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HPB: the Official Journal of the International Hepato Pancreato Biliary Association

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https://read.qxmd.com/read/31005494/feasibility-and-safety-of-liver-transplantation-or-resection-after-transarterial-radioembolization-with-yttrium-90-for-unresectable-hepatocellular-carcinoma
#1
Ismail Labgaa, Parissa Tabrizian, Joseph Titano, Edward Kim, Swan N Thung, Sander Florman, Myron Schwartz, Emmanuel Melloul
BACKGROUND: The benefit of transarterial radioembolization (TARE) in patients with unresectable hepatocellular carcinoma (HCC) is increasingly evidenced. However, data on outcome of liver transplantation or resection after TARE remain scarce. This study aimed to assess the safety and feasibility of surgery after TARE in patients with unresectable HCC. METHODS: Patients exclusively undergoing TARE followed by either orthotopic liver transplantation (OLT) or liver resection (LR) for HCC between 2012 and 2016 were included...
April 17, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/31005493/is-hepatectomy-safe-following-yttrium-90-therapy-a-multi-institutional-international-experience
#2
Laleh G Melstrom, Oliver S Eng, Mustafa Raoof, Gagandeep Singh, Yuman Fong, Karen Latorre, Gi H Choi, Riad Salem, David J Bentrem, Robert Lewandowski, Eleftherios Makris, George Poultsides, Vikrom K Dhar, Seetharam Chadalavada, Shimul A Shah, Aileen C Johnson, Aarti Sekhar, Darren Kies, Shishir K Maithel, Flavio Rocha, Adnan Alseidi, Jeroen Hagendoorn, Inne H M Borel Rinkes, Alexander V Fisher, Sean Ronnekleiv-Kelly, Sharon M Weber, Emily R Winslow, Daniel E Abbott
BACKGROUND: Single institution reports demonstrate variable safety profiles when liver-directed therapy with Yttrium-90 (Y-90) is followed by hepatectomy. We hypothesized that in well-selected patients, hepatectomy after Y90 is feasible and safe. METHODS: Nine institutions contributed data for patients undergoing Y90 followed by hepatectomy (2008-2017). Clinicopathologic and perioperative data were analyzed, with 90-day morbidity and mortality as primary endpoints...
April 17, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/31000338/local-referrals-as-a-strategy-for-increasing-value-of-surgical-care-among-medicare-patients-undergoing-liver-and-pancreatic-surgery
#3
Katiuscha Merath, Qinyu Chen, Adrian Diaz, Morgan Johnson, Rittal Mehta, Mary Dillhoff, Jordan Cloyd, Timothy M Pawlik
BACKGROUND: The focus of the current Medicare payment reform is to increase value - i.e. improve health care quality while lowering costs. This study sought to define cost variation and surgical quality among hospitals within small geographic areas typical of work commute patterns. METHODS: Medicare Provider Analysis and Review (MEDPAR) Inpatient Files was used to identify patients undergoing elective liver and pancreatic surgery between 2013 and 2015. Hospitals were assigned to combined statistical areas (CSAs) based on zip codes...
April 15, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30992198/evaluating-the-learning-curve-for-laparoscopic-liver-resection-a-comparative-study-between-standard-and-learning-curve-cusum
#4
Asma Sultana, Peter Nightingale, Ravi Marudanayagam, Robert P Sutcliffe
BACKGROUND: Laparoscopic liver resection (LLR) requires training in both hepatobiliary surgery and advanced laparoscopy. Available data on LLR learning curves are derived from pioneer surgeons. The aims of this study were to evaluate the LLR learning curve for second generation surgeons, and to compare different CUSUM methodology with and without risk adjustment. METHODS: Retrospective analysis of a prospective database of 111 consecutive patients who underwent LLR by two surgeons at a single centre between 2011 and 2016...
