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American Journal of Physiology. Renal Physiology

https://read.qxmd.com/read/38634138/podocyte-specific-silencing-of-acid-sphingomyelinase-gene-to-abrogate-hyperhomocysteinemia-induced-nlrp3-inflammasome-activation-and-glomerular-inflammation
#1
JOURNAL ARTICLE
Dandan Huang, Jason M Kidd, Yao Zou, Xiaoyuan Wu, Ningjun Li, Todd W B Gehr, Pin-Lan Li, Guangbi Li
Acid Sphingomyelinase has been reported to increase tissue ceramide and thereby mediate hHcy-induced glomerular NLRP3 inflammasome activation, inflammation, and sclerosis. In the present study, we tested whether somatic podocyte-specific silencing of Smpd1 gene attenuates hHcy-induced NLRP3 inflammasome activation and associated exosome release in podocytes and thereby suppresses glomerular inflammatory response and injury. In vivo , somatic podocyte-specific Smpd1 gene silencing almost blocked hHcy-induced glomerular NLRP3 inflammasome activation in Podocre mice compared to control littermates...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634137/animal-models-to-study-cognitive-impairment-of-chronic-kidney-disease
#2
REVIEW
Pedro H Imenez Silva, Marion Pepin, Andreja Figurek, Eugenio Gutiérrez-Jiménez, Mickaël Bobot, Anna Iervolino, Francesco Mattace-Raso, Ewout J Hoorn, Matthew A Bailey, Lucie Hénaut, Rikke Nielsen, Sebastian Frische, Francesco Trepiccione, Gaye Hafez, Hande O Altunkaynak, Nicole Endlich, Robert Unwin, Giovambattista Capasso, Vesna Pesic, Ziad Massy, Carsten A Wagner, Connect Consortium
Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD) and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives and society...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634136/commensal-microbiota-regulate-aldosterone
#3
JOURNAL ARTICLE
Brittni N Moore, Alexandra D Medcalf, Rachel Q Muir, Chudan Xu, Francine Z Marques, Jennifer L Pluznick
The gut microbiome regulates many important host physiological processes associated with cardiovascular health and disease; however, the impact of the gut microbiome on aldosterone is unclear. Investigating whether gut microbiota regulate aldosterone can offer novel insights into how the microbiome affects blood pressure. In this study, we aimed to determine whether gut microbiota regulate host aldosterone. We employed enzyme-linked immunosorbent assays (ELISAs) to assess plasma aldosterone and plasma renin activity (PRA) in female and male mice in which gut microbiota are intact, suppressed, or absent...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634135/double-negative-t-cells-have-a-reparative-role-after-experimental-severe-ischemic-acute-kidney-injury
#4
JOURNAL ARTICLE
Kyungho Lee, Sepideh Gharaie, Johanna T Kurzhagen, Andrea M Newman-Rivera, Lois J Arend, Sanjeev Noel, Hamid Rabb
T cells mediate organ injury and repair. A proportion of unconventional kidney T cells called double-negative (DN) T cells (TCR+ CD4- CD8- ), with anti-inflammatory properties, were previously demonstrated to protect from early injury in moderate experimental AKI. However, their role in repair after AKI has not been studied. We hypothesized that DN T cells mediate repair after severe AKI. C57B6 mice underwent severe (40min) unilateral ischemia-reperfusion injury (IRI). Kidney DN T cells were studied by flow cytometry and compared to gold-standard anti-inflammatory CD4+ Tregs...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634134/influence-of-proteolytic-cleavage-of-enac-s-gamma-subunit-upon-na-and-k-handling
#5
JOURNAL ARTICLE
Evan C Ray, Andrew Nickerson, Shaohu Sheng, Rolando Carrisoza-Gaytán, Tracey Lam, Allison Marciszyn, Lei Zhang, Alexa Jordahl, Chunming Bi, Aaliyah Winfrey, Zhaohui Kou, Sebastien Gingras, Annet Kirabo, Lisa M Satlin, Thomas R Kleyman
