David Wallach, Thangavelu U Arumugam, Mark P Boldin, Giuseppina Cantarella, Koluman A Ganesh, Yuri Goltsev, Tanya M Goncharov, Andrew V Kovalenko, Akhil Rajput, Eugene E Varfolomeev, Si Qing Zhang
Signals emanating from receptors of the tumor necrosis factor/nerve growth factor (TNF/NGF) family control practically all aspects of immune defense and, as such, constitute potential targets for therapeutic intervention through rational drug design. Indeed, arrest of these signals by blocking ligand-receptor interactions enables effective suppression of a variety of activities that are implicated in various pathologies, such as T and B lymphocyte activation and growth, inflammation, fibroblast proliferation, and cell death...
2002: Arthritis Research