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Japanese Journal of Infectious Diseases

https://read.qxmd.com/read/38296541/inactivation-of-sars-cov-2-in-serum-using-physical-methods
#21
JOURNAL ARTICLE
Toshihiko Harada, Hirofumi Fujimoto, Shuetsu Fukushi, Koji Ishii, Ken-Ichi Hanaki
Since 2019, many studies on COVID-19, which has caused extensive damage as a pandemic, have been ongoing worldwide. These include serological and biochemical studies using sera from patients and animal models. Testing with these sera must be performed after the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Heat treatment, UV irradiation, and/or gamma-ray irradiation are used to inactivate viruses in serum. Determining the inactivation conditions that ensure the inactivation of viruses and minimize the effect on test results after inactivation is important to ensure worker safety and accuracy of test results...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38296540/efficacy-of-cefiderocol-a-novel-siderophore-cephalosporin-against-multi-drug-resistant-acinetobacter-baumannii-clinical-isolates-in-japan
#22
JOURNAL ARTICLE
Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Satoshi Nishida, Yusuke Yoshino
Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important pathogen that causes nosocomial infections and is resistant to almost all antibiotics, including carbapenems. Cefiderocol is a novel siderophore cephalosporin that is active against a broad spectrum of Gram-negative bacteria. However, the susceptibility of MDRAB from Japan to cefiderocol has not yet been reported. In this study, we measured the minimum inhibitory concentrations (MICs) of antibiotics, including cefiderocol, against MDRAB clinical isolates collected during a nosocomial outbreak from 2009 to 2010 at Teikyo University Hospital in Japan...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38296539/biofilm-eradication-of-stenotrophomonas-maltophilia-by-levofloxacin-and-trimethoprim-sulfamethoxazole
#23
JOURNAL ARTICLE
José Mauricio Del Río-Chacón, Fabián Rojas-Larios, Paola Bocanegra-Ibarias, Daniel Salas-Treviño, Francisco Espinoza-Gómez, Adrián Camacho-Ortiz, Samantha Flores-Treviño
Stenotrophomonas maltophilia is a non-fermenting Gram-negative drug-resistant pathogen causing healthcare-associated infections. Clinical isolates from Mexico were assessed for biofilm production by crystal violet staining. Antimicrobial susceptibility was evaluated using the broth microdilution method in planktonic and biofilm cells. The effect of antibiotics on the biofilm was visualized by fluorescence microscopy. Fifty isolates were included in the study, of which 28.0% were biofilm producers (64.2% from blood and 35...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38296538/relationship-of-toll-like-receptor-7-9-and-10-polymorphisms-on-the-severity-of-covid-19
#24
JOURNAL ARTICLE
Burcu Bayyurt, Sevgi Baltacı, Nil Özbilüm Şahin, Serdal Arslan, Mehmet Bakır
COVID-19 is an pandemic that is still affecting today and has caused many deaths. Toll-like receptor (TLR) have an important role in the binding of disease agents to host cell, disease susceptibility and severity, host disease resistance, In this study, we investigated frequencies of TLR7 (C.4-151 A/G), TLR9 (T-1486C and G2848A), and TLR10 (720A/C and 992T/A) single nucleotide polymorphisms (SNPs) in 150 cases with COVID-19 and 171 control samples. We also observed whether TLR7, 9, and 10 were related with the COVID-19 disease severity...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38296537/antimicrobial-resistance-patterns-of-common-gram-negative-microorganisms-isolated-from-patients-with-lower-respiratory-tract-infection-in-a-teaching-hospital-in-vietnam
#25
JOURNAL ARTICLE
Hoang Huy Le, An Van Nguyen, Luong Huy Vu, Vinh Thi Ha Nguyen, Hoa Quynh Pham, Hung Van Le, Son Thai Nguyen, Hong Thu Le, Hung Viet Dinh, Nam Van Le, Tuan Dinh Le, Minh Nhat Le, Viet Hoang Nguyen, Kien Trung Hoang, Hai Ha Long Le
This cross-sectional study investigated the antimicrobial resistance (AMR) patterns of Gram-negative pathogens isolated from 4,789 hospitalized patients with lower respiratory tract infections (LRTIs). Of the collected specimens, 1,325 (27.7%) specimens tested positive for Gram-negative bacteria. The most prevalent isolates were Acinetobacter baumannii (38.6%), Pseudomonas aeruginosa (33.5%), Klebsiella pneumoniae (18.7%), Escherichia coli (5.6%), and Klebsiella aerogenes (3.5%). Antimicrobial resistance analysis revealed high resistance rates among A...
January 31, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38267044/importance-of-toxin-genes-and-polymerase-chain-reaction-based-open-reading-frame-type-analyses-for-severe-staphylococcus-aureus-infection-in-children
#26
JOURNAL ARTICLE
Noriko Takeuchi, Naruhiko Ishiwada
No abstract text is available yet for this article.
2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38171850/pancreatic-injury-is-associated-with-poor-prognosis-in-severe-fever-with-thrombocytopenia-syndrome
#27
JOURNAL ARTICLE
Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were included in the analysis from April 2016 to April 2022. Multivariable logistic regression analysis showed that pancreatic injury (OR=3...
