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Breast Cancer Research: BCR

C Van Berckelaer, C Rypens, P van Dam, L Pouillon, M Parizel, K A Schats, M Kockx, W A A Tjalma, P Vermeulen, S van Laere, F Bertucci, C Colpaert, L Dirix
BACKGROUND: Inflammatory breast cancer (IBC) is a rare and rapidly progressive form of invasive breast cancer. The aim of this study was to explore the clinical evolution, stromal tumour-infiltrating lymphocytes (sTIL) infiltration and programmed death-ligand 1 (PD-L1) expression in a large IBC cohort. PATIENTS AND METHODS: Data were collected prospectively from patients with IBC as part of an international collaborative effort since 1996. In total, 143 patients with IBC starting treatment between June 1996 and December 2016 were included...
February 18, 2019: Breast Cancer Research: BCR
Yoshimi Endo Greer, Samuel F Gilbert, Brunilde Gril, Rajesh Narwal, Danielle L Peacock Brooks, David A Tice, Patricia S Steeg, Stanley Lipkowitz
BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists are attractive anti-tumor agents because of their capability to induce apoptosis in cancer cells by activating death receptors (DR) 4 and 5 with little toxicity against normal cells. Despite an attractive mechanism of action, previous clinical efforts to use TRAIL receptor agonists have been unsuccessful. In this study, we examined MEDI3039, a highly potent multivalent DR5 agonist, in breast cancer cell lines and in vivo models...
February 18, 2019: Breast Cancer Research: BCR
Manabu Emi, Ryungsa Kim, Kazuaki Tanabe, Yoko Uchida, Tetsuya Toge
After the publication of this work [1] errors were noticed in Figs. 1a, 6a, and 8a-in which the β-actin bands were mistakenly presented.
February 17, 2019: Breast Cancer Research: BCR
Bastien Nguyen, David Venet, Matteo Lambertini, Christine Desmedt, Roberto Salgado, Hugo Mark Horlings, Françoise Rothé, Christos Sotiriou
BACKGROUND: Although parity and age at first pregnancy are among the most known extrinsic factors that modulate breast cancer risk, their impact on the biology of subsequent breast cancer has never been explored in depth. Recent data suggest that pregnancy-induced tumor protection is different according to breast cancer subtypes, with parity and young age at first pregnancy being associated with a marked reduction in the risk of developing luminal subtype but not triple negative breast cancer...
February 15, 2019: Breast Cancer Research: BCR
Alexandra J White, Clarice R Weinberg, Ellen S O'Meara, Dale P Sandler, Brian L Sprague
BACKGROUND: Breast density is strongly related to breast cancer. Identifying associations between environmental exposures and density may elucidate relationships with breast cancer. Metals and polycyclic aromatic hydrocarbons (PAHs) may influence breast density via oxidative stress or endocrine disruption. METHODS: Study participants (n = 222,581) underwent a screening mammogram in 2011 at a radiology facility in the Breast Cancer Surveillance Consortium. Zip code residential levels of airborne PAHs and metals (arsenic, cadmium, chromium, cobalt, lead, manganese, mercury, nickel, and selenium) were assessed using the 2011 EPA National Air Toxics Assessment...
February 13, 2019: Breast Cancer Research: BCR
Ya-Ling Hsu, Meng-Chi Yen, Wei-An Chang, Pei-Hsun Tsai, Yi-Chung Pan, Ssu-Hui Liao, Po-Lin Kuo
BACKGROUND: Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lung metastatic niches are not fully understood. METHODS: Specific gene contributions to lung metastasis were identified by comparing gene profiles of 4T1 tumors metastasizing to various organs via microarray...
February 12, 2019: Breast Cancer Research: BCR
Nicholas G Smith, Rekha Gyanchandani, Osama S Shah, Grzegorz T Gurda, Peter C Lucas, Ryan J Hartmaier, Adam M Brufsky, Shannon Puhalla, Amir Bahreini, Karthik Kota, Abigail I Wald, Yuri E Nikiforov, Marina N Nikiforova, Steffi Oesterreich, Adrian V Lee
BACKGROUND: Breast cancer is the most common invasive cancer among women worldwide. Next-generation sequencing (NGS) has revolutionized the study of cancer across research labs around the globe; however, genomic testing in clinical settings remains limited. Advances in sequencing reliability, pipeline analysis, accumulation of relevant data, and the reduction of costs are rapidly increasing the feasibility of NGS-based clinical decision making. METHODS: We report the development of MammaSeq, a breast cancer-specific NGS panel, targeting 79 genes and 1369 mutations, optimized for use in primary and metastatic breast cancer...