April 13, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30982739/nomogram-for-predicting-postoperative-pancreatic-fistula
#5
Yunghun You, In W Han, Dong W Choi, Jin S Heo, Youngju Ryu, Dae J Park, Seong H Choi, Sunjong Han
BACKGROUND: Previous studies analyzed risk factors for postoperative pancreatic fistula (POPF) and developed risk prediction tool using scoring system. However, no study has built a nomogram based on individual risk factors. This study aimed to evaluate individual risks of POPF and propose a nomogram for predicting POPF. METHODS: From 2007 to 2016, medical records of 1771 patients undergoing pancreaticoduodenctomy were reviewed retrospectively. Variables with p < 0...
April 11, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30979646/kras-mutational-status-impacts-pathologic-response-to-pre-hepatectomy-chemotherapy-a-study-from-the-international-genetic-consortium-for-liver-metastases
#6
Georgios A Margonis, Neda Amini, Nikolaos Andreatos, Kazunari Sasaki, Jack McVey, Muhammad B Mirza, Samuel Warner, Stefan Buettner, Carlotta Barbon, Jane Wang, Alessandra Pulvirenti, Anastasios Angelou, Carsten Kamphues, Efstathios Antoniou, Emmanouil Pikoulis, Timothy M Pawlik, Klaus Kaczirek, George Poultsides, Doris Wagner, Itaru Endo, Katsunori Imai, Federico Aucejo, Martin E Kreis, Christopher L Wolfgang, Matthew J Weiss
BACKGROUND: A major response to pre-hepatectomy chemotherapy has been associated with improved survival in patients who undergo resection of colorectal liver metastases (CRLM). However, the role of tumor biology, as exemplified by overall and codon-specific KRAS mutational status, in predicting response to chemotherapy is not well defined. METHODS: Pathologic response was characterized as minor or major depending on the percentage of remnant viable cells (>50% vs <50%, respectively)...
April 9, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30975599/the-inflammatory-response-after-laparoscopic-and-open-pancreatoduodenectomy-and-the-association-with-complications-in-a-multicenter-randomized-controlled-trial
#7
Jony van Hilst, David J Brinkman, Thijs de Rooij, Susan van Dieren, Michael F Gerhards, Ignace H de Hingh, Misha D Luyer, Hendrik A Marsman, Tom M Karsten, Olivier R Busch, Sebastiaan Festen, Michal Heger, Marc G Besselink
BACKGROUND: The systemic inflammatory response seen after surgery seems to be related to postoperative complications. A reduction of the inflammatory response through minimally invasive surgery might therefore be the mechanism via which postoperative outcome could be improved. The aim of this study was to investigate if postoperative inflammatory markers differed between laparoscopic (LPD) and open pancreatoduodenectomy (OPD) and if there was a relationship between inflammatory markers and the occurrence of postoperative complications...
April 8, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30967335/detailed-reporting-is-of-utmost-importance-when-a-controversial-treatment-is-being-evaluated
#8
LETTER
Bergthor Björnsson, Per Sandström
No abstract text is available yet for this article.
April 6, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30962135/is-progression-in-the-future-liver-remnant-a-contraindication-for-second-stage-hepatectomy
#9
Lionel Jouffret, Jacques Ewald, Ugo Marchese, Jonathan Garnier, Marine Gilabert, Djamel Mokart, Gilles Piana, Jean-Robert Delpero, Olivier Turrini
BACKGROUND: Two-stage hepatectomy (TSH) strategy is used to treat patients with bilobar colorectal liver metastasis (CLM). However, many patients do not undergo the second hepatectomy owing to disease progression in the future liver remnant (FLR) after portal vein embolization (PVE). This study aimed to assess the impact of disease progression in the FLRs of patients who completed the first hepatectomy. METHODS: 68 consecutive patients underwent the first hepatectomy followed by PVE...
April 6, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30962138/postoperative-nutritional-benefits-of-proximal-parenchymal-pancreatectomy-for-low-grade-malignant-lesions-in-the-pancreatic-head
#10
Kazufumi Umemoto, Takahiro Tsuchikawa, Toru Nakamura, Keisuke Okamura, Takehiro Noji, Toshimichi Asano, Yoshitsugu Nakanishi, Kimitaka Tanaka, Satoshi Hirano
BACKGROUND: Outcomes of proximal parenchymal pancreatectomy (PPP) as compared to pancreatoduodenectomy (PD) have not been reported. The aim of this study was to describe the short- and long-term outcomes of patients with low-grade pancreatic head lesions who underwent PPP or PD. METHODS: Patients who underwent PPP or PD for low-grade lesions between 2009 and 2017 were included. Operative factors including postoperative complications and nutritional indicators during the first-year postoperatively were compared...
