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Clinical & Experimental Ophthalmology

Robert J Casson, Glyn Chidlow, John Pm Wood
No abstract text is available yet for this article.
February 19, 2019: Clinical & Experimental Ophthalmology
Alessandro Invernizzi, Mariano Cozzi, Giovanni Staurenghi
Optical coherence tomography (OCT) has dramatically changed the understanding and management of uveitis and other ocular conditions. Currently, OCT angiography (OCTA) combines structural information with the visualization of blood flow within the imaged area. The aim of this review is to present the basic principles of OCT and OCTA interpretation and to investigate the role of these imaging techniques in the diagnosis and management of uveitis. Common complications of intraocular inflammation such as macular edema and inflammatory choroidal neovascularization are often diagnosed and followed with OCT/OCTA scans...
February 4, 2019: Clinical & Experimental Ophthalmology
Chien-Chia Su, Chia-Ying Tsai, Tzu-Hsun Tsai, I-Ju Tsai
IMPORTANCE: The association between visual deficits and attention disorders has been reported but remains unproven. BACKGROUND: The objective of this study was to evaluate the risk of attention-deficit hyperactivity disorder (ADHD) in children with amblyopia. DESIGN: Population-based, cohort study. PARTICIPANTS: The dataset from the Taiwan National Health Insurance Research Database in 2000-2010. METHODS: A total of 6817 patients aged <18 years with newly diagnosed amblyopia were identified...
January 20, 2019: Clinical & Experimental Ophthalmology
Ebony Liu, Jose Estevez, Georgia Kaidonis, Mark Hassall, Russell Phillips, Grant Raymond, Niladri Saha, George H C Wong, Jagjit Gilhotra, Kathryn Burdon, John Landers, Tim Henderson, Henry Newland, Stewart Lake, Jamie E Craig
IMPORTANCE: Five year survival rates in patients undergoing vitrectomy for diabetic retinopathy (DR) vary from 68-95%. No study has been conducted in an Australian population. BACKGROUND: We aimed to determine the survival rates of patients undergoing diabetic vitrectomy in an Australian population. DESIGN: Retrospective audit, tertiary centre hospitals and private practices PARTICIPANTS: All individuals in South Australia and the Northern Territory who underwent their first vitrectomy for diabetic complications between 1st January 2007 to 31st December 2011 METHODS: An audit of all eligible participants has been completed previously...
January 20, 2019: Clinical & Experimental Ophthalmology
Bing Liu, Xiongze Zhang, Lan Mi, Yuting Peng, Feng Wen
IMPORTANCE: Chorodial structure in subtypes of polypoidal choroidal vasculopathy. BACKGROUND: To evaluate choroidal vascularity in the eyes of patients with polypoidal choroidal vasculopathy (PCV) with and without choroidal vascular hyperpermeability (CVH). DESIGN: A hospital-based retrospective study. PARTICIPANTS: Fifty-eight PCV patients (28 with CVH; 30 without CVH) and 30 normal controls were included in this study...
January 20, 2019: Clinical & Experimental Ophthalmology
Colin S Tan, Wei Kiong Ngo, Louis W Lim, Nikolle W Tan, Tock Han Lim
IMPORTANCE: It is important to identify features of polypoidal choroidal vasculopathy (PCV) that differentiate it from typical neovascular age-related macular degeneration (nAMD) on various imaging modalities, including fluorescein angiography (FA). BACKGROUND: PCV was thought to be indistinguishable from nAMD using FA alone. In real-world practice, indocyanine-green angiography may often be unavailable or contraindicated. DESIGN: Analysis of FA images from a prospective, multicentre study...
January 16, 2019: Clinical & Experimental Ophthalmology
Markus Lenzhofer, Inga Kersten-Gomez, Arsham Sheybani, Husayn Gulamhusein, Clemens Strohmaier, Melchior Hohensinn, H Burkhard Dick, Wolfgang Hitzl, Lisa Eisenkopf, Fady Sedarous, Iqbal I Ahmed, Herbert A Reitsamer
No abstract text is available yet for this article.
December 22, 2018: Clinical & Experimental Ophthalmology
Colin S Tan, Dominic S Ting, Louis W Lim
IMPORTANCE: Multicolour is a new imaging technology and its sensitivity for detecting polypoidal choroidal vasculopathy (PCV) and age-related macular degeneration (AMD) has not been well described. BACKGROUND: To evaluate the accuracy of multicolour imaging compared to colour fundus photography (CFP) in differentiating AMD and PCV from normal eyes, and in detecting PCV. DESIGN: Prospective cohort study at a tertiary referral center. PARTICIPANTS: Fifty consecutive patients with PCV or AMD...
December 22, 2018: Clinical & Experimental Ophthalmology
Mario Matthaei, Christoph Leitl, Claus Cursiefen, Ludwig M Heindl
No abstract text is available yet for this article.
December 22, 2018: Clinical & Experimental Ophthalmology
Pauline Khoo, Kenneth G-J Ooi, Stephanie Watson
Meibomian gland dysfunction is one of the most common ocular disorders encountered by ophthalmologists and is the leading cause of evaporative dry eye. The disease causes significant morbidity in the population such that patients seek treatment. Multiple clinical studies on pharmacological and mechanical interventions for the treatment of meibomian gland dysfunction have been evaluated. However, there is limited comparative clinical evidence for the effectiveness of these interventions. This review paper aims to report the clinical evidence for pharmaceutical interventions for meibomian gland dysfunction in order to guide clinicians in the management of the disease...
