Journals International Journal of Medic...

International Journal of Medical Microbiology : IJMM
Youqi Ji, Bingqian Zhuo, Tao Jiang, Mengyuan Chen, Wei Xu, Yuhuan Shen, Dongqing Cheng, Yumei Ge
BACKGROUND: Talaromyces marneffei (T. marneffei) is a thermal dimorphic fungus, which can cause lung or blood stream infection in patients, often life-threatening. However, endocarditis caused by T. marneffei has not been reported. For elderly patients with implanted cardiac devices or artificial valves, the prevention and treatment of infective endocarditis should not be ignored. METHODS: This is a descriptive study of a T. marneffei endocarditis by joint detection of cardiac ultrasound examination, peripheral blood DNA metagenomics Next Generation Sequencing (mNGS), and in vitro culture...
February 21, 2024: International Journal of Medical Microbiology: IJMM
Johanna Kessel, Anna-Catharina Rossaert, Tilman Lingscheid, Jan Grothe, Thomas Harrer, Christoph Wyen, Daniela Tominski, T Bollinger, Anna Katharina Kehr, Sven Kalbitz, Christian Hoffmann, Oliver Cornely, Uwe Koppe, Christoph Stephan, Volker Rickerts
Cryptococcosis is the most prevalent fungal infection of the central nervous system worldwide. We performed a retrospective multicenter cohort study to gain insights into the epidemiology of cryptococcosis in Germany. We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis...
February 16, 2024: International Journal of Medical Microbiology: IJMM
Anika Wahl, Martin A Fischer, Kathleen Klaper, Annelie Müller, Stefan Borgmann, Johannes Friesen, Klaus-Peter Hunfeld, Arkadius Ilmberger, Susanne Kolbe-Busch, Michael Kresken, Norman Lippmann, Christoph Lübbert, Matthias Marschner, Bernd Neumann, Niels Pfennigwerth, Michael Probst-Kepper, Jürgen Rödel, Marco H Schulze, Andreas E Zautner, Guido Werner, Yvonne Pfeifer
BACKGROUND: Klebsiella (K.) pneumoniae is a ubiquitous Gram-negative bacterium and a common coloniser of animals and humans. Today, K. pneumoniae is one of the most persistent nosocomial pathogens worldwide and poses a severe threat/burden to public health by causing urinary tract infections, pneumonia and bloodstream infections. Infections mainly affect immunocompromised individuals and hospitalised patients. In recent years, a new type of K. pneumoniae has emerged associated with community-acquired infections such as pyogenic liver abscess in otherwise healthy individuals and is therefore termed hypervirulent K...
February 8, 2024: International Journal of Medical Microbiology: IJMM
Anna Borodova, Aziz Amadou Diallo, Rebekah Wood, Ousmane Tounkara, Carlos Rocha, Mouctar Bayo, Lena Landsmann, Mahamoud Sama Cherif, Matthias Borchert, Carolin Meinus, Ibrahima Nabé, Sekou Doumbouya, Kamis Mamadou Diallo, Mamadou Diallo, Mardjan Arvand, Sophie A Müller
Across the globe, hand hygiene (HH) is promoted to fight the spread of healthcare associated infections. Despite multiplongoing HH campaigns and projects, the healthcare associated infection rates remain high especially in low- and middle-income countries. In the narrative overview presented here, we aim to share objectives, framework, successes and challenges of our long-term partnership in Guinea to offer guidance for other projects aiming to sustainably improve HH.
February 5, 2024: International Journal of Medical Microbiology: IJMM
Katharina Hueppe, Jan Ortman, Hannah Gauselmann, Sabine Santibanez, Annette Mankertz
Measles and rubella are targeted for elimination in the WHO region Europe. To reach the elimination goal, vaccination coverage of 95% must be achieved and sustained, the genotype information has to be provided for 80% of all outbreaks and transmission chains of a certain variant must not be detected for >12 months. The latter information is collected at Germany's National Reference Center Measles, Mumps, Rubella (NRC MMR). We describe here an outbreak of measles occurring in Hildesheim. The outbreak comprised 43 cases and lasted 14 weeks...
