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Asian Journal of Andrology

Shao-Ming Lu, Xiao Li, Shi-Li Wang, Xiao-Li Yang, Yan-Zhen Xu, Ling-Ling Huang, Jiao-Long Liu, Fei-Fei Cai, Zi-Jiang Chen
Antisperm antibodies (ASAs) are assumed to be a possible causative factor for male infertility, with ASAs detected in 5%-15% of infertile men but in only 1%-2% of fertile ones. It remains unclear whether ASAs have an adverse effect on the outcome of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). This study investigated differences in the rates of fertilization, pregnancy, and live births associated with serum ASA-positive and ASA-negative men following IVF or ICSI. Five hundred and fifty-four consecutive infertile couples undergoing IVF (n = 399) or ICSI (n = 155) were included...
January 29, 2019: Asian Journal of Andrology
Rui-Ling Tang, Li-Qing Fan
While hallmarks of rodent spermatogonia stem cell biomarkers' heterogeneity have recently been identified, their stage and subset distributions remain unclear. Furthermore, it is currently difficult to accurately identify subset-specific SSC marker distributions due to the poor nuclear morphological characteristics associated with fixation in 4% paraformaldehyde. In the present study, testicular cross-sections and whole-mount samples were Bouin fixed to optimize nuclear resolution and visualized by immunohistochemistry (IHC) and immunofluorescence (IF)...
January 29, 2019: Asian Journal of Andrology
Hai-Tao Zhang, Zhe Zhang, Jia Cao, Wen-Hao Tang, Hong-Liang Zhang, Kai Hong, Hao-Cheng Lin, Han Wu, Qing Chen, Hui Jiang
Previous studies suggest that air pollution has a negative effect on semen quality. However, most studies are cross-sectional and the results are controversial. This study investigated the associations between air pollutants (PM2.5 , PM10 , SO2 , NO2 , CO, and O3 ) and semen quality among sperm donation candidates, especially when the air pollution was artificially controlled in Beijing, China. We analyzed 8945 semen samples in the human sperm bank of Peking University Third Hospital (Beijing, China) from October 2015 to May 2018...
January 22, 2019: Asian Journal of Andrology
Gang Song, Geng-Yan Xiong, Yu Fan, Cong Huang, Yong-Ming Kang, Guang-Jie Ji, Jin-Chao Chen, Zhong-Cheng Xin, Li-Qun Zhou
The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. The clinicopathological factors, including tumor diameter, cryptorchidism history, ultrasound findings, serum alpha-fetoprotein, and human chorionic gonadotropin (HCG) levels, were collected retrospectively for statistical analysis...
January 15, 2019: Asian Journal of Andrology
Jeremy Yuen-Chun Teoh, Chi-Kwok Chan, Maggie Haitian Wang, Chi-Ho Leung, Eddie Shu-Yin Chan, Peter Ka-Fung Chiu, Chi-Hang Yee, Hon-Ming Wong, Simon See-Ming Hou, Chi-Fai Ng
It is largely unknown whether lower urinary tract symptoms (LUTS) or acute retention of urine (AROU) is linked to shorter life expectancy in men. We conducted a multicenter, retrospective database analysis of patients undergoing transurethral resection of prostate (TURP) to study their relationships. Multivariate Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were performed. We further performed an age- and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region (Hong Kong, China)...
January 15, 2019: Asian Journal of Andrology
Ying Shen, Huan-Xun Yue, Fu-Ping Li, Feng-Yun Hu, Xiao-Liang Li, Qian Wan, Wen-Rui Zhao, Ji-Gang Jing, Di-Ming Cai, Xiao-Hui Jiang
No abstract text is available yet for this article.
January 11, 2019: Asian Journal of Andrology
Rakesh Sharma, Sajal Gupta, Ralf Henkel, Ashok Agarwal
Lack of standardized, reproducible protocols and reference values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow cytometry. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay combined with flow cytometry routinely used for diagnostic measurement of sperm DNA fragmentation (SDF) is a unique example. Any change in the setting of the standard instrument, including upgrades of hardware or software, can lead to different results and may affect clinicians' decision for treatment...