December 18, 2018: Clinical & Experimental Ophthalmology
Samantha Sii, Giacinto Triolo, Keith Barton
The CyPass Micro-Stent (Alcon, Fort Worth, USA) is a minimally invasive glaucoma surgical (MIGS) device, implanted into the supra-choroidal space. The CyPass was FDA approved in July 2016 and CE marked in Europe. It was withdrawn voluntarily by the manufacturer in August 2018.
December 15, 2018: Clinical & Experimental Ophthalmology
Mustafa Iftikhar, Bushra Usmani, Abanti Sanyal, Saleema Kherani, Simrat Sodhi, Saghar Bagheri, Etienne M Schönbach, Nadia Junaid, Hendrik P N Scholl, Syed M A Shah
IMPORTANCE: It is important to establish reliable outcome measures to detect progression in retinitis pigmentosa (RP). BACKGROUND: To evaluate progression of RP using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimetry (MP). DESIGN: Retrospective longitudinal study at a tertiary teaching hospital. PARTICIPANTS: 205 eyes of 106 patients with RP with 1 to 5 y of follow-up...
December 15, 2018: Clinical & Experimental Ophthalmology
Alexander R Newman, Nicholas H Andrew
IMPORTANCE: The demand for glaucoma care is projected to increase significantly with the ageing population. BACKGROUND: To characterise trends in Australian practice patterns for glaucoma management over the 15-year period between 2003 and 2017. DESIGN: Retrospective audit. SAMPLES: The Medicare eligible population. METHODS: Audit of Medicare Benefits Schedule item number reimbursements in the private healthcare sector, and dispensed Pharmaceutical Benefits Scheme prescriptions...
December 13, 2018: Clinical & Experimental Ophthalmology
Harrison Y Bennett, Rylan A Hayes, Stephen O'Hagan
No abstract text is available yet for this article.
December 12, 2018: Clinical & Experimental Ophthalmology
Eoi Jong Seo, Taewoong Um, Young Hee Yoon
IMPORTANCE: Analyzing choroidal flow in central serous chorioretinopathy (CSC) with novel device BACKGROUND: To examine the abnormal morphology of choriocapillary flow with optical coherence tomography angiography (OCTA) according to the presence of subretinal fluid (SRF) in CSC. DESIGN: A hospital-based retrospective study PARTICIPANTS: We analyzed OCTA results of 68 eyes (68 patients) diagnosed as CSC with or without SRF (active and resolved CSC, respectively) at the Asan Medical Center...
December 5, 2018: Clinical & Experimental Ophthalmology
J Daniel Lafreniere, James T Toguri, Rishi R Gupta, Arif Samad, Dan M O'Brien, John Dickinson, Alan Cruess, Melanie E M Kelly, Mark E Seamone
BACKGROUND: Exogenous endophthalmitis is a potential complication of intraocular surgery and frequently results in visual impairment. Current treatment involves administration of intravitreal (IVT) antibiotics with or without vitrectomy surgery. Evidence for the use of adjunctive anti-inflammatory agents is conflicting. We set out to determine if bevacizumab, a humanized monoclonal IgG1 antibody targeted against vascular endothelial growth factor (VEGF), has anti-inflammatory properties in experimental models of Gram-positive and Gram-negative inflammation...
November 28, 2018: Clinical & Experimental Ophthalmology
Stuart Keel, Peter van Wijngaarden
No abstract text is available yet for this article.
November 28, 2018: Clinical & Experimental Ophthalmology
Henry B Wallace, Stuti L Misra, Sunny S Li, James McKelvie
IMPORTANCE: Intraocular pressure is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry. BACKGROUND: To determine the effect of cataract surgery and corneal incision size on corneal biomechanics. DESIGN: Prospective randomised trial PARTICIPANTS: One-hundred prospectively enrolled patients qualifying for cataract surgery METHODS: Participants were randomised to clear corneal incisions with a 2...
November 25, 2018: Clinical & Experimental Ophthalmology
Ruiping Gu, Wenyi Tang, Boya Lei, Chen Jiang, Fang Song, Gezhi Xu
BACKGROUND: This study aimed to investigate the neuroprotective function of a synthesized glucocorticoid-induced leucine zipper peptide (GILZ-p) in a light-induced retinal degeneration model. METHODS: The GILZ98-134 peptide was synthesized and injected intravitreally into Sprague Dawley rats. Retinal injury was then induced in the rats by exposing their eyes to constant white light (5000 lux) for 24 h. The activation of retinal caspases-9/3 and the release of cytochrome c from the mitochondria to the cytosol were measured at 1, 3, 5 and 7 days after light injury...
November 25, 2018: Clinical & Experimental Ophthalmology
Genevieve F Oliver, Jillian M Carr, Justine R Smith
Recently recognised forms of uveitis include intraocular inflammations that occur during or following one of several emerging infectious diseases: chikungunya fever, dengue, Zika virus disease and Ebola virus disease. Anterior, intermediate, posterior and pan- uveitis have been described in individuals infected with chikungunya virus. Persons who contract dengue or Zika viruses also may develop different types of uveitis in the course of the infection: maculopathy is a common manifestation of dengue eye disease, and Zika eye disease may cause hypertensive anterior uveitis or mimic a white dot syndrome...
November 25, 2018: Clinical & Experimental Ophthalmology
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