journal
https://read.qxmd.com/read/38466515/the-potential-use-of-nanozyme-in-aging-and-age-related-diseases
#1
REVIEW
Amirsasan Gorgzadeh, Paria Arab Amiri, Saman Yasamineh, Basim Kareem Naser, Khairia Abdulrahman Abdulallah
The effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the prevalence of age-related diseases such as cardiovascular and neurological conditions, type 2 diabetes, osteoporosis, and cancer...
March 11, 2024: Biogerontology
https://read.qxmd.com/read/38441836/a-comprehensive-model-for-the-biochemistry-of-ageing-senescence-and-longevity
#2
REVIEW
Hiskias Gerrit Keizer, R Brands, Ronald Sake Oosting, Willem Seinen
Various models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis...
March 5, 2024: Biogerontology
https://read.qxmd.com/read/38441835/telomeres-in-health-and-longevity-special-issue-in-memory-of-alexey-olovnikov
#3
EDITORIAL
Ivan A Olovnikov
In this special issue we commemorate theoretical biologist Alexey Olovnikov (1936-2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging from telomere length dynamics in wild animal populations to problems of telomere maintenance during human space flight...
March 5, 2024: Biogerontology
https://read.qxmd.com/read/38436793/regulation-of-enpp5-a-senescence-associated-secretory-phenotype-factor-prevents-skin-aging
#4
JOURNAL ARTICLE
Kento Takaya, Kazuo Kishi
Aging negatively affects the appearance and texture of the skin owing to the accumulation of senescent fibroblasts within the dermis. Senescent cells undergo abnormal remodeling of collagen and the extracellular matrix through an inflammatory histolytic senescence-associated secretory phenotype (SASP). Therefore, suppression of SASP in senescent cells is essential for the development of effective skin anti-aging therapies. Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5), an extracellular signaling molecule, has been implicated in vascular aging and apoptosis; however, its role in SASP remains unclear...
March 4, 2024: Biogerontology
https://read.qxmd.com/read/38403802/the-sglt2-inhibitor-empagliflozin-inhibits-skeletal-muscle-fibrosis-in-naturally-aging-male%C3%A2-mice-through-the-ampk%C3%AE-mmp9-tgf-%C3%AE-1-smad-pathway
#5
JOURNAL ARTICLE
Qixuan Huang, Jie Chen, Siqi Liao, Jiangchuan Long, Ronghua Fang, Yusen He, Peiyun Chen, Dongfang Liu
With advancing age, the incidence of sarcopenia increases, eventually leading to a cascade of adverse events. However, there is currently a lack of effective pharmacological treatment for sarcopenia. Sodium-glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin demonstrates anti-fibrotic capabilities in various organs. This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age...
February 26, 2024: Biogerontology
https://read.qxmd.com/read/38353919/cell-type-specific-and-differential-expression-of-linc-rsas-long-noncoding-rna-declines-in-the-testes-during-ageing-of-the-rat
#6
JOURNAL ARTICLE
Ajay Kumar Danga, Sukhleen Kour, Anita Kumari, Pramod C Rath
Long noncoding RNAs (lncRNAs) have emerged as major regulators of gene expression, chromatin structure, epigenetic changes, post-transcriptional processing of RNAs, translation of mRNAs into proteins as well as contributing to the process of ageing. Ageing is a universal, slow, progressive change in almost all physiological processes of organisms after attaining reproductive maturity and often associated with age-related diseases. Mammalian testes contain various cell-types, vast reservoir of transcriptome complexity, produce haploid male gametes for reproduction and testosterone for development and maintenance of male sexual characters as well as contribute genetic variation to the species...
February 14, 2024: Biogerontology
https://read.qxmd.com/read/38349436/renal-aging-and-mitochondrial-quality-control
#7
REVIEW
Xiuli Guo, Jiao Wang, Yinjie Wu, Xinwang Zhu, Li Xu
Mitochondria are dynamic organelles that participate in different cellular process that control metabolism, cell division, and survival, and the kidney is one of the most metabolically active organs that contains abundant mitochondria. Perturbations in mitochondrial homeostasis in the kidney can accelerate kidney aging, and maintaining mitochondrial homeostasis can effectively delay aging in the kidney. Kidney aging is a degenerative process linked to detrimental processes. The significance of aberrant mitochondrial homeostasis in renal aging has received increasing attention...
