Saikam Law, Brian Oldfield, Wah Yang
ChatGPT/GPT-4 is a conversational large language model (LLM) based on artificial intelligence (AI). The potential application of LLM as a virtual assistant for bariatric healthcare professionals in education and practice may be promising if relevant and valid issues are actively examined and addressed. In general medical terms, it is possible that AI models like ChatGPT/GPT-4 will be deeply integrated into medical scenarios, improving medical efficiency and quality, and allowing doctors more time to communicate with patients and implement personalized health management...
April 12, 2024: Obesity Reviews
Xiyan Liu, Huayi Sun, Lixia Zheng, Jian Zhang, Han Su, Bingjie Li, Qianhui Wu, Yunchan Liu, Yingxi Xu, Xiaoyu Song, Yang Yu
Adipose tissue is the first and primary target organ of obesity and the main source of circulating miRNAs in patients with obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose-derived miRNAs and their role as early predictors of various obesity-related complications. Literature searches in the PubMed and Web of Science databases using terms related to miRNAs, obesity, and adipose tissue. Pre-miRNAs from the Human MicroRNA Disease Database, known to regulate obesity-related metabolic disorders, were combined for intersection processing...
April 8, 2024: Obesity Reviews
Suhaniya N S Samarasinghe, Eduard Ostarijas, Matthew J Long, Simon Erridge, Sanjay Purkayastha, Georgios K Dimitriadis, Alexander D Miras
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. This systematic review, meta-analysis, and meta-regression aims to compare the effect of insulin sensitizer pharmacotherapy on metabolic and reproductive outcomes in women with PCOS and overweight or obesity. We searched online databases MEDLINE via OVID, EMBASE,, and EudraCT for trials published from inception to November 13, 2023. Inclusion criteria were double-blind, randomized controlled trials in women diagnosed with PCOS, body mass index (BMI) ≥ 25 kg/m2 , which reported metabolic or reproductive outcomes...
April 4, 2024: Obesity Reviews
David Eagle, Anna Holleman, Brianda Barrera Olvera, Elizabeth Blackwood
OBJECTIVE: This systematic review aims to summarize the current body of evidence concerning the prevalence of obesity among clergy (i.e., the officially designated leaders of a religious group) in the United States. METHOD: From November 2022 to February 2023, five databases, one data repository, and gray matter were searched for articles and data sources. The search was restricted to articles published or raw data collected from 2001 to 2021. Study quality was assessed with a template, and heterogeneity was assessed using the <mml:math xmlns:mml="https://www...
April 4, 2024: Obesity Reviews
Calvin Diep, Sandra Lee, Yuanxin Xue, Maggie Xiao, Bianca Pivetta, Julian F Daza, James J Jung, Duminda N Wijeysundera, Karim S Ladha
Preoperative depression is prevalent among patients undergoing metabolic and bariatric surgery (MBS) and is a potentially modifiable risk factor. However, the impact of preoperative depression on MBS outcomes has not been systematically reviewed. A search of MEDLINE, Embase, Cochrane, and PsychINFO (inception to June 2023) was conducted for studies reporting associations between preoperative depression and any clinical or patient-reported outcomes after MBS. Eighteen studies (5 prospective and 13 retrospective) reporting on 5933 participants were included...
April 4, 2024: Obesity Reviews
Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Yi Wang, Fuxingzi Li, Ling-Qing Yuan
Exosomes are extracellular vesicles, measuring 40-160 nm in diameter, that are released by many cell types and tissues, including adipose tissue. Exosomes are critical mediators of intercellular communication and their contents are complex and diverse. In recent years, accumulating evidence has proved that multiple adipose tissue-derived exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play pivotal roles in the pathogenesis of diverse metabolic diseases, such as obesity...
April 4, 2024: Obesity Reviews
Tatiana Almeida de Moraes Campos, Virginia Gaissionok Mariz, Alessandra Pinheiro Mulder, Cintia Chaves Curioni, Flávia Fioruci Bezerra
The determination of energy requirements in clinical practice is based on basal metabolic rate (BMR), frequently predicted by equations that may not be suitable for individuals with severe obesity. This systematic review and meta-analysis examined the accuracy and precision of BMR prediction equations in adults with severe obesity. Four databases were searched in March 2021 and updated in May 2023. Eligible studies compared BMR prediction equations with BMR measured by indirect calorimetry. Forty studies (age: 28-55 years, BMI: 40...
