journal
https://read.qxmd.com/read/38432930/oxidative-stress-and-antioxidant-capacity-in-patients-with-endometrioma
#1
JOURNAL ARTICLE
Go Ichikawa, Yasuyuki Negishi, Ryo Tsuchiya, Lilika Higuchi, Tatsunori Shiraishi, Mariko Ikeda, Hanako Kaseki, Rimpei Morita, Shunji Suzuki
BackgroundEndometriosis has several clinical features, including dysmenorrhea, infertility, and endometrioma (EMO). Although oxidative stress status is closely related to endometriosis, it is unclear how the balance between oxidative stress capacity and antioxidant capacity correlates with treatment of or factors that worsen endometriosis. In this study, we used peritoneal fluid from patients with EMO to investigate the role of oxidative stress capacity and antioxidant capacity.Materials and MethodsParticipants with EMO (n = 30) and without EMO (uterine myoma, n = 13) were enrolled...
March 2, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38432929/performance-of-a-large-language-model-on-japanese-emergency-medicine-board-certification-examinations
#2
JOURNAL ARTICLE
Yutaka Igarashi, Kyoichi Nakahara, Tatsuya Norii, Nodoka Miyake, Takashi Tagami, Shoji Yokobori
Background Emergency physicians need a broad range of knowledge and skills to address critical medical, traumatic, and environmental conditions. Artificial intelligence (AI), including large language models (LLMs), has potential applications in healthcare settings; however, the performance of LLMs in emergency medicine remains unclear.Methods To evaluate the reliability of information provided by ChatGPT, an LLM was given the questions set by the Japanese Association of Acute Medicine in its board certification examinations over a period of 5 years (2018-2022) and programmed to answer them twice...
March 2, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38432928/changes-in-treatment-conditions-for-patients-receiving-hemodialysis-at-nippon-medical-school-hospital-during-the-covid-19-pandemic
#3
JOURNAL ARTICLE
Naoko Shimoda, Yukinao Sakai, Takuya Nishino, Sayuri Kawasaki, Akio Hirama, Tetsuya Kashiwagi, Masato Iwabu
BACKGROUND: The COVID-19 pandemic has had an enormous impact on hemodialysis patients. This study investigated changes in hemodialysis treatment at our hospital after the start of the pandemic. METHODS: We analyzed data from the Diagnosis Procedure Combination (DPC) system. Data for inpatients receiving dialysis during collection periods A (before the COVID-19 pandemic) and B (after the start of the COVID-19 pandemic) were extracted and compared. The numbers of inpatients and new patients, the number of patients admitted (by department), duration of stay, mortality, place of residence, surgical procedures, and DPC classification were compared...
March 2, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38432927/difficulties-nurses-report-in-caring-for-patients-with-bone-metastases-and-their-expectations-after-participating-in-a-bone-metastasis-cancer-board-a-questionnaire-study
#4
JOURNAL ARTICLE
Tsunemi Kitagawa, Yasuyuki Kitagawa, Yoichiro Aoyagi, Tokifumi Majima
BACKGROUND: Patients with bone metastases often face physical, mental, and social challenges that require multidisciplinary management. To improve treatment and practice, we conducted a questionnaire survey to assess nurses' opinions of problems related to caring for patients with bone metastases. In addition, we investigated nurses' perceptions of bone metastases after participating in a Bone Metastasis Cancer Board (BMCB). METHODS: An anonymous questionnaire survey on problems in bone metastasis treatment and the BMCB was conducted...
March 2, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38233127/current-status-of-robotic-hepatobiliary-and-pancreatic-surgery
#5
JOURNAL ARTICLE
Keisuke Minamimura, Yuto Aoki, Youhei Kaneya, Satoshi Matsumoto, Hiroki Arai, Daisuke Kakinuma, Yukio Oshiro, Yoichi Kawano, Masanori Watanabe, Yoshiharu Nakamura, Hideyuki Suzuki, Hiroshi Yoshida
Laparoscopic surgery is performed worldwide and has clear economic and social benefits in terms of patient recovery time. It is used for most gastrointestinal surgical procedures, but laparoscopic surgery for more complex procedures in the esophageal, hepatobiliary, and pancreatic regions remains challenging. Minimally invasive surgery that results in accurate tumor dissection is vital in surgical oncology, and development of surgical systems and instruments plays a key role in assisting surgeons to achieve this...