February 3, 2024: International Journal of Medical Microbiology: IJMM
Angelika Fruth, Christina Lang, Tobias Größl, Thomas Garn, Antje Flieger
Shiga toxin-producing E. coli (STEC), including the subgroup of enterohemorrhagic E. coli (EHEC), are important bacterial pathogens which cause diarrhea and the severe clinical manifestation hemolytic uremic syndrome (HUS). Genomic surveillance of STEC/EHEC is a state-of-the-art tool to identify infection clusters and to extract markers of circulating clinical strains, such as their virulence and resistance profile for risk assessment and implementation of infection prevention measures. The aim of the study was characterization of the clinical STEC population in Germany for establishment of a reference data set...
February 1, 2024: International Journal of Medical Microbiology: IJMM
Kathleen Klaper, Hana Tlapák, Regina Selb, Klaus Jansen, Dagmar Heuer
Numbers of infections with Neisseria gonorrhoeae are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae pose an important public-health issue. The integration of genomic, phenotypic and epidemiological data to monitor Neisseria gonorrhoeae fosters our understanding of the emergence and spread of AMR in Neisseria gonorrhoeae and helps to inform therapy guidelines and intervention strategies. Thus, the Gonococcal resistance surveillance (Go-Surv-AMR) was implemented at the Robert Koch Institute in Germany in 2021 to obtain molecular, phenotypic and epidemiological data on Neisseria gonorrhoeae isolated in Germany...
January 29, 2024: International Journal of Medical Microbiology: IJMM
Daniele Pantano, Alexander W Friedrich
The threat of multidrug-resistant organisms (MDROs) and antimicrobial resistance (AMR) are real and increasing every day. They affect not only healthcare systems but also communities, causing economic and public health concerns. Governments must take action to tackle AMR and prevent the spread of MDROs and regional hubs have a critical role to play in achieving this outcome. Furthermore, bacteria have no borders, consequently, cooperation networks should be extended between countries as a crucial strategy for achieving the success of infection control...
January 26, 2024: International Journal of Medical Microbiology: IJMM
Alla Heider, Marianne Wedde, Viola Weinheimer, Stephanie Döllinger, Masyar Monazahian, Ralf Dürrwald, Thorsten Wolff, Brunhilde Schweiger
Interspecies transmission of influenza A viruses (IAV) from pigs to humans is a concerning event as porcine IAV represent a reservoir of potentially pandemic IAV. We conducted a comprehensive analysis of two porcine A(H1N1)v viruses isolated from human cases by evaluating their genetic, antigenic and virological characteristics. The HA genes of those human isolates belonged to clades 1C.2.1 and 1C.2.2, respectively, of the A(H1N1) Eurasian avian-like swine influenza lineage. Antigenic profiling revealed substantial cross-reactivity between the two zoonotic H1N1 viruses and human A(H1N1)pdm09 virus and some swine viruses, but did not reveal cross-reactivity to H1N2 and earlier human seasonal A(H1N1) viruses...
January 24, 2024: International Journal of Medical Microbiology: IJMM
Benedikt Schrenker, Anna Zimmermann, Thorsten Koch, Grit Walther, Ronny Martin, Daniel Kampik, Oliver Kurzai, Johanna Theuersbacher
PURPOSE: Fusarium keratitis is a severe infection of the anterior eye, frequently leading to keratoplasty or surgical removal of the affected eye. A major risk factor for infection is the use of contact lenses. Inadequate hygiene precautions and mold-growth permissive storage fluids are important risk factors for fungal keratitis. The aim of this study was to comparatively analyze contact lens storage fluids disinfection efficacy against Fusarium species. METHODS: Eleven commercially available storage fluids were tested...