January 8, 2019: Asian Journal of Andrology
Kai Cui, Yang Luan, Zhe Tang, Chuan-Chang Li, Tao Wang, Shao-Gang Wang, Zhong Chen, Ji-Hong Liu
The aim of this study was to investigate the mechanism by which a diet inducing high hyperhomocysteinemia (HHcy) leads to the deterioration of erectile function in rats and whether this is inhibited by expression of the human tissue kallikrein-1 (hKLK1) gene. We established a rat model of HHcy by feeding methionine (Met)-rich diets to male Sprague-Dawley (SD) rats. Male wild-type SD rats (WTRs) and transgenic rats harboring the hKLK1 gene (TGRs) were fed a normal diet until 10 weeks of age. Then, 30 WTRs were randomly divided into three groups as follows: the control (n = 10) group, the low-dose (4% Met, n = 10) group, and the high-dose (7% Met, n = 10) group...
January 1, 2019: Asian Journal of Andrology
Kadiliya Jueraitetibaike, Zheng Ding, Dan-Dan Wang, Long-Ping Peng, Jun Jing, Li Chen, Xie Ge, Xu-Hua Qiu, Bing Yao
Vitamin D deficiency is a common health issue around the world. We therefore evaluated the associations of semen quality with both serum and seminal plasma vitamin D levels and studied the mechanisms underlying these by incubating spermatozoa with 1,25(OH)2 D In vitro. Two hundred and twenty-two men were included in our study. Vitamin D was detected using an electrochemiluminescence method. Spermatozoa used for In vitro experiments were isolated by density gradient centrifugation. Positive relationships of serum 25(OH)D with semen volume and seminal plasma fructose were identified...
January 1, 2019: Asian Journal of Andrology
Xiao-Xi Li, Fang Chen, Shou-Lin Li, Yi-Chen Huang, Yi-Qing Lv, Yan Chen, Hui-Zhen Sun, Hua Xie
No abstract text is available yet for this article.
January 1, 2019: Asian Journal of Andrology
Yu Fan, Lu Yang, Qiang Wei, Yu Ding, Zhuang Tang, Ping Tan, Tao Lin, Duan Guo, Shi Qiu
Prostate inflammation (PI) is closely related to the development and progression of chronic prostatic diseases: benign prostatic hyperplasia and prostate cancer. Toll-like receptor (TLR) 2 has been reported to be associated with inflammatory diseases, such as infections, autoimmune diseases, and cancers. Meanwhile, TLR10, which can form heterodimers with TLR2, has been considered an orphan receptor without an exact function. The present study therefore aims to examine the effects of TLR2 and TLR10 on PI. Prostate samples and clinical data were obtained from the patients diagnosed with benign prostatic hyperplasia...
January 1, 2019: Asian Journal of Andrology
Li Zhang, Yi Liu, Xian-Guo Chen, Yong Zhang, Jing Chen, Zong-Yao Hao, Song Fan, Li-Gang Zhang, He-Xi Du, Chao-Zhao Liang
MicroRNAs (miRNAs) are considered to be involved in the pathogenic initiation and progression of chronic nonbacterial prostatitis (CNP); however, the comprehensive expression profile of dysregulated miRNAs, relevant signaling pathways, and core machineries in CNP have not been fully elucidated. In the current research, CNP rat models were established through the intraprostatic injection of carrageenan into the prostate. Then, next-generation sequencing was performed to explore the miRNA expression profile in CNP...
December 25, 2018: Asian Journal of Andrology
Jung Kwon Kim, Jung Jun Kim, Taek Won Gang, Tae Kyun Kwon, Hong Sup Kim, Seung Chul Park, Jae-Shin Park, Jong-Yeon Park, Seok Joong Yoon, Youn-Soo Jeon, Jin Seon Cho, Kwan Joong Joo, Sung-Hoo Hong, Seok-Soo Byun
We aimed to evaluate the current nationwide trend, efficacy, safety, and quality of life (QoL) profiles of hormone treatment in real-world practice settings for prostate cancer (PCa) patients in Korea. A total of 292 men with any biopsy-proven PCa (TanyNanyMany) from 12 institutions in Korea were included in this multi-institutional, observational study of prospectively collected data. All luteinizing hormone-releasing hormone (LHRH) agonists were allowed to be investigational drugs. Efficacy was defined as (1) the rate of castration (serum testosterone ≤50 ng dl-1 ) at 4-week visit and (2) breakthrough (serum testosterone >50 ng dl-1 after castration)...