March 9, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/36823120/relapse-of-acquired-hemophilia-a-after-covid-19-infection
#6
JOURNAL ARTICLE
Atsushi Marumo, Hisae Sugihara, Ikuko Omori, Eriko Morishita
Acquired hemophilia A (AHA) is a rare disease in which an autoantibody causes bleeding by interacting with and inhibiting the coagulation activity of endogenous factor VIII (FVIII). Most cases of AHA are idiopathic; known causes include autoimmune diseases, malignant tumors, pregnancy, drugs, and viral infections. An 86-year-old man was diagnosed with AHA based on the following results: an activated partial thromboplastin time (aPTT) extension of 130.7 seconds, presence of an inhibitor pattern in a mixing study, an endogenous factor VIII (FVIII) level of <1%, and an FVIII inhibitor titer of >5...
January 20, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38233126/smoking-related-interstitial-fibrosis-and-smoker-s-macrophages
#7
JOURNAL ARTICLE
Namiko Taniuchi, Yoshinobu Saito, Norio Motoda, Masahiro Seike
Smoking-related interstitial lung diseases (SRILDs) are a group of heterogeneous diffuse pulmonary parenchymal diseases associated with tobacco exposure. Smoking-related interstitial fibrosis (SRIF) is relatively recent, a pathologically defined form of SRILDs. SRIF is characterized by the accumulation of macrophages in the alveolar spaces, which is associated with interstitial inflammation and fibrosis. The macrophages frequently contain light brown pigment and are called 'smoker' s macrophages'. Patients with SRIF who have clinical evidence of interstitial lung disease are most commonly relatively young, heavy smokers with abnormalities on chest computed tomography showing ground-glass opacities, peripheral consolidation, and reticulation...
January 16, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38233125/changes-in-metamorphopsia-in-patients-undergoing-treatment-for-vitreoretinal-disorders
#8
JOURNAL ARTICLE
Fumiki Okamoto
PURPOSE: To quantify and compare the severity of metamorphopsia in patients undergoing vitrectomy for vitreoretinal disorders. METHODS: Data were collected evaluated from 319 patients with vitreoretinal disorders, including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch retinal vein occlusion (BRVO-CME), CME with central retinal vein occlusion (CRVO), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD)...
January 16, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38233124/clinicopathological-characteristics-of-everolimus-associated-interstitial-lung-disease-a-single-center-consecutive-analysis
#9
JOURNAL ARTICLE
Yoshinobu Saito, Yasuhiro Terasaki, Takeru Kashiwada, Toru Tanaka, Hiroyuki Takei, Go Kimura, Yukihiro Kondo, Tetsuro Kawagoe, Akira Matsushita, Rintaro Noro, Yuji Minegishi, Koichiro Kamio, Masahiro Seike, Akihiko Gemma
BACKGROUND: Everolimus, a mammalian target of rapamycin inhibitor used as an antineoplastic drug, is associated with a remarkably high incidence of interstitial lung disease (ILD). The clinical and pathological characteristics of ILD caused by everolimus have not been thoroughly investigated; therefore, we aimed to elucidate the features of everolimus-associated ILD. METHODS: We retrospectively reviewed the medical records of patients who received everolimus for cancer treatment at our hospital...
January 16, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38233123/human-adipose-tissue-derived-stem-cells-inhibit-coronary-artery-vasculitis-in-a-mouse-model-of-kawasaki-disease
#10
JOURNAL ARTICLE
Ryohei Fukunaga, Takahiro Ueda, Ryosuke Matsui, Toshikazu Itabashi, Ryuji Fukazawa, Noriko Nagi-Miura, Yasuhiko Itoh
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (ADSCs) are used for the treatment of various diseases because of their rapid proliferation and high anti-inflammatory and tissue repair properties. Kawasaki disease is a systemic vasculitis with coronary arteritis and aneurysms occurring in pediatric patients. In this study, we examined serologically and pathologically whether the administration of human ADSCs (hADSCs) to a mouse model of Kawasaki disease could suppress vasculitis...
January 16, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38462443/finite-element-analysis-of-the-effect-of-femoral-prosthesis-varus-and-valgus-angle-installation-on-the-lateral-compartment-in-unicompartmental-knee-arthroplasty
#11
JOURNAL ARTICLE
Yonggui Wang, Chongyang Xu, Bo Yang, Fei Yu, Ai Guo
BACKGROUND: This study used finite element analysis (FEA) to investigate the effect of varus and valgus angle on the lateral compartment in unicompartmental knee arthroplasty (UKA). METHODS: One patient who underwent UKA was enrolled as the subject. Thirteen working conditions of the femoral prosthesis were simulated at varus and valgus angles of 0°, 2°, 4°, 6°, 8°, 10°, and 12°. A load of 1,000 N was applied downward along the mechanical axis of the femur, and the highest stress values on the surface of the polyethylene liner, cancellous bone under the tibial prosthesis, cartilage of femur lateral condyle, lateral meniscus, and tibial lateral plateau cartilage in each model were recorded...
