable antiretroviral therapy and MSM without HIV between February 2021 and November 2022. Serum free testosterone levels, sex hormone-binding globulins and other associated hormones were measured...
May 24, 2024: Journal of Microbiology Immunology and Infection
Hsiao-Lun Huang, Chun-Yi Lu, Yun-Chung Liu, Tu-Hsuan Chang, Ting-Yu Yen, Kuan-Ying A Huang, Hung-Jen Tang, Luan-Yin Chang, Li-Min Huang
INTRODUCTION: COVID-19 poses risks and leads to complications for vulnerable populations, including children. Unreported cases of COVID-19 among children hinder our understanding of the true disease burden. In this study, we aimed to investigate the proportion of children who report no prior infection to SARS-CoV-2 but who nevertheless exhibit serological evidence of prior infection. METHODS: Between November 2022 and February 2023, we recruited children and adolescents under 19 years of age who lacked a prior history of SARS-CoV-2 infection...
May 11, 2024: Journal of Microbiology Immunology and Infection
Ming-Jui Tsai, Hsin-Yun Sun, Li-Hsin Su, Kuan-Yin Lin, Wang-Da Liu, Yu-Shan Huang, Guan-Jhou Chen, Yi-Ching Su, Wen-Chun Liu, Sui-Yuan Chang, Chien-Ching Hung
BACKGROUND: Mycoplasma genitalium is an emerging etiology of sexually transmitted infections (STIs) with increasing resistance to antimicrobials. Surveillance on the epidemiology of M. genitalium infection and antimicrobial resistance is warranted. METHODS: Between September 2021 and August 2023, people with HIV (PWH) and people without HIV (PWoH) at risk of STIs were screened for M. genitalium infection using a multiplex polymerase-chain-reaction assay of specimens collected from the rectum, urethra, oral cavity, and vagina...
May 11, 2024: Journal of Microbiology Immunology and Infection
Meng-Chiu Pai, Yun-Chung Liu, Ting-Yu Yen, Kuan-Ying Huang, Chun-Yi Lu, Jong-Min Chen, Ping-Ing Lee, Luan-Yin Chang, Li-Min Huang
BACKGROUND: Human parainfluenza viruses (HPIVs) commonly cause childhood respiratory illness requiring hospitalization in Taiwan. This study aimed to investigate clinical severity and identify risk factors predisposing to severe disease in hospitalized children with HPIV infection. METHODS: We included hospitalized patients with lab-confirmed HPIV infection from 2007 to 2018 and collected their demographic and clinical characteristics. Patients with ventilator support, intravenous inotropic agents, and extracorporeal membrane oxygenation were defined as severe cases...
May 10, 2024: Journal of Microbiology Immunology and Infection
Chun-Hsien Chen, Chin-Wei Kuo, Chih-Ming Tsai, Zih-Bin Hong, Ching-Han Lai, Tzu-Yi Chan, Wei-Chen Lin
INTRODUCTION: Lung cancer is one of the most prevalent malignancies worldwide. Substantial research has illuminated the intricate interplay between microorganisms and human health, revealing their role in disease regulation. Trichomonads is a flagellated protozoan in the human cavity and have been previously identified as a pathogen associated with pneumonia, contributing to tissue chronic inflammation and carcinogenesis. METHODS: Nested polymerase chain reaction methods were employed to scrutinize the prevalence of trichomonads in the bronchovesicular fluid of patients diagnosed with lung cancer...
May 8, 2024: Journal of Microbiology Immunology and Infection
Yi-Wen Huang, Ming-Chih Yu, Chih-Bin Lin, Jen-Jyh Lee, Chou-Jui Lin, Shun-Tien Chien, Chih-Hsin Lee, Chen-Yuan Chiang
BACKGROUND: Pre-extensively drug-resistant tuberculosis (pre-XDR-TB), defined as multidrug-resistant TB (MDR-TB) with additional resistance to any fluoroquinolone (FQ) is difficult to treat. We assessed whether the use of new or repurposed drugs (bedaquiline, delamanid, linezolid, carbapenem, clofazimine, pretomanid) mitigated treatment failure of pre-XDR-TB. METHODS: MDR-TB patients managed in the Taiwan MDR-TB consortium between July 2009-December 2019 were eligible...
