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Journals Current Issues in Molecular Bi...

Current Issues in Molecular Biology

https://read.qxmd.com/read/38534790/the-role-of-urothelial-cancer-associated-1-in-gynecological-cancers
#1
REVIEW
Eleni Nousiopoulou, Kleio Vrettou, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Panagiotis Tsikouras, Nikolaos Nikolettos, Konstantinos Nikolettos, Iason Psilopatis
Gynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various cancers. Urothelial cancer-associated 1 (UCA1) is a lncRNA, first found deregulated in bladder cancer, and many studies have exposed its oncogenic effects in more tumors since. However, the role of UCA1 in gynecological malignancies is still unclear. This review aims to analyze and define the role of UCA1 in GC, in order to identify its potential use as a diagnostic, prognostic, or therapeutic biomarker of GC...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534789/genetic-insights-into-the-extremely-dwarf-hibiscus-syriacus-var-micranthus-complete-chloroplast-genome-analysis-and-development-of-a-novel-dcaps-marker
#2
JOURNAL ARTICLE
Soon-Ho Kwon, Hae-Yun Kwon, Hanna Shin
This study explored the chloroplast (cp) genomes of three Hibiscus syriacus (HS) specimens endemic to Korea possessing unique ornamental and conservation values: the dwarf H. syriacus var. micranthus (HSVM), renowned for its small stature and breeding potential; HS 'Tamra', a cultivar from Korea's southernmost islands, noteworthy for its distinctive beauty; and HS Natural Monument no. 521 (N.M.521), a specimen of significant lifespan and height. Given the scarcity of evolutionary studies on these specimens, we assembled and analyzed their cp genomes...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534788/the-opposite-functions-of-cd30-ligand-isoforms
#3
JOURNAL ARTICLE
Ignat Printsev, Elyas Alalli, Janine Bilsborough
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell differentiation, cell death/survival, and cytokine production. The signaling pair has been implicated in hematopoietic malignancies and inflammatory disease, and a chemotherapy-CD30 antibody combination for the treatment of Hodgkin and other lymphomas has been developed...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534787/unveiling-the-molecular-mechanism-of-trastuzumab-resistance-in-skbr3-and-bt474-cell-lines-for-her2-positive-breast-cancer
#4
JOURNAL ARTICLE
Anna Kokot, Sachin Gadakh, Indrajit Saha, Ewa Gajda, Michał Łaźniewski, Somnath Rakshit, Kaustav Sengupta, Ayatullah Faruk Mollah, Michał Denkiewicz, Katarzyna Górczak, Jürgen Claesen, Tomasz Burzykowski, Dariusz Plewczynski
HER2-positive breast cancer is one of the most prevalent forms of cancer among women worldwide. Generally, the molecular characteristics of this breast cancer include activation of human epidermal growth factor receptor-2 (HER2) and hormone receptor activation. HER2-positive is associated with a higher death rate, which led to the development of a monoclonal antibody called trastuzumab, specifically targeting HER2. The success rate of HER2-positive breast cancer treatment has been increased; however, drug resistance remains a challenge...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534786/the-ethyl-acetate-extract-of-caulerpa-microphysa-promotes-collagen-homeostasis-and-inhibits-inflammation-in-the-skin
#5
JOURNAL ARTICLE
Kuo-Yun Lu, Li-Ching Cheng, Zheng-Ci Hung, Ze-Ying Chen, Chuang-Wei Wang, Hsin-Han Hou
Inflammation and collagen-degrading enzymes' overexpression promote collagen decomposition, which affects the structural integrity of the extracellular matrix. The polysaccharide and peptide extracts of the green alga Caulerpa microphysa ( C. microphysa ) have been proven to have anti-inflammatory, wound healing, and antioxidant effects in vivo and in vitro. However, the biological properties of the non-water-soluble components of C. microphysa are still unknown. In the present study, we demonstrated the higher effective anti-inflammatory functions of C...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534785/cellular-organelle-related-transcriptomic-profile-abnormalities-in-neuronopathic-types-of-mucopolysaccharidosis-a-comparison-with-other-neurodegenerative-diseases