The ENaC γ subunit is essential for homeostasis of Na+ , K+ , and body fluid. Dual γ subunit cleavage before and after a short inhibitory tract allows dissociation of this tract, increasing channel open probability (PO ), in vitro . Cleavage proximal to the tract occurs at a furin recognition sequence (143 RKRR146 , in the mouse γ subunit). Loss of furin-mediated cleavage prevents in vitro activation of the channel by proteolysis at distal sites. We hypothesized that 143 RKRR146 mutation to 143 QQQQ146 (γQ4 ) in 129/Sv mice would reduce ENaC PO , impair flow-stimulated flux of Na+ (JNa ) and K+ (JK ) in perfused collecting ducts, reduce colonic amiloride-sensitive short circuit current (ISC ), and impair Na+ , K+ , and body fluid homeostasis...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634133/effect-of-the-dash-diet-on-the-sodium-chloride-cotransporter-and-aquaporin-2-in-urinary-extracellular-vesicles
#6
JOURNAL ARTICLE
Dana Bielopolski, Luca Musante, Ewout J Hoorn, Henrik Molina, Douglas Barrows, Thomas Carroll, Michael A Harding, Samantha Upson, Adam Qureshi, Max M Weder, Jonathan N Tobin, Rhonda G Kost, U Erdbrügger
The Dietary Approach to Stop Hypertension (DASH) diet, with its low sodium and high potassium content, acts like a diuretic by reducing sodium reabsorption in the kidney's distal convoluted tubule but without the side effects. Previous studies based on animal models didn't explore changes in human ion channel proteins. Recent insights into urinary extracellular vesicles (uEVs) suggest they reflect kidney tissue and physiological modifications. In our inpatient study, we shifted hypertensive volunteers from an American diet to the DASH diet, examining changes in those with stage 1 untreated hypertension...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634132/jak-inhibition-during-the-early-phase-of-sars-cov-2-infection-worsens-kidney-injury-by-suppressing-endogenous-antiviral-activity-in-mice
#7
JOURNAL ARTICLE
Hibiki Sakai, Hiroyasu Kamuro, Nagisa Tokunoh, Takeshi Izawa, Shigeyuki Tamiya, Ayaha Yamamoto, Shota Tanaka, Daisuke Okuzaki, Chikako Ono, Yoshiharu Matsuura, Yoshiaki Okada, Yasuo Yoshioka, Yasushi Fujio, Masanori Obana
Coronavirus disease 2019 (COVID-19) induces respiratory dysfunction as well as kidney injury. Although the kidney is considered a target organ of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and affected by COVID-19-induced cytokine storm, the mechanisms of renal reaction in SARS-CoV-2 infection are unknown. In this study, a murine COVID-19 model was induced by nasal infection with mouse-adapted SARS-CoV-2 (MA10). MA10 infection induced body weight loss along with lung inflammation in mice four days after infection...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634131/cannabinoid-receptor-type-1-activation-causes-a-water-diuresis-by-inducing-an-acute-central-diabetes-insipidus-in-mice
#8
JOURNAL ARTICLE
Joshua L Rein, Ken Mackie, Thomas R Kleyman, Lisa M Satlin
Cannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634130/keratin-5-basal-cells-are-temporally-regulated-developmental-and-tissue-repair-progenitors-in-bladder-urothelium
#9
JOURNAL ARTICLE
Brian Becknell, Mohammad El-Harakeh, Felipe Rodriguez-Tirado, Kelly M Grounds, Birong Li, Macie Kercsmar, Xin Wang, Ashley R Jackson
Urothelium forms a distensible yet impermeable barrier, senses and transduces stimuli, and defends the urinary tract from mechanical, chemical and bacterial injuries. Biochemical and genetic labeling studies support the existence of one or more progenitor populations with the capacity to rapidly regenerate the urothelium following injury, but slow turnover, a low mitotic index, and inconsistent methodologies obscure progenitor identity. The progenitor properties of basal Keratin 5 urothelial cells (K5-UC) have been previously investigated, but those studies focused on embryonic or adult bladder urothelium...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38634129/raising-serum-uric-acid-with-a-uricase-inhibitor-worsens-pkd-in-rat-and-mouse-models
#10
JOURNAL ARTICLE
Anjana Chaudhary, Zhibin He, Daniel J Atwood, Makoto Miyazaki, Ozgur A Oto, Allen Davidoff, Charles L Edelstein
Humans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum uric acid in rodents. There were 2 aims of the study in polycystic kidney disease (PKD): 1) to determine whether increasing serum uric acid with the uricase inhibitor, oxonic acid, resulted in faster cyst growth and 2) to determine whether treatment with the xanthine oxidase inhibitor, oxypurinol, reduced the cyst growth caused by oxonic acid...
