Walter Zobl, Annette Bitsch, Jonathan Blum, Jan J W A Boei, Liliana Capinha, Giada Carta, Jose Castell, Enrico Davoli, Christina Drake, Ciaran P Fisher, Muriel M Heldring, Barira Islam, Paul Jennings, Marcel Leist, Damiano Pellegrino-Coppola, Johannes P Schimming, Kirsten E Snijders, Laia Tolosa, Bob van de Water, Barbara M A van Vugt-Lussenburg, Paul Walker, Matthias M Wehr, Lukas S Wijaya, Sylvia E Escher
Hazard assessment (HA) requires toxicity tests to allow deriving protective points of departure (PoDs) for risk assessment irrespective of a compound's mode of action (MoA). The scope of in vitro test batteries (ivTB) thereby necessitated for systemic toxicity is still unclear. We explored the protectiveness regarding systemic toxicity of an ivTB with a scope, which was guided by previous findings from rodent studies, where examining six main targets, including liver and kidney, was sufficient to predict the guideline scope-based PoD with high probability...
December 4, 2023: ALTEX