February 13, 2024: Biogerontology
https://read.qxmd.com/read/38310618/a-crispr-base-editing-approach-for-the-functional-assessment-of-telomere-biology-disorder-related-genes-in-human-health-and-aging
#8
JOURNAL ARTICLE
Gustavo Borges, Yahya Benslimane, Lea Harrington
Telomere Biology Disorders (TBDs) are a group of rare diseases characterized by the presence of short and/or dysfunctional telomeres. They comprise a group of bone marrow failure syndromes, idiopathic pulmonary fibrosis, and liver disease, among other diseases. Genetic alterations (variants) in the genes responsible for telomere homeostasis have been linked to TBDs. Despite the number of variants already identified as pathogenic, an even more significant number must be better understood. The study of TBDs is challenging since identifying these variants is difficult due to their rareness, it is hard to predict their impact on the disease onset, and there are not enough samples to study...
February 4, 2024: Biogerontology
https://read.qxmd.com/read/38252370/linking-telomere-dynamics-to-evolution-life-history-and-environmental-change-perspectives-predictions-and-problems
#9
REVIEW
Pat Monaghan
This perspectives paper considers the value of studying telomere biology outside of a biomedical context. I provide illustrative examples of the kinds of questions that evolutionary ecologists have addressed in studies of telomere dynamics in non-model species, primarily metazoan animals, and what this can contribute to our understanding of their evolution, life histories and health. I also discuss why the predicted relationships between telomere dynamics and life history traits, based on the detailed cellular studies in humans and model organisms, are not always found in studies in other species...
January 22, 2024: Biogerontology
https://read.qxmd.com/read/38240923/sustained-exposure-to-high-glucose-induces-differential-expression-of-cellular-senescence-markers-in-murine-macrophages-but-impairs-immunosurveillance-response-to-senescent-cells-secretome
#10
JOURNAL ARTICLE
Bhawna Diwan, Rahul Yadav, Rohit Goyal, Rohit Sharma
The influence of chronic diseases on various facets of macrophage cellular senescence is poorly understood. This study evaluated the impact of chronic hyperglycemia on the induction of cellular senescence and subsequent immunosurveillance functions in RAW264.7 macrophages. Macrophages were cultured under normal glucose (NG; 5 mM), high glucose (HG; 20 mM), and very high glucose (VHG; 40 mM) conditions and assessed for markers of cellular senescence. Hyperglycemia induced strong upregulation of SA-β-gal activity, and loss of PCNA and Lamin B1 gene expression while markers of cell cycle arrest generally decreased...
January 19, 2024: Biogerontology
https://read.qxmd.com/read/38206540/seven-knowledge-gaps-in-modern-biogerontology
#11
EDITORIAL
Suresh I S Rattan
About a year ago, members of the editorial board of Biogerontology were requested to respond to a query by the editor-in-chief of the journal as to what one question within their field of ageing research still needs to be asked and answered. This editorial is inspired by the wide range and variety of questions, ideas, comments and suggestions received in response to that query. The seven knowledge gaps identified in this article are arranged into three main categories: evolutionary aspects of longevity, biological survival and death aspects, and heterogeneity in the progression and phenotype of ageing...
January 11, 2024: Biogerontology
https://read.qxmd.com/read/38183523/age-and-dietary-restriction-modulate-mitochondrial-quality-in-quadriceps-femoris-muscle-of-male-mice
#12
JOURNAL ARTICLE
Ting-Rui Zhang, Chun-Hsien Chiang, Tzu-Chieh Hsu, Chih-Yun Wang, Ching-Yi Chen
Dietary restriction (DR) is a potential intervention for ameliorating ageing-related damages. Mitochondrial quality control is the key mechanism for regulating cellular functions in skeletal muscle. This study aimed to explore the effect of age and DR on the homeostasis of mitochondrial quality control in skeletal muscle. To study the effect of age on mitochondrial homeostasis, young (3 months old) male C57BL/6J mice were fed ad libitum (AL) until 7 (Young), 14 (Middle), and 19 months (Aged) of age. For the DR intervention, 60% of AL intake was given to the mice at 3 months of age until they reached 19 months of age (16 months)...
January 6, 2024: Biogerontology
https://read.qxmd.com/read/38150088/gut-microbiota-influence-frailty-syndrome-in-older-adults-mechanisms-and-therapeutic-strategies
#13
REVIEW
Xiao-Ming Wang, Lu Fan, Chen-Chen Meng, Yun-Jiao Wang, Li-E Deng, Zhuo Yuan, Jun-Ping Zhang, Yan-Yang Li, Shi-Chao Lv
Frailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults with frailty...
December 27, 2023: Biogerontology
https://read.qxmd.com/read/38150087/telomeres-cellular-senescence-and-aging-past-and-future
#14
REVIEW
Madeline Eppard, João F Passos, Stella Victorelli
Over half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can influence telomere shortening beyond the confines of the end-replication problem and how telomeres can exert their impact on aging, even in the absence of significant shortening...
