Per-Henrik Zahl
No abstract text is available yet for this article.
September 20, 2023: Breast Cancer Research: BCR
Rifat Jan, Min Huang, Joan Lewis-Wambi
No abstract text is available yet for this article.
September 19, 2023: Breast Cancer Research: BCR
Marcus Sundén, Sofia Norgren, Robert Lundqvist, Anne Andersson, Malin Sund, Oskar Hemmingsson
BACKGROUND: Breast cancer liver metastases (BCLM) is a common cause of breast cancer-related death. The prognostic and predictive value of receptor expression and St Gallen classification is challenged by receptor status discordance in distant metastases. The aim of this study was to determine the rate of receptor conversion from breast cancer to BCLM and the impact on survival. METHOD: Patients registered with BCLM in two Swedish national cancer registers were recruited retrospectively...
September 13, 2023: Breast Cancer Research: BCR
Rhianna Rachael Romany Blyth, Charles N Birts, Stephen A Beers
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear. The inflammatory adipose microenvironment is central to breast cancer progression and has been shown to favour breast cancer cell growth and to reduce efficacy of anti-cancer treatments. Thus, it is imperative to further our understanding of the inflammatory microenvironment seen in breast cancer patients with obesity. Three-dimensional (3D) in vitro models offer a key tool in increasing our understanding of such complex interactions within the adipose microenvironment...
September 11, 2023: Breast Cancer Research: BCR
P Neven, P A Fasching, S Chia, G Jerusalem, M De Laurentiis, S-A Im, K Petrakova, G V Bianchi, M Martín, A Nusch, G S Sonke, L De la Cruz-Merino, J T Beck, J P Zarate, Y Wang, A Chakravartty, C Wang, D J Slamon
BACKGROUND: The phase III MONALEESA-3 trial included first- (1L) and second-line (2L) patients and demonstrated a significant overall survival (OS) benefit for ribociclib + fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC) in the final protocol-specified and exploratory (longer follow-up) OS analyses. At the time of these analyses, the full OS benefit of 1L ribociclib was not completely characterized because the median OS (mOS) was not reached...
August 31, 2023: Breast Cancer Research: BCR
Lauren A Hapach, Wenjun Wang, Samantha C Schwager, Devika Pokhriyal, Emily D Fabiano, Cynthia A Reinhart-King
BACKGROUND: Intratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we phenotypically sorted human breast cancer cells based on migratory potential. When injected into mice, highly migratory cells were weakly metastatic and weakly migratory cells were highly metastatic. The purpose of this study was to determine whether these weakly and highly migratory cells interact with each other in vitro or in vivo. METHODS: To assess the relationship between heterogeneity in cancer cell migration and metastatic fitness, MDA-MB-231 and SUM159PT triple negative breast cancer cells were phenotypically sorted into highly migratory and weakly migratory subpopulations and assayed separately and in a 1:1 mixture in vitro and in vivo for metastatic behaviors...
August 30, 2023: Breast Cancer Research: BCR
L Lukas Löfling, Nathalie C Støer, Bettina Kulle Andreassen, Giske Ursin, Edoardo Botteri
BACKGROUND: Previous studies assessed the prognostic effect of aspirin, statins, and metformin in breast cancer (BC) patients, with inconclusive results. METHODS: We performed a nationwide population-based cohort study to evaluate if post-diagnostic use of low-dose aspirin, statins, and metformin was associated with BC-specific survival. Women aged ≥ 50 years and diagnosed with BC in 2004-2017, who survived ≥ 12 months after diagnosis (follow-up started 12 months after diagnosis), were identified in the Cancer Registry of Norway...
August 30, 2023: Breast Cancer Research: BCR
Wei Yang, Meiyu Xu, Shuoqi Xu, Qingxian Guan, Shuaiming Geng, Juanhong Wang, Wei Wei, Hongwei Xu, Ying Liu, Yong Meng, Ming-Qing Gao
BACKGROUND: The interface zone, area around invasive carcinoma, can be thought of as the actual tissue of the tumor microenvironment with precedent alterations for tumor invasion. However, the heterogeneity and characteristics of the microenvironment in the interface area have not yet been thoroughly explored. METHODS: For in vitro studies, single-cell RNA sequencing (scRNA-seq) was used to characterize the cells from the tumor zone, the normal zone and the interface zone with 5-mm-wide belts between the tumor invasion front and the normal zone...