#6
JOURNAL ARTICLE
Karolina Wiśniewska, Lidia Gaffke, Magdalena Żabińska, Grzegorz Węgrzyn, Karolina Pierzynowska
Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) degradation. As a result, GAGs accumulate in lysosomes, impairing the proper functioning of entire cells and tissues. There are 14 types/subtypes of MPS, which are differentiated by the kind(s) of accumulated GAG(s) and the type of a non-functional lysosomal enzyme. Some of these types (severe forms of MPS types I and II, MPS III, and MPS VII) are characterized by extensive central nervous system disorders...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534784/micro-nano-plastics-and-their-potential-impact-on-human-gut-health-a-narrative-review
#7
REVIEW
Carlo Covello, Federica Di Vincenzo, Giovanni Cammarota, Marco Pizzoferrato
Microplastics and nanoplastics (MNPs) are becoming an increasingly severe global problem due to their widespread distribution and complex impact on living organisms. Apart from their environmental impact, the effects of MNPs on living organisms have also continued to attract attention. The harmful impact of MNPs has been extensively documented in marine invertebrates and larger marine vertebrates like fish. However, the research on the toxicity of these particles on mammals is still limited, and their possible effects on humans are poorly understood...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534783/an-elevated-il10-mrna-combined-with-lower-tnfa-mrna-level-in-active-rheumatoid-arthritis-peripheral-blood
#8
JOURNAL ARTICLE
Georgi Vasilev, Viktoria Vasileva, Mariana Ivanova, Spaska Stanilova, Irena Manolova, Lyuba Miteva
We aimed to investigate the expression of pro-inflammatory cytokine genes TNFA , IL6 , IL12B , IL23 , IL18 and immunoregulatory genes FOXP3 , TGFB1 , and IL10 in the peripheral blood of patients with rheumatoid arthritis (RA) at messenger ribonucleic acid (mRNA) level. The total RNA was isolated from peripheral blood samples. Real-time quantitative PCR was used to perform TaqMan-based assays to quantify mRNAs from 8 target genes. IL23A was upregulated (1.7-fold), whereas IL6 (5-fold), FOXP3 (4-fold), and IL12B (2...
March 20, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534782/clinical-genomic-analysis-of-1261-patients-with-ehlers-danlos-syndrome-outlines-an-articulo-autonomic-gene-network-entome
#9
JOURNAL ARTICLE
Golder N Wilson, Vijay S Tonk
Systematic evaluation of 80 history and 40 history findings diagnosed 1261 patients with Ehlers-Danlos syndrome (EDS) by direct or online interaction, and 60 key findings were selected for their relation to clinical mechanisms and/or management. Genomic testing results in 566 of these patients supported EDS relevance by their differences from those in 82 developmental disability patients and by their association with general rather than type-specific EDS findings. The 437 nuclear and 79 mitochondrial DNA changes included 71 impacting joint matrix (49 COL5 ), 39 bone (30 COL1/2/9/11 ), 22 vessel (12 COL3/8VWF) , 43 vessel-heart (17 FBN1 /11 TGFB / BR) , 59 muscle (28 COL6/12 ), 56 neural (16 SCN9A / 10A / 11A ), and 74 autonomic (13 POLG /25porphyria related)...
March 19, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534781/bio-chemoinformatics-driven-analysis-of-nsp7-and-nsp8-mutations-and-their-effects-on-viral-replication-protein-complex-stability
#10
JOURNAL ARTICLE
Bryan John J Subong, Takeaki Ozawa
The nonstructural proteins 7 and 8 (nsp7 and nsp8) of SARS-CoV-2 are highly important proteins involved in the RNA-dependent polymerase (RdRp) protein replication complex. In this study, we analyzed the global mutation of nsp7 and nsp8 in 2022 and 2023 and analyzed the effects of mutation on the viral replication protein complex using bio-chemoinformatics. Frequently occurring variants are found to be single amino acid mutations for both nsp7 and nsp8. The most frequently occurring mutations for nsp7 which include L56F, L71F, S25L, M3I, D77N, V33I and T83I are predicted to cause destabilizing effects, whereas those in nsp8 are predicted to cause stabilizing effects, with the threonine to isoleucine mutation (T89I, T145I, T123I, T148I, T187I) being a frequent mutation...