December 28, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38171849/dysregulated-leukotriene-metabolism-in-covid-19-patients
#28
JOURNAL ARTICLE
Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz
The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group, both non-ICU and ICU groups had lower levels of 5-LO and mRNA expression...
December 28, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38171848/first-detection-of-the-jingmen-tick-virus-in-amblyomma-testudinarium-ticks-from-the-kanto-district-japan
#29
JOURNAL ARTICLE
Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa
In 2010, the Jingmen tick virus (JMTV) was discovered in ticks in China and has been shown to be distributed in several regions worldwide. Recently, cases of JMTV infection in humans have been reported in China and Kosovo, attracting much attention as an emerging tick-borne disease. In this study, we detected the JMTV genome in Amblyomma testudinarium ticks collected in Kanagawa Prefecture, Japan, during tick-borne virus surveillance conducted in the Kanto district. Phylogenetic analysis revealed that the new JMTV strain is closely related to previous strains detected in Japan...
December 28, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38171847/molecular-epidemiology-of-human-metapneumovirus-before-and-after-covid-19-in-east-japan-in-2017-2022
#30
JOURNAL ARTICLE
Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto
Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G) gene sequences, and the A2 subgroup is further separated into three subdivisions A2a, A2b (A2b1), and A2c (A2b2). The appearance of subgroup A2c viruses carrying a 180- or 111-nucleotide duplication in the G gene (A2c180nt-dup or A2c111nt-dup ) have been reported in Japan and Spain. The pandemic of coronavirus disease 2019 (COVID-19) disrupted the epidemiological kinetics of other respiratory viruses, including hMPV...
December 28, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38171846/cross-neutralization-activities-of-antibodies-against-18-lyssavirus-glycoproteins
#31
JOURNAL ARTICLE
Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda
Some lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with expression plasmids of the glycoproteins of all 18 lyssaviruses were prepared, and cross-reactivity was evaluated via virus-neutralization tests using RABV, European bat lyssavirus-1 (EBLV-1), Duvenhage virus (DUVV), Mokola virus (MOKV), and Lagos bat virus (LBV)...
December 28, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030273/bacterial-infections-versus-viral-infections-preference-of-abo-blood-group-phenotype-patient
#32
JOURNAL ARTICLE
Jamil Mohammed Abduh Saeed Obaid, Fadhl Ahmed Saeed Al-Gashaa
Several studies have established an association between the blood group type and susceptibility to infections. This study aimed to evaluate a correlation between the blood group type and the susceptibility to infection. 558 patients were enrolled in this study who attended at the Althawra Hospital, Ibb city, from March to August 2018. A blood sample was analyzed for complete blood count (CBC) and blood group. High frequency of infections affecting the digestive system (26.4%), while the less affected system is the urogenital system 5...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030272/high-prevalence-of-carbapenem-resistant-enterobacterales-producing-oxa-48-among-carbapenem-resistant-isolates-in-a-regional-hospital-in-central-taiwan
#33
JOURNAL ARTICLE
Lii-Tzu Wu, Hong-Thuy Vy Nguyen, Se-Chin Ke, Yi-Pei Lin, Yi-Chun Pang, Ming-Kai Guo, Chih-Ming Chen
In response to rising carbapenem-resistant Enterobacterales (CRE), our study investigated carbapenemase-producing Klebsiella pneumoniae and non-K. pneumoniae epidemiology and genetics. We collected 76 clinical Enterobacterales and four stool surveillance Escherichia coli isolates resistant to ertapenem or imipenem. Using PCR and DNA sequencing, we assessed carbapenemases, extended-spectrum β-lactamases, and AmpC β-lactamases. Molecular typing via pulsed-field gel electrophoresis (PFGE) and a conjugation experiment examining resistance gene transfer were conducted...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030271/establishment-of-reference-reagents-for-single-radial-immunodiffusion-assay-on-the-2022-23-seasonal-influenza-vaccine-in-japan-and-their-quality-validation
#34
JOURNAL ARTICLE
Noriko Shimasaki, Tomoko Kuwahara, Haruna Nishijima, Kazuya Nakamura, Kayoko Sato, Keiko Murano, Shigeyuki Itamura, Yukiko Akahori, Emi Takashita, Noriko Kishida, Tomoko Arita, Mina Nakauchi, Makoto Takeda, Hideki Hasegawa, Akihide Ryo, Yuichi Harada
Potency test of influenza vaccine is currently performed using a single-radial-immunodiffusion (SRID) assay, which requires a reference antigen and anti-hemagglutinin (HA) serum as reference reagents. The reagents must be newly prepared each time the strain used for vaccine production is changed. Establishing reference reagents with consistent quality is, therefore, crucial to accurately and precisely conduct vaccine potency tests. Here, we established the reference reagents for the SRID assay to conduct lot release tests of quadrivalent influenza vaccines in Japan for the 2022/23 influenza season...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030270/difficulty-in-serologic-screening-for-subclinical-rubella-during-pregnancy