January 23, 2024: International Journal of Medical Microbiology: IJMM
Anne Zemella, Kerstin Beer, Franziska Ramm, Dana Wenzel, Ariane Düx, Kevin Merkel, Sebastien Calvignac-Spencer, Daniel Stern, Martin B Dorner, Brigitte G Dorner, Navena Widulin, Thomas Schnalke, Cornelia Walter, Anne Wolbert, Bernhard G Schmid, Annette Mankertz, Sabine Santibanez
Measles is a highly contagious airborne viral disease. It can lead to serious complications and death and is preventable by vaccination. The live-attenuated measles vaccine (LAMV) derived from a measles virus (MV) isolated in 1954 has been in use globally for six decades and protects effectively by providing a durable humoral and cell-mediated immunity. Our study addresses the temporal stability of epitopes on the viral surface glycoprotein hemagglutinin (H) which is the major target of MV-neutralizing antibodies...
January 20, 2024: International Journal of Medical Microbiology: IJMM
Kirsten Hanke, Vera Rykalina, Uwe Koppe, Barbara Gunsenheimer-Bartmeyer, Dagmar Heuer, Karolin Meixenberger
Advances in the molecular epidemiological studies of the Human Immunodeficiency Virus (HIV) at the Robert Koch Institute (RKI) by laboratory and bioinformatic automation should allow the processing of larger numbers of samples and more comprehensive and faster data analysis in order to provide a higher resolution of the current HIV infection situation in near real-time and a better understanding of the dynamic of the German HIV epidemic. The early detection of the emergence and transmission of new HIV variants is important for the adaption of diagnostics and treatment guidelines...
January 20, 2024: International Journal of Medical Microbiology: IJMM
Christiane Cuny, Franziska Layer-Nicolaou, Guido Werner, Wolfgang Witte
Staphylococcus aureus and other staphylococcal species are resident and transient multihost colonizers as well as conditional pathogens. Especially S. aureus represents an excellent model bacterium for the "One Health" concept because of its dynamics at the human-animal interface and versatility with respect to host adaptation. The development of antimicrobial resistance plays another integral part. This overview will focus on studies at the human-animal interface with respect to livestock farming and to companion animals, as well as on staphylococci in wildlife...
January 18, 2024: International Journal of Medical Microbiology: IJMM
Sergio Buenestado-Serrano, Marta Herranz, Álvaro Otero-Sobrino, Andrea Molero-Salinas, Cristina Rodríguez-Grande, Amadeo Sanz-Pérez, María José Durán Galván, Pilar Catalán, Roberto Alonso, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma
BACKGROUND: SARS-CoV-2 genomic analysis has been key to the provision of valuable data to meet both epidemiological and clinical demands. High-throughput sequencing, generally Illumina-based, has been necessary to ensure the widest coverage in global variant tracking. However, a speedier response is needed for nosocomial outbreak analyses and rapid identification of patients infected by emerging VOCs. An alternative based on nanopore sequencing may be better suited to delivering a faster response when required; however, although there are several studies offering side-by-side comparisons of Illumina and nanopore sequencing, evaluations of the usefulness in the hospital routine of the faster availability of data provided by nanopore are still lacking...
January 18, 2024: International Journal of Medical Microbiology: IJMM
Sonja Jacobsen, Mirko Faber, Britta Altmann, Andreas Mas Marques, C-Thomas Bock, Sandra Niendorf
Human norovirus is a major cause of viral gastroenteritis in all age groups. The virus is constantly and rapidly changing, allowing mutations and recombination events to create great diversity of circulating viruses. With the start of the COVID-19 pandemic in 2020, a wide range of public health measures were introduced worldwide to control human-to-human transmission of SARS-CoV-2. In Germany, control measures such as distance rules, contact restrictions, personal protection equipment as well as intensive hand hygiene were introduced...