December 27, 2023: Biogerontology
https://read.qxmd.com/read/38150086/berberis-vulgaris-l-extract-supplementation-exerts-regulatory-effects-on-the-lifespan-and-healthspan-of-drosophila-through-its-antioxidant-activity-depending-on-the-sex
#15
JOURNAL ARTICLE
Denis Golubev, Elena Platonova, Nadezhda Zemskaya, Oksana Shevchenko, Mikhail Shaposhnikov, Polina Nekrasova, Sergey Patov, Umida Ibragimova, Nikita Valuisky, Alexander Borisov, Xenia Zhukova, Svetlana Sorokina, Roman Litvinov, Alexey Moskalev
Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of Berberis vulgaris L. extract. Here we show that extract of Berberis vulgaris L. can, depending on concentrate, increases lifespan up to 6%, promote healthspan (stress resistance up to 35%, locomotor activity up to 25%, integrity of the intestinal barrier up to 12%, metabolic rate up to 5%) of Drosophila melanogaster (in vitro) and exhibits antioxidant (using red blood cell tests) and antiglycation activity (using glycation of bovine serum albumin) (in vitro)...
December 27, 2023: Biogerontology
https://read.qxmd.com/read/38109001/application-potential-of-senolytics-in-clinical-treatment
#16
REVIEW
Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong
Of the factors studied in individual ageing, the accumulation of senescent cells has been considered as an essential cause of organ degeneration to eventually initiate age-related diseases. Cellular senescence is attributed to the accumulation of damage for an inducement in the activation of cell cycle inhibitory pathways, resulting the cell permanently withdraw from the cell proliferation cycle. Further, senescent cells will activate the inflammatory factor secretion pathway to promote the development of various age-related diseases...
December 18, 2023: Biogerontology
https://read.qxmd.com/read/38109000/telomere-length-and-cancer-risk-finding-goldilocks
#17
REVIEW
Sharon A Savage
Telomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common germline genetic variants but shortens with age and is susceptible to certain environmental exposures. Cellular senescence or apoptosis are normally triggered when telomeres reach a critically short length, but cancer cells overcome these protective mechanisms and continue to divide despite chromosomal instability. Rare germline variants in telomere maintenance genes cause exceedingly short telomeres for age (< 1st percentile) and the telomere biology disorders, which are associated with elevated risks of bone marrow failure, myelodysplastic syndrome, acute myeloid leukemia, and squamous cell carcinoma of the head/neck and anogenital regions...
December 18, 2023: Biogerontology
https://read.qxmd.com/read/38064115/how-soon-do-metabolic-alterations-and-oxidative-distress-precede-the-reduction-of-muscle-mass-and-strength-in-wistar-rats-in-aging-process
#18
JOURNAL ARTICLE
Malu Cristina de Araújo Montoro Lima, Matheus Felipe Zazula, Luiz Fernando Martins, Stephanie Rubiane Carvalhal, Ana Tereza Bittencourt Guimarães, Luiz Claudio Fernandes, Katya Naliwaiko
Here we investigate metabolic changes, the antioxidant system and the accumulation of oxidative damage in muscles with different fiber types during the aging process in Wistar rats and try to map how sooner the changes occur. To do so, 30 male Wistar rats were submitted to behavioral evaluation to determine voluntary strength in the 11, 15, and 19 month old rats, measuring the energy metabolism, antioxidant system, oxidative damage and structure in the soleus and extensor digitorum longus muscles. We detected structural and metabolic changes in both muscles, especially in the EDL of 15 month old rats and in the soleus of 19 month old rats...
December 8, 2023: Biogerontology
https://read.qxmd.com/read/38006538/an-underappreciated-peculiarity-of-late-life-human-mortality-kinetics-assessed-through-the-lens-of-a-generalization-of-the-gompertz-makeham-law
#19
JOURNAL ARTICLE
A Golubev
Much attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0 e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging...
November 25, 2023: Biogerontology
https://read.qxmd.com/read/37987889/telomere-shortening-induces-aging-associated-phenotypes-in-hipsc-derived-neurons-and-astrocytes
#20
JOURNAL ARTICLE
Jasmine Harley, Munirah Mohamad Santosa, Chong Yi Ng, Oleg V Grinchuk, Jin-Hui Hor, Yajing Liang, Valerie Jingwen Lim, Wee Wei Tee, Derrick Sek Tong Ong, Shi-Yan Ng
Telomere shortening is a well-established hallmark of cellular aging. Telomerase reverse transcriptase (TERT) plays a crucial role in maintaining the length of telomeres, which are specialised protective caps at the end of chromosomes. The lack of in vitro aging models, particularly for the central nervous system (CNS), has impeded progress in understanding aging and age-associated neurodegenerative diseases. In this study, we aimed to explore the possibility of inducing aging-associated features in cell types of the CNS using hiPSC (human induced pluripotent stem cell) technology...
November 21, 2023: Biogerontology
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