#35
JOURNAL ARTICLE
Kazuya Hiiragi, Ryosuke Shindo, Satoru Shinoda, Mika Okuda, Keiko Tanaka-Taya, Kentaro Kurasawa, Etsuko Miyagi, Shigeru Aoki
In Japan, rubella antibodies are measured in all pregnant women in order to detect subclinical infection. The study aimed to assess the validity of measuring rubella antibodies to detect subclinical rubella among pregnant women in Japan. This single-center, retrospective study measured rubella hemagglutination inhibition (HI) titers and rubella-specific IgM antibody index values (IgM-values). IgM-values were measured by enzyme immunoassay, and IgM-values > 1.2 were considered positive. Of 14965 pregnant women who were included, 186 (1...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030269/a-case-of-legionella-pneumophila-serogroup-13-pneumonia-based-on-the-detection-of-serogroup-specific-genes-in-culture-negative-sputum
#36
JOURNAL ARTICLE
Junji Seto, Jun Takahashi, Mika Sampei, Tatsuya Ikeda, Katsumi Mizuta
Legionella pneumophila serogroup (SG) 1, the main cause of Legionnaires' disease, can be diagnosed with urinary antigen testing kits; however, lower respiratory tract specimen culture is necessary to identify L. pneumophila SG 2-15. We attempted to detect L. pneumophila SG-specific genes in a culture-negative sputum specimen from a patient with pneumonia suspected to have Legionnaires' disease. Two multiplex PCR methods targeting L. pneumophila were modified and amplicons considered to be SG13 specific were detected...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030268/development-of-molecular-based-screening-test-for-hepatitis-b-virus-in-human-plasma-samples
#37
JOURNAL ARTICLE
Kevser Hanne Altın, Esra Agel
Despite the HBV vaccine being routinely administered in many countries, the death rate remains significant. Antiviral medications are available for the treatment of HBV infection, but patients encounter various serious complications in cases of chronic HBV infection. The failure of serological tests to detect early viral replication prevents early treatment response. Recently, many studies have demonstrated significant advantages of the loop-mediated isothermal amplification (LAMP) assay over serological testing and PCR for the rapid detection of microbial pathogens...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38030267/cleavage-activation-of-respiratory-viruses-half-a-century-of-history-from-sendai-virus-to-sars-cov-2
#38
JOURNAL ARTICLE
Makoto Takeda
For many viruses, cleavage activation of membrane fusion protein by host proteases is required for infection. This knowledge is based on the historical studies on Sendai virus in the 1970s. From the 1970s to the 1990s, the avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and host proteases' cleavage activation of viral membrane fusion proteins (hemagglutinin and fusion proteins). In these viruses, the cleavage of viral membrane fusion proteins by furin is the basis for their high virulence...
November 30, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/37914294/the-long-term-serological-profile-of-coronavac-vaccine-based-on-comorbidities-and-history-of-sars-cov-2-infection-in-indonesia
#39
JOURNAL ARTICLE
Syahrul Chilmi, Tanti Adelia Kesuma, Purwa Adrianta Wibawa, Hani Susianti, Agustin Iskandar, Indah Adhita Wulanda, Caesarius Singgih Wahono, Kusworini Handono
CoronaVac emerged as one of the most widely administered COVID-19 vaccine in Indonesia. Previous research has documented various figures regarding its effectiveness in protecting against COVID-19 in several countries. Therefore, this research aims to assess the long-term immunogenicity profile in individuals with comorbidities or history of SARS-CoV-2 infection. The level of total anti-N Ig and anti-S-RBD Ig at 7 weeks and 26 weeks after receiving the second dose was observed in 194 health workers. The participants were divided into groups based on their comorbidities and history of SARS-CoV-2 infection...
October 31, 2023: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/37914293/impact-of-covid-19-and-closed-transmission-of-sars-cov-2-during-the-first-wave-in-toyama-prefecture-japan-march-30-to-may-18-2020
#40
JOURNAL ARTICLE
Kosuke Tamura, Noriko Inasaki, Masae Itamochi, Yumiko Saga, Takahisa Shimada, Shunsuke Yazawa, Hitoshi Sasajima, Chikako Kawashiri, Emiko Yamazaki, Tomomi Ichikawa, Hiroyasu Kaya, Yoshihiro Yamamoto, Yoshitomo Morinaga, Seiji Yamashiro, Satoshi Nomura, Shinichi Takeda, Hiroyuki Itoh, Koujiro Hirota, Yukio Horie, Norikazu Hirano, Tsuyoshi Sekizuka, Makoto Kuroda, Hideki Tani, Kazunori Oishi
We studied 226 patients in Toyama Prefecture, notified with COVID-19 during the first wave between March 30 and May 18, 2020. Of the 226 patients, 22 (9.7%) died, of whom most (95%) were aged ≥65 years. A large cluster comprising 59 patients (41 residents and 18 staff members) was identified in a nursing home on April 17. No deaths occurred among the staff members, but 12 of the 41 cases in residents (29%) died. Although the Ct values were significantly lower in the 20-64 and the ≥65 years age-groups than in the age <20 years age-group, no correlation was found between the Ct values and the severity, fatal outcome, or secondary infection...
October 31, 2023: Japanese Journal of Infectious Diseases
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