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Current Atherosclerosis Reports

Mahmoud Al Rifai, Miguel Cainzos-Achirica, Michael J Blaha, Kelly Arps, David A Wood, Roger S Blumenthal, John W McEvoy
PURPOSE OF REVIEW: In this review, we discuss a new paradigm for atherosclerotic cardiovascular disease (ASCVD) prevention that is focused on cultivating cardiovascular wellness through the promotion of "health factors." RECENT FINDINGS: Cardiovascular prevention efforts have contributed to falling rates of ASCVD over the past five decades. However, contemporary increases in obesity and diabetes have led to a recent slowing in the annual decline of ASCVD death rates...
February 12, 2019: Current Atherosclerosis Reports
Marie-Pierre St-Onge, Faris M Zuraikat
PURPOSE OF REVIEW: This review investigates the potential bi-directional relation between sleep and diet in considering their contribution to cardiovascular health. We further explore the involvement of the gut microbiome in the relationships between poor sleep and dietary intakes and increased cardiovascular disease (CVD) risk. RECENT FINDINGS: There is strong evidence that sleep restriction leads to unhealthy food choices and increased energy intake. The diet may impact sleep, as well...
February 12, 2019: Current Atherosclerosis Reports
Linda C Tapsell, Elizabeth P Neale, Yasmine Probst
PURPOSE OF REVIEW: The relationship between dietary patterns and cardiovascular disease has been the subject of much research, but an important methodological consideration is the interdependence between the nutrient composition of foods and the recognition of healthy dietary patterns. This review considers some of the challenges in researching dietary patterns with implications for translation to public health promotions. RECENT FINDINGS: A number of statistical methods have emerged for analysing dietary patterns using population dietary data...
February 11, 2019: Current Atherosclerosis Reports
Djeniffer Elias da Silva, Antônio José Grande, Leonardo Roever, Gary Tse, Tong Liu, Giuseppe Biondi-Zoccai, Joni Márcio de Farias
PURPOSE OF REVIEW: High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appraise the evidence base on the effects of HIIT in comparison to mild- or moderate-intensity interval training (MMIIT) on glycemic control inT2DM. RECENT FINDINGS: A total of 5 RCT met the inclusion criteria...
February 2, 2019: Current Atherosclerosis Reports
Narendra N Khanna, Ankush D Jamthikar, Deep Gupta, Matteo Piga, Luca Saba, Carlo Carcassi, Argiris A Giannopoulos, Andrew Nicolaides, John R Laird, Harman S Suri, Sophie Mavrogeni, A D Protogerou, Petros Sfikakis, George D Kitas, Jasjit S Suri
PURPOSE OF THE REVIEW: Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using traditional risk factor-based calculators either underestimates or overestimates the CV risk. Advancements in medical imaging have facilitated early and accurate CV risk stratification compared to conventional cardiovascular risk calculators...
January 25, 2019: Current Atherosclerosis Reports
D A Cadilhac, S S Rajan, J Kim
No abstract text is available yet for this article.
January 25, 2019: Current Atherosclerosis Reports
Silke Walter, Iris Q Grunwald, Stefan A Helwig, Andreas Ragoschke-Schumm, Michael Kettner, Mathias Fousse, Martin Lesmeister, Klaus Fassbender
No abstract text is available yet for this article.
January 25, 2019: Current Atherosclerosis Reports
Sridevi Devaraj, Simona Valleggi, David Siegel, Ishwarlal Jialal
A portion of this article was previously published as part of an article titled "Human C-reactive protein and the metabolic syndrome" in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9. doi: 10.1097/MOL.0b013e32832ac03e.
January 25, 2019: Current Atherosclerosis Reports
Sridevi Devaraj, David Siegel, Ishwarlal Jialal
A portion of this article was previously published as part of an article titled "Human C-reactive protein and the metabolic syndrome" in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9.
January 21, 2019: Current Atherosclerosis Reports
R Preston Mason
PURPOSE OF REVIEW: Treatment of hypercholesterolemia with statins results in significant reductions in cardiovascular risk; however, individuals with well-controlled low-density lipoprotein cholesterol (LDL-C) levels, but persistent high triglycerides (TG), remain at increased risk. Genetic and epidemiologic studies have shown that elevated fasting TG levels are associated with incident cardiovascular events. At effective doses, omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower TG levels but may have additional atheroprotective properties compared to other TG-lowering therapies such as niacin and fibrates...
January 12, 2019: Current Atherosclerosis Reports
Xiaoming Jia, Payal Kohli, Salim S Virani
PURPOSE OF REVIEW: Omega-3 fatty acids (ω-3 FA) are among the most well-recognized health supplements but their cardiovascular benefits have long been controversial owing to inconsistent results from previous cardiovascular outcomes trials (CVOT). In this article, we provide a short review of existing literature followed by recent randomized clinical trial data, with a discussion of the potential clinical implications of these new findings. RECENT FINDINGS: Data from the randomized, controlled trial REDUCE-IT, when viewed within the context of other recently published trials ASCEND and VITAL, add to a growing body of evidence on the use of ω-3 FA therapies in the treatment of atherosclerotic cardiovascular disease (ASCVD)...