2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38462442/usefulness-of-the-palliative-prognostic-index-in-predicting-prognosis-when-considering-the-transition-from-hospital-to-home-care-in-patients-with-terminal-stage-cancer
#12
JOURNAL ARTICLE
Shiho Sakaguchi, Masahiro Sakaguchi, Shunsuke Honma, Tomohiro Yagi, Gakuji Osawa, Akira Hirano, Hiroki Yamaguchi, Takayuki Hisanaga, Shunichi Shiozawa
BACKGROUND: No accurate prognostic tool is available for patients with cancer who spend their final days at home. In this study, we examined whether performance status (PS) and the palliative prognostic index (PPI), a well-known prognostic tool in palliative care units, could be used to predict prognosis in the home care setting at the time of intervention by home physicians. SUBJECTS AND METHODS: Using medical records, we conducted a retrospective analysis of 132 patients who were referred to the Home Clinic Naginoki for home care for terminal stages of carcinoma in situ...
2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38462441/medical-economic-effect-of-pharmaceutical-interventions-by-board-certified-pharmacists-in-palliative-pharmacy-for-patients-with-cancer-using-medical-narcotics-in-japan-a-multicenter-retrospective-study
#13
JOURNAL ARTICLE
Takehiro Kawashiri, Hideki Sugawara, Katsuya Makihara, Rintaro Ohno, Yoshihiro Miyamoto, Noriaki Hidaka, Mayako Uchida, Hisamitsu Takase
BACKGROUND: The Japanese Society for Pharmaceutical Palliative Care and Sciences specializes in pharmacology in the field of palliative medicine. More than 700 board-certified pharmacists in palliative pharmacy (BCPPP) are actively involved in palliative pharmacotherapy at various hospitals and pharmacies. The purpose of this study was to determine the economic effect of pharmaceutical interventions by BCPPPs. METHODS: This multicenter retrospective study included 27 medical centers and analyzed the medical economic effect of interventions by BCPPPs (17 pharmacists) and non-BCPPPs (24 pharmacists) on patients using medical narcotics for cancer pain in September 2021...
2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38462440/ganglia-induced-tarsal-tunnel-syndrome
#14
JOURNAL ARTICLE
Kenta Koketsu, Kyongsong Kim, Takato Tajiri, Toyohiko Isu, Daijiro Morimoto, Rinko Kokubo, Hiroyuki Dan, Akio Morita
BACKGROUND: Tarsal tunnel syndrome (TTS) is a common entrapment neuropathy that is sometimes elicited by ganglia in the tarsal tunnel. METHODS: Between August 2020 and July 2022, we operated on 117 sides with TTS. This retrospective study examined data from 8 consecutive patients (8 sides: 5 men, 3 women; average age 67.8 years) with an extraneural ganglion in the tarsal tunnel. We investigated the clinical characteristics and surgical outcomes for these patients...
2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38072422/atypical-clinical-courses-of-graves-disease-confound-differential-diagnosis-of-hyperthyroidism
#15
JOURNAL ARTICLE
Yuji Yamaguchi, Fumitaka Okajima, Hitoshi Sugihara, Masato Iwabu, Naoya Emoto
BACKGROUND: This study examined the appropriateness of the current paradigm for differential diagnosis of painless thyroiditis and Graves' disease (GD) in patients with thyrotoxicosis. METHODS: We retrospectively evaluated the clinical course of 343 consecutive patients with hyperthyroidism diagnosed by Tc-99m pertechnetate thyroid uptake (TcTU) testing at our hospital from January 2011 to December 2017. RESULTS: Of the 263 patients with normal or high TcTU levels (≥1...