February 8, 2019: Breast Cancer Research: BCR
Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María Del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano
BACKGROUND: Breast cancer patients under neoadjuvant chemotherapy includes a heterogeneous group of patients who eventually develop distal disease, not detectable by current methods. We propose the use of exosomal miRNAs and circulating tumor cells as diagnostic and predictive biomarkers in these patients. METHODS: Fifty-three breast cancer women initially diagnosed with localized breast cancer under neoadjuvant chemotherapy were prospectively enrolled in this study...
February 6, 2019: Breast Cancer Research: BCR
Daniela Schwarzenbacher, Christiane Klec, Barbara Pasculli, Stefanie Cerk, Beate Rinner, Michael Karbiener, Cristina Ivan, Raffaela Barbano, Hui Ling, Annika Wulf-Goldenberg, Stefanie Stanzer, Gabriel Rinnerthaler, Herbert Stoeger, Thomas Bauernhofer, Johannes Haybaeck, Gerald Hoefler, Stephan Wenzel Jahn, Paola Parrella, George Adrian Calin, Martin Pichler
BACKGROUND: Non-coding RNAs and especially microRNAs have been discovered to act as master regulators of cancer initiation and progression. The aim of our study was to discover and characterize the function of yet functionally uncharacterized microRNAs in human breast carcinogenesis. METHODS: In an unbiased approach, we utilized an established model system for breast cancer (BC) stem cell formation ("mammosphere assay") to identify whole miRNome alterations in breast carcinogenesis...
February 1, 2019: Breast Cancer Research: BCR
Dong-Yu Wang, Deena M A Gendoo, Yaacov Ben-David, James R Woodgett, Eldad Zacksenhaus
BACKGROUND: Triple-negative breast cancer (TNBC) represents a heterogeneous group of ER- and HER2-negative tumors with poor clinical outcome. We recently reported that Pten-loss cooperates with low expression of microRNA-145 to induce aggressive TNBC-like lesions in mice. To systematically identify microRNAs that cooperate with PTEN-loss to induce aggressive human BC, we screened for miRNAs whose expression correlated with PTEN mRNA levels and determined the prognostic power of each PTEN-miRNA pair alone and in combination with other miRs...
January 31, 2019: Breast Cancer Research: BCR
Simon Peter Gampenrieder, Andreas Peer, Christian Weismann, Matthias Meissnitzer, Gabriel Rinnerthaler, Johanna Webhofer, Theresa Westphal, Marina Riedmann, Thomas Meissnitzer, Heike Egger, Frederike Klaassen Federspiel, Roland Reitsamer, Cornelia Hauser-Kronberger, Katharina Stering, Klaus Hergan, Brigitte Mlineritsch, Richard Greil
BACKGROUND: Patients with early breast cancer (EBC) achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) have a favorable prognosis. Breast surgery might be avoided in patients in whom the presence of residual tumor can be ruled out with high confidence. Here, we investigated the diagnostic accuracy of contrast-enhanced MRI (CE-MRI) in predicting pCR and long-term outcome after NACT. METHODS: Patients with EBC, including patients with locally advanced disease, who had undergone CE-MRI after NACT, were retrospectively analyzed (n = 246)...
January 31, 2019: Breast Cancer Research: BCR
Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A Moatamed, Clara E Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk
BACKGROUND: Cancer is frequently associated with tumor-related anemia, and many chemotherapeutic agents impair hematopoiesis, leading to impaired quality of life for affected patients. The use of erythropoiesis-stimulating agents has come under scrutiny after prospective clinical trials using recombinant erythropoietin to correct anemia reported increased incidence of thromboembolic events and cancer-related deaths. Furthermore, previous preclinical reports indicated expansion of the pool of breast cancer-initiating cells when erythropoietin was combined with ionizing radiation...
January 30, 2019: Breast Cancer Research: BCR
Richard M Fleming, Matthew R Fleming, Tapan K Chaudhuri, William C Dooley, Andrew McKusick
No abstract text is available yet for this article.
January 29, 2019: Breast Cancer Research: BCR
Yunjun Xiao, Junjie Xia, Liping Li, Yuebin Ke, Jinquan Cheng, Yaojie Xie, Winnie Chu, Polly Cheung, Jean Hee Kim, Graham A Colditz, Rulla M Tamimi, Xuefen Su
BACKGROUND: Epidemiologic evidence suggests that certain dietary patterns were associated with breast cancer risk, but the results have been inconclusive. We assessed the associations between different dietary patterns and the risk of breast cancer by conducting a meta-analysis of observational studies. METHODS: Relevant articles were searched in PubMed, Embase, and Cochrane library databases through September 2017. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) comparing the highest and lowest categories of Western and prudent dietary patterns were combined by using the random-effects meta-analyses...
