Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Paola Torelli, Cinzia Finocchi, Florindo d'Onofrio, Luigi d'Onofrio, Renata Rao, Stefano Messina, Laura Di Clemente, Angelo Ranieri, Massimo Autunno, Giuliano Sette, Bruno Colombo, Antonio Carnevale, Marco Aguggia, Miriam Tasillo, Francesco Zoroddu, Fabio Frediani, Massimo Filippi, Carlo Tomino, Stefania Proietti, Stefano Bonassi
BACKGROUND: To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/month), and multiple preventive treatment failures. METHODS: This is a prospective, cohort, real-life study at 28 headache centers on consecutive patients affected by HFEM or CM with multiple preventive treatment failures who were prescribed subcutaneous fremanezumab (225 mg monthly/675 mg quarterly) for ≥ 24 weeks...
March 23, 2023: Journal of Headache and Pain
Zhijian Cao, Wenjing Yu, Luping Zhang, Jiajia Yang, Jiafei Lou, Maosheng Xu, Zhengxiang Zhang
BACKGROUND: The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of metabolites in pain regulatory pathway of acute migraine attack. METHODS: Thirty male Sprague-Dawley (SD) rats were randomly divided into three groups: blank, control, model groups. Then, blank group was intraperitoneally injected with ultrapure water, while control group injected with saline and model group injected with Glyceryl Trinitrate (GTN)...
March 20, 2023: Journal of Headache and Pain
Jiahui He, Mengting Zhou, Fanglin Zhao, Hongrong Cheng, Hao Huang, Xiaopei Xu, Jian Han, Wenwu Hong, Faming Wang, Yujin Xiao, Jinjin Xia, Kaiming Liu
BACKGROUND: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of some metabolic and mitochondrial diseases. This study aimed to assess whether the presence of migraine affects serum levels of FGF-21 and GDF-15, and taking metabolic disorders into account as potential confounding factors...
March 20, 2023: Journal of Headache and Pain
Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
BACKGROUND: Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intracranial pressure (ICP) of CVST. METHODS: In this retrospective study from January 2019 through December 2021, we consecutively enrolled patients with a first-time confirmed diagnosis of CVST by contrast-enhanced magnetic resonance venography (CE-MRV) or computed tomography venography (CTV)...
March 17, 2023: Journal of Headache and Pain
Sait Ashina, Agustin Melo-Carrillo, Ajayi Toluwanimi, Nicolas Bolo, Edina Szabo, David Borsook, Rami Burstein
BACKGROUND: The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, and/or occurrence of headache after exposure to triggers or aura episodes in treatment-responders (≥ 50% reduction in monthly migraine days [MMD]), super-responders (≥ 70%), non-responders (< 50%) and super non-responders (< 30%)...
March 16, 2023: Journal of Headache and Pain
H Genc, B Baykan, H Bolay, D Uluduz, I Unal-Cevik, N Kissani, O Luvsannorov, M Togha, A A Ozdemir, A Ozge
BACKGROUND: Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essential for planning appropriate diagnostic and therapeutic approaches, the primary goals of this multi-centric study are to carry out inter-regional comparisons by using current diagnostic criteria with evaluations of neurologists to delineate headache burden. METHODS: A cross-sectional study between April 1 and May 16, 2022 was conducted with the participation of 13 countries from the Middle East, Asia, and Africa...
March 13, 2023: Journal of Headache and Pain
Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Ali Alhoashle, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur, Gal Ifergane
BACKGROUND: Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians' knowledge. We assessed the variability in migraine diagnosis rates in different communities under universal national health coverage in Israel. METHODS: In this population-based retrospective, observational, cohort study, adult (≥18 years) migraine patients were identified in the computerized database of the southern district of the Clalit Health Services Health Maintenance Organization (HMO) based on recorded diagnosis and/or purchase of specific anti-migraine acute medication (triptans)...
March 13, 2023: Journal of Headache and Pain
Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Kei Ishizuchi, Satoko Hori, Ryo Takemura, Jin Nakahara, Tsubasa Takizawa
BACKGROUND: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond to traditional preventive treatment options. However, since CGRPmAb has been available for only 2 years in Japan, the difference between good and poor responders remains unknown. We aimed to investigate the clinical characteristics of patients with migraine in Japan who responded well to CGRPmAb based on real-world data...
March 9, 2023: Journal of Headache and Pain
Timothy J Steiner, Andreas Husøy, Hallie Thomas, Lars Jacob Stovner
In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from the individual participants in adult population-based studies and child and adolescent schools-based studies, are being collated in two databases, which will be powerful resources for research and teaching and rich information sources for health policy.Here we briefly describe the structure and content of these databases, and announce the intention to make them available in due course as a free good...
March 6, 2023: Journal of Headache and Pain
Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra M Raghava, Frauke Wolfram, Henrik B W Larsson, Messoud Ashina
No abstract text is available yet for this article.
March 6, 2023: Journal of Headache and Pain
Xiaolin Wang, Weinan Na, Ying Yang, Wenwen Zhang, Junxia Zhao, Tingting Zhang, Yuanji Zhou, Hua Liu, Dong Zhao, Shengyuan Yu
To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and childbirth (group J1, onset before menarche; group J2, onset between menarche and childbirth; group J3, onset after childbirth). By comparing migraine (side, location, aggravated by routine physical activity, NRS score, frequency, accompanying symptoms, with premonitory symptom (PS) and trigger, sum of PS and trigger) and migraine-related factors [chronic daily headache, medicine overused headache, body mass index (BMI), education level, exercise status, sleep status, consumption of tea/coffee/alcohol, patient health questionnaire-9 (PHQ-9) score and generalized anxiety disorder-7, (GAD-7) score)] among groups, it was found that the J1 group and the J2 group presented more typical migraine features than the J3 group; 2) the J3 group was more prone to emotion and sleep disorders, weight management issues, frequent migraine attacks and medication overuse...
