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Progress in Transplantation

Simon J W Oczkowski, Pamela Durepos, John Centofanti, Erika Arsenau, Sonny Dhanani, Deborah J Cook, Maureen O Meade
INTRODUCTION: Rates of successful organ donation vary between otherwise comparable intensive care units (ICUs). The ICU staff have a unique perspective into the facilitators and barriers underlying this variation in successful deceased organ donation. RESEARCH QUESTION: What do ICU staff perceive to be the most meaningful facilitators and barriers to deceased organ donation? DESIGN: We designed and conducted a survey of all disciplines working in the ICU to ascertain the perceived facilitators and barriers to donation in an academic tertiary care hospital...
March 21, 2019: Progress in Transplantation
Chih-Ying Lu, Ming-Jenn Chen, Yu-Feng Tian
No abstract text is available yet for this article.
March 18, 2019: Progress in Transplantation
Elizabeth C Lorenz, Fernando G Cosio, Shari L Bernard, Steven D Bogard, Brian R Bjerke, Elizabeth N Geissler, Steven W Hanna, Walter K Kremers, Yijing Cheng, Mark D Stegall, Andrea L Cheville, Nathan K LeBrasseur
INTRODUCTION: Frailty and decreased physical performance are associated with poor outcomes after kidney transplant. Less is known about their relationship with pretransplant outcomes. The aim of this study was to characterize associations between frailty and physical performance with death on the kidney transplant waiting list. DESIGN: Since December 2014, high-risk kidney transplant candidates at our center (age > 59, diabetic and/or history of >3 years dialysis) have undergone frailty and physical performance testing using Fried Criteria and the Short Physical Performance Battery...
March 17, 2019: Progress in Transplantation
Ramon Antônio Oliveira, Jorge Marcelo Padilla Mancero, Dalila Fernanda Faria, Vanessa de Brito Poveda
BACKGROUND: Surgical site infection is an important complication in the postoperative period among liver transplant recipients. However, little is known about the risk factors in this patient group. Therefore, the objective of this study was to analyze the incidence and risk factors for surgical site infections among adult liver transplant recipients. METHODS: Medical records of adult liver transplant recipients from January 1, 2009, to December 31, 2015, were analyzed in this retrospective cohort study...
March 7, 2019: Progress in Transplantation
Sameer Imtiaz, Alvin H Li, Amit X Garg, Sonny Dhanani, Seonaid Nolan
No abstract text is available yet for this article.
March 7, 2019: Progress in Transplantation
Robert S Ream, Matthew G Clark, Eric S Armbrecht
INTRODUCTION: A recent study of pediatric organ donation after the neurologic determination of death (DNDD) demonstrated an association between the use of donor management goals (DMGs) by organ procurement organizations (OPOs) and organ yield. OBJECTIVE: To describe the pediatric DMGs used by OPOs and any association between specific DMGs and organ yield. DESIGN: Query of US OPOs who utilized DMGs in the care of pediatric DNDD organ donors from 2010 to 2013...
March 7, 2019: Progress in Transplantation
Nadine T Breslin, David M Salerno, Veli K Topkara, Farhana Latif, Susan Restaino, Koji Takeda, Hiroo Takayama, Maryjane Farr, Paolo C Colombo, Douglas L Jennings
INTRODUCTION: Amiodarone use prior to heart transplant is independently associated with a higher rate of severe primary graft dysfunction and in-hospital mortality. Amiodarone may also alter the pharmacokinetics of medications metabolized via cytochrome P450. No data exist regarding the interaction between pretransplant amiodarone and tacrolimus concentrations. DESIGN: Single-center retrospective study of transplant patients between January 1, 2014, and June 30, 2016...
March 7, 2019: Progress in Transplantation
Derek A DuBay, Nataliya V Ivankova, Ivan Herbey, David T Redden, Cheryl Holt, Laura Siminoff, Mona N Fouad, Thomas A Morinelli, Michelle Y Martin
INTRODUCTION: Studies demonstrate that family notification is much less frequent in African Americans than in Caucasians. Familial notification of one's decision to become a registered organ donor (ROD) is important to ensure adherence to the decedent's donation decision and to disseminate prodonation attitudes. The purpose of this study was to explore the experiences of familial notification among recent African American RODs and to identify intervention strategies to overcome potential barriers to the notification process...
March 7, 2019: Progress in Transplantation
Jason T Cheng, Laura J Denham, Pedro W Baron
No abstract text is available yet for this article.
March 7, 2019: Progress in Transplantation
Michelle Liu, Shahid Husain, Olusegun Famure, Yanhong Li, S Joseph Kim
BACKGROUND: Posttransplant lymphoproliferative disorder (PTLD) is a severe complication after kidney transplantation. This study examined the incidence, risk factors, clinical management, and outcomes of PTLD in a cohort of kidney transplant recipients. DESIGN: This single-center cohort study included 1642 patients transplanted from January 1, 2000, to December 31, 2012, with follow-up until December 31, 2013. The incidence and risk factors for PTLD were examined using a Cox proportional hazards model...
March 7, 2019: Progress in Transplantation
Jack Stevens, Dmitry Tumin, Kelly L Shaffer, Leonard Bickman, Kimberly E Hoagwood, Don Hayes
INTRODUCTION: With 116 000 people waiting for transplants and 8000 patients dying annually on waiting lists, the United States has a considerable organ shortage. An insufficient number of Americans have registered to become organ donors when obtaining driver's licenses or ID cards. Across states, there is considerable variability in organ donor registration rates as well as driver's license applications. METHODS: The purpose of this project was to describe the variability in the phrasing of the organ donor registration question by state bureaus of motor vehicles as well as other application questions that might influence this decision...
March 7, 2019: Progress in Transplantation
Tamar Ashkenazi, Avraham Steinberg, Jonathan Cohen
BACKGROUND: The Council of the Chief Rabbinate formally accepted neurologically declared death as an indication of death for all legal and religious purposes following changes made to practice parameters in order to comply with Jewish Law (halacha). This removed Jewish-legal barriers for organ donation. We surveyed the Zionist ultra-Orthodox community to identify the reasons for their continued reluctance to donate. METHODS: A questionnaire was designed to assess personal, cultural, religious, and system-related considerations relating to organ donation...
January 1, 2019: Progress in Transplantation
Antonio Ríos Zambudio, Ana Isabel López-Navas, Gregorio Garrido, Marco Antonio Ayala-García, María José Sebastián, Antonio Miguel Hernández, Pablo Ramírez, Pascual Parrilla
INTRODUCTION: Latin American immigrants comprise an important population group in the United States. The purpose of this study was to analyze the attitude toward living kidney donation found among Latin American citizens who are residents in Florida and to identify the psychosocial variables affecting their attitude. MATERIAL AND METHODS: A sample of Latin American residents in the state of Florida was randomly obtained and stratified by nationality, age, and sex (n = 1524)...
December 30, 2018: Progress in Transplantation
Luca Cima, Francesco Nacchia, Claudio Ghimenton, Giovanni Valotto, Luigino Boschiero, Stefano Gobbo, Gianluigi Zaza, Desley Neil, Claudia Mescoli, Francesca Vanzo, Antonietta D'Errico, Caterina Ghimenton, Massimo Rugge, Marilena Casartelli-Liviero, Matteo Brunelli, Luca Novelli, Albino Eccher
BACKGROUND: Acute kidney injury is a treatable entity although difficult to recognize without diagnostic biopsy. We investigated the potential association between clinically defined deceased donors and acute kidney injury with preimplantation histological findings and recipient outcomes. METHODS: Kidney biopsies from donors were classified using the Acute Kidney Injury Network criteria and assessed for percentage glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular narrowing with the Remuzzi score and for acute tubular necrosis...
March 2019: Progress in Transplantation
Helen Chou, Jaclyn Groh, Kerri Nicholson, Katelyn Krivchenia, Don Hayes, Joseph D Tobias, Dmitry Tumin
Pediatric transplant recipients experience barriers to social functioning, including participation in school and work, but our understanding of barriers to these activities is limited by insufficient data collection and standardization. Existing studies rely on cross-sectional surveys of transplant survivors that are subject to survivorship and nonresponse bias, or analyses of large registry data that lack detail on educational progress and work participation. We report our experience using the electronic medical record to retrospectively review work and educational attainment in this population, and identify specific barriers that were encountered and how they were addressed by the patient and care team...
December 25, 2018: Progress in Transplantation
Marianna Yumi Kawashima Vasconcelos, Ana Rafaela Felippini Lopes, Ênio David Mente, Orlando Castro-E-Silva, Cristina Maria Galvão, Karina Dal Sasso-Mendes
INTRODUCTION: The advanced stage of liver disease causes impairments in the quality of life due to the physiological symptoms, besides the social and emotional stress. The aim of this study was to evaluate the quality of life of candidates for liver transplantation in specialized center in the interior of the state of São Paulo, Brazil. METHODS: An observational study was carried out, with a quantitative approach. The sample was of convenience with the participation of 50 candidates for liver transplantation...
December 25, 2018: Progress in Transplantation
Elisa J Gordon, Catherine Wicklund, Jungwha Lee, Richard R Sharp, John Friedewald
INTRODUCTION: There is debate over whether Apolipoprotein L1 (APOL1) gene risk variants contribute to African American (AA) live donors' (LD) increased risk of kidney failure. Little is known about factors influencing physicians' integration of APOL1 genetic testing of AA LDs into donor evaluation. DESIGN: We conducted a cross-sectional survey, informed by Roger's Diffusion of Innovations theory, among nephrology and surgeon members of the American Society of Nephrology, American Society of Transplantation, and American Society of Transplant Surgeons about their practices of and attitudes about APOL1 genetic testing of AA potential LDs...
December 13, 2018: Progress in Transplantation
Alicia B Lichvar, Christopher R Ensor, Adriana Zeevi, Matthew R Morrell, Joseph M Pilewski, J W Awori Hayanga, Jonathan D'Cunha, John F McDyer, Andrej A Petrov
BACKGROUND: Hypogammaglobulinemia (HGG), immunoglobulin G (IgG) <700 mg/dL, is associated with infections, chronic lung allograft dysfunction, and death following lung transplantation. This study evaluates the use of on-demand intravenous IgG in lung transplant recipients with HGG. MATERIALS AND METHODS: This single-center retrospective cohort study of adult lung recipients evaluated 3 groups, no, untreated (u), or treated (t) HGG at first IgG administration or a matched time posttransplant...
December 11, 2018: Progress in Transplantation
Jesus M Casida, Pamela Combs, Sarah E Schroeder, Caty Johnson
BACKGROUND: A mixed-method study of role stress and work intensity among nurse practitioners (NPs) in mechanical circulatory support (MCS) programs in the United States reported a qualitative data related to burnout. We empirically investigated this phenomenon by pursuing the following specific aims: (1) describe levels of personal burnout (PB), work-related (WB) burnout, and client-related burnout (CB) and quality of work life (QOWL) among MCS-NPs; (2) determine the relationship between burnout and QOWL variables; and (3) identify which type of burnout is a predictor of QOWL...
December 5, 2018: Progress in Transplantation
Ivo Abraham, Razan Alsheikh, Karen MacDonald
No abstract text is available yet for this article.
December 5, 2018: Progress in Transplantation
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