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American Journal of Physiology. Renal Physiology

https://read.qxmd.com/read/38385174/sex-differences-in-sympathetic-activity-and-vascular-stiffness-in-adults-with-chronic-kidney-disease-ckd
#21
JOURNAL ARTICLE
Matias G Zanuzzi, Jinhee Jeong, Dana R DaCosta, Jeanie Park
BACKGROUND: Chronic kidney disease (CKD) is characterized by sympathetic nervous system (SNS) overactivity that contributes to increased vascular stiffness and cardiovascular risk. While it is well established that SNS activity and vascular stiffness are substantially elevated in CKD, whether sex differences in autonomic and vascular function exist in CKD remains unknown. We tested the hypothesis that compared to females, males with CKD have higher baseline sympathetic activity that is related to increased arterial stiffness...
February 22, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38385173/human-soluble-prorenin-receptor-expressed-in-mouse-renal-collecting-duct-show-sex-specific-effect-on-cardiorenal-function
#22
JOURNAL ARTICLE
Gertrude Arthur, Audrey Poupeau, Katherine Biel, Jeffrey L Osborn, Ming Gong, Terry D Hinds, Volkhard Lindner, Analia S Loria
Soluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamics in male and female mice fed a regular chow...
February 22, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38357719/distinct-developmental-reprogramming-footprint-of-macrophagesduring-acute-kidney-injury-across-species
#23
JOURNAL ARTICLE
Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou
Acute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures...
February 15, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38299216/-strategies-to-mitigate-acute-kidney-injury-risk-during-physical-work-in-hot-environments
#24
REVIEW
Abdulaziz Masoud, Zachary J McKenna, Zidong Li, Michael R Deyhle, Christine M Mermier, Zachary J Schlader, Fabiano T Amorim
Prolonged physical work in the heat can reduce renal function and increase the risk of acute kidney injury (AKI). This is concerning given that the latest climate change projections forecast a rise in global temperature as well as the frequency, intensity, and duration of heatwaves. This means that outdoor and indoor workers in the agriculture or construction industries will be exposed to higher heat stress in the years ahead. Several studies indicate a higher incidence of chronic kidney disease from nontraditional origins (CKDnt) in individuals exposed to high temperatures, intense physical work, and/or recurrent dehydration...
February 1, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38299215/rodent-models-of-aki-and-aki-ckd-transition-an-update-in-2024
#25
REVIEW
Ying Fu, Yu Xiang, Qingqing Wei, Daria Ilatovskaya, Zheng Dong
Despite known drawbacks, rodent models are essential tools in the research of renal development, physiology, and pathogenesis. In the past decade, rodent models have been developed and used to mimic different etiologies of acute kidney injury (AKI), AKI to chronic kidney disease (CKD) transition or progression, and AKI with comorbidities. These models have been applied for both mechanistic research and preclinical drug development. However, current rodent models have their limitations, especially since they often do not fully recapitulate the pathophysiology of AKI in human patients, and thus need further refinement...
February 1, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38299214/c-terminal-fragment-of-fibroblast-growth-factor-fgf-23-improves-heart-function-in-murine-models-of-high-intact-fgf23
#26
JOURNAL ARTICLE
Ming Chang Hu, James A Reneau, Mingjun Shi, Masaya Takahashi, Gaozhi Chen, Moosa Mohammadi, Orson W Moe
Cardiovascular disease (CVD) is the major cause of death in chronic kidney disease (CKD) and is associated with high circulating fibroblast growth factor (FGF)-23 levels. It is unresolved whether high circulating FGF-23 is a mere biomarker or pathogenically contributes to cardiomyopathy. It is also unknown whether the C-terminal FGF23 peptide (cFGF23), a natural FGF23 antagonist proteolyzed from intact FGF23 (iFGF23), retards CKD progression and improves cardiomyopathy. We addressed these questions in three murine models with high endogenous FGF23 and cardiomyopathy...
