Daniela Merlotti, Domenico Rendina, Guido Cavati, Veronica Abate, Alberto Falchetti, Christian Mingiano, Ranuccio Nuti, Luigi Gennari
INTRODUCTION: Paget's disease of bone (PDB) is a focal bone disorder caused by a marked dysregulation of osteoblasts and osteoclasts in basic multicellular units, leading to abnormal and disorganized deposition of collagen fibers (the so-called 'woven bone'). Therefore, pagetic bones are increased in size, and at increased risk for bone pain, deformities, fractures, osteoarthritis, and, more rarely, neoplastic degeneration. AREAS COVERED: In this review, we revise the available information concerning the pharmacological treatment of PDB...
March 28, 2023: Expert Opinion on Pharmacotherapy