April 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38601986/long-term-follow-up-of-trek-1-ko-mice-reveals-the-development-of-bladder-hypertrophy-and-impaired-bladder-smooth-muscle-contractility-with-age
#11
JOURNAL ARTICLE
Alison Xiaoqiao Xie, Nao Iguchi, Anna P Malykhina
Stretch-activated two-pore-domain potassium (K2 P) channels play important roles in many visceral organs, including the urinary bladder. The TWIK-related potassium channel, TREK-1, is the predominantly expressed K2 P channel in the urinary bladder of humans and rodents. Downregulation of TREK-1 channels was observed in the urinary bladder of patients with detrusor overactivity, suggesting their involvement in the pathogenesis of voiding dysfunction. This study aimed to characterize the long-term effects of TREK-1 on bladder function by using global and smooth muscle specific TREK-1 knock out (KO) mice...
April 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38601985/esm-1-mediates-transcriptional-polarization-associated-with-diabetic-kidney-disease
#12
JOURNAL ARTICLE
Alexandre Gaudet, Xiaoyi Zheng, Neeraja Kambham, Vivek Bhalla
Esm-1, endothelial cell-specific molecule-1, is a susceptibility gene for diabetic kidney disease (DKD) and is a secreted proteoglycan, with notable expression in kidney, which attenuates inflammation and albuminuria. However , little is known about Esm1 expression in mature tissues in the presence or absence of diabetes. We utilized publicly available single-cell RNA sequencing data to characterize Esm1 expression in 27,786 renal endothelial cells (RECs) obtained from four human and three mouse databases. We validated our findings using bulk transcriptome data from 20 healthy subjects and 41 patients with DKD and using RNAscope...
April 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38601984/mechanisms-and-implications-of-podocyte-autophagy-in-chronic-kidney-disease
#13
REVIEW
Rachel Njeim, Sandra Merscher, Alessia Fornoni
Autophagy is a protective mechanism through which cells degrade and recycle proteins and organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence underscores the significant impact of dysregulated autophagy on podocyte injury in chronic kidney disease. In this review, we provide a comprehensive overview of the diverse types of autophagy and their regulation in cellular homeostasis, with a specific emphasis on podocytes. Furthermore, we discuss recent findings that focus on the functional role of different types of autophagy during podocyte injury in chronic kidney disease...
April 11, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545652/renal-vascular-control-during-normothermia-and-passive-heat-stress-in-healthy-younger-men-and-women
#14
JOURNAL ARTICLE
Jessica A Freemas, Morgan L Worley, Mikaela C Gabler, Hayden W Hess, Curtis S Goss, Tyler B Baker, Blair D Johnson, Christopher L Chapman, Zachary J Schlader
We tested the hypothesis that the renal vasoconstrictor and vasodilator responses will be greater in younger women compared to men during passive heat stress. Twenty-five healthy adults [12 women (early follicular phase), 13 men] completed two experimental visits, heat stress or normothermic time-control, assigned in a block-randomized crossover design. During heat stress, core temperature was increased by ~0.8°C in the first hour before commencing a 2-min cold pressor test (CPT). Core temperature remained clamped and at one-hour post-CPT, subjects ingested a whey protein shake (1...