December 8, 2023: Journal of Nippon Medical School
https://read.qxmd.com/read/38072421/effectiveness-of-repetitive-hyperbaric-oxygen-therapy-for-chronic-limb-threatening-ischemia
#16
JOURNAL ARTICLE
Gen Takagi, Sonoko Kirinoki-Ichikawa, Shuhei Tara, Ikuyo Takagi, Masaaki Miyamoto
BACKGROUND: Lower extremity artery disease is strongly associated with morbidity and is typically addressed through revascularization interventions. We assessed the clinical outcomes of patients with chronic limb-threatening ischemia (CLTI) without revascularization who did and did not undergo repetitive hyperbaric oxygen therapy (HBOT). METHODS: Between April 2002 and March 2017, the records of 58 patients with CLTI (Rutherford classification 4 in 19% and 5 in 81%) were evaluated retrospectively...
December 8, 2023: Journal of Nippon Medical School
https://read.qxmd.com/read/38072420/distribution-of-splenic-arterial-flow-and-segmental-spleen-volume-for-partial-splenic-arterial-embolization
#17
JOURNAL ARTICLE
Junji Ueda, Yasuhiro Mamada, Nobuhiko Taniai, Masato Yoshioka, Akira Matsushita, Satoshi Mizutani, Youichi Kawano, Tetsuya Shimizu, Tomohiro Kanda, Hideyuki Takata, Hiroyasu Furuki, Yuto Aoki, Mampei Kawashima, Toshiyuki Irie, Takashi Ohno, Takahiro Haruna, Hiroshi Yoshida
INTRODUCTION: The spleen is a lymphatic organ that manages immune surveillance of the blood, produces blood cells, and helps filter the blood, remove old blood cells, and fight infection. The normal splenic weight is approximately 65-265 g. This study evaluated spleen volume and segmental volume. METHODS: 121 patients who underwent enhanced CT at our center were analyzed. The spleen was divided into upper, middle, and lower segments according to arterial flow area, and the volume of each segment was measured...
December 8, 2023: Journal of Nippon Medical School
https://read.qxmd.com/read/38072419/usefulness-of-self-selected-scenarios-for-simple-triage-and-rapid-treatment-method-using-virtual-reality
#18
JOURNAL ARTICLE
Satoshi Harada, Ryotaro Suga, Kensuke Suzuki, Shinnosuke Kitano, Kenji Fujimoto, Kenji Narikawa, Mayumi Nakazawa, Satoo Ogawa
BACKGROUND: Repeated triage training is necessary to maintain and improve the accuracy of simple triage and rapid treatment (START), a popular triage method. Virtual reality (VR) may be more effective than conventional training methods. This study aimed to verify the educational usefulness of START using VR originally developed for students. METHODS: A VR was initially developed with a function that allowed students to select the triage procedure and its evaluation...
December 8, 2023: Journal of Nippon Medical School
https://read.qxmd.com/read/38072418/safety-and-feasibility-of-laparoscopic-liver-resection-with-the-clamp-crush-method-using-the-bisect
#19
JOURNAL ARTICLE
Masato Yoshioka, Tetsuya Shimizu, Junji Ueda, Mampei Kawashima, Toshiyuki Irie, Takahiro Haruna, Takashi Ohno, Youichi Kawano, Yoshiaki Mizuguchi, Akira Matsushita, Nobuhiko Taniai, Hiroshi Yoshida
BACKGROUND: Various energy devices are available for resection of the liver parenchyma during laparoscopic liver resection (LLR). We have historically performed liver resections using the Cavitron Ultrasonic Surgical Aspirator (CUSA). More recently, we have used new bipolar forceps (BiSect; Erbe Elektromedizin GmbH, Tübingen, Germany) to perform clamp-crush dissection with good results. The BiSect is a reusable bipolar forceps with a laparoscopic dissecting forceps tip and both an incision mode and coagulation mode...
December 8, 2023: Journal of Nippon Medical School
https://read.qxmd.com/read/38072417/methylation-of-plk-1-potentially-drives-bendamustine-resistance-in-leukemia-cells
#20
JOURNAL ARTICLE
Toshikazu Itabashi, Takahiro Ueda, Ryohei Fukunaga, Takeshi Asano, Yasuhiko Itoh
BACKGROUND: Drug resistance remains a significant impediment in leukemia treatment. While Bendamustine hydrochloride (BH) stands out as a promising therapeutic agent for non-Hodgkin' s lymphoma and mantle cell lymphoma, the mechanisms of resistance to BH are not yet fully understood. Our study focuses on elucidating the mechanisms behind bendamustine resistance in leukemia cells, with a specific emphasis on epigenetics. METHODS: Bendamustine-resistant cells were cultivated from human B cell lymphoblastic leukemia cell lines through systematic and sustained exposure to bendamustine, using the limiting dilution method...
December 8, 2023: Journal of Nippon Medical School
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