March 28, 2024: Obesity Reviews
Louise Padgett, June Stevens, Carolyn Summerbell, Wendy Burton, Elizabeth Stamp, Laura McLarty, Holly Schofield, Maria Bryant
Effect sizes from previously reported trials are often used to determine the meaningful change in weight in childhood obesity prevention interventions because information on clinically meaningful differences is lacking. Estimates from previous trials may be influenced by statistical significance; therefore, it is important that they have a low risk of type 1 error. A systematic review and meta-analysis were conducted to report on the design of child obesity prevention randomized controlled trials and effectiveness according to risk of type 1 error...
March 26, 2024: Obesity Reviews
Kainat Shariq, Tariq Jamal Siddiqi, Harriette Van Spall, Stephen J Greene, Marat Fudim, Adam D DeVore, Ambarish Pandey, Javed Butler, Muhammad Shahzeb Khan
Obesity is a worsening public health epidemic that remains challenging to manage. Obesity substantially increases the risk of cardiovascular diseases and presents a significant financial burden on the healthcare system. Digital health interventions, specifically telemedicine, may offer an attractive and viable solution for managing obesity. During the COVID-19 pandemic, the need for a safer alternative to in-person visits led to the increased popularity of telemedicine. Multiple studies have tested the efficacy of telemedicine modalities, including digital coaching via videoconferencing sessions, e-health monitoring using wearable devices, and asynchronous forms of communication such as online chatrooms with counselors...
March 26, 2024: Obesity Reviews
Ayse Nur Aksoy, Julie Abayomi, Nicola Relph, Thomas Butler
Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disease, causing a heavy burden on healthcare systems worldwide, with related complications and anti-diabetes drug prescriptions. Recently, it was demonstrated that T2DM can be put into remission via significant weight loss using low-carbohydrate diets (LCDs) and very low-energy diets (VLEDs) in individuals with overweight and obesity. Clinical trials demonstrated remission rates of 25-77%, and metabolic improvements such as improved blood lipid profile and blood pressure were observed...
March 21, 2024: Obesity Reviews
Hao Wang, Qianqian Ma, Youpeng Chen, Ling Luo, Junzhao Ye, Bihui Zhong
BACKGROUND: Emerging treatment methods, including exercise, diet, and drugs, for nonalcoholic fatty liver disease have been proposed. However, the differences in their efficacy have not been determined. We aimed to compare the effects of these treatments excluding surgery via a systematic review and network meta-analysis of randomized controlled trials. DATA SOURCE: The data sources included PubMed, Embase, Web of Science and Cochrane up to February 1st, 2023. The endpoints consisted of body mass index (BMI), serum markers of metabolism and liver injury markers, liver fat content, and stiffness...
March 21, 2024: Obesity Reviews
Jamie L Benham, Kathryn S Corbett, Jennifer M Yamamoto, Caitlin McClurg, Terhi Piltonen, Bulent O Yildiz, Rong Li, Aya Mousa, Chau Thien Tay, Poli Mara Spritzer, Helena Teede, Jacqueline A Boyle, Wendy A Brown
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females. Modest weight loss improves reproductive and metabolic PCOS features. While lifestyle modifications and pharmacotherapies remain first-line weight loss strategies, bariatric surgery is emerging as a potentially effective treatment. We performed a systematic review and meta-analysis of published literature to examine the impact of bariatric surgery in PCOS to inform the 2023 International PCOS Evidence-based Guidelines. Electronic databases were searched for observational studies and trials comparing pharmacologic or lifestyle treatments to bariatric surgery in women with PCOS or bariatric surgery in women with or without PCOS...
March 16, 2024: Obesity Reviews
Tianli Xiao, Zehua Huang, Chanjuan Zheng, Binh Quach, Yulian Zhu, Feifei Li, Wei Liang, Julien Baker, Christoph Reichetzeder, Berthold Hocher, Yide Yang
Mounting evidence shows that bisphenol A (BPA) is associated with metabolic risk factors. The aim of this study was to review related epidemiologic studies and conduct a meta-analysis to quantitatively estimate the association between BPA and metabolic syndrome. Four electronic databases were systematically searched to identify suitable articles. A total of 47 published studies were finally included. Two studies involved metabolic syndrome. Of the 17, 17, 14, and 13 studies on the relationship between BPA with abdominal obesity, blood pressure, fasting plasma glucose, and dyslipidemia, 10, 6, 3, and 4 studies were included in the meta-analysis, respectively...