January 18, 2024: International Journal of Medical Microbiology: IJMM
Anna Maria Oschmann-Kadenbach, Christoph Schaudinn, Leonard Borst, Carsten Schwarz, Katharina Konrat, Mardjan Arvand, Astrid Lewin
Mycobacteroides abscessus is one of the most resistant bacteria so far known and causes severe and hard to treat lung infections in predisposed patients such as those with Cystic Fibrosis (CF). Further, it causes nosocomial infections by forming biofilms on medical devices or water reservoirs. An eye-catching feature of M. abscessus is the growth in two colony morphotypes. Depending on the presence or absence of glycopeptidolipids on the cell surface, it forms smooth or rough colonies. In this study, a porous glass bead biofilm model was used to compare biofilm formation, biofilm organization and biofilm matrix composition in addition to the antimicrobial susceptibility of M...
January 18, 2024: International Journal of Medical Microbiology: IJMM
Yuguang Fu, Marianne Wedde, Sigrun Smola, Djin-Ye Oh, Thorsten Pfuhl, Jürgen Rissland, Michael Zemlin, Fidelis A Flockerzi, Rainer M Bohle, Andrea Thürmer, Susanne Duwe, Barbara Biere, Janine Reiche, Brunhilde Schweiger, Christin Mache, Thorsten Wolff, Georg Herrler, Ralf Dürrwald
Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized. A patient (age group 5-15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined. Autopsy revealed hemorrhagic pneumonia as major pathological manifestation...
January 11, 2024: International Journal of Medical Microbiology: IJMM
Ran Duan, Dongyue Lyu, Shuai Qin, Junrong Liang, Wenpeng Gu, Qun Duan, Weiwei Wu, Deming Tang, Haonan Han, Xiaojin Zheng, Jinxiao Xi, Asaiti Bukai, Xinmin Lu, Peng Zhang, Dan Zhang, Meng Xiao, Huaiqi Jing, Xin Wang
Pasteurella multocida is a zoonotic pathogen causing serious diseases in humans and animals. Here, we report P. multocida from wildlife on China's Qinghai-Tibet plateau with a novel capsular serotype, forming a single branch on the core-genome phylogenetic tree: four strains isolated from dead Himalayan marmot (Marmota himalayana) and one genome assembled from metagenomic sequencing of a dead Woolly hare (Lepus oiostolus). Four of the strains were identified as subspecies multocida and one was septica. The mouse model showed that the challenge strain killed mice within 24 h at an infectious dose of less than 300 bacteria...
January 5, 2024: International Journal of Medical Microbiology: IJMM
Petra Gastmeier, Axel Kola, Frank Schwab, Michael Behnke, Christine Geffers
PURPOSE: Data from the intensive care component of the German hospital infection surveillance system (KISS) was used to investigate the epidemiology of pathogens responsible for the most frequent device-associated infections and their development over time. METHOD: The 10 most common pathogens were identified for ventilator-associated lower respiratory tract infections (VALRTI), catheter associated urinary tract infections (CAUTI), and central venous catheter associated bloodstream infections (CVC-BSI)...
December 22, 2023: International Journal of Medical Microbiology: IJMM
Felix Reichert, Simon Brinkwirth, Niels Pfennigwerth, Sebastian Haller, Lena Sophie Fritsch, Tim Eckmanns, Guido Werner, Sören Gatermann, Jörg B Hans
The rapid increase of OXA-244-producing Escherichia coli, predominantly driven by genetically clustered isolates of sequence type (ST)38, has been observed in at least nine European countries, including Germany. However, the reasons for the spread of OXA-244-producing E. coli remain unclear. Here, we aim to evaluate the possibility of prolonged carriage. We identified a total of six different patients with repeated detection of OXA-244-producing E. coli isolates, which were subjected to both short and long-read whole-genome sequencing (WGS)...
December 19, 2023: International Journal of Medical Microbiology: IJMM
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