April 26, 2024: Journal of Microbiology Immunology and Infection
Kyoung Hwa Lee, Eun Hwa Lee, Kyu-Na Lee, Yebin Park, Young Goo Song, Kyung Do Han, Sang Hoon Han
BACKGROUND: As the group at high risk for sepsis is increasing with the aging of the population, physical activity (PA), which has beneficial effects on various diseases, needs to be considered as a personalized prevention strategy for sepsis without direct anti-sepsis drug. PURPOSE: To examine the association between the amount of PA (based on intensity, duration, and frequency) and the incidence rates of sepsis and mortality after sepsis. METHODS: This was a large-scale, retrospective, longitudinal cohort study using data from the Korean National Health Insurance Service and the biennial general health screening program...
April 26, 2024: Journal of Microbiology Immunology and Infection
Wei-Te Lee, Chih-Lin Huang, Rong-Jyh Lin, Chao-Ju Chen, Kuan-Li Wu, June-Der Lee, Yue-Chiu Su
No abstract text is available yet for this article.
April 24, 2024: Journal of Microbiology Immunology and Infection
Chih-Cheng Lai, Po-Ren Hsueh
No abstract text is available yet for this article.
April 22, 2024: Journal of Microbiology Immunology and Infection
Anh Le Xuan, Feng-Yang Hsu, Po-Ren Hsueh, Wei-Hao Lin, Hung-Han Chen, Ming-Tang Chiou, Chao-Nan Lin
This study investigated antimicrobial resistance in Salmonella enterica serovar Choleraesuis (S. Choleraesuis) isolates from diseased pigs in Taiwan (2015-2020). Among 272 isolates, florfenicol (96.7%), enrofloxacin (96.3%), doxycycline (91.2%), gentamicin (84.6%), and tiamulin (80.5%) exhibited high resistance. 99.3% of the isolates were resistant to at least one antibiotic, and 97.8% of the isolates were multidrug resistant. This study illustrated that S. Choleraesuis isolates exhibited high resistance to antimicrobials currently used in the Taiwanese swine industry...
April 16, 2024: Journal of Microbiology Immunology and Infection
Chun-Kai Huang, Jei-Yie Huang, Chin-Hao Chang, Shang-Jie Tsai, Chin-Chung Shu, Hao-Chien Wang, Kuo-Liong Chien
BACKGROUND: Tuberculosis (TB) remains prevalent worldwide, and anti-TB drugs are associated with drug-induced liver injury (DILI). Statins have pleiotropic effects which may decrease inflammation and achieve immunomodulation. However, few studies have investigated the pleiotropic effects of statins on the risk of DILI. The purpose of this study was to investigate whether statins prevent anti-tuberculosis DILI among active TB patients on standard anti-TB drug therapy. METHODS: We conducted a hospital-based retrospective cohort study using claims data from the Integrated Medical Database of National Taiwan University Hospital (NTUH-iMD)...
April 8, 2024: Journal of Microbiology Immunology and Infection
Yu-Lin Lee, Chun-Eng Liu, Hung-Jen Tang, Yu-Tsung Huang, Yao-Shen Chen, Po-Ren Hsueh
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has contributed to the spread of antimicrobial resistance, including carbapenem-resistant Enterobacterales. METHODS: This study utilized data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) surveillance program in Taiwan. Enterobacterales from patients with bloodstream infections (BSIs) were collected and subjected to antimicrobial susceptibility testing and β-lactamase gene detection using a multiplex PCR assay...
April 7, 2024: Journal of Microbiology Immunology and Infection
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