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Journal of Headache and Pain

Minna A Korolainen, Samu Kurki, Mariann I Lassenius, Iiro Toppila, Madlaina Costa-Scharplatz, Timo Purmonen, Markku Nissilä
BACKGROUND: The highest prevalence of migraine is detected among people who are of working age. The aim of this study was to assess the burden of migraine in an occupational health care setting using real world data collected as a part of routine clinical practice. METHODS: This retrospective register study included migraineurs using occupational health care at the private health care provider Terveystalo. An age and gender matched control population was established for comparison...
February 12, 2019: Journal of Headache and Pain
William B Young, J Ivan Lopez, John F Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B Lipton, Andrew M Blumenfeld
BACKGROUND: OnabotulinumtoxinA is effective in preventing chronic migraine (CM); however, the benefit of onabotulinumtoxinA in patients with CM with daily headache is unknown because these patients are typically excluded from clinical trials. This subanalysis of the COMPEL Study assessed the efficacy and safety of onabotulinumtoxinA in people with CM with and without daily headache. METHODS: In total, 715 patients received onabotulinumtoxinA 155 U with or without concomitant oral preventive treatment...
February 1, 2019: Journal of Headache and Pain
Doga Vuralli, Anne-Sophie Wattiez, Andrew F Russo, Hayrunnisa Bolay
Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relevant headache models. Pain can be assessed in animals using behavioral alterations, which includes sensory-discriminative, affective-emotional and cognitive aspects. Spontaneous behavioral alterations such as increased grooming, freezing, eye blinking, wet dog shake and head shake and decreased locomotion, rearing, food or water consumption observed during pain episodes are oftentimes easy to translate into clinical outcomes, but are giving little information about the localization and modality of the pain...
January 31, 2019: Journal of Headache and Pain
William B Young, J Ivan Lopez, John F Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B Lipton, Andrew M Blumenfeld
BACKGROUND: OnabotulinumtoxinA is effective in treating chronic migraine (CM), but there are limited data assessing how allodynia affects preventive treatment responses. This subanalysis of the 108-week, multicenter, open-label COMPEL Study assessed the efficacy and safety of onabotulinumtoxinA in people with CM with and without allodynia. METHODS: Patients (n = 715) were treated with onabotulinumtoxinA 155 U every 12 weeks for 9 treatment cycles. The Allodynia Symptom Checklist was used to identify patients with allodynia (scores ≥3)...
January 22, 2019: Journal of Headache and Pain
Ruth Ruscheweyh, Diana Pereira, Monika I Hasenbring, Andreas Straube
BACKGROUND: The role of avoidance and endurance behaviour is well established in chronic musculoskeletal pain, but less is known about its significance in migraine. METHODS: The Avoidance-Endurance Questionnaire behavioural subscales, the Pain Disability Index (PDI), the Migraine Disability Assessment Scale (MIDAS) and the Hospital Anxiety and Depression Scale (HADS) were obtained from 128 migraine patients (90 episodic, 38 chronic). Sixty nine of them were re-evaluated after 3-6 months...
January 18, 2019: Journal of Headache and Pain
Nico Sollmann, Nina Mathonia, Dominik Weidlich, Michaela Bonfert, Sebastian A Schroeder, Katharina A Badura, Tabea Renner, Florian Trepte-Freisleder, Carl Ganter, Sandro M Krieg, Claus Zimmer, Ernst J Rummeny, Dimitrios C Karampinos, Thomas Baum, Mirjam N Landgraf, Florian Heinen
BACKGROUND: Research in migraine points towards central-peripheral complexity with a widespread pattern of structures involved. Migraine-associated neck and shoulder muscle pain has clinically been conceptualized as myofascial trigger points (mTrPs). However, concepts remain controversial, and the identification of mTrPs is mostly restricted to manual palpation in clinical routine. This study investigates a more objective, quantitative assessment of mTrPs by means of magnetic resonance imaging (MRI) with T2 mapping...
January 18, 2019: Journal of Headache and Pain
Zhi Y Zhou, Yan W Yu, Di Wu, Hong X Liu, Jing Xiang, Ting Wu, Qi Q Chen, Xiao S Wang
OBJECTIVE: The present study aimed to preliminary explore the abnormal neuromagnetic activation in female migraine patients between attacks using magnetoencephalography (MEG) and pattern reversed visual evoked magnetic fields (PR-VEFs). METHODS: A total of 17 female migraine subjects during the headache-free phase and 17 healthy controls (HC) were studied using a 275-channel magnetoencephalography (MEG) system. In this study, visual evoked magnetic fields (VEFs) were generated by a pattern-reversal check as the visual stimulus...
January 16, 2019: Journal of Headache and Pain
Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas, Paolo Martelletti
BACKGROUND AND AIM: Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab). The aim of this document by the European Headache Federation (EHF) is to provide an evidence-based and expert-based guideline on the use of the monoclonal antibodies acting on the calcitonin gene-related peptide for migraine prevention...
January 16, 2019: Journal of Headache and Pain
Arn M J M van den Maagdenberg, Dale R Nyholt, Verneri Anttila
Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA sequence variants that affect risk for migraine types. Most of the variants, which are all single nucleotide polymorphisms (SNPs), show robust association with migraine as evidenced by the fact that the vast majority replicate in subsequent independent studies. However, despite thorough bioinformatic efforts aimed at linking the migraine risk SNPs with genes and their molecular pathways, there remains quite some discussion as to how successful this endeavour has been, and their current practical use for the diagnosis and treatment of migraine patients...