April 5, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30962137/robotic-versus-conventional-laparoscopic-distal-pancreatic-resection-a-systematic-review-and-meta-analysis
#11
REVIEW
Sivesh K Kamarajah, Nathania Sutandi, Stuart R Robinson, Jeremy J French, Steven A White
BACKGROUND: Robotic surgery offers theoretical advantages to conventional laparoscopic surgery including improved instrument dexterity, 3D visualization and better ergonomics. This review aimed to determine if these theoretical advantages translate into improved patient outcomes in patients undergoing distal pancreatectomy through laparoscopic (LDP) or robotic (RDP) approaches. METHOD: A systematic literature search was conducted for studies reporting minimally invasive surgery for distal pancreatectomy...
April 5, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30962136/laparoscopic-versus-open-liver-resection-in-the-posterosuperior-segments-a-sub-group-analysis-from-the-oslo-comet-randomized-controlled-trial
#12
Davit L Aghayan, Åsmund A Fretland, Airazat M Kazaryan, Mushegh A Sahakyan, Vegar J Dagenborg, Bjørn Atle Bjørnbeth, Kjersti Flatmark, Ronny Kristiansen, Bjørn Edwin
BACKGROUND: Laparoscopic liver resection in the posterosuperior segments is technically challenging. This study aimed to compare the perioperative outcomes for laparoscopic and open resection of colorectal liver metastases located in the posterosuperior segments. METHODS: This was a subgroup analysis of the OSLO-COMET randomized controlled trial, where 280 patients were randomly assigned to open or laparoscopic parenchyma-sparing liver resections of colorectal metastases...
April 5, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30962134/diagnosis-and-management-of-postpancreatectomy-hemorrhage-a-systematic-review-and-meta-analysis
#13
REVIEW
A Floortje van Oosten, F Jasmijn Smits, Daniël A F van den Heuvel, Hjalmar C van Santvoort, I Quintus Molenaar
BACKGROUND: Postpancreatectomy hemorrhage is a potentially lethal complication after pancreatic resection. The objective of this systematic review is to provide insight in the current status of incidence, detection, management and clinical outcomes of late postpancreatectomy hemorrhage. METHODS: A systematic search was conducted on the literature from February 2007 to July 2018 in PubMed, Embase and the Cochrane library. Included were clinical studies with clinical outcomes on late postpancreatectomy hemorrhage defined according to the International Study Group of Pancreatic Surgery definition (i...
April 5, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30956162/prognostic-relevance-of-preoperative-bilirubin-adjusted-serum-carbohydrate-antigen-19-9-in-a-multicenter-subset-analysis-of-179-patients-with-distal-cholangiocarcinoma
#14
Louisa Bolm, Ekaterina Petrova, Jürgen Weitz, Felix Rückert, Uwe A Wittel, Frank Makowiec, Hryhoriy Lapshyn, Peter Bronsert, Bettina M Rau, Igor E Khatkov, Dirk Bausch, Tobias Keck, Ulrich F Wellner, Marius Distler
BACKGROUND: Distal cholangiocarcinoma (DCC) is a rare malignancy and validated prognostic markers remain scarce. We aimed to evaluate the role of serum CA19-9 as a potential biomarker in DCC. METHODS: Patients operated for DCC at 6 high-volume surgical centers from 1994 to 2015 were identified from prospectively maintained databases. Patient baseline characteristics, surgical and histopathological parameters, as well as overall survival after resection were assessed for correlation with preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 (CA19-9)...