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545651/the-calcium-sensing-receptor-casr-has-only-a-pth-dependent-role-in-the-acute-response-of-renal-phosphatetransporters-to-phosphate-intake
#15
JOURNAL ARTICLE
Arezoo Daryadel, Catharina J Küng, Betül Haykir, Sibylle Sabrautzki, Martin Hrabě de Angelis, Nati Hernando, Isabel Rubio-Aliaga, Carsten A Wagner
The kidney controls systemic inorganic phosphate (Pi) levels by adapting reabsorption to Pi intake. Renal Pi reabsorption is mostly mediated by sodium-phosphate cotransporters NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) which are tightly controlled by various hormones including parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). PTH and FGF23 rise in response to Pi intake and decrease NaPi-IIa and NaPi-IIc brush border membrane abundance enhancing phosphaturia. Phosphaturia and transporter regulation occur even in the absence of PTH and FGF23 signalling...
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545650/-mfsd12-depletion-reduces-cystine-accumulation-without-improvement-in-proximal-tubular-function-in-experimental-models-for-cystinosis
#16
JOURNAL ARTICLE
Tjessa Bondue, Laleh Khodaparast, Ladan Khodaparast, Sara Cairoli, Bianca Maria Goffredo, Rik Gijsbers, Lambertus van den Heuvel, Elena Levtchenko
Cystinosis is an autosomal recessive lysosomal storage disorder, caused by mutations in the CTNS gene , resulting in an absent or altered cystinosin (CTNS) protein. Cystinosin exports cystine out of the lysosome, with a malfunction resulting in cystine accumulation and a defect in other cystinosin-mediated pathways. Cystinosis is a systemic disease, but the kidneys are the first and most severely affected organs. In the kidney, the disease initially manifests as a generalized dysfunction in the proximal tubules (also called renal Fanconi syndrome)...
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545649/2024-carl-w-gottschalk-distinguished-lectureship-of-the-american-physiological-society-renal-section
#17
EDITORIAL
Robert A Fenton, David H Ellison
No abstract text is available yet for this article.
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545648/atavistic-behavior-of-macrophages-in-the-injured-kidney
#18
EDITORIAL
Karl A Nath
No abstract text is available yet for this article.
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38545647/regulation-of-the-water-channel-aquaporin-2-by-cullin-e3-ubiquitin-ligases
#19
JOURNAL ARTICLE
Sathish K Murali, James A McCormick, Robert A Fenton
Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in response to VP. Cullin-RING ubiquitin ligases (CRLs) are multi-subunit E3 ligases involved in ubiquitylation and degradation of their target proteins, eight of which are expressed in the collecting duct. Here, we utilized an established cell model of the collecting duct (mpkCCD14 cells) to study the role of Cullins in modulating AQP2...
March 28, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38511222/sparsentan-ameliorates-glomerular-hypercellularity-and-inflammatory-gene-networks-induced-by-iga1-igg-immune-complexes-in-a-mouse-model-of-iga-nephropathy
#20
JOURNAL ARTICLE
Colin Reily, Zina Moldoveanu, Tiziano Pramparo, Stacy Hall, Zhi-Qiang Huang, Terri Rice, Lea Novak, Radko Komers, Celia P Jenkinson, Jan Novak
IgA nephropathy (IgAN), is characterized by glomerular deposition of immune complexes (IC) consisting of IgA1 with O -glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific IgG autoantibodies. These ICs induce kidney injury, and in the absence of disease-specific therapy, up to 40% of IgAN patients progress to kidney failure. IgA1 with its clustered O -glycans is unique to humans, which hampered development of small-animal models of IgAN. Here, we used a model wherein engineered IC (EIC) formed from human Gd-IgA1 and recombinant human IgG autoantibody are injected into nude mice to induce glomerular injury mimicking human IgAN...
March 21, 2024: American Journal of Physiology. Renal Physiology
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