March 1, 2023: Journal of Headache and Pain
Ying Yang, Fanchao Meng, Hanyu Zhu, Lei Zhang, Guangshuang Lu, Shaobo Xiao, Jiaji He, Shengyuan Yu, Ruozhuo Liu
BACKGROUND: Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, risk factors, and clinical characteristics of HDH and reappraise the HDH diagnostic criteria in the International Classification of Headache Disorders 3 (ICHD-3). METHODS: One hundred and fifty-four patients completed this randomized cross-sectional study...
February 28, 2023: Journal of Headache and Pain
Bianca Raffaelli, Mira Fitzek, Lucas H Overeem, Elisabeth Storch, Maria Terhart, Uwe Reuter
BACKGROUND: Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at all to total migraine freedom. In this study, we aimed to compare clinical characteristics between super-responders (SR) and non-responders (NR) to CGRP(-receptor) mAbs. METHODS: We performed a retrospective cohort study at the Headache Center, Charité - Universitätsmedizin Berlin...
February 27, 2023: Journal of Headache and Pain
Thien Phu Do, Mikala Dømgaard, Simon Stefansen, Timothy J Steiner, Messoud Ashina
INTRODUCTION: Worldwide, far from all of those who would benefit make use of headache services, largely because of clinical, social, and political barriers to access. Identifying the factors contributing to low healthcare utilization can generate evidence to guide health policy. Our purpose here is better to characterize healthcare utilization patterns in Denmark. METHODS: The Headache in Denmark (HINDER) study is a nationwide cross-sectional survey of people with headache, conducted using SurveyXact (Rambøll Group A/S, Copenhagen)...
February 24, 2023: Journal of Headache and Pain
Håkan Ashina, Rune H Christensen, Haidar Muhsen Al-Khazali, Afrim Iljazi, Daniel Tolnai, Anna K Eigenbrodt, Henrik B W Larsson, Henrik W Schytz, Ulrich Lindberg, Faisal Mohammad Amin
OBJECTIVE: To examine whether white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) are more prevalent in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI), compared with healthy controls. METHODS: A magnetic resonance imaging (MRI) study of adults with persistent post-traumatic headache attributed to mild TBI and age- and gender-matched healthy controls. A semi-structured interview and validated self-report instruments were used to record data on demographics, clinical characteristics, and comorbidities...
February 24, 2023: Journal of Headache and Pain
Xueyan Zhang, Wei Wang, Xiaoyan Bai, Yanliang Mei, Hefei Tang, Ziyu Yuan, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui, Yonggang Wang
BACKGROUND: New daily persistent headache (NPDH) is a rare primary headache that is highly disabling. The pathophysiology of NDPH is still unclear, and we aimed to reveal the underlying mechanism of NDPH through functional magnetic resonance imaging (fMRI) analysis. METHODS: In this cross-sectional study, thirty patients with NDPH and 30 healthy controls (HCs) were recruited. The blood oxygen level-dependent (BOLD) sequences of all participants were obtained using the GE 3...
February 23, 2023: Journal of Headache and Pain
Xiuhong Ge, Luoyu Wang, Lei Pan, Haiqi Ye, Xiaofen Zhu, Sandra Fan, Qi Feng, Quan Du, Wenhua Yu, Zhongxiang Ding
OBJECTIVE: This study aimed to combine voxel-based morphometry, deformation-based morphometry, and surface-based morphometry to analyze gray matter volume and cortex shape in classical trigeminal neuralgia patients. METHODS: This study included 79 classical trigeminal neuralgia patients and age- and sex-matched 81 healthy controls. The aforementioned three methods were used to analyze brain structure in classical trigeminal neuralgia patients. Spearman correlation analysis was used to analyze the correlation of brain structure with the trigeminal nerve and clinical parameters...
February 21, 2023: Journal of Headache and Pain
Yan Zhou, Liusheng Gong, Yushu Yang, Linjie Tan, Lili Ruan, Xiu Chen, Hua Luo, Jianghai Ruan
OBJECTIVE: The changes in resting-state functional networks and their correlations with clinical traits remain to be clarified in migraine. Here we aim to investigate the brain spatio-temporal dynamics of resting-state networks and their possible correlations with the clinical traits in migraine. METHODS: Twenty Four migraine patients without aura and 26 healthy controls (HC) were enrolled. Each included subject underwent a resting-state EEG and echo planar imaging examination...
February 20, 2023: Journal of Headache and Pain
Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska-Prosół, Dilara Onan, Karol Marschollek, Wietse Wiels, Petr Mikulenka, Fatemeh Farham, Cédric Gollion, Anne Ducros
Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk...
February 20, 2023: Journal of Headache and Pain
V J Gallardo, J B Gómez-Galván, L Asskour, M Torres-Ferrús, A Alpuente, E Caronna, P Pozo-Rosich
BACKGROUND: Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing evidence shows that disease-related intrinsic factors together with lifestyle (environmental factors), influence epigenetic mechanisms and in turn, diseases. Hence, the main objective of this exploratory study was to find differentially expressed miRNAs (DE miRNA) in peripheral blood mononuclear cells (PBMC) of patients with migraine compared to healthy controls in a well-controlled homogeneous cohort of non-menopausal women...
February 17, 2023: Journal of Headache and Pain
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