March 15, 2024: Obesity Reviews
Alberte Laura Oest Müllertz, Rasmus Michael Sandsdal, Simon Birk Kjaer Jensen, Signe Sørensen Torekov
Potent incretin-based therapy shows promise for the treatment of obesity along with reduced incidence of cardiovascular events in patients with preexisting cardiovascular disease and obesity. This study assessed the efficacy and safety of the incretin-based obesity treatments, once-weekly subcutaneous semaglutide 2.4 mg and tirzepatide 10 or 15 mg, in people with obesity without diabetes. Of the 744 records identified, seven randomized controlled trials (n = 5140) were included. Five studies (n = 3288) investigated semaglutide and two studies (n = 1852) investigated tirzepatide...
March 11, 2024: Obesity Reviews
Lili Li, Ping Wang, Xudong Jiao, Song Qin, Zhengyi Liu, Yanrui Ye, Yipeng Song, Hu Hou
Obesity, a burgeoning worldwide health system challenge, is associated with multiple chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified lipids with mitigating and anti-inflammatory effects in diabetes. Increasing work has shown that FAHFAs exert antioxidant activity and enhance autophagy in neuronal cells and cardiomyocytes. We systematically summarized the biological activities of FAHFAs, including their regulatory effects on diabetes and inflammation, antioxidant activity, and autophagy augmentation...
March 10, 2024: Obesity Reviews
Anne Jacobs, Valerie M Monpellier, Bart Torensma, Evangelia E Antoniou, Ignace M C Janssen, Rob A E M Tollenaar, Anita T M Jansen
INTRODUCTION: Multiple factors are related to lower weight loss after bariatric surgery. This review and meta-analysis evaluates the influence of several mental and behavioral factors on weight loss. METHOD: Six electronic databases were searched. Percentage excess weight loss (%EWL) was calculated for all moderator and non-moderator groups of the variables: symptoms of depression, anxiety and binge eating, compliance, physical activity, quality of life, and body image...
March 7, 2024: Obesity Reviews
Marufa Sultana, Melanie Nichols, Jane Jacobs, Derin Karacabeyli, Steven Allender, Rachel Novotny, Vicki Brown
Multicomponent and multisectoral community-based interventions (CBIs) have proven potential in preventing overweight and obesity in children. Synthesizing evidence on the outcomes collected and reported in such CBIs is critical for the evidence of effectiveness and cost-effectiveness. This systematic review aimed to identify the range of outcomes and outcome measurement instruments collected and reported in multisectoral and multicomponent CBIs for obesity prevention in children. A systematic search updated an existing review and extended the search to 11 academic databases (2017-2023) and gray literature...
March 3, 2024: Obesity Reviews
Muhammad Aaqib Shamim, Pradeep Dwivedi, Naushaba Akhtar, Prakisini Satapathy, Sarvesh Rustagi, Bijaya K Padhi, Ranjit Sah
No abstract text is available yet for this article.
March 3, 2024: Obesity Reviews
Kaisheng Yuan, Xu Zhang, Bing Wu, Ruiqi Zeng, Ruixiang Hu, Cunchuan Wang
This study conducted a bibliometric analysis using the Web of Science Core Collection (WOSCC) to explore the relationship between diabetes mellitus and bariatric surgery (BS) from January 1985 to August 2023. No publications were found between 1985 and 1998. However, from 1998 to 2023, a total of 9,496 English articles were identified, accumulating 291,289 citations (241,563 excluding self-citations) and achieving an H-Index of 197. Leading contributors to the field were the United States, China, and Italy...
February 29, 2024: Obesity Reviews
Luc L Hagenaars, Laura A Schmidt, Joost Oude Groeniger, Marleen P M Bekker, Fleur Ter Ellen, Evelyne de Leeuw, Frank J van Lenthe, Karen M Oude Hengel, Karien Stronks
Despite evidence for the effectiveness of policies that target obesogenic environments, their adoption remains deficient. Using methods and concepts from complexity and political science (Stock-and-Flow analysis and Punctuated Equilibrium Theory) and a qualitative literature review, we developed system maps to identify feedback loops that hinder policymaking on mitigating obesogenic environments and feedback loops that could trigger and sustain policy change. We found numerous self-reinforcing feedback loops that buttress the assumption that obesity is an individual problem, strengthening the biomedical and commercial weight-loss sectors' claim to "ownership" over solutions...
February 29, 2024: Obesity Reviews
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