March 18, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534780/effects-of-rpl1001-gene-deletion-on-cell-division-of-fission-yeast-and-its-molecular-mechanism
#11
JOURNAL ARTICLE
Wen Yu, Rongmei Yuan, Mengnan Liu, Ke Liu, Xiang Ding, Yiling Hou
The rpl1001 gene encodes 60S ribosomal protein L10, which is involved in intracellular protein synthesis and cell growth. However, it is not yet known whether it is involved in the regulation of cell mitosis dynamics. This study focuses on the growth, spore production, cell morphology, the dynamics of microtubules, chromosomes, actin, myosin, and mitochondria of fission yeast ( Schizosaccharomyces pombe ) to investigate the impact of rpl1001 deletion on cell mitosis. RNA-Seq and bioinformatics analyses were also used to reveal key genes, such as hsp16 , mfm1 and isp3 , and proteasome pathways...
March 18, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534779/autosomal-recessive-rod-cone-dystrophy-with-mild-extra-ocular-manifestations-due-to-a-splice-affecting-variant-in-bbs9
#12
Iris Deitch, Sofia Itskov, Daan Panneman, Aasem Abu Shtaya, Tal Saban, Yael Goldberg, Miriam Ehrenberg, Frans P M Cremers, Susanne Roosing, Tamar Ben-Yosef
Bardet-Biedl syndrome (BBS), one of the most common forms of syndromic inherited retinal diseases (IRDs), is characterized by the combination of retinal degeneration with additional extra-ocular manifestations, including obesity, intellectual disability, kidney disease, polydactyly and other skeletal abnormalities. We observed an Israeli patient with autosomal recessive apparently non-syndromic rod-cone dystrophy (RCD). Extra-ocular findings were limited to epilepsy and dental problems. Genetic analysis with a single molecule molecular inversion probes-based panel that targets the exons and splice sites of 113 genes associated with retinitis pigmentosa and Leber congenital amaurosis revealed a homozygous rare missense variant in the BBS9 gene (c...
March 18, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534778/genetic-and-environmental-factors-in-autoimmune-thyroid-disease-exploring-associations-with-selenium-levels-and-novel-loci-in-a-latvian-cohort
#13
JOURNAL ARTICLE
Sabine Upmale-Engela, Ieva Vaivode, Raitis Peculis, Helena Litvina, Tatjana Zake, Andrejs Skesters, Deniss Gogins, Vita Rovite, Ilze Konrade
The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production...
March 17, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534777/the-nlrp3-inflammasome-gene-is-overexpressed-in-hidradenitis-suppurativa-lesions-a-preliminary-study-on-the-role-of-pyroptosis-in-disease-pathogenesis
#14
JOURNAL ARTICLE
Piotr K Krajewski, Weronika Szukała, Jacek C Szepietowski
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls...
March 16, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534776/the-influence-of-neurotrophins-on-the-brain-lung-axis-conception-pregnancy-and-neonatal-period
#15
REVIEW
Federica D'Amico, Cecilia Lugarà, Giovanni Luppino, Carlo Giuffrida, Ylenia Giorgianni, Eleonora Maria Patanè, Sara Manti, Antonella Gambadauro, Mariarosaria La Rocca, Tiziana Abbate
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs...
March 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534775/complete-mitochondrial-genomes-of-nedyopus-patrioticus-new-insights-into-the-color-polymorphism-of-millipedes
#16
JOURNAL ARTICLE
Gaoji Zhang, Tangjun Xu, Yukun Chen, Wei Xu, Yinuo Wang, Yuanyuan Li, Fuyuan Zhu, Hongyi Liu, Honghua Ruan
There has been debate about whether individuals with different color phenotypes should have different taxonomic status. In order to determine whether the different color phenotypes of Nedyopus patrioticus require separate taxonomic status or are simply synonyms, here, the complete mitochondrial genomes (mitogenomes) of two different colored N. patrioticus , i.e., red N. patrioticus and white N. patrioticus , are presented. The two mitogenomes were 15,781 bp and 15,798 bp in length, respectively. Each mitogenome contained 13 PCGs, 19 tRNAs, 2 rRNAs, and 1 CR, with a lack of trnI , trnL2 , and trnV compared to other Polydesmida species...