August 29, 2023: Breast Cancer Research: BCR
Marisol Castillo-Castrejon, Barbara Mensah Sankofi, Stevi Johnson Murguia, Abasi-Ama Udeme, Hoaning Howard Cen, Yi Han Xia, Nisha S Thomas, William L Berry, Kenneth L Jones, Vincent R Richard, Rene P Zahedi, Christoph H Borchers, James D Johnson, Elizabeth A Wellberg
BACKGROUND: Obesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive tumors. Body mass index (BMI) is used to define obesity, but it may not be the best predictor of breast cancer risk or prognosis on an individual level. Adult weight gain is an independent indicator of breast cancer risk. Our previous work described a murine model of obesity, ER-positive breast cancer, and weight gain and identified fibroblast growth factor receptor (FGFR) as a potential driver of tumor progression...
August 22, 2023: Breast Cancer Research: BCR
Shuiyi Liu, Weiqun Chen, Hui Hu, Tianzhu Zhang, Tangwei Wu, Xiaoyi Li, Yong Li, Qinzhi Kong, Hongda Lu, Zhongxin Lu
No abstract text is available yet for this article.
August 21, 2023: Breast Cancer Research: BCR
Mustapha Abubakar, Alyssa Klein, Shaoqi Fan, Scott Lawrence, Karun Mutreja, Jill E Henry, Ruth M Pfeiffer, Maire A Duggan, Gretchen L Gierach
BACKGROUND: Emerging data indicate that variations in quantitative epithelial and stromal tissue composition and their relative abundance in benign breast biopsies independently impact risk of future invasive breast cancer. To gain further insights into breast cancer etiopathogenesis, we investigated associations between epidemiological factors and quantitative tissue composition metrics of the normal breast. METHODS: The study participants were 4108 healthy women ages 18-75 years who voluntarily donated breast tissue to the US-based Susan G...
August 15, 2023: Breast Cancer Research: BCR
Feng Zhou, Guimei Yang, Liting Xue, Yajing Liu, Yao Guo, Ji Zhu, Linlin Yuan, Peng Gu, Feng Tang, Jinwen Shan, Renhong Tang
BACKGROUND: Targeted estrogen receptor degradation has been approved to effectively treat ER + breast cancers. Due to the poor bioavailability of fulvestrant, the first generation of SERD, many efforts were made to develop oral SERDs. With the approval of Elacestrant, oral SERDs demonstrated superior efficacy than fulvestrant. However, due to the poor ability of known SERDs to penetrate the blood-brain barrier (BBB), breast cancer patients with brain metastasis cannot benefit from clinical SERDs...
August 14, 2023: Breast Cancer Research: BCR
Mindy C DeRouen, Juan Yang, Yuqing Li, Adrian A Franke, Anne N Tome, Kami K White, Brenda Y Hernandez, Yurii Shvetsov, Veronica Setiawan, Anna H Wu, Lynne R Wilkens, Loïc Le Marchand, Lenora W M Loo, Iona Cheng
BACKGROUND: Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal breast cancer risk. Epidemiologic evidence for 27HC in breast cancer risk is limited, particularly in multiethnic populations. METHODS: In a nested case-control study of 1470 breast cancer cases and 1470 matched controls within the Multiethnic Cohort Study, we examined associations of pre-diagnostic circulating 27HC with breast cancer risk among African American, Japanese American, Native Hawaiian, Latino, and non-Latino White postmenopausal females...
August 14, 2023: Breast Cancer Research: BCR
M G Muoio, M Pellegrino, V Rapicavoli, M Talia, G Scavo, V Sergi, V Vella, S Pettinato, M G Galasso, R Lappano, D Scordamaglia, F Cirillo, A Pulvirenti, D C Rigiracciolo, M Maggiolini, A Belfiore, E M De Francesco
No abstract text is available yet for this article.
August 10, 2023: Breast Cancer Research: BCR
Pooja Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Annelie Augustinsson, Thaïs Baert, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Javier Benitez, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E Castelao, Stephen J Chanock, Georgia Chenevix-Trench, Emilie Cordina-Duverger, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugué, A Heather Eliassen, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine D Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G Giles, Anna González-Neira, Felix Grassmann, Anne Grundy, Pascal Guénel, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Susan E Hankinson, Elaine F Harkness, Bernd Holleczek, Reiner Hoppe, John L Hopper, Richard S Houlston, Anthony Howell, David J Hunter, Christian Ingvar, Karolin Isaksson, Helena Jernström, Esther M John, Michael E Jones, Rudolf Kaaks, Renske Keeman, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W Kurian, James V Lacey, Diether Lambrechts, Nicole L Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A Murphy, William G Newman, Sune F Nielsen, Børge G Nordestgaard, Aaron Norman, Katie M O'Brien, Janet E Olson, Alpa V Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J Ruddy, Dale P Sandler, Christopher G Scott, Mitul Shah, Xiao-Ou Shu, Ann Smeets, Melissa C Southey, Jennifer Stone, Rulla M Tamimi, Jack A Taylor, Lauren R Teras, Katarzyna Tomczyk, Melissa A Troester, Thérèse Truong, Celine M Vachon, Sophia S Wang, Clarice R Weinberg, Hans Wildiers, Walter Willett, Stacey J Winham, Alicja Wolk, Xiaohong R Yang, M Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M Dunning, Paul D P Pharoah, Montserrat García-Closas, Marjanka K Schmidt, Peter Kraft, Roger L Milne, Sara Lindström, Douglas F Easton, Jenny Chang-Claude
BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium...