January 11, 2019: Journal of Headache and Pain
Hedvig Komáromy, Mingchen He, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Edit Bosnyák, David Kamson Olayinka, Flóra John, Anita Trauninger, Zoltán Pfund
BACKGROUND/AIM: Migraine-related intracerebral white matter lesions (WMLs) are likely to be microvascular in nature and can be found in all hemispheric lobes. The aim of this study was to investigate migraine patients with or without WMLs to see the effects of these tissue damages on cortical thickness and volume. The role of migraine characteristics (duration of headache, attack frequency, estimated lifetime attack number, aura) was also tested. METHODS: As study participants, 161 female migraine patients (63 with aura; 52 with WMLs) and 40 age-matched healthy female subjects were enrolled in the study...
January 10, 2019: Journal of Headache and Pain
Jing Ren, Jing Xiang, Yueqiu Chen, Feng Li, Ting Wu, Jingping Shi
BACKGROUND: Although altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research in migraine patients during resting state, it is unknown whether this alteration can be detected in task-related networks. The present study aimed to investigate the abnormalities of the frequency-specific somatosensory-related network in migraine patients by using MEG. METHODS: Twenty-two migraineurs in the interictal phase and twenty-two sex- and age-matched healthy volunteers were studied using a whole-head magnetoencephalography (MEG) system...
January 9, 2019: Journal of Headache and Pain
Rachel Potter, Siew Wan Hee, Frances Griffiths, Katherine Dodd, Eleanor Hoverd, Martin Underwood, Manjit Matharu
BACKGROUND: For a trial of supportive self-management for people with chronic headache we needed to develop and validate a telephone classification interview that can be used by a non-headache specialist to classify common chronic headache types in primary care. We aimed to specifically: exclude secondary headaches other than medication overuse, exclude primary headache disorders other than migraine and tension type headache (TTH), distinguish between chronic migraine and chronic TTH, and identify medication overuse headache...
January 8, 2019: Journal of Headache and Pain
Licia Grazzi, Cristina Tassorelli, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
Following publication of the original article [1], the authors notified us that a part of the Figure 3 legend was omitted during proofing stage.
January 7, 2019: Journal of Headache and Pain
Stefanie Förderreuther, Qi Zhang, Virginia L Stauffer, Sheena K Aurora, Miguel J A Láinez
BACKGROUND: Maintenance of effect following treatment with galcanezumab compared to placebo in adult patients with episodic or chronic migraine was evaluated. METHODS: In 2 similarly designed studies of patients with episodic migraine (6 months) and 1 study of patients with chronic migraine (3 months), patients randomized in a 1:1:2 ratio received a subcutaneous injection of galcanezumab 120 mg/month (after an initial loading dose of 240 mg) or 240 mg/month or placebo...
December 29, 2018: Journal of Headache and Pain
Paolo Martelletti, Piero Barbanti, Licia Grazzi, Giulia Pierangeli, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Cristina Tassorelli, Eric Liebler, Marina de Tommaso
Following publication of the original article [1], the authors notified us o that the Table 1 citation within the legend was not presented as initially requested.
December 18, 2018: Journal of Headache and Pain
(no author information available yet)
After publication of this supplement [1], it was brought to our attention that e-mail errors were apparent in the following abstracts. This has now been included in this correction.
December 6, 2018: Journal of Headache and Pain
Jasem Y Al-Hashel, Samar Farouk Ahmed, Fatemah J Alshawaf, Raed Alroughani
BACKGROUND: Traditional Medicine (TM) is widely accepted to be used for the treatment headache disorders in Kuwait however, researches remain poorly documented. We aimed to study the frequency of TM use and its impact in the primary headache patients. METHODS: This is a cross sectional self-reported efficacy study, which was conducted in Headache clinic in Kuwait throughout 6 months. Patients who were diagnosed with primary headache disorders of both genders aged from 18 to 65 years were included...
December 4, 2018: Journal of Headache and Pain
Zoë Delaruelle, Tatiana A Ivanova, Sabrina Khan, Andrea Negro, Raffaele Ornello, Bianca Raffaelli, Alberto Terrin, Dimos D Mitsikostas, Uwe Reuter
BACKGROUND: The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and female sex hormones could have an influence on the course of primary headaches. This review aims to summarise the most relevant and recent literature on this topic. METHODS: Two independent reviewers searched PUBMED in a systematic manner. Search strings were composed using the terms LH, FSH, progesteron*, estrogen*, DHEA*, prolactin, testosterone, androgen*, headach*, migrain*, "tension type" or cluster...
November 29, 2018: Journal of Headache and Pain
Kedar Manandhar, Ajay Risal, Mattias Linde, Timothy J Steiner
BACKGROUND: Headache disorders are an important global public-health problem, but under-diagnosed, undertreated and under-prioritized. Deficiencies in health care for headache, present everywhere, are likely to be greater in poorly-resourced countries. This study reports on health-care utilization for headache in Nepal, a low-income country with high headache burden. METHODS: We took data from a cross-sectional, nationwide population-based door-to-door survey, with multistage cluster random sampling...
November 28, 2018: Journal of Headache and Pain
Paolo Martelletti, Todd J Schwedt, Michel Lanteri-Minet, Rebeca Quintana, Veruska Carboni, Hans-Christoph Diener, Elena Ruiz de la Torre, Audrey Craven, Annette Vangaa Rasmussen, Simon Evans, Annik K Laflamme, Rachel Fink, Donna Walsh, Paula Dumas, Pamela Vo
BACKGROUND: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure. METHODS: This study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific region) using an online survey administered to adults with migraine who reported ≥4 MMDs in the 3 months preceding survey administration, with pre-specified criteria of 90% having used preventive migraine treatment (80% with history of ≥1 treatment failure)...
November 27, 2018: Journal of Headache and Pain
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