April 5, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30956165/use-of-a-modified-delphi-approach-to-develop-research-priorities-in-hpb-surgery-across-the-united-kingdom
#15
Stephen R Knight, Samir Pathak, Alan Christie, Louise Jones, Jonathan Rees, Hayley Davies, Michael S J Wilson, Peter Vaughan-Shaw, Keith Roberts, Giles Toogood, Ewen M Harrison, Mark A Taylor
BACKGROUND: Research prioritisation can help identify clinically relevant questions and encourage high-quality, patient-centred research. Delphi methodology aims to develop consensus opinion within a group of experts, with recent Delphi projects helping to define the research agenda and funding within several medical and surgical specialties. METHODS: All members of the Association of Upper Gastrointestinal Surgeons (AUGIS) were asked to submit clinical research questions using an online survey (Phase 1)...
April 4, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30956164/prediction-of-discharge-destination-following-major-hepatectomy
#16
David A Mahvi, Linda M Pak, Adam C Fields, Richard D Urman, Jason S Gold, Edward E Whang
BACKGROUND: Anatomic hepatectomies can be associated with complicated post-operative recoveries, often with discharge to post-acute care facilities. This study identifies preoperative and intraoperative factors associated with increased risk for non-home discharge destination after major hepatectomy. METHODS: Patients undergoing major hepatectomy were identified in the NSQIP Targeted Hepatectomy Dataset (2014-2016). Multivariable logistic regression was performed...
April 4, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30956163/peer-review-of-mortality-after-pancreaticoduodenectomy-in-australia
#17
Claire L Stevens, Jessica L Reid, Wendy J Babidge, Guy J Maddern
BACKGROUND: The data within the Australian and New Zealand Audit of Surgical Mortality (ANZASM) provides a unique opportunity to consider the contributing factors to perioperative deaths as determined by peer review. Consideration of the factors contributing to mortality after pancreaticoduodenectomy (PD) can provide greater insight into how deaths can be prevented. METHODS: ANZASM data from 1 January 2010 to 30 Jun 2017 was reviewed and all deaths following PD were selected for analysis...
April 4, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30926331/impact-of-open-and-minimally-invasive-resection-of-symptomatic-solid-benign-liver-tumours-on-symptoms-and-quality-of-life-a-systematic-review
#18
REVIEW
Belle V van Rosmalen, Jan Jaap de Graeff, Marcel J van der Poel, Ilja E de Man, Marc Besselink, Mohammad Abu Hilal, Olivier R Busch, Joanne Verheij, Thomas M van Gulik
BACKGROUND: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking. METHODS: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985-April 2018)...
March 27, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30926330/implementation-and-first-results-of-a-mandatory-nationwide-audit-on-liver-surgery
#19
Leonie R van der Werf, Niels F M Kok, Carlijn I Buis, Dirk J Grünhagen, Frederik J H Hoogwater, Rutger Jan Swijnenburg, Marcel den Dulk, Kees C H C Dejong, Joost M Klaase
BACKGROUND: The Dutch Hepato Biliary Audit (DHBA) was initiated in 2013 to assess the national quality of liver surgery. This study aimed to describe the initiation and implementation of this audit along with an overview of the results and future perspectives. METHODS: Registry of patients undergoing liver surgery for all primary and secondary liver tumors in the DHBA is mandatory. Weekly, benchmarked information on process and outcome measures is reported to surgical teams...
March 26, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30926329/combined-hepatic-and-portal-vein-embolization-as-preparation-for-major-hepatectomy-a-systematic-review
#20
REVIEW
Francesco Esposito, Chetana Lim, Eylon Lahat, Chaya Shwaartz, Rony Eshkenazy, Chady Salloum, Daniel Azoulay
BACKGROUND: Some patients remain deemed unsuitable for resection after portal vein embolization (PVE) because of insufficient hypertrophy of the future remnant liver (FRL). Hepatic and portal vein embolization (HPVE) has been shown to induce hypertrophy of the FRL. The aim of this study was to provide a systematic review of the available literature on HPVE as preparation for major hepatectomy. METHODS: The literature search was performed on online databases. Studies including patients who underwent preoperative HPVE were retrieved for evaluation...
March 26, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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