August 9, 2023: Breast Cancer Research: BCR
Laurel A Habel, Stacey E Alexeeff, Ninah Achacoso, Vignesh A Arasu, Aimilia Gastounioti, Lawrence Gerstley, Robert J Klein, Rhea Y Liang, Jafi A Lipson, Walter Mankowski, Laurie R Margolies, Joseph H Rothstein, Daniel L Rubin, Li Shen, Adriana Sistig, Xiaoyu Song, Marvella A Villaseñor, Mark Westley, Alice S Whittemore, Martin J Yaffe, Pei Wang, Despina Kontos, Weiva Sieh
BACKGROUND: Breast density is strongly associated with breast cancer risk. Fully automated quantitative density assessment methods have recently been developed that could facilitate large-scale studies, although data on associations with long-term breast cancer risk are limited. We examined LIBRA assessments and breast cancer risk and compared results to prior assessments using Cumulus, an established computer-assisted method requiring manual thresholding. METHODS: We conducted a cohort study among 21,150 non-Hispanic white female participants of the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California who were 40-74 years at enrollment, followed for up to 10 years, and had archived processed screening mammograms acquired on Hologic or General Electric full-field digital mammography (FFDM) machines and prior Cumulus density assessments available for analysis...
August 6, 2023: Breast Cancer Research: BCR
Nuria G Martínez-Illescas, Silvia Leal, Patricia González, Osvaldo Graña-Castro, Juan José Muñoz-Oliveira, Alfonso Cortés-Peña, María Gómez-Gil, Zaira Vega, Verónica Neva, Andrea Romero, Miguel Quintela-Fandino, Eva Ciruelos, Consuelo Sanz, Sofía Aragón, Leisy Sotolongo, Sara Jiménez, Eduardo Caleiras, Francisca Mulero, Cristina Sánchez, Marcos Malumbres, María Salazar-Roa
A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis)...
August 4, 2023: Breast Cancer Research: BCR
Huijuan Dai, Wenting Xu, Lulu Wang, Xiao Li, Xiaonan Sheng, Lei Zhu, Ye Li, Xinrui Dong, Weihang Zhou, Chenyu Han, Yan Mao, Linli Yao
The communication between tumor cells and tumor microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and take part in breast cancer formation and progression. Here, by comparing the gene expression patterns in CAFs and normal fibroblasts, we found SPRY2 expression was significantly decreased in CAFs and decreased SPRY2 expression was correlated with worse prognosis in breast cancer patients. SPRY2 knockdown in fibroblasts promoted tumor growth and distant metastasis of breast cancer in mice...
July 28, 2023: Breast Cancer Research: BCR
Annika Möhl, Sabine Behrens, Fabian Flaßkamp, Nadia Obi, Annika Kreienbrinck, Bernd Holleczek, Kathleen Gali, Jenny Chang-Claude, Heiko Becher
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death worldwide. The aim of this study was to examine if CVD affects the mortality of women after a breast cancer diagnosis and population controls differently. METHODS: The analysis included a total of 3,555 women, diagnosed with primary stage 1-3 breast cancer or in situ carcinoma between 2002 and 2005 and 7,334 controls breast cancer-free at recruitment, all aged 50-74 years, who were followed-up in a German breast cancer case-control study until June, 30 2020...
July 27, 2023: Breast Cancer Research: BCR
Chanjuan Zheng, Xi Xu, Muyao Wu, Lian Xue, Jianyu Zhu, Hongzhuo Xia, Siyu Ding, Shujun Fu, Xinyu Wang, Yian Wang, Guangchun He, Xia Liu, Xiyun Deng
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with limited therapeutic options readily available. Immunotherapy such as immune checkpoint inhibition has been investigated in TNBC but still encounters low overall response. Neutrophils, the most abundant leukocytes in the body, are increasingly recognized as an active cancer-modulating entity. In the bloodstream, neutrophils escort circulating tumor cells to promote their survival and stimulate their proliferation and metastasis...
July 26, 2023: Breast Cancer Research: BCR
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