March 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534774/exploring-the-genomic-landscape-of-bacillus-paranthracis-pumb_17-as-a-proficient-phosphatidylcholine-specific-phospholipase-c-producer
#17
JOURNAL ARTICLE
Vesselin Baev, Ivan Iliev, Yordan Stefanov, Marinela Tsankova, Mariana Marhova, Elena Apostolova, Mariyana Gozmanova, Galina Yahubyan, Sonya Kostadinova
Phospholipases find versatile applications across industries, including detergent production, food modification, pharmaceuticals (especially in drug delivery systems), and cell signaling research. In this study, we present a strain of Bacillus paranthracis for the first time, demonstrating significant potential in the production of phosphatidylcholine-specific phospholipase C (PC-PLC). The investigation thoroughly examines the B. paranthracis PUMB_17 strain, focusing on the activity of PC-PLC and its purification process...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534773/-n-3-methylbutyl-benzisoselenazol-3-2h-one-exerts-antifungal-activity-in-vitro-and-in-a-mouse-model-of-vulvovaginal-candidiasis
#18
JOURNAL ARTICLE
Xiuyi Liang, Agata J Pacuła-Miszewska, Richa Vartak, Milankumar Prajapati, Haiyan Zheng, Caifeng Zhao, Ganming Mao, Ketankumar Patel, Natalya U Fedosova, Jacek Ścianowski, Blase Billack
In the present work, we evaluated the antifungal activities of two novel ebselen analogs, N -allyl-benzisoselenazol-3(2H)-one ( N -allyl-bs) and N -3-methylbutylbenzisoselenazol-3(2H)-one ( N -3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans . N -3mb-bs was more active than the N -allyl-bs compound. It is noteworthy that the concentration of N -3mb-bs observed to inhibit fungal growth by 50% (18...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534772/5-aza-upregulates-socs3-and-ptpn6-shp1-inhibiting-stat3-and-potentiating-the-effects-of-ag490-against-primary-effusion-lymphoma-cells
#19
JOURNAL ARTICLE
Michele Di Crosta, Andrea Arena, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone
Epigenetic modifications, including aberrant DNA methylation occurring at the promoters of oncogenes and oncosuppressor genes and histone modifications, can contribute to carcinogenesis. Aberrant methylation mediated by histone methylatransferases, alongside histones, can affect methylation of proteins involved in the regulation of pro-survival pathways such as JAK/STAT and contribute to their activation. In this study, we used DNA or histone demethylating agents, 5-Azacytidine (5-AZA) or DS-3201 (valemetostat), respectively, to treat primary effusion lymphoma (PEL) cells, alone or in combination with AG490, a Signal transducer and activator of transcription 3 (STAT3) inhibitor...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534771/prognostic-value-of-p63-expression-in-muscle-invasive-bladder-cancer-and-association-with-molecular-subtypes-preliminary-report
#20
JOURNAL ARTICLE
Francesca Sanguedolce, Ugo Giovanni Falagario, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Stefano Ascani, Simona Tortorella, Gian Maria Busetto, Angelo Cormio, Giuseppe Carrieri, Luigi Cormio
There is an ongoing need for biomarkers that could reliably predict the outcome of BC and that could guide the management of this disease. In this setting, we aimed to explore the prognostic value of the transcription factor P63 in patients with muscle-invasive bladder cancer (MIBC) having undergone radical cystectomy. The correlation between P63 expression and clinicopathological features (tumor stage, nodes involvement, patterns of muscularis propria invasion, papillary architecture, anaplasia, concomitant carcinoma in situ, lymphovascular invasion, perineural invasion, necrosis) and molecular subtyping (basal and luminal type tumors) was tested in 65 radical cystectomy specimens and matched with cancer-specific survival (CSS) and overall survival (OS)...
March 14, 2024: Current Issues in Molecular Biology
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