December 25, 2018: Asian Journal of Andrology
Yin-Wei Chen, Yong-Hua Niu, Hao Xu, Dao-Qi Wang, Hong-Yang Jiang, Gaurab Pokhrel, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Gonadotropin therapy is commonly used to induce virilization and spermatogenesis in male isolated hypogonadotropic hypogonadism (IHH) patients. In clinical practice, 5.6%-15.0% of male IHH patients show poor responses to gonadotropin treatment; therefore, testosterone (T) supplementation can serve as an alternative therapy to normalize serum T levels and promote virilization. However, treatment with exogenous T impairs spermatogenesis and suppresses intratesticular T levels. This retrospective study aimed to determine whether oral testosterone undecanoate (TU) supplementation together with human chorionic gonadotropin (hCG) would negatively affect spermatogenesis in IHH patients compared with hCG alone...
December 25, 2018: Asian Journal of Andrology
Andrea Sansone, Danilo Alunni Fegatelli, Carlotta Pozza, Giorgio Fattorini, Rosa Lauretta, Marianna Minnetti, Francesco Romanelli, Pierleone Lucatelli, Mario Corona, Mario Bezzi, Francesco Lombardo, Andrea Lenzi, Daniele Gianfrilli
Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who underwent percutaneous treatment, had a minimum of 12 months' ultrasound imaging follow-up, and had no other conditions affecting testicular volume...
December 25, 2018: Asian Journal of Andrology
Diana Itzhakov, Yeshayahu Nitzan, Haim Breitbart
To interact with the egg, the spermatozoon must undergo several biochemical and motility modifications in the female reproductive tract, collectively called capacitation. Only capacitated sperm can undergo acrosomal exocytosis, near or on the egg, a process that allows the sperm to penetrate and fertilize the egg. In the present study, we investigated the involvement of cyclic adenosine monophosphate (cAMP)-dependent processes on acrosomal exocytosis. Inhibition of protein kinase A (PKA) at the end of capacitation induced acrosomal exocytosis...
December 18, 2018: Asian Journal of Andrology
Tian-Xin Zhao, Bin Liu, Yue-Xin Wei, Yi Wei, Xiang-Liang Tang, Lian-Ju Shen, Chun-Lan Long, Tao Lin, Sheng-De Wu, Guang-Hui Wei
We investigated the associations of clinical and socioeconomic factors with delayed orchidopexy for cryptorchidism in China. A retrospective study was conducted on cryptorchid boys who underwent orchidopexy at Children's Hospital at Chongqing Medical University in China from January 2012 to December 2017. Of 2423 patients, 410 (16.9%) received timely repair by 18 months of age, beyond which surgery was considered delayed. Univariate analysis suggested that the laterality of cryptorchidism (P = 0.001), comorbidities including inguinal hernia/scrotal hydrocele (P < 0...
December 18, 2018: Asian Journal of Andrology
Ifrah Alam Malik, Damayanthi Durairajanayagam, Harbindar Jeet Singh
Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Leptin is necessary for normal reproductive function, but when present in excess, it can have detrimental effects on the male reproductive system...
December 11, 2018: Asian Journal of Andrology
Alessandra Petrozzi, Francesco Pallotti, Marianna Pelloni, Antonella Anzuini, Antonio Francesco Radicioni, Andrea Lenzi, Donatella Paoli, Francesco Lombardo
Inhibin B is a gonadal hormone that downregulates the pituitary production of follicle-stimulating hormone (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. This retrospective study evaluates hormonal and semen parameters of 290 normozoospermic patients attending the Laboratory of Seminology - Sperm Bank "Loredana Gandini" (Rome, Italy) for cryopreservation of seminal fluid following a diagnosis of testicular cancer (TC group) and 117 healthy, normozoospermic men as a control group (CTR group)...
December 7, 2018: Asian Journal of Andrology
Mevlana Derya Balbay, Abdullah Erdem Canda
No abstract text is available yet for this article.
December 7, 2018: Asian Journal of Andrology
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