January 10, 2019: Current Atherosclerosis Reports
Amy Cheney, Kathleen E Kearney, William Lombardi
ᅟ: Chronic total occlusions (CTOs) are an important and increasingly recognized subgroup of coronary lesions, documented in at least 30%, but up to 52% of patients with coronary artery disease (CAD) undergoing coronary angiography. Percutaneous coronary intervention (PCI) of these lesions is increasingly pursued, with excellent success rates. PURPOSE OF REVIEW: It is known that gender differences exist in the presentation of CAD, as well as in clinical outcomes after routine PCI; however, it is not well described how these differences pertain to management of CTOs...
November 7, 2018: Current Atherosclerosis Reports
Maki Tsujita, Anna Wolska, Daniel A P Gutmann, Alan T Remaley
PURPOSE OF REVIEW: Summarize the initial discovery of discoidal high-density lipoprotein (HDL) in human plasma and review more recent innovations that span the use of reconstituted nanodisc HDL for membrane protein characterization to its use as a drug carrier and a novel therapeutic agent for cardiovascular disease. RECENT FINDINGS: Using a wide variety of biophysical techniques, the structure and composition of endogenous discoidal HDL have now largely been solved...
November 5, 2018: Current Atherosclerosis Reports
Sahar Naderi
Spontaneous coronary artery dissection (SCAD) is a non-inflammatory, non-atherosclerotic cause of acute myocardial infarction (AMI) that, by definition, is not iatrogenic or due to trauma. It is a condition that predominantly affects pre- or perimenopausal women without the traditional risk factors for cardiovascular disease. PURPOSE OF REVIEW: In this review, we will discuss the epidemiology, diagnosis, and management of this condition, with an emphasis on the ongoing research needed to better understand how to care for patients with SCAD...
October 29, 2018: Current Atherosclerosis Reports
Carson Keck, Marian Taylor
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is known to be an increasing cause of mortality among women, particularly postmenopausal women. Hormone replacement therapy (HRT) is a topic that has been investigated over the past decade for its known impact on the cardiovascular system. This review summarizes the evidence and current opinion on the associations between HRT and CVD, evidence both supporting and against HRT use as a prevention to the development of coronary heart disease (CHD)...
October 22, 2018: Current Atherosclerosis Reports
Carlo W Cereda, Jean-Marc Olivot
PURPOSE OF REVIEW: Patients with transient ischemic attacks (TIAs) have a higher risk for stroke and vascular events. Specialized and organized management, if rapidly initiated in the emergency department (ED), reduces the vascular burden of TIA. This review summarizes the rationale for optimal triage of patients suspected with TIA in the ED, focusing on early diagnosis confirmation, individual risk stratification, and management. RECENT FINDINGS: New evidence is emerging on the yield of integrating clinical scales with advanced neuroimaging of the vessels and brain for improved diagnosis and risk stratification in patients with TIA...
September 25, 2018: Current Atherosclerosis Reports
Gary Tse, George Bazoukis, Leonardo Roever, Tong Liu, William K K Wu, Martin C S Wong, Adrian Baranchuk, Panagiotis Korantzopoulos, Dimitrios Asvestas, Konstantinos P Letsas
Tpeak-Tend interval, the time difference between the peak and the end of the T-wave, reflects the degree of dispersion of repolarization. Its prolongation has been associated with higher risks of developing ventricular arrhythmias and sudden cardiac death in different pro-arrhythmic conditions such as Brugada and long QT syndromes. In this review, we will provide a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree...
September 17, 2018: Current Atherosclerosis Reports
Rose Mary Ferreira Lisboa da Silva, Anaisa Silva Roever Borges, Nilson Penha Silva, Elmiro Santos Resende, Gary Tse, Tong Liu, Leonardo Roever, Giuseppe Biondi-Zoccai
PURPOSE OF REVIEW: Resting heart rate is an independent risk factor for all-cause and cardiovascular mortality in patients with heart failure. The main objectives are to discuss the prognosis of heart rate, its association with coronary atherosclerosis, and the modalities of control of the heart rate in sinus rhythm and in the rhythm of atrial fibrillation in patients with chronic heart failure. RECENT FINDINGS: As a therapeutic option for control heart rate, medications such as beta-blockers, digoxin, and finally ivabradine have been studied...
September 17, 2018: Current Atherosclerosis Reports
Razi Khan, Eric Rheaume, Jean-Claude Tardif
PURPOSE: The purpose of this review was to examine the role of IL-1β in the inflammatory process central to the development of atherosclerosis and to discuss current clinical evidence for treatments targeting IL-1β in coronary artery disease. RECENT FINDINGS: IL-1β has been shown to modulate atherosclerotic plaque progression by upregulating the synthesis of adhesion molecules on endothelial cells, as well increasing activation and proliferation of vascular smooth muscle cells...
September 15, 2018: Current Atherosclerosis Reports
Sharda S Anroedh, K Martijn Akkerhuis, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Milos Brankovic, Evelyn Regar, Robert-Jan van Geuns, Patrick W Serruys, Joost Daemen, Nicolas M van Mieghem, Eric Boersma, Isabella Kardys
PURPOSE OF REVIEW: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome. RECENT FINDINGS: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE)...
September 14, 2018: Current Atherosclerosis Reports
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