January 29, 2019: Breast Cancer Research: BCR
Youdinghuan Chen, Yue Wang, Lucas A Salas, Todd W Miller, Kenneth Mark, Jonathan D Marotti, Arminja N Kettenbach, Chao Cheng, Brock C Christensen
BACKGROUND: BRCA1-mutated cancers exhibit deficient homologous recombination (HR) DNA repair, resulting in extensive copy number alterations and genome instability. HR deficiency can also arise in tumors without a BRCA1 mutation. Compared with other breast tumors, HR-deficient, BRCA1-like tumors exhibit worse prognosis but selective chemotherapeutic sensitivity. Presently, patients with triple negative breast cancer (TNBC) who do not respond to hormone endocrine-targeting therapy are given cytotoxic chemotherapy...
January 25, 2019: Breast Cancer Research: BCR
Aurélie Chiche, Amandine Di-Cicco, Laura Sesma-Sanz, Laura Bresson, Pierre de la Grange, Marina A Glukhova, Marisa M Faraldo, Marie-Ange Deugnier
BACKGROUND: The adult mammary epithelium is composed of basal and luminal cells. The luminal lineage comprises two major cell populations, positive and negative for estrogen and progesterone receptors (ER and PR, respectively), both containing clonogenic progenitor cells. Deregulated ER/PR- luminal progenitor cells are suspected to be at the origin of basal-type triple-negative (TNBC) breast cancers, a subtype frequently associated with loss of P53 function and MET signaling hyperactivation...
January 25, 2019: Breast Cancer Research: BCR
Abdi Ghaffari, Victoria Hoskin, Gulisa Turashvili, Sonal Varma, Jeff Mewburn, Graeme Mullins, Peter A Greer, Friedemann Kiefer, Andrew G Day, Yolanda Madarnas, Sandip SenGupta, Bruce E Elliott
BACKGROUND: Limited understanding of the cancer biology of metastatic sites is a major factor contributing to poor outcomes in cancer patients. The regional lymph nodes are the most common site of metastasis in most solid cancers and their involvement is a strong predictor of relapse in breast cancer (BC). We have previously shown that ezrin, a cytoskeletal-membrane linker protein, is associated with lymphovascular invasion and promotes metastatic progression in BC. However, the efficacy of pharmacological inhibition of ezrin in blocking cancer cell migration and metastasis remains unexplored in BC...
January 24, 2019: Breast Cancer Research: BCR
Marie-Julie Nokin, Justine Bellier, Florence Durieux, Olivier Peulen, Gilles Rademaker, Maude Gabriel, Christine Monseur, Benoit Charloteaux, Lieven Verbeke, Steven van Laere, Patrick Roncarati, Michael Herfs, Charles Lambert, Jean Scheijen, Casper Schalkwijk, Alain Colige, Jo Caers, Philippe Delvenne, Andrei Turtoi, Vincent Castronovo, Akeila Bellahcène
BACKGROUND: Elevated aerobic glycolysis rate is a biochemical alteration associated with malignant transformation and cancer progression. This metabolic shift unavoidably generates methylglyoxal (MG), a potent inducer of dicarbonyl stress through the formation of advanced glycation end products (AGEs). We have previously shown that the silencing of glyoxalase 1 (GLO1), the main MG detoxifying enzyme, generates endogenous dicarbonyl stress resulting in enhanced growth and metastasis in vivo...
January 23, 2019: Breast Cancer Research: BCR
Fredrik Strand, Edward Azavedo, Roxanna Hellgren, Keith Humphreys, Mikael Eriksson, John Shepherd, Per Hall, Kamila Czene
BACKGROUND: High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being diagnosed with a large-sized or interval breast cancer. METHODS: Within a prospective cohort of 63,130 women, we examined 891 women who were diagnosed with incident breast cancer. For 386 women, retrospective localized density assessment was possible...
January 22, 2019: Breast Cancer Research: BCR
Ketil A Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson, Gunhild M Mælandsmo
BACKGROUND: Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable of reshaping the tumor microenvironment, turning "cold" tumors "hot" through a significant increase in tumor-infiltrating lymphocytes...
January 22, 2019: Breast Cancer Research: BCR
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