February 1, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38299213/activation-of-farnesoid-x-receptor-retards-expansion-of-renal-collecting-duct-cells-derived-cysts-via-inhibition-of-cftr-mediated-cl-secretion
#27
JOURNAL ARTICLE
Nipitpon Srimai, Kanlayanee Tonum, Sunhapas Soodvilai
The transcription factor farnesoid X receptor (FXR) regulates energy metabolism. Specifically, FXR functions to regulate CFTR-mediated Cl- secretion in intestinal epithelial cells. Therefore, this study aimed to investigate the role of FXR in CFTR-mediated Cl- secretion in renal tubular cells, and to further elucidate its effects on renal cyst formation and growth. CFTR-mediated Cl- transport was evaluated via short-circuit current ( I SC ) measurements in MDCK cell monolayers and primary rat inner medullary collecting duct (IMCD) cells...
February 1, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38269409/ks-wnk1-is-required-for-the-renal-response-to-extreme-changes-in-potassium-intake
#28
JOURNAL ARTICLE
Jessica Paola Bahena-Lopez, Laura Vergara, Valeria De la Peña, Miguel A Gutiérrez-Gallardo, Paulina López-Ibargüen, Janeth Alejandra García, Héctor Carbajal-Contreras, Norma Vázquez, Ruth Rincón-Heredia, Felipe Masso, Norma A Bobadilla, María Castañeda-Bueno, David H Ellison, Gerardo Gamba, María Chávez-Canales
KS-WNK1 is an isoform of WNK1 kinase that is predominantly found in the distal convoluted tubule of the kidney. The precise physiological function of KS-WNK1 remains unclear. Some studies suggest that it could play a role in regulating potassium renal excretion by modulating the activity of the Na+ -Cl- cotransporter (NCC). However, changes in the potassium diet from normal to high failed to reveal a role for KS-WNK1, but under a normal potassium diet, the expression of KS-WNK1 is negligible. It is only detectable when mice are exposed to a low potassium diet...
January 25, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38269408/mitochondria-derived-reactive-oxygen-species-contribute-to-synergistic-interaction-of-diabetes-and-hypertension-in-causing-chronic-kidney-injury
#29
JOURNAL ARTICLE
Zhen Wang, Yiling Fu, Alexandre A da Silva, Jussara M do Carmo, Alan Mouton, Ana Carolina M Omoto, Xuan Li, Jaylan Sears, John E Hall
Diabetes (DM) and hypertension (HTN) are major risk factors for chronic kidney injury, together accounting for >70% of end-stage renal disease. The combination of DM and HTN significantly accelerates development of renal injury; however, the underlying mechanisms of this synergy are still poorly understood. This study assessed whether mitochondria (MT) dysfunction is essential in developing renal injury in a rat model with combined DM and HTN. Type 1 DM was induced in Wistar rats by streptozotocin (STZ)...
January 25, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38269407/the-apical-70-ps-potassium-k-channel-in-the-thick-ascending-limb-of-henle-s-loop-is-a-large-conductance-na-and-cl-activated-k-na-1-1-like-channel
#30
JOURNAL ARTICLE
Elise de Combiens, Nadia Frachon, Lydie Cheval, Stéphane Lourdel, Marc Paulais
Apical potassium channels are crucial for thick ascending limb (TAL) of Henle's loop transport function. The ROMK ( KNCJ1 ) gene encodes a 30-pS K channel whose loss of function causes the reduced NaCl reabsorption in the TAL associated with Type 2 Bartter's syndrome. In contrast, the molecular basis of a functionally ROMK-related 70-pS K channel is still unclear. The aim of this study was to highlight new specific channel properties that may give insights on its molecular identity. Using the patch-clamp technique on the apical membrane of mouse split-open TAL tubules, we observed that 70-pS K channel activity, but not ROMK channel activity, increases with the internal Na+ and Cl- concentrations, with relative 50 % effective concentrations ( EC50 ) and Hill coefficients ( nH ) of 40...
January 25, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38234299/elevated-luminal-inorganic-phosphate-suppresses-intestinal-zn-absorption-in-5-6-nephrectomized-rats
#31
JOURNAL ARTICLE
Yosuke Okumura, Kotaro Abe, Shoko Sakai, Yuki Kamei, Yuki Mori, Yuichiro Adachi, Masaki Takikawa, Ayano Kitamura, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Taiho Kambe, Hironori Yamamoto, Yutaka Taketani
Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is often impaired; however, the mechanism underlying Zn malabsorption remains unclear. Here, we evaluated intestinal Zn absorption capacity in a rat model of CKD induced by 5/6 nephrectomy (5/6 Nx). Rats were given Zn and the incremental area under the plasma Zn concentration-time curve (iAUC) was measured, as well as expression of ZIP4, an intestinal Zn transporter...
January 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38234298/guidelines-on-antibody-use-for-physiology-research
#32
JOURNAL ARTICLE
Heddwen L Brooks, Lisandra E de Castro Brás, Keith R Brunt, Megan A Sylvester, Michelle S Parvatiyar, Padmini Sirish, Shyam S Bansal, Rasheed Sule, Ashley L Eadie, Mark A Knepper, Robert A Fenton, Merry L Lindsey, Kristine Y DeLeon-Pennell, Aldrin V Gomes
Antibodies are one of the most used reagents in scientific laboratories and are critical components for a multitude of experiments in physiology research. Over the last decade, concerns about many biological methods, including those that use antibodies, have arisen as many labs were unable to reproduce the scientific data obtained in other laboratories. While some of the lack of reproducibility may be due to inadequate reporting of detailed methods, the use of unvalidated antibodies was identified as a major source of results that lacked reproducibility...
January 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38234297/-intranasal-administration-of-sugarcane-ash-causes-chronic-kidney-disease-in-rats
#33
JOURNAL ARTICLE
Carlos A Roncal-Jimenez, Keegan L Rogers, Arthur Stem, Julia Wijkstrom, Annika Wernerson, Jacob Fox, Ramon Garcia Trabanino, Stephen Brindley, Gabriela Garcia, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Fumihiko Sasai, Manuel Urra, Gabriel Cara-Fuentes, L Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Butler Dawson, Magdalena Madero, Jared M Brown, Richard J Johnson
Background. Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing to chronic kidney disease of unknown etiology (CKDu). However, while the administration of manufactured silica nanoparticles is known to cause chronic tubulointerstitial disease in rats, the effect of administering sugarcane ash on kidney pathology remains unknown. Here we investigate whether sugarcane ash can induce CKD in rats. Methods . Sugarcane ash was administered for 13 weeks into the nares of rats (5 mg/day for 5d/week), and blood, urine and kidney tissues were collected at 13 weeks (at the end of ash administration) and in a separate group of rats at 24 weeks (11 weeks after stopping ash administration)...
January 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38207098/rusting-from-the-inside-kidney-specific-ferroportin-deficiency-and-associated-iron-overload-dictates-susceptibility-to-acute-kidney-injury-and-fibrosis
#34
EDITORIAL
Yogesh Scindia
No abstract text is available yet for this article.
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205546/exercise-for-chronic-kidney-disease-patients-from-cells-to-systems-to-function
#35
REVIEW
Jared M Gollie, Alice S Ryan, Sabyasachi Sen, Samir S Patel, Peter F Kokkinos, Michael O Harris-Love, Joel D Scholten, Marc R Blackman
Chronic kidney disease (CKD) is among the leading causes of death and disability in the United States, affecting an estimated 800 million adults globally. The underlying pathophysiology of CKD is complex creating challenges to its management. Primary risk factors for the development and progression of CKD include diabetes mellitus, hypertension, age, obesity, diet, inflammation, and physical inactivity. The high prevalence of diabetes and hypertension in patients with CKD increases the risk for secondary consequences such as cardiovascular disease and peripheral neuropathy...
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205545/is-fibroblast-growth-factor-23-the-main-culprit-for-cardiovascular-disease-in-chronic-kidney-disease
#36
EDITORIAL
Carsten A Wagner, Isabel Rubio Aliaga, Daniela Egli-Spichtig
No abstract text is available yet for this article.
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205543/collecting-duct-water-permeability-inhibition-by-egf-is-associated-with-decreased-camp-pka-activity-and-aqp2-phosphorylation-at-ser269
#37
JOURNAL ARTICLE
Chung-Lin Chou, Kavee Limbutara, Anika R Kao, Jevin Z Clark, Ellen H Nein, Viswanathan Raghuram, Mark A Knepper
Prior studies showed that epidermal growth factor (EGF) inhibits vasopressin-stimulated osmotic water permeability in the renal collecting duct. Here, we investigated the underlying mechanism. Using isolated perfused rat inner medullary collecting ducts (IMCDs), we found that addition of EGF to the peritubular bath significantly decreased 1-deamino-8-D-arginine vasopressin (dDAVP)-stimulated water permeability, confirming prior observations. The inhibitory effect of EGF on water permeability was associated with a reduction in intracellular cyclic AMP levels and protein kinase A (PKA) activity...
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205542/energy-depletion-by-cell-proliferation-sensitizes-the-kidney-epithelial-cells-to-injury
#38
JOURNAL ARTICLE
Pierre Galichon, Morgane Lannoy, Li Li, Justine Serre, Sophie Vandermeersch, David Legouis, M Todd Valerius, Juliette Hadchouel, Joseph V Bonventre
Acute kidney injury activates both proliferative and anti-proliferative pathways, the consequences of which are not fully elucidated. If an initial proliferation of the renal epithelium is necessary for the successful repair, the persistence of proliferation markers is associated with the occurrence of chronic kidney disease. We hypothesized that proliferation in stress conditions impacts cell viability and renal outcomes. We found that proliferation is associated with cell death after various stresses in kidney cells...
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205541/zebrafish-as-a-model-for-podocyte-research
#39
REVIEW
Maximilian Schindler, Nicole Endlich
Podocytes, specialized postmitotic cells, are central players in various kidney-related diseases. Zebrafish have become a valuable model system for studying podocyte biology because they are genetically easy to manipulate, transparent and their glomerular structure is similar to that of mammals. This review provides an overview of the knowledge of podocyte biology in zebrafish larvae, with particular focus on their essential contribution to understanding the mechanisms that underlie kidney diseases as well as supporting drug development...
January 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205540/fasting-mimicking-diet-in-diabetic-mice-partially-preserves-glomerular-endothelial-glycocalyx-coverage-without-changing-the-diabetic-metabolic-environment
#40
JOURNAL ARTICLE
Anouk I M van der Velden, Angela Koudijs, Sander Kooijman, Rosalie G J Rietjens, Wendy M P J Sol, M Cristina Avramut, Gangqi Wang, Patrick C N Rensen, Ton J Rabelink, Johan van der Vlag, Bernard M van den Berg
Intermittent fasting has become of interest for its possible metabolic benefits and reduction of inflammation and oxidative damage, all of which play a role in pathophysiology of diabetic nephropathy. We tested in a streptozotocin (60mg/kg) induced diabetic ApoE-KO mouse model whether repeated fasting mimicking diet (FMD) prevents glomerular damage. Diabetic mice received 5 FMD cycles in 10 weeks and during cycles 1 and 5 caloric measurements were performed. After 10 weeks, glomerular endothelial morphology was determined together with albuminuria, urinary heparanase-1 (HPSE-1) activity, and spatial mass spectrometry imaging (MSI) to identify specific glomerular metabolic dysregulation...
January 11, 2024: American Journal